Clinical trials: Unconscious
Pneumonia
Improving Oral Care to Reduce Hospital-Acquired Pneumonia (HAP) in the Acute Neurologically Impaired Adult
Hypothesis: The investigators hypothesize that the current oral protocol is sub-optimal and an enhanced protocol will decrease the incidence of hospital acquired pneumonia (HAP)in the acute, non-intubated, care-dependent…
- Trial name
- NCT01498601
- Testing
- Enhanced oral care protocol
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- Fraser Health
Trauma, Craniocerebral Trauma
Early Versus Late Intubation Trial in Physician Manned Emergency Medical Services
This study looks at advanced airway management in critically ill or injured patients treated by physician manned emergency medical services, comparing early (on-scene) intubation to late (emergency department) intubation.
- Conditions
- Trauma, Craniocerebral Trauma, Intracerebral Hemorrhage, Seizures
- Trial name
- ELITE (NCT01730001)
- Testing
- Early Intubation, Late intubation
- Where
- 2 sites in Norway
- Sponsor
- Norwegian Air Ambulance Foundation
Heart Arrest, Coma
Pilot Clinical Study of the LRS ThermoSuit™ System in Post Arrest Patients
The purpose of this study is to determine if the Life Recovery Systems Thermosuit(R) System is able to quickly and conveniently cool patients who are comatose after resuscitation from cardiac arrest.
- Trial name
- NCT00410969
- Testing
- ThermoSuit(R) System
- Where
- 2 sites in Canada
- Volunteers
- 27 people
- Sponsor
- Life Recovery Systems
Terminal Illness, End-of-Life Care
Non-Invasive Detection and Preservation of Neurocognitive Signals in the Peri-Death Period Using Brain-Computer Interface and Artificial Intelligence
Background: Recent electroencephalography (EEG) data indicate that the transition from clinical death to cellular death is marked by highly organized neurophysiological events, including significant surges in gamma-band power…
- Conditions
- Terminal Illness, End-of-Life Care, Death, Brain Death
- Trial name
- NeuroCogPresv (NCT07477028)
- Volunteers
- 20 people
- Sponsor
- Noah Tech, Corp.
Age-related Cataract
Study On The Performance And Safety Of The REVISYON SDS 100 Device On Visual Acuity In Subjects With Cataract
Single arm, unmasked study to evaluate the performance and safety of the REVISYON SDS 100 Device for the non-invasive treatment of vision loss in age-related cataract.
- Trial name
- NCT05396547
- Testing
- Treated with REVISYON SDS 100 Device
- Where
- 11 sites in Latvia, Lithuania and 1 more
- Volunteers
- 114 people
- Sponsor
- Edinburgh Biosciences Ltd
Syncope
The Management of Transient Loss of Consciousness and Suspected Syncope in European Emergency Departments
Prospective multi centre cohort study examining the clinical presentation, diagnostic tests, and management of adult Emergency Department (ED) patients presenting with Transient Loss of Consciousness (TLOC) either…
- Trial name
- SEED (NCT05571254)
- Testing
- Data collection
- Where
- 57 sites in Albania, Austria and 16 more
- Volunteers
- 952 people
- Sponsor
- NHS Lothian
Traumatic Brain Injury With Brief Loss of Consciousness, Post-Concussion Syndrome
mTBI Mechanisms of Action of HBO2 for Persistent Post-Concussive Symptoms
Purpose of this study is to investigate the mechanisms of action of hyperbaric oxygen therapy for persistent post-concussive symptoms after mild tramatic brain injury
- Trial name
- BIMA (NCT01611194)
- Testing
- Hyperbaric oxygen (HBO2) at 1.5 atms
- Where
- 5 sites in United States
- Volunteers
- 71 people
- Sponsor
- U.S. Army Medical Research and Development Command
Nursing Student
The Effect of Simulation on Nursing Education
The aim of this study was to evaluate the effect of computer-based virtual reality (VR) simulation on students' knowledge, satisfaction and self-confidence in teaching oral care practice in the unconscious patient.
- Trial name
- NCT06724003
- Testing
- Computer-based virtual reality simulation
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Giresun University
PHYSIOLOGICAL PHENOMENA
Importance of Liver Innervation for the Osmopressor Response in Humans
In patients with autonomic dysfunction water drinking elicits a pressor response mediated by sympathetic activation. If any, in healthy subjects there is only a slight increase in blood pressure.
- Trial name
- HEP-Reflex (NCT01237431)
- Testing
- 500ml water intake
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Hannover Medical School
Hypoxic Ischemic Encephalopathy
Targeted Temperature Management After In-Hospital Cardiac Arrest
The purpose of this study is to determine whether targeted temperature management at 36.0˚C(TTM-36) in patients who remain unconscious after resuscitation from in-hospital cardiac arrest(IHCA) will reduce death and disability…
- Trial name
- TTM36-IHCA (NCT02578823)
- Testing
- Arctic Sun®, Arcticgel™, Conventional antipyretic treatment
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Asan Medical Center
Syncope
Hypersensitive Troponin Performance to Identify Syncope at Risk of Serious Adverse Events in the Short Term
Syncope, a frequent reason for emergency room visits and hospitalization, is a symptom of three major etiological entities: cardiac causes, vaso-reflex causes and orthostatic hypotension.
- Trial name
- TROPOCOPE (NCT03528161)
- Testing
- Measurement of hypersensitive troponin
- Where
- France
- Volunteers
- 248 people
- Sponsor
- University Hospital, Toulouse
Dementia, Persistent Vegetative State
A Study to Tailor Advance Directives
In this study, hospitalized patients will first be surveyed regarding their interest in a traditional advanced directive (AD) and then in a modified AD.
- Conditions
- Dementia, Persistent Vegetative State, Terminally Ill
- Trial name
- NCT00121004
- Testing
- Advance Directive Selection
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Type1diabetes, Hypoglycemia Unawareness
The Effect Lactate Administration on Cerebral Blood Flow During Hypoglycemia
It is thought that altered brain lactate handling is involved in the development of impaired awareness of hypoglycemia (IAH), i.e. the inability to timely detect hypoglycemia in people with type 1 diabetes (T1DM).
- Trial name
- NCT03730909
- Testing
- Sodium Lactate, Sodium chloride
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Radboud University Medical Center
Conditions of Brain
Electrophysiological Tests on Unconscious Patient
Most patients with minimal consciousness status in Critical Care Units (CCU) are considered as an 'unconscious patient' with a neurological examination.
- Trial name
- NCT03858400
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people
- Sponsor
- Nevsehir Public Hospital
Critical Illness, Loss of Consciousness
Developing Strategies to Facilitate Consent of Legally Authorized Representatives to Clinical Trials
This study aims to gather insights into the perceptions of legal representatives regarding the recruitment process for clinical trials in the intensive care setting when the patients cannot decide for themselves.
- Trial name
- NCT06471400
- Testing
- interview
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital Freiburg
Consciousness Disorders
Measuring Brain Complexity to Detect and Predict Recovery of Consciousness in the ICU
Disorders of consciousness (DoC) caused by severe brain injury affect millions of people worldwide each year. A patient's level of consciousness in the intensive care unit (ICU) significantly impacts the recovery from disability…
- Trial name
- COMPASS (NCT06568536)
- Testing
- Repeated behavioral assessments, functional electroencephalography and brain imagery, TMS-EEG
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- Massachusetts General Hospital
Consciousness Disorders
Validation of the Russian Version of Coma Recovery Scale-Revised (CRS-R)
The purpose of this study is to validate Russian version of Coma Recovery Scale - Revised and to assess its psychometric properties.
- Trial name
- NCT03060317
- Testing
- Examination with neurological scales.
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Research Center of Neurology, Russia
Bradycardia, Syncope, Vasovagal
Comparison of Focal Cryoablation vs. Radiofrequency Cardioneuroablation for Bradyarrhythmias
Bradyarrhythmias are conditions where the heart beats too slowly, causing symptoms like dizziness, fainting, and fatigue. In some patients, these slow heart rhythms are caused by overactivity of the vagus nerve (the part of the…
- Conditions
- Bradycardia, Syncope, Vasovagal, Sick Sinus Syndrome, Atrioventricular Block
- Trial name
- CRYO-CNA vs RF (NCT07671898)
- Testing
- Focal Cryoablation, Radiofrequency Catheter Ablation
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Heart Arrest, Out-Of-Hospital, Computed Tomography
Head Computed Tomography for Predicting Neurological Outcome After Cardiac Arrest
The European Resuscitation Council (ERC) and the European Society of Intensive Care Medicine (ESICM) joint guidelines for post-resuscitation care recommend a multimodal approach to prognostication of neurological outcome.
- Conditions
- Heart Arrest, Out-Of-Hospital, Computed Tomography, Unconsciousness, Neurologic Deficits
- Trial name
- NCT03913065
- Testing
- CT
- Where
- Sweden
- Volunteers
- 400 people
- Sponsor
- Lund University
Syncope
International Study on Syncope of Uncertain Etiology
This is a multi-center, prospective, observational study enrolling 400 patients with suspected or certain neurally-mediated syncope, who undergo carotid sinus massage, tilt testing and Implantable Loop Recorder (ILR)implantation.
- Trial name
- NCT00120094
- Where
- 3 sites in Italy, United Kingdom
- Volunteers
- 400 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS