Clinical trials: Uncertainty
Healthy Volunteers
Cross-sectional Analysis of Non-technical Attributes and Surgical Experience in Surgical Staff, Trainees and Applicants.
This study consists of an analysis of the communication styles and attitudes towards risk and uncertainty (i.e. non-technical attributes) in a surgical population with varying clinical experience.
- Trial name
- NCT03728088
- Testing
- Rating scales concerning non-technical attributes
- Volunteers
- 120 people
- Sponsor
- University Ghent
Depression, Anxiety
Income Volatility and Mental Health, Full Experiment
Income instability is a defining aspect of the lives of the poor, who also disproportionately suffer from poor mental and physical health.
- Conditions
- Depression, Anxiety, Blood Pressure
- Trial name
- NCT06988410
- Testing
- Work opportunities
- Where
- Ghana
- Volunteers
- 2,267 people, healthy volunteers welcome
- Sponsor
- Cornell University
Colorectal Cancer
SCar-biopsies After Malignant Colorectal Polypectomy of Uncertain RAdicality
After endoscopic removal of a colorectal polyp that harbors (unexpected) adenocarcinoma, pathology usually can not guarantee a radical resection from an oncological point of view.
- Trial name
- SCAPURA (NCT02328664)
- Testing
- Flexible sigmoidoscopy or colonoscopy
- Where
- 36 sites in Netherlands
- Volunteers
- 246 people
- Sponsor
- Dr. Frank ter Borg MD PhD
Parkinson's Disease, Primary Parkinsonism
A Trial of 18F-AV-133 Positron Emission Tomography (PET) Imaging to Differentiate Subjects With Parkinson's Disease (PD) From Other Movement Disorders
The purpose of this study is to determine whether 18F-AV-133 PET scans can be used to differentiate subjects with Parkinson's Disease from other movement disorders.
- Conditions
- Parkinson's Disease, Primary Parkinsonism, Lewy Body Parkinson's Disease
- Trial name
- NCT01550484
- Testing
- 18F-AV-133
- Where
- 15 sites in United States, Australia
- Volunteers
- 170 people
- Sponsor
- Avid Radiopharmaceuticals
Monoclonal Gammopathy of Undetermined Significance (MGUS), Myelodysplastic Syndromes
Study of MGUS, Smoldering Myeloma, Early MDS and CLL to Assess Molecular Events of Progression and Clinical Outcome
Blood cancers occur when the molecules that control normal cell growth are damaged. Many of these changes can be detected by directly examining parts of the cancer or cells in blood.
- Conditions
- Monoclonal Gammopathy of Undetermined Significance (MGUS), Myelodysplastic Syndromes, Hematological Malignancies, B-cell Malignancy, Low-grade
- Trial name
- NCT02269592
- Where
- 7 sites in United States
- Volunteers
- 10,000 people
- Sponsor
- Dana-Farber Cancer Institute
Uncertainty, Communication Research
Trial of Simulation-based Mastery Learning to Communicate Diagnostic Uncertainty
The goal of this study is to teach emergency medicine resident physicians to communicate more effectively with patients at the time of emergency department discharge in the setting of diagnostic uncertainty (i.e.
- Conditions
- Uncertainty, Communication Research, Emergency Medicine
- Trial name
- NCT04021771
- Testing
- Educational Curriculum Intervention
- Where
- 2 sites in United States
- Volunteers
- 109 people
- Sponsor
- Thomas Jefferson University
Generalized Anxiety Disorder
A Single-Component CBT for GAD
Generalized Anxiety Disorder (GAD) is a chronic condition that is characterized by excessive and uncontrollable worry and anxiety. In Canada, 3 to 4% of the population suffer from GAD at any point in time.
- Trial name
- NCT02552108
- Testing
- Behavioural experiments for intolerance of uncertainty (BE-IU)
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universite du Quebec en Outaouais
Cardiovascular Diseases, Heart Diseases
Physician Uncertainty Reduction for Hypertension
The purpose of this study is to test the theory that a major factor in poor blood pressure (BP) control is that physicians fail to intensify antihypertensive therapy for their patients.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension
- Trial name
- NCT00201084
- Testing
- Uncertainty reduction
- Where
- United States
- Volunteers
- 670 people
- Sponsor
- Baylor College of Medicine
Anxiety Postoperative, Patient Non-Compliance
Psychological and Physical Distress and Care Needs in Operable Lung Cancer Patients Receiving Surgery
The lung cancer is the most has the life minacity in all kinds of cancers, and it also remains the most common cause of cancer-related death in the world.
- Conditions
- Anxiety Postoperative, Patient Non-Compliance, Psychological Distress
- Trial name
- NCT01362842
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Coronary Heart Disease (CHD)
Scalable Clinical Oversight of Large Language Models Via Uncertainty Triangulation
This prospective, multi-reader, randomized crossover trial evaluates SCOUT (Scalable Clinical Oversight via Uncertainty Triangulation), a model-agnostic meta-verification framework that selectively defers unreliable large…
- Trial name
- SCOUT (NCT07414966)
- Testing
- SCOUT-Assisted Review Workflow, Standard Manual Review Workflow
- Volunteers
- 7 people
- Sponsor
- China National Center for Cardiovascular Diseases
Syncope
International Study on Syncope of Uncertain Etiology
This is a multi-center, prospective, observational study enrolling 400 patients with suspected or certain neurally-mediated syncope, who undergo carotid sinus massage, tilt testing and Implantable Loop Recorder (ILR)implantation.
- Trial name
- NCT00120094
- Where
- 3 sites in Italy, United Kingdom
- Volunteers
- 400 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Breast Cancer, Breast Lesions of Uncertain Malignant Potential (B3 Lesions)
BRCA1, RASSF1A and PTEN Methylation in Breast Lesions of Uncertain Malignant Potential
This prospective interventional diagnostic study evaluates the clinical utility of methylation analysis of BRCA1, RASSF1A and PTEN genes in breast lesions of uncertain malignant potential (B3 lesions).
- Trial name
- NCT07416500
- Testing
- MS-MLPA Methylation Analysis
- Where
- Slovenia
- Volunteers
- 301 people
- Sponsor
- Institute of Oncology Ljubljana
Sexual Assault, Alcohol Intoxication
Examining the Role of Sensitivity to Uncertain Threat and Alcohol Response in Risk for Alcohol Use Disorder Following Sexual Assault in College Women
The goal of this clinical trial is to determine whether women who engage in heavy drinking with a history of sexual assault (SA) victimization show heightened baseline reactivity to uncertain threat (U-threat), whether alcohol…
- Trial name
- NCT07894289
- Testing
- Alcohol
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- Ohio State University
Generalized Anxiety Disorder
Effects and Mechanisms of Change of Internet Delivered Cognitive Behavior Therapy for Generalized Anxiety Disorder
The goal of this clinical trial is to compare two psychological treatments for Generalized Anxiety Disorder. The main questions it aims to answer are: How well do these treatments work compared to earlier studies? Is one of the…
- Trial name
- ORIGAMI (NCT05849493)
- Testing
- Metacognitive Internet delivered Cognitive Behavior Therapy, Intolerance of uncertainty based Internet delivered Cognitive Behavior Therapy
- Where
- Sweden
- Volunteers
- 400 people
- Sponsor
- Karolinska Institutet
Prostate Cancer
Reducing the Effects of Active Surveillance Stress, Uncertainty and Rumination Thru Engagement in Mindfulness Education
We propose to examine the efficacy of couples-based mindfulness-based stress reduction (MBSR) on positive and negative psychological responses to active surveillance (AS) and AS adherence, with a sample of men on AS and their…
- Trial name
- REASSUREME (NCT02871752)
- Testing
- Health promotion
- Where
- 4 sites in United States
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Parkinsonian Syndromes
A Study to Assess Changes in Clinical Management After DaTSCAN Imaging of Subjects With Clinically Uncertain Parkinsonism or an Illness With Similar Symptoms
Patients come to their doctor showing possible symptoms of a movement disorder. It is possible that these symptoms may get worse over time. There is more than one disease that can cause such symptoms.
- Trial name
- NCT00382967
- Testing
- DaTSCAN SPECT imaging
- Where
- 2 sites in United States, France
- Volunteers
- 273 people
- Sponsor
- GE Healthcare
ER-positive Her2-negative Early Breast Cancer
Assessment of Genomic Test Impact on Shared Decision of Adjuvant Chemotherapy in ER-positive, Her2-negative Early Breast Cancer
The need/benefit of adjuvant chemotherapy could be negligible for a certain category of patient with newly diagnosed unilateral non metastatic breast cancer.
- Trial name
- OPTIGEN (NCT03080428)
- Testing
- Genomic test
- Sponsor
- UNICANCER
Heart Failure
Preparatory Work for a Trial of Adjuncts to Diuretic Treatment in Patients Hospitalised With Heart Failure: Addressing Uncertainties and Building Consensus
Aims and Objectives 1. Choose which adjunctive therapies, at what dose, and for how long 2. Choose the dose(s) of IV furosemide to be used as the comparator 3. Choose primary and secondary outcomes 4.
- Trial name
- Pre-MAMMOTH-HF (NCT07281040)
- Testing
- Patient and carer panel using nominal group approach and thematic analysis
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Neoplasm, Uncertain Whether Benign or Malignant
Coordinate Regulation of Transfusions by Uploading
Currently in the Toulouse University Hospital, the organization of transfusion care for patients requiring regular transfusions is based on reading the biological results received by fax before confirming or disproving a planned…
- Trial name
- RTT (NCT02851225)
- Testing
- telemedicine transmission of biological results
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Toulouse
Generalized Anxiety Disorder
6-Session Treatment for Generalized Anxiety Disorder
Generalized Anxiety Disorder (GAD) is a chronic condition that is characterized by excessive and uncontrollable worry and anxiety. In Canada, 3 to 4% of the population suffer from GAD at any point in time.
- Trial name
- NCT03433625
- Testing
- Behavioural experiments for intolerance of uncertainty (BE-IU)
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Universite du Quebec en Outaouais