Clinical trials: Unconscious
Organ Transplant Failure or Rejection, Brain Death
Calcineurin Inhibitor in NEuRoloGically Deceased Donors to Decrease Kidney delaYed Graft Function (CINERGY)
The investigators hypothesize that preconditioning neurologically deceased organ donors with the calcineurin inhibitor tacrolimus will improve short and long-term transplant survival without causing harm.
- Conditions
- Organ Transplant Failure or Rejection, Brain Death, Ischemic Reperfusion Injury
- Trial name
- CINERGY (NCT05148715)
- Testing
- Tacrolimus
- Where
- 9 sites in Canada
- Volunteers
- 414 people
- Sponsor
- Université de Sherbrooke
Traumatic Brain Injury
Sodium Lactate in Severe TBI
This is a safety phase 2 clinical trial of intravenous infusion of sodium lactate in patients with severe TBI. This study is intended for patients in the acute setting in an intensive care unit at centers that have been selected…
- Trial name
- NCT06701760
- Testing
- Sodium Lactate
- Volunteers
- 264 people
- Sponsor
- University of California, Los Angeles
Brain Injury Traumatic Mild, Brain Injuries
Screening Emotions in Adolescents at the Hospital for mTBI
The goal of this observational study is to develop and validate a clinical tool to predict which adolescents aged 11 to less than 18 years of age with mild traumatic brain injury (mTBI) are at an increased risk for developing…
- Conditions
- Brain Injury Traumatic Mild, Brain Injuries, Brain Injuries, Acute, Head Injury With Intracranial Hemorrhage
- Trial name
- SEARCH-mTBI (NCT06370520)
- Testing
- Validated Questionnaires, Questionnaires, Clinician / Medical Record Variables
- Where
- 6 sites in United States
- Volunteers
- 2,592 people
- Sponsor
- University of California, Davis
Trauma, Nervous System, Brain Trauma
Characterization of the Sleep-Wake Cycle in Traumatic Brain Injury Patients with a Disorder of Consciousness
Each year in France, 160,000 peoples suffer from a mild or severe traumatic brain injury (TBI). Sleep plays a crucial role in the process of brain plasticity, which is essential for neurological and cognitive recovery.
- Trial name
- SLEEPDOC (NCT06766513)
- Testing
- Actimetry, Subjective assessments, questionnaire
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Hospices Civils de Lyon
Patients in Minimally Conscious State After a Severe Brain Injury (e.g., Anoxia, Traumatic Brain Injury, Stroke)
tDCS in MCS: Repeated Stimulations
In this study researchers will apply transcranial direct current stimulation (tDCS) for 5 consecutive days in chronic patients in minimally conscious state (MCS).
- Trial name
- tDCS in MCS (NCT02019615)
- Testing
- transcranial direct current stimulation
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- University of Liege
Syncope, Vasovagal
Cardiac Autonomic Dysfunction in Diabetics Patients With Syncope
Study hypothesis: cardiac autonomic dysfunction may affect vaso vagal syncope recurrences in type 2 patients with diabetes vs. patients without diabetes.
- Trial name
- NCT03717207
- Testing
- ecg Holter,, cardiac scintigraphy
- Where
- Italy
- Volunteers
- 242 people
- Sponsor
- University of Campania Luigi Vanvitelli
Unconscious State
The Effect of BIS Monitorization to Intraoperative Anesthetic Consumption During Coronary Artery Surgery
213 patients undergoing elective on-pump coronary artery bypass grafting (CABG) were enrolled into this prospective-clinical trial.After hundred and sixty three patients were excluded due to various reasons, 50 patients were…
- Trial name
- NCT02520947
- Testing
- BIS, Desflurane
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Baskent University Ankara Hospital
Coma
Fluctuation of Rhymicity to Predict Recovery
BRIEF SUMMARY : In the most severe cases of brain injuries, intensive care may allow patients with altered consciousness to survive despite a significant risk of heavy sequelae.
- Trial name
- FR2 (NCT04444648)
- Testing
- No intervention
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Hospices Civils de Lyon
Critical Illness, Near-Death Experience
Incidence of Episodes of (Dis)Connected Consciousness Among Emergency Patients Admitted in the Resuscitation Room
This observational study aims to describe the incidence of episodes of disconnected consciousness (including near-death experience (NDE)) and episodes of connected consciousness in patients admitted to the resuscitation room, who…
- Conditions
- Critical Illness, Near-Death Experience, Consciousness, Loss of, Quality of Life
- Trial name
- NCT06362525
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Liege
Healthy, Unconscious
External Nitric Oxide Measurement Through SNO Degradation
In this study, we aim to explore the feasibility of a novel, noninvasive SNO assay to acquire physiological SNO quantification from various parts of the human body and test this new method of analysis.
- Trial name
- NCT04903535
- Testing
- Alonefire SV003 10W 365nm UV Flashlight
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Indiana University
Brain Diseases, Vegetative State
Chinese Validation of the Simplified Evaluation of CONsciousness Disorders（SECONDs）
The aim of this study was to translate the SECONDs from French into Chinese and assess the validity and reliability of the Chinese version of the SECONDs .
- Conditions
- Brain Diseases, Vegetative State, Unconsciousness, Central Nervous System Diseases
- Trial name
- NCT05496985
- Testing
- Simplified Evaluation of CONsciousness Disorders (SECONDs)
- Where
- China
- Volunteers
- 49 people
- Sponsor
- Hangzhou Normal University
Healthy Amateur Divers
Effects of Voluntary Neck Extension on Cerebral Blood Flow, in Breath-hold Divers Ending an Apnoea of Two Minutes or More.
The aim of this study is to demonstrate the effect of the voluntary neck extension in the occurrence of an increase in the pulsatility index of the right internal carotid artery in the amateur diver, realizing an apnea of two…
- Trial name
- APNECK (NCT03210857)
- Testing
- apnea performing
- Where
- France
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Bradycardia, Syncope, Vasovagal
Comparison of Focal Cryoablation vs. Radiofrequency Cardioneuroablation for Bradyarrhythmias
Bradyarrhythmias are conditions where the heart beats too slowly, causing symptoms like dizziness, fainting, and fatigue. In some patients, these slow heart rhythms are caused by overactivity of the vagus nerve (the part of the…
- Conditions
- Bradycardia, Syncope, Vasovagal, Sick Sinus Syndrome, Atrioventricular Block
- Trial name
- CRYO-CNA vs RF (NCT07671898)
- Testing
- Focal Cryoablation, Radiofrequency Catheter Ablation
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Stress, Psychological, Maternal Health
Caring for Providers to Improve Patient Experience (CPIPE) Trial
The activities described in this proposal are aimed at addressing health care provider stress and unconscious bias to improve quality of maternal health care, particularly related to the person-centered dimensions of care-i.e.
- Conditions
- Stress, Psychological, Maternal Health, Healthcare Provider, Adverse Outcomes
- Trial name
- CPIPE (NCT06085105)
- Testing
- CPIPE Training, Peer support groups, Mentorship
- Where
- 2 sites in Ghana, Kenya
- Volunteers
- 6,379 people
- Sponsor
- University of California, San Francisco
Pain, Opioid Use
Nociception-Level (NOL) for the Assessment of Pain in Patient Unable to Self-Report
In this study we aimed to investigate the performance and effectiveness of NOL and/or NOLedge as a tool for pain assessment in geriatric and critical ill non communicating patients.
- Conditions
- Pain, Opioid Use, Dementia, Unconscious
- Trial name
- MoNOLog (NCT04581642)
- Testing
- PMD200
- Where
- Israel
- Volunteers
- 33 people
- Sponsor
- Medasense Biometrics Ltd
Vegetative State, Minimally Conscious State
Multichannel tDCS to Reduce Hypertonia in Patients With Prolonged DOC
Previous studies showed that transcranial direct current stimulation (tDCS) transiently improves performance of motor function in stroke patients, as well as decrease muscle hypertonia.
- Conditions
- Vegetative State, Minimally Conscious State, Spasticity, Muscle, Disorder of Consciousness
- Trial name
- NCT03797573
- Testing
- tDCS
- Where
- Belgium
- Volunteers
- 17 people
- Sponsor
- University of Liege
Post-Anoxic Coma, Postanoxic Enchephalopathie
Cracking Coma: Towards EEG and MRI Based Precision Medicine After Cardiac Arrest
Rationale: 30-70% of comatose patients admitted to the intensive care unit (ICU) after cardiac arrest never regain consciousness as a result of post anoxic encephalopathy (PAE).
- Trial name
- NCT03308305
- Where
- 3 sites in Netherlands
- Volunteers
- 94 people
- Sponsor
- Rijnstate Hospital
Coma
Multimodal Resonance Imaging for Outcome Prediction on Coma Patients
Stroke, traumatic head injury, subarachnoid hemorrhage and cerebral anoxia are main causes of a coma condition implying severe brain damage and thus, poor prognosis.
- Trial name
- MRI-Coma (NCT00577954)
- Testing
- Multimodal MRI
- Where
- France
- Volunteers
- 417 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Disorder Related to Lung Transplantation, Brain Death
Ex-Vivo Lung Perfusion to Increase the Number of Organs for Transplantation
The recent introduction of ex-vivo lung perfusion (EVLP) as a tool to evaluate and recondition lungs from marginal donors has opened a new era in the field of lung transplantation.
- Conditions
- Disorder Related to Lung Transplantation, Brain Death, Graft Failure, Primary Graft Dysfunction
- Trial name
- EVLP_MI (NCT01967953)
- Testing
- EVLP Group
- Where
- Italy
- Volunteers
- 7 people
- Sponsor
- Policlinico Hospital
Syncope
Creation of a Syncope Channel for Patients Admitted to the Emergency Department for Loss of Consciousness and Not Hospitalized: Etiological Predictivity (Before/After Study)
The main aim of this study is to assess the value of creating a "syncope pathway" to optimize diagnostic performance in patients admitted to the emergency department for syncope and not hospitalized, compared with the previous…
- Trial name
- Sync'Hope (NCT06503653)
- Testing
- syncope channel, routine care
- Where
- France
- Volunteers
- 52 people
- Sponsor
- Versailles Hospital