Clinical trials: Unconscious
Traumatic Brain Injury With Brief Loss of Consciousness
The Clinical Research on the Relationship Between Depression and Gut Microbiota in TBI Patients
Microbiome studies may be highlighted as crucial in the development of depression for TBI patients. The microbiota-gut-brain connection may further provide an opportunity for microbiota manipulation to treat the TBI patients with…
- Trial name
- NCT02874027
- Testing
- The TBI patients with depression
- Where
- China
- Volunteers
- 50 people
- Sponsor
- General Hospital of Ningxia Medical University
Anesthesia, Consciousness, Loss of
Detection and Classification of Levels of Consciousness Using Parietal EEG-fNIRS During Anesthesia
The current evaluations of the levels of consciousness during anesthesia have limited precision. This can produce negative clinical consequences such as intraoperative awareness or neurological damage due to under- or…
- Trial name
- NCT05112042
- Where
- Chile
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Diabetes Mellitus, Hypoglycemia Unawareness
Prevention Through Intervention: Telehealth Solution to Deter 911 Calls Due to Hypoglycemia
This study aims to standardize and evaluate the benefits of the Prevention to Intervention program offered by the Birmingham Fire and Rescue Service.
- Conditions
- Diabetes Mellitus, Hypoglycemia Unawareness, Hypoglycemia, Hypoglycemia Acute
- Trial name
- NCT03665870
- Testing
- Hypoglycemia Education
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Alabama at Birmingham
Syncope, Seizures
Observational and Diagnostical Study on Transient Allostatic Responses of Thyroid Function After Syncopation and Seizure
Changes of thyroid function may occur after short loss of consciousness, but they haven't been systematically evaluated up to now, although occasional observations suggest temporal increases in TSH concentration.
- Trial name
- Thyro-Syncope (NCT04879147)
- Testing
- Evalution of thyroid function
- Where
- 4 sites in Germany
- Volunteers
- 350 people
- Sponsor
- Ruhr University of Bochum
Symptomatic Neurogenic Orthostatic Hypotension
Clinical Effect of Ampreloxetine (TD-9855) for Treating Symptomatic nOH in Subjects With Primary Autonomic Failure
A Phase 3 study to evaluate efficacy, safety, and tolerability of ampreloxetine (TD-9855) in subjects with primary autonomic failures (MSA, PD, or PAF) and symptomatic nOH with up to 4 weeks of treatment.
- Trial name
- SEQUOIA (NCT03750552)
- Testing
- ampreloxetine
- Where
- 125 sites in United States, Australia and 17 more
- Volunteers
- 195 people
- Sponsor
- Theravance Biopharma
Cardiac Pacemaker, Arrythmia
Aveir DR Real-World Evidence Post-Approval Study
The purpose of this post-approval study is to evaluate the long-term safety of the dual-chamber Aveir DR leadless pacemaker using real-world evidence methods.
- Conditions
- Cardiac Pacemaker, Arrythmia, Bradycardia
- Trial name
- NCT05935007
- Testing
- Aveir DR Leadless Pacemaker System
- Where
- United States
- Volunteers
- 1,805 people
- Sponsor
- Abbott Medical Devices
Syncope, Vasovagal
Wearable Monitor in Patients With Syncope
The main purpose of this study is to assess the reliability of a new patient's self-administered wearable watch-type BP monitor in detecting episodes of hypotensive (pre)syncope.
- Trial name
- Watch-VD (NCT05782647)
- Testing
- HeartGuide cuffless BP monitor
- Where
- Italy
- Volunteers
- 81 people
- Sponsor
- Istituto Auxologico Italiano
Arrhythmia, Palpitations
7-Day MEMO Patch Monitoring for Arrhythmia Detection in Patients With Palpitations
"This exploratory prospective clinical study aims to evaluate the diagnostic yield of a 7-day adhesive electrocardiographic (ECG) monitoring device (MEMO Patch) in detecting cardiac arrhythmias in patients presenting with…
- Conditions
- Arrhythmia, Palpitations, Syncope
- Trial name
- NCT07728552
- Testing
- MEMO Patch, 24-Hour Holter Monitor
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- HUINNO Co., Ltd
Type 1 Diabetes Mellitus
Strategies to Improve Islet Survival
Type 1 diabetes is an autoimmune disease in which the insulin-producing pancreatic beta cells are destroyed, resulting in poor blood sugar control.
- Trial name
- NCT00464555
- Testing
- Islet transplant, Antithymocyte globulin, Basiliximab
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Syncope, Vasovagal
Closed Loop Stimulation for Neuromediated Syncope (SPAIN Study)
Physiological stimulation therapy effectiveness will be proved with contractility sensor or CLS sensor (Closed Loop Stimulation), in BIOTRONIK CLS pacemakers to prevent from neuromediated syncope.
- Trial name
- SPAIN (NCT01621464)
- Testing
- Pacemaker with Closed Loop Stimulation (CLS sensor)
- Where
- Spain
- Volunteers
- 55 people
- Sponsor
- Spanish Society of Cardiology
Type 1 Diabetes Mellitus With Hypoglycemia
A Safety, Tolerability, and Efficacy Study of VC-02™ Combination Product in Subjects With Type 1 Diabetes Mellitus and Hypoglycemia Unawareness
VC02-101 will evaluate an experimental cell replacement therapy intended to provide a functional cure to subjects with Type 1 Diabetes and Hypoglycemia Unawareness.
- Trial name
- NCT03163511
- Testing
- VC-02 Combination Product
- Where
- 10 sites in United States, Belgium and 1 more
- Volunteers
- 49 people
- Sponsor
- ViaCyte
Parkinson's Disease
Requirement of Propofol for Induction of Unconsciousness in Patients With Parkinson's Disease
Parkinson's disease (PD) is the second most prevalent neurodegenerative disease. The investigators clinical experience showed a trend of delayed emergence among patients undergoing deep brain stimulator (DBS) implantation and…
- Trial name
- NCT01998204
- Where
- China
- Volunteers
- 62 people
- Sponsor
- Changhai Hospital
Disorders of Consciousness, Severe Brain Injury
Use of Analgesic Treatment to Reduce Signs of Pain in Patients With Disorders of Consciousness.
The purpose of this study is to characterize and improve pain and nociception management in patients with disorders of consciousness (DOC).
- Conditions
- Disorders of Consciousness, Severe Brain Injury, Post-comatose Non-communicative Patients, Vegetative State
- Trial name
- NCT04330547
- Testing
- Analgesic administration
- Where
- Belgium
- Volunteers
- 19 people
- Sponsor
- University of Liege
Syncope, Vasovagal, Bradycardia
National Registry of Cardioneuroablation in Recurrent Reflex Syncope
This registry aims to collect patient data on cardioneuroablation for vasovagal syncope from multiple centers in France. The aim is to evaluate success rates, compare techniques and help institutions set up their own…
- Conditions
- Syncope, Vasovagal, Bradycardia, Heart Arrest
- Trial name
- CANVAS-R (NCT06159764)
- Testing
- Cardioneuroablation
- Where
- 14 sites in France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Bordeaux
Atrial Fibrillation, Atrial Fibrillation (Prevention of Stroke)
Registry Initiative Across Borders for Atrial Fibrillation in Africa
Atrial fibrillation is a penalizing disease in several ways: morbidity and mortality, health costs. Several multicenter registries have been published.
- Conditions
- Atrial Fibrillation, Atrial Fibrillation (Prevention of Stroke), ATRIAL FIBRILLATION, Syncope
- Trial name
- RIBATAFRICA-AF (NCT06674304)
- Where
- Morocco
- Volunteers
- 3,000 people
- Sponsor
- Mohammed VI University Hospital
Traumatic Brain Injury With Loss of Consciousness
Mesenchymal Stromal Cells for Traumatic Brain Injury
Traumatic Brain Injury (TBI) is an alteration of brain function caused by an external force. Long-term mortality in TBI is substantial, TBI survivors can develop chronic progressive disabilities and have a life expectancy…
- Trial name
- MATRIx (NCT06163833)
- Testing
- Mesenchymal stromal cell low dosage-80*10^6 cells, Mesenchymal stromal cell low dosage-160*10^6 cells
- Where
- 3 sites in Italy
- Volunteers
- 78 people
- Sponsor
- Fondazione IRCCS San Gerardo dei Tintori
Brain Death
Validation of the Apnea Test Performed by High-flow Oxygen Therapy in Patients With Clinical Brain Death
Brain death is a clinical and paraclinical diagnosis established in a known etiological context. It involves the irreversible destruction of cerebral functions in a beating-heart individual.
- Trial name
- APNEAFLOW (NCT05950178)
- Testing
- Apnea test under high-flow oxygenation
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Cardiopulmonary Failure, Myocardial Infarction (MI)
COR-INSIGHT: Optimizing Cardiovascular and Cardiopulmonary Outcomes with AI-Driven Multiplexed Indications Using COR ECG Wearable
The COR-INSIGHT trial aims to evaluate the effectiveness of Peerbridge COR advanced ambulatory ECG wearables (COR 1.0 and COR 2.0) in accurately and non-invasively detecting cardiovascular and cardiopulmonary conditions using…
- Conditions
- Cardiopulmonary Failure, Myocardial Infarction (MI), Heart Decompensation, Heart Failure
- Trial name
- COR-INSIGHT (NCT06763549)
- Testing
- SUBPROTOCOL A, SUBPROTOCOL B, SUBPROTOCOL C
- Where
- United States
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Peerbridge Health, Inc
Syncope, Arrest
Urgent Medical and Surgical Conditions During Flights
The aim of this study is to evaluate the incidence and status of urgent medical conditions. After defining the urgent situations, the investigators will evaluate the adequacy of the standard medical kits and trainings.
- Conditions
- Syncope, Arrest, Vertigo, Pain
- Trial name
- NCT02457455
- Where
- Turkey (Türkiye)
- Volunteers
- 1,312 people
- Sponsor
- Antalya Training and Research Hospital
Syncope, Presyncope
Abbott Brady 3T MRI PMCF
The objective of this post-market, clinical follow up (PMCF) study, is to confirm the long-term safety of the Tendril STS and Isoflex leads, implanted with the Assurity MRI™ or Endurity MRI™ pacemakers, in patients undergoing a…
- Conditions
- Syncope, Presyncope, Fatigue, Disorientation
- Trial name
- NCT03786640
- Testing
- 3T MRI scan
- Where
- 9 sites in Estonia, France and 3 more
- Volunteers
- 3 people
- Sponsor
- Abbott Medical Devices