Clinical trials: Unconscious
Poisoning, Consciousness, Level Altered
Non-invasive Airway Management of Comatose Poisoned Emergency Patients
A decreased level of consciousness is a common reason for presentation to the emergency department (ED) and is often the result of intoxication (up to 1% of all ED visits and 3% of ICU admission).
- Conditions
- Poisoning, Consciousness, Level Altered, Comatose
- Trial name
- NICO (NCT04653597)
- Testing
- Close monitoring, Endotracheal intubation
- Where
- France
- Volunteers
- 237 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Unconsciousness
The Impact of Different Recovery Positions on the Perfusion of the Lower Forearm and Comfort
Introduction: A side-lying recovery position is recommended when victims are unresponsive but breathing normally and, hence, do not require cardiopulmonary resuscitation.
- Trial name
- NCT05587179
- Testing
- recovery position
- Where
- Belgium
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Centre for Evidence-Based Practice, Belgium
Syncope
Non-Pharmacologic Therapy for Neurocardiogenic Syncope
This study will examine whether certain procedures that do not involve the use of medications can reduce symptoms of neurocardiogenic syncope (SIN-ku-pe), or a condition involving recurrent fainting.
- Trial name
- NCT00096902
- Testing
- Tilt table test
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Blood Donors
Addressing Fear and Risk of Vasovagal Reactions Among High School Donors
In this study, high school donors will be asked about their blood donation-related fears prior to their donation. Half of the donors reporting fear will be assigned to a brief coping skills intervention.
- Trial name
- NCT03835299
- Testing
- Fear Intervention
- Where
- United States
- Volunteers
- 4,035 people
- Sponsor
- Ohio University
Vasovagal Syncope
Prevention of Syncope Trial 6 - Atomoxetine in Vasovagal Syncope
Objective: To determine if atomoxetine 40 mg bid (bis in die) in patients ≥18 years old with recurrent vasovagal syncope will better prevent syncope during tilt testing than placebo.
- Trial name
- POST6 (NCT02500732)
- Testing
- Atomoxetine
- Where
- Canada
- Volunteers
- 57 people
- Sponsor
- University of Calgary
Anoxic Coma, Cardiac Arrest (CA)
Assessment of Structural Brain Changes Related to Anoxic Coma Using High-field and Very Low Field Mobile MRI
Standard predictors of outcome after cardiac arrest (CA) have substantial limitations in terms of reliability and generalizability.
- Conditions
- Anoxic Coma, Cardiac Arrest (CA), Anoxia-Ischemia, Brain, Coma
- Trial name
- CUBE (NCT07177755)
- Testing
- High-field and very-low-field MRI acquisitions
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Brain Diseases, Vegetative State
Chinese Validation of the Simplified Evaluation of CONsciousness Disorders（SECONDs）
The aim of this study was to translate the SECONDs from French into Chinese and assess the validity and reliability of the Chinese version of the SECONDs .
- Conditions
- Brain Diseases, Vegetative State, Unconsciousness, Central Nervous System Diseases
- Trial name
- NCT05496985
- Testing
- Simplified Evaluation of CONsciousness Disorders (SECONDs)
- Where
- China
- Volunteers
- 49 people
- Sponsor
- Hangzhou Normal University
Anesthesia
Remifentanil and Midazolam on Propofol for Loss of Consciousness in Elderly Patients
Propofol is a well-known induction agent which can provide sound and quick hypnosis with anti-emetic effects. However, dose dependent hypotension or bradycardia have reported while using this agent.
- Trial name
- NCT02818387
- Testing
- Propofol, Remifentanil, Midazolam
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Gangnam Severance Hospital
Anesthesia, Unconsciousness
The Neural Mechanisms of Anesthesia and Human Consciousness (Part 6)
Positron Emission Tomography (PET), Magnetic Resonance Imaging (MRI) and electroencephalography (EEG) studies will be carried out to reveal the neural correlates of consciousness.
- Trial name
- NCT02624401
- Testing
- Dexmedetomidine, Propofol, S-ketamine
- Where
- Finland
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Turku
Syncope, Blood Injury Phobia
fMRI in Blood Phobia Syncope
We plan to study patient who faint in response to the sight of blood and compare them to healthy subjects who do not. We are going to use a special type of MRI scan (functional MRI) to determine if there are differences in brain…
- Conditions
- Syncope, Blood Injury Phobia, Autonomic Dysfunction
- Trial name
- NCT00715065
- Testing
- fMRI Scan
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Vanderbilt University
Dehydration, Syncope and Collapse
Effectiveness of a Wearable Hydration Device
Dehydration among older adults a costs billions of dollars in US healthcare every year because no robust solution exists to detect changes in hydration and prevent negative outcomes. In this project, TritonX Technologies Inc.
- Trial name
- DRINK (NCT06788795)
- Testing
- Device with Phone App, Device without Phone App
- Volunteers
- 150 people
- Sponsor
- MetroHealth Medical Center
Posttraumatic Stress Disorder, Pseudopheochromocytoma
Clinical Autonomic Disorders: A Training Protocol
Background: The autonomic nervous system helps control things that happen automatically in the body, like blood pressure, heart rate, and digestion. When it doesn t work properly, it s called dysautonomia.
- Conditions
- Posttraumatic Stress Disorder, Pseudopheochromocytoma, Healthy Volunteers, Neurocardiogenic Syncope
- Trial name
- NCT02154009
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Pain
Pupillometry - Future of Objective Pain Reaction Measurement While Unconscious
This study aims to assess the usefulness of pupillometry as a nociceptive indicator during elective orotracheal intubation in patients given intravenous lignocaine pre-intubation as compared to a placebo pre-intubation.
- Trial name
- NCT04000126
- Testing
- Pupil reflex dilation measurement (PRD), PPI (Pupillary Pain Index), lidocaine
- Where
- Poland
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Warmia and Mazury
Syncope, Syncope, Vasovagal
Head-up Tilt Test in Patients With Reflex Syncope and Asystolic Response Who Received a Dual-chamber Pacemaker With the Closed Loop Stimulation (CLS) and Participated in the BIOSync Trial
The purpose of this study is to explore changes in patients' hemodynamic parameters during the Head-Up Tilt Test ("HUTT") and their timing with respect to onset of the Closed Loop Stimulation (CLS) pacing.
- Trial name
- BIO|Sync-HUTT (NCT06038708)
- Where
- 2 sites in Italy
- Volunteers
- 20 people
- Sponsor
- Biotronik SE & Co. KG
Chronic Vegetative State
The Impact of RPh201 on CVS Patients: Clinical and fMRI Measurements
The investigators are studying the impact of RPh201 on chronic vegetative patients. RPh201 has been reported to induce neuronal regeneration in animal models.
- Trial name
- CVS (NCT01417299)
- Testing
- RPh201, saline
- Sponsor
- Hadassah Medical Organization
Syncope
Evaluation of Chronic Orthostatic Intolerance
This study will conduct tests with patients with primary chronic orthostatic intolerance (COI) to learn more about this disorder of the autonomic nervous system.
- Trial name
- NCT00069693
- Where
- 3 sites in United States, Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Loss of Consciousness
Alteration of Temporal Organization of EEG Microstate Sequences During Propofol-induced Loss of Consciousness
Temporal dynamics of the EEG microstates show scale-free monofractal properties. This means that information is encoded in the same way at different scales.
- Trial name
- Fractal (NCT02125214)
- Testing
- Target Controlled Infusion system (Orchestra Base Primea, Fresenius, France)
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Julien Maillard
Symptomatic Neurogenic Orthostatic Hypotension
Phase 3 Open-Label Extension Study of TD-9855 for Treating Symptomatic nOH in Subjects With Primary Autonomic Failure
A Phase 3, multi-center, open-label study to evaluate the safety and tolerability of ampreloxetine in subjects with primary autonomic failures (MSA, PD, and PAF) and symptomatic nOH over 182 weeks.
- Trial name
- OAK (NCT04095793)
- Testing
- ampreloxetine
- Where
- 55 sites in United States, Australia and 16 more
- Volunteers
- 110 people
- Sponsor
- Theravance Biopharma
Disorder of Consciousness, Minimally Conscious State
Temporal Interference Stimulation for Disorders of Consciousness
This study aims to investigate whether a new non-invasive brain stimulation technique, called temporal interference stimulation, can influence brain activity and potentially improve signs of consciousness in patients with severe…
- Conditions
- Disorder of Consciousness, Minimally Conscious State, Vegetative State, Unresponsive Wakefulness Syndrome
- Trial name
- NCT07874178
- Testing
- Temporal Interference
- Volunteers
- 4 people
- Sponsor
- Centre Hospitalier Universitaire de Liege
Persistent Vegetative State
18F-FDG PET/CT in Diagnostic Patients of Disorder of Consciousness
Clinical examinations are difficult to discriminate between vegetative state and minimally conscious state. the diagnostic and prognostic usefulness of neuroimaging methods has not been established in a clinical setting.
- Trial name
- NCT02999490
- Testing
- 18F-FDG
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command