Clinical trials: Unconscious
Pain, Opioid Use
Nociception-Level (NOL) for the Assessment of Pain in Patient Unable to Self-Report
In this study we aimed to investigate the performance and effectiveness of NOL and/or NOLedge as a tool for pain assessment in geriatric and critical ill non communicating patients.
- Conditions
- Pain, Opioid Use, Dementia, Unconscious
- Trial name
- MoNOLog (NCT04581642)
- Testing
- PMD200
- Where
- Israel
- Volunteers
- 33 people
- Sponsor
- Medasense Biometrics Ltd
Arrhythmias, Cardiac, Bradycardia
One Hospital ClinicalService Project
The One Hospital ClinicalService Project is an integrated system composed by a network of International Hospital Departments, a clinical data repository and a shared environment for the collection, management, analysis and…
- Conditions
- Arrhythmias, Cardiac, Bradycardia, Syncope
- Trial name
- OHCS (NCT01007474)
- Testing
- Implantable Cardioverter-Defibrillator (ICD), Implantable Pacemaker Generator (IPG), Implantable Loop Recorder (ILR)
- Where
- 41 sites in Germany, Iceland and 7 more
- Sponsor
- Medtronic Italia
Healthy
Effect of Dietary Salt Supplemantation in Vasovagal Syncope Prophylaxis: A Clinical Trial
Syncope is a syndrome consisting of a relatively short period of temporary and self-limited loss of consciousness caused by transient diminution of blood flow to the brain (most often the result of systemic hypotension).
- Trial name
- NCT00465946
- Testing
- Salt Supplementation
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Syncope
Evaluating an Emergency Department Observation Syncope Protocol for Older Adults
Syncope, defined as a transient loss of consciousness, accounts for over 700,000 annual U.S. emergency department visits and may herald a life-threatening condition in older adults (age≥60 years).
- Trial name
- NCT01003262
- Testing
- Emergency Department Observation Protocol, Unstructured, inpatient evaluation
- Where
- 4 sites in United States
- Volunteers
- 123 people
- Sponsor
- University of California, Los Angeles
Disorders of Consciousness, Minimally Conscious State
Aiming for a Better Understanding and Improvement of the Diagnosis and Prognosis of Patients With Disorders of Consciousness Through Multimodal Observations
Improved treatment of severe brain injuries has resulted in increased survival rates. While some of these patients regain consciousness after a transient state of coma, others may develop a disorder of consciousness (DoC).
- Conditions
- Disorders of Consciousness, Minimally Conscious State, Unresponsive Wakefulness Syndrome, Caregivers
- Trial name
- PerBrain (NCT04798456)
- Testing
- Coma scales, Imaging, electrophysiology, body signals, and brain stimulation, Questionnaires
- Where
- 4 sites in France, Germany and 2 more
- Volunteers
- 150 people
- Sponsor
- Paris Brain Institute (ICM)
Type 1 Diabetes, Hypoglycemia
Impact of Hypoglycemia Unawareness on Brain Metabolism Cognition in T1DM
The research study is designed to examine the impact of low blood sugar on brain function in individuals with Type 1 Diabetes who have frequent and severe hypoglycemia (low blood sugar) compared to those who do not.
- Trial name
- NCT00575783
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Yale University
Syncope, Pediatric
Pediatric Adhesion and New Dermal Approach Study
The purpose of this study is to see if the Zio® monitor device can be worn by children for up to 14-days and to determine if the skin preparation process will provide good adherence to the skin and clear signal quality.
- Conditions
- Syncope, Pediatric, Congenital Athymia, Congenital Heart Disease
- Trial name
- PANDA (NCT07118124)
- Testing
- Zio monitor
- Where
- 4 sites in United States
- Volunteers
- 36 people
- Sponsor
- iRhythm Technologies, Inc.
Consciousness Disorder, Brain Injuries
Neural, Behavioural, and Clinical Effects of tDCS in PDOC; Feasibility Study
This study evaluates the feasibility of an experimental protocol that combines advanced multi-modal imaging of the brain with clinical and behavioural scales to characterise the neural, behavioural, and clinical effects of…
- Conditions
- Consciousness Disorder, Brain Injuries, Vegetative State, Minimally Conscious State
- Trial name
- RAINDROP (NCT04248946)
- Testing
- Transcranial direct current stimulation
- Where
- 2 sites in United Kingdom
- Volunteers
- 15 people
- Sponsor
- University of Birmingham
Syncope
Diagnostic Yield of an Ambulatory Patch Monitor in Unexplained Emergency Department Syncope: A Pilot Study (PATCH-ED)
Syncope is a common Emergency Department (ED) presentation but the underlying diagnosis is not apparent in 60% of patients after assessment and serious adverse event rate is 7% at one month with most having acute cardiovascular…
- Trial name
- PATCH-ED (NCT02683174)
- Testing
- Novel ambulatory patch (ZIO® XT Patch), BNP and hs-troponin I at 0 and 3 hours post ED attendance
- Where
- United Kingdom
- Volunteers
- 86 people
- Sponsor
- NHS Lothian
Type 1 Diabetes Mellitus
Propranolol in Treating Hypoglycemia Unawareness
Impaired awareness of hypoglycemia is common in type 1 diabetes (T1DM) patients. Impaired hypoglycemia awareness increases severe hypoglycemia risk by six-fold.
- Trial name
- NCT03161964
- Testing
- Propranolol 80 Mg Oral Capsule, Extended Release
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Anu Sharma
Irreversible Loss of Brain Function (ILBF)
Automated Screening for Clinically Ascertained Loss of Cerebral Functions
Rationale: The low organ donation rate in Germany is associated with the inadequate identification of patients at risk of developing irreversible loss of brain function (ILBF; i.e. brain death).
- Trial name
- DETECT-IVE (NCT06293170)
- Testing
- DETECT, Conventional care
- Where
- Germany
- Volunteers
- 4,800 people
- Sponsor
- Technische Universität Dresden
Unconsciousness, Apnea, Postanesthetic
Race-Specific Propofol Titration to Effect for Procedural Sedation
Prospectively evaluate newly established guidelines and make clinicians aware of inter-racial difference in propofol sensitivity.
- Conditions
- Unconsciousness, Apnea, Postanesthetic, Sedative Overdose, Hypoxemia
- Trial name
- NCT03290859
- Testing
- Titrate propofol monotherapy infusion to effect
- Where
- United States
- Volunteers
- 2,780 people
- Sponsor
- University of Florida
Bariatric Surgery
Glycemic Patterns After Bariatric Surgery and High Glycemic Variability and Hypoglycemia Unawareness Risk Factors
To study the glycemic patterns of patients undergoing bariatric surgery and what are the risk factors capable of predicting episodes of unnoticed hypoglycemia and high glycemic variability, evaluating patients who underwent…
- Trial name
- NCT05728320
- Testing
- Glucose monitoring with flash glucose monitor
- Where
- Brazil
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University
Syncope, Vasovagal
Influence of Yoga in Patients With Neurocardiogenic Syncope
Syncope is a common problem that many clinicians may encounter in various outpatient settings. Neurocardiogenic syncope (NCS) is a benign condition characterized by a self limited episode of systemic hypotension.
- Trial name
- SYNC - YOGA (NCT01695525)
- Testing
- Yoga
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Dhanunjaya Lakkireddy, MD, FACC
Coma
Beneficial Effects of Music on Cognition and Consciousness Level
Exposure to music improves cognitive function in 'healthy' participants and in brain-damaged patients. However, it is still difficult to understand what precisely in music causes a positive effect : are they emotional components…
- Trial name
- MUSICOREVEIL (NCT02742506)
- Testing
- Electroencephalography (EEG)
- Where
- France
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Cardiac Arrythmias, Syncope
Confirm Rx™ Versus Reveal LINQ™ - Which is More Reliable in Data Transmission? A Randomized Clinical Study
This study will compare the reliability and timeliness in data transmission of the Abbott Confirm Rx™ loop recorder with the Medtronic Reveal LINQ™ loop recorder.
- Conditions
- Cardiac Arrythmias, Syncope, Atrial Fibrillation, Atrial Flutter
- Trial name
- NCT03720639
- Testing
- Abbott, Inc Confirm Rx™ versus Medtronic, Inc Reveal LINQTM
- Where
- 2 sites in United States
- Volunteers
- 209 people
- Sponsor
- Sparrow Clinical Research Institute
Death, Brain
Efficacy of High-Flow Humidified Oxygen (HFHO) in Apneic Oxygenation for Apnea Testing: A Comparison With Continuous Positive Airway Pressure (CPAP)
Brain death (BD) is characterized by a severe brain injury resulting in irreversible loss of all brain and brainstem functions, while other organs may remain viable.
- Trial name
- APNEAFLO2W (NCT07640009)
- Testing
- Apnea test under HHFO followed by an apnea test under CPAP., Apnea test under CPAP followed by an apnea test under HHFO.
- Where
- 4 sites in France
- Volunteers
- 28 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Loss of Consciousness of Unspecified Duration, Cerebral Laceration and Contusion
The Clinical Research on the Relationship Between Circadian Rhythm and Gut Microbiota in TBI Patients
Microbiome studies may be highlighted as crucial in the development of sleep disorder for TBI patients. The microbiota-gut-brain connection may further provide an opportunity for microbiota manipulation to treat the TBI patients…
- Conditions
- Loss of Consciousness of Unspecified Duration, Cerebral Laceration and Contusion, Traumatic Brain Injury
- Trial name
- NCT02849028
- Testing
- sleep disorder
- Where
- China
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- General Hospital of Ningxia Medical University
Minimally Conscious State, Vegetative State
The Effects of Olfactory Stimulation on Diagnosis and Prognosis of DOC Patients
Analyze the behavioral response of patients with disorders of consciousness through olfactory stimulation, compare the response of olfactory stimulation in patients with different consciousness, and analyze the impact of…
- Trial name
- NCT03732092
- Testing
- Coma Recovery Scale-Revised
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Jing Wang
Orthostatic Hypotension, Reflex Syncope
Fainting Detection And Early Warning In Syncope Evaluation Study (ARISE)
To characterize the impact of orthostatic hypotension (OH) and Vasovagal syncope on signals measured using a wearable Holter monitor in the clinic and ambulatory setting.
- Trial name
- ARISE (NCT07502599)
- Testing
- Wearable holter monitor
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Boston Scientific Corporation