Clinical trials: Unconscious
Diabetes, Hypoglycemia Unawareness
The Effect of Antecedent Hypoglycaemia on β2-adrenergic Sensitivity
Hypoglycaemia unawareness is a common complication in patients with type 1 diabetes and with insulin-treated type 2 diabetes of long duration.
- Trial name
- NCT00160056
- Testing
- Hypoglycemia
- Where
- Netherlands
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Disorders of Consciousness, Severe Brain Injury
Transcranial Temporal Interference Stimulation In Severely Brain Injured Patients With Disorders of Consciousness
The purpose of this academic lead study is to explore the effect of noninvasive neuromodulation of the CM-pf via tTIS for patients with disorders of consciousness.
- Conditions
- Disorders of Consciousness, Severe Brain Injury, Unresponsive Wakefulness Syndrome, Minimally Conscious State
- Trial name
- NCT06851156
- Testing
- tTIS
- Where
- 2 sites in China
- Volunteers
- 10 people
- Sponsor
- Xijing Hospital
Respiratory Insufficiency, Shock
Comparison of Central and Peripheral Venous Catheters
The purpose of this study is to compare the mechanical and infectious complications of peripheral versus central venous catheters in critically ill patients. Group allocation will be performed by randomization.
- Conditions
- Respiratory Insufficiency, Shock, Coma
- Trial name
- NCT00122707
- Testing
- catheters
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Organ Transplantation From Brain-dead Donors
Cooling to Optimize Organ Life in Donor Study
The purpose of this study is to assess the feasibility and safety of mild-to-moderate hypothermia as an in-vivo organ preservation strategy compared to normothermia in 60 brain-dead organ donors.
- Trial name
- COOLDonor (NCT01544530)
- Testing
- Cold isotonic fluid and central venous hypothermia catheter
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Pittsburgh
Syncope, Postural Tachycardia Syndrome
EEG Characteristics in Youth POTS and/or Syncope
Orthostatic intolerance refers to symptoms that occur with standing and improve or resolve with recumbency. Few studies have evaluated orthostatic intolerance symptoms by electroencephalography (EEG), and none of those studies…
- Conditions
- Syncope, Postural Tachycardia Syndrome, Orthostatic Intolerance
- Trial name
- NCT02167412
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Nationwide Children's Hospital
Syncope, Pulmonary Embolism
Prevalence of Pulmonary Embolism in Patients With Syncope
All patients consecutively referred with the first episode of transient and short-lasting loss of consciousness will have a diagnostic workup for the assessment of the most common causes of syncope, and will be evaluated for the…
- Trial name
- PESY (NCT01797289)
- Testing
- Lung CT or V/Q scanning in patients with a high pre-test clinical probability of PE and/or a positive D-dimer
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- University of Padova
Critical Illness, Respiratory Failure
Intubation Checklist in the Intensive Care Unit
This retrospective study aims to explore whether the introduction of a preprocedural checklist for intubation in the intensive care unit (ICU) is associated with a lower incidence of intubation-related complications.
- Conditions
- Critical Illness, Respiratory Failure, Unconsciousness
- Trial name
- CHECC (NCT06791317)
- Testing
- Checklist
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Karolinska University Hospital
Anesthesia Brain Monitor, Anesthesia
Elucidating the Neural Correlates of Anesthesia-induced Unconsciousness in Neonates
This study will try to elucidate the neural responses of neonatal patients to surgery-level propofol infusions during induction and maintenance of anesthesia.
- Conditions
- Anesthesia Brain Monitor, Anesthesia, Neonatal Surgery
- Trial name
- NeoNCC (NCT07601854)
- Volunteers
- 64 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Atrial Fibrillation, Syncope
BIO|CONCEPT.BIOMONITOR III
The objective of the study is to confirm the safety and efficacy of the BIOMONITOR III system. Furthermore, the insertion procedure, the use and handling of the incision and insertion tools and the sensing quality of the…
- Conditions
- Atrial Fibrillation, Syncope, Tachyarrhythmia
- Trial name
- NCT03850327
- Testing
- BIOMONITOR III
- Where
- 7 sites in Australia
- Volunteers
- 48 people
- Sponsor
- Biotronik SE & Co. KG
Ventilator Associated Pneumonia
Antibiotic Prophylaxis for Early Ventilator-associated Pneumonia in Neurological Patients
This study seeks to assess whether coma patients really benefit from the use of antibiotics as a prophylactic for reducing the incidence of early ventilator-associated pneumonia in this population group.
- Trial name
- NAVPRO (NCT01118403)
- Testing
- Sultamicillin
- Where
- Colombia
- Sponsor
- Hospital Pablo Tobón Uribe
Traumatic Brain Injury With Prolonged Loss of Consciousness
A Trial to Determine the Feasibility and Effectiveness of Early Multisensory Stimulation Intervention in Patients in the Trauma-Neurosurgical Intensive Care Unit (TNICU) Following Severe Acquired Brain Injury
St. Michael's Hospital (SMH) provides service to individuals with some of the most severe brain injuries and intensive care needs in Canada.
- Trial name
- NCT02589223
- Testing
- Multisensory Stimulation, Control
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- Unity Health Toronto
Pressure Ulcer
Prevention of Pressure Ulcer by Lateral Tilt Bed in Neurocritical Care
Patient positioning is an essential part of a preventive strategy for neurocritical care patients. The aim of the study will be to determine whether the positioning of the bed is the same or better compared to the positioning of…
- Trial name
- PULAT-NC (NCT04078477)
- Testing
- Body positioning
- Where
- Czechia
- Volunteers
- 300 people
- Sponsor
- Regional Hospital Liberec
Syncope, Heart Block
Syncope: Pacing or Recording in the Later Years
Syncope affects about 50% of Canadians, is the cause of 1 - 2% of all emergency room visits, and probably is responsible for CDN $250 million in health care spending each year.
- Conditions
- Syncope, Heart Block, Conduction Disorder of the Heart
- Trial name
- Spritely (NCT01423994)
- Testing
- pacemaker, implantable loop recorder
- Where
- 17 sites in United States, Canada and 3 more
- Volunteers
- 120 people
- Sponsor
- Canadian Institutes of Health Research (CIHR)
Unallocated Pancreas Organs
Expanding Pancreas Donor Pool by Evaluation of Unallocated Organs After Brain Death - The EXPLORE Study
Pancreas graft quality directly affects morbidity and mortality rates after pancreas transplantation (PTx). The criteria for pancreas graft allocation are restricted, which has decreased the number of available organs.
- Trial name
- NCT04127266
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Dr. A. Mehrabi
Disorder of Consciousness, Comatose
Prognostication of Recovery in Early Disorders of Consciousness Study
The goal of this study is to determine the extent to which neuroimaging metrics (e.g., functional MRI) are associated with the current level of consciousness, and future consciousness recovery, in patients with disorders of…
- Conditions
- Disorder of Consciousness, Comatose, Coma; Prolonged, Vegetative State
- Trial name
- PREDICT (NCT07074678)
- Testing
- Functional MRI (fMRI)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Caregiver Distress, Emotional Distress
The Coma Family Program (COMA-F): A Resilience Program for Caregivers of Patients With Severe Acute Brain Injury
The purpose of this research study is to determine whether COMA-F is more efficacious at reducing emotional distress in caregivers of patients with severe acute brain injuries, compared to health education control.
- Conditions
- Caregiver Distress, Emotional Distress, Caregivers, Resilience
- Trial name
- COMA-F (NCT07331324)
- Testing
- Coma Family Program 1, Coma Family Program 2
- Where
- 4 sites in United States
- Volunteers
- 150 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Phobia
Treating Phobia With Multivoxel Neuro-reinforcement
Specific phobias and other anxiety disorders represent a major mental health problem, and present a significant challenge to researchers because effective treatment usually involves repeated exposure to feared stimuli, and the…
- Trial name
- NCT03655262
- Testing
- Unconscious Neuro-reinforcement
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of California, Los Angeles
Other Specified Hypotension, Syncope
Acarbose and Older Adults With Postprandial Hypotension
The current proposal will determine if blocking carbohydrate intake in the small intestine with Acarbose can be a possible therapy for older adults with (PPH) Post Prandial Hypotension (a drop of blood pressure after eating)…
- Trial name
- PPH (NCT01914133)
- Testing
- Acarbose
- Where
- Canada
- Volunteers
- 42 people
- Sponsor
- Kenneth Madden
Minimally Conscious State
Therapeutic Effects of Animal-assisted Therapy for Patients in a Minimally Conscious State
The aim of this study is to investigate the effects of animal-assisted occupational therapy on patient's consciousness, measured via the achievement of predefined, patient-specific goals.
- Trial name
- MCS Therapy (NCT03910959)
- Testing
- Animal-assisted therapy, Conventional therapy
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University of Basel
Ventricular Ejection Fraction, LVF
AI-Enabled Direct-from-ECG Ejection Fraction (EF) Severity Assessment Using COR ECG Wearable Monitor
This prospective, multicenter, cluster-randomized controlled study aims to evaluate the accuracy of an investigational artificial intelligence (AI) Software as a Medical Device (SaMD) designed to compute ejection fraction (EF)…
- Conditions
- Ventricular Ejection Fraction, LVF, LV Dysfunction, Atrial Enlargement
- Trial name
- EFACT (NCT06699056)
- Testing
- 15-minutes of sitting during COR ECG Acquistion
- Where
- 8 sites in United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Peerbridge Health, Inc