Clinical trials: Uncertainty
Unrecognized Condition
SKin Uncertainties Modeling
The study is based on measurement device and will provide a database of viscoelastic properties of the forearm skin among healthy volunteers.
- Trial name
- SKUM (NCT04995549)
- Testing
- Cutiscan® CS 100
- Where
- France
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Besancon
High-risk Pregnancy
Affirmation-Based Information for Stress Reduction in High-Risk Pregnancy
This study examined whether providing affirmation-based information to high-risk pregnant women admitted to the obstetrics emergency department could reduce stress levels and intolerance of uncertainty.
- Trial name
- NCT07407322
- Testing
- Affirmation + Information Group
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Nilgun Avci
Neuroblastoma
Nurse Case Manager Model on Neuroblastoma Caregiver's Uncertainty
Clinical Problem and Significance: The incidence of neuroblastoma is about 30 cases a year in Taiwan. The five-year survival rate of neuroblastom is near 50% in Taiwan.
- Trial name
- NCMM (NCT01525251)
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Obsessive-Compulsive Disorder
Decision-making Impairments in OCD: An Integrated Behavioral Economics Model
The investigators are examining whether conditions of ambiguity during decision-making may prime intolerance of uncertainty beliefs (i.e., difficulties coping with ambiguity, unpredictability, and the future) and lead to impaired…
- Trial name
- NCT03420495
- Testing
- Decision-Making Tasks
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Diagnostic Uncertainty
Targeted EHR-based Communication of Diagnostic Uncertainty in the ED
The goal of the clinical trial is to evaluate the preliminary effectiveness and the implementation feasibility of the Targeted EHR-based Communication about Uncertainty (TECU) strategy in improving the quality of care transitions…
- Trial name
- TECU (NCT06638021)
- Testing
- Targeted EHR-based Communication of Diagnostic Uncertainty (TECU)
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Thomas Jefferson University
Stress
Where Does Hope Fit In? The Relationship Between Hope, Uncertainty, and Coping Efficacy in Mothers of Children With Duchenne/Becker Muscular Dystrophy
Background: Children with Duchenne/Becker Muscular Dystrophy (DBMD) slowly lose muscle function. They usually die at a young age. Some mothers adapt to the demands of caring for a child with this disease better than others.
- Trial name
- NCT02194725
- Where
- United States
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- National Human Genome Research Institute (NHGRI)
Mental Disorders, Mood Disorders
Group Transdiagnostic Cognitive Behavioural Therapy for Intolerance of Uncertainty Versus Applied Relaxation
Many people find uncertainty distressing, but for some, it may become overwhelming and drive persistent anxiety, worry, and avoidance.
- Conditions
- Mental Disorders, Mood Disorders, Anxiety Disorders, Generalized Anxiety Disorder
- Trial name
- OBSCURA (NCT07866794)
- Testing
- Group Transdiagnostic Cognitive Behavioural Therapy for Intolerance of Uncertainty (CBT-IU), Group Transdiagnostic Applied Relaxation (AR)
- Where
- United Kingdom
- Volunteers
- 135 people
- Sponsor
- Medical Research Council Cognition and Brain Sciences Unit
Generalized Anxiety Disorder
Cognitive-behavioral Therapy for Generalized Anxiety Disorder in Primary Care
The feasibilty and preliminary comparative effectiveness of two methods of cognitive-behavioral therapy - metacognitive therapy and intolerance of uncertainty therapy - for primary care patients with generalized anxiety disorder…
- Trial name
- NCT03621371
- Testing
- Metacognitive therapy, Intolerance of uncertainty therapy
- Where
- Sweden
- Volunteers
- 64 people
- Sponsor
- Karolinska Institutet
Monoclonal Gammopathy of Uncertain Significance
Zanubrutinib Treatment in Patients With IgM Monoclonal Gammopathy and Antri-MAG Related Polyneuropathy
The objective of this investigator-initiated phase II single-arm open-label clinical trial is to investigate neurological response rate, safety and tolerability of Zanubrutinib 320 mg daily in combination with Rituximab 375 mg/m2…
- Trial name
- MAGNAZ (NCT05939037)
- Testing
- Zanubrutinib Oral Product
- Where
- Netherlands
- Volunteers
- 35 people
- Sponsor
- UMC Utrecht
Liver Diseases
Uncertainty Management Intervention
The goal of this study is to improve symptoms and quality of life for end-stage liver disease patients awaiting a liver transplant and their caregivers by providing them with the resources and tools to self-manage their complex…
- Trial name
- NCT00938795
- Testing
- Uncertainty Management Intervention, Comparison Conditions for Liver Transplant
- Where
- 4 sites in United States
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- Duke University
Coronary Artery Disease
Zotarolimus-eluting Endeavor Sprint Stent in Uncertain DES Candidates (ZEUS) Study
To prospectively evaluate in a multicenter open label trial whether the use of zotarolimus-eluting ENDEAVOR Stent implantation in patients at low restenosis or at high bleeding or thrombotic risk will decrease the incidence of…
- Trial name
- ZEUS (NCT01385319)
- Testing
- Bare metal stent implantation, zotarolimus eluting stent
- Where
- 16 sites in Hungary, Italy and 2 more
- Volunteers
- 1,606 people
- Sponsor
- Marco Valgimigli
Intolerance of Uncertainty, Anxiety
Test of Target Engagement of Ambiguity Aversion
The present work aims to test whether a single session intervention alters ambiguity aversion, both in terms of people's decision making and their brain responses to ambiguous choices.
- Conditions
- Intolerance of Uncertainty, Anxiety, Intolerance of Uncertainty; Anxiety, Depression, Anxiety
- Trial name
- NCT06962527
- Testing
- Uncertainty-focused single session intervention, Maintaining a healthy lifestyle single session intervention
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Uncertainty, Advanced Cancer
Uncertainty in Illness in Palliative Care: an Intervention for Family Caregivers
Background: The increase of chronic diseases has reached an increase in the suffering of advanced diseases and an inability of health care systems to give access to the population that suffers them.
- Conditions
- Uncertainty, Advanced Cancer, Family Members, Quality of Life
- Trial name
- NCT03518970
- Testing
- Nursing intervention
- Volunteers
- 60 people
- Sponsor
- Universidad Nacional de Colombia
Infant, Premature, Infant, Low Birth Weight
Global Survey on Newborns' HOspitalisation and Parental Experiences - the HOPE Study
This study aims to explore parents' experiences and emotional burdens related to their newborn's hospital stay using an online survey.
- Conditions
- Infant, Premature, Infant, Low Birth Weight, Parents, Life Change Events
- Trial name
- HOPE (NCT06827028)
- Testing
- N/A, no intervention, participation in survey
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Global Foundation for the Care of Newborn Infants
Peripheral Nerve Stimulation in MRI, Electric Stimulation
Uncertainty Analysis of Computational Model to Simulate Neurostimulation Caused by Gradient Fields in MRI
The aim of this research project is to quantify the uncertainty of current state-of-the art anatomical phantoms and computational models for predicting neurostimulation induced by time-varying magnetic fields (so-called gradient…
- Trial name
- NEUROMAN (NCT04674787)
- Testing
- Peripheral nerve stimulation provocation study
- Where
- Switzerland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Bryn Lloyd
Nursing
Effectiveness of Calgary Family Intervention Model in Caregivers
Effectiveness of Calgary family intervention model improving on uncertainty, family functioning, and resilience in caregivers of infants and toddlers undergoing open-heart surgery.Research hypothesis is The experimental group of…
- Trial name
- NCT06004622
- Testing
- Calgary Family Intervention Model
- Where
- Taiwan
- Volunteers
- 64 people
- Sponsor
- National Taiwan University Hospital
Generalized Anxiety Disorder, Emotional Disorder
Acceptability/Feasibility of IU Intervention
Anxiety disorders are prominent mental health burdens, affecting roughly 1 in 5 adults annually, and a third of individuals over the course of their life.
- Trial name
- CLUE (NCT05172427)
- Testing
- 14 days of EMI, Uncertainty reappraisal training
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Ohio University
Children With Medical Complexity (CMC), Multiple Chronic Conditions
Developing an Innovative Decision Support Tool for Pediatric Neuromuscular Scoliosis
The goal of this pilot hybrid type I efficacy/implementation trial is to assess a newly developed decision support tool patients, parents, and providers to use during surgical treatment decision making for neuromuscular scoliosis…
- Conditions
- Children With Medical Complexity (CMC), Multiple Chronic Conditions, Neuromuscular Scoliosis, Shared Decision Making
- Trial name
- NCT07167927
- Testing
- Decision support tool
- Where
- 2 sites in United States
- Volunteers
- 110 people
- Sponsor
- University of Utah
Thyroid Cancer
Use of a Decision Aid to Resolve Uncertainty About Radioactive Iodine Treatment in Patients With Intermediate Risk Thyroid Cancer
The goal of this study is to learn if a decision aid (DA) website helps people with thyroid cancer make informed decisions about radioactive iodine (RAI) treatment.
- Trial name
- NCT06980103
- Testing
- Decision Aid, Usual Care
- Where
- 3 sites in United States
- Volunteers
- 408 people
- Sponsor
- Georgetown University
Stroke, Acute, Ischemic Stroke, Acute
Endovascular Therapy for Large Core Patients With Uncertain Response to Thrombectomy
The purpose of this study is to assess the safety and efficacy of endovascular thrombectomy in both an early and extended time window in patients with large strokes due to large artery occlusion.
- Trial name
- OUTER LIMITS (NCT06961487)
- Testing
- EndovascularThrombectomy, Endovascular thrombectomy with any FDA-approved device
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Stanford University