Clinical trials: Unconscious
Stammering
Modifying Unconscious Tongue Movements in Adults With Developmental Stammer.
This is a pilot randomised controlled trial investigating whether using modification of saccadic eye movements can control lateral unconscious tongue positioning and enhance fluency in adults with a confirmed developmental…
- Trial name
- NCT04310436
- Testing
- Modifying saccades by looking down to naval., Modifying saccades by looking in air.
- Where
- Ireland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Institute of Technology, Sligo
Coma; Prolonged, Amantadine
Benefits of Amantadine in Patients With Coma State
The study was a single center observational-prospective study and approved by local ethics committee. Patients in coma state due to traumatic brain injury, cardiac arrest or ischemic stroke who are older than 18 years of age were…
- Trial name
- NCT03443037
- Testing
- amantadine sulphate
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Dokuz Eylul University
Traumatic Brain Injury With Prolonged Loss of Consciousness, Stroke
Evaluation of Consciousness by Brain-computer Interface in Severely Brain Damaged Patients
The objective of this study is to show that the measurement of auditory and vibro-tactile evoked potentials, or the recording of the EEG signal during a motor imaging task, can be used in routine clinical situations to explore…
- Conditions
- Traumatic Brain Injury With Prolonged Loss of Consciousness, Stroke, Brain Hypoxia
- Trial name
- AWAKE (NCT03998930)
- Testing
- Clinical evaluation of consciousness by the Coma Recovery Scale Revised (CRS-R)
- Where
- 4 sites in France
- Volunteers
- 9 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Fatigue, Stress
The U.S. Embryologist Fatigue Study
The purpose of the study is to determine physical and mental health issues of U.S. embryologists related to their occupational characteristics, and how workplace fatigue and burnout may affect their quality of life, cynicism…
- Conditions
- Fatigue, Stress, Burnout, Professional, Musculoskeletal Pain
- Trial name
- FUSE (NCT05326802)
- Where
- United States
- Volunteers
- 246 people
- Sponsor
- TMRW Life Sciences
Traumatic Brain Injury With Loss of Consciousness
Effect of Early Coma Arousal Therapy on Conscious Level Recovery and Cognition in Traumatic Brain Injury
PURPOSE: The aim of this study is to investigate the effect of early coma arousal therapy on conscious level and cognitive function in sever traumatic brain injury patients.
- Trial name
- NCT05521815
- Testing
- Coma arousal therapy, Selected physiotherapy program
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Cairo University
Brain Death, Apnea
Apnea Tests as the Methods of Brain Death Diagnosis.
Apnea test (AT) is the most important clinical test performed usually at the end of brain death (BD) diagnosis procedure. Traditional insufflation apnea test (I-AT) cannot be completed in patients with extremely compromised lung…
- Conditions
- Brain Death, Apnea, Pupillary Anomaly
- Trial name
- DiagBD (NCT03281993)
- Testing
- CPAP AT
- Volunteers
- 76 people
- Sponsor
- Pomeranian Medical University Szczecin
Syncope, Vasovagal, Neurally-Mediated
The Tilt Test-Induced REsponse in Closed-loop Stimulation (TIRECS) Study
Multicentre, prospective, double blinded, randomized study designed as an intrapatient comparison to evaluate the effects of the Biotronik Closed-loop Stimulation algorithm on prevalence and timing of haemodynamic variations and…
- Trial name
- TIRECS (NCT02573649)
- Testing
- Closed-loop Stimulation on first, Closed-loop Stimulation off first
- Where
- 2 sites in Italy
- Volunteers
- 30 people
- Sponsor
- Azienda Ospedaliera Cardinale G. Panico
Patients With Traumatic Brain Injury, Coma, Traumatic
Family-Centered Affective Stimulation for Patients With Traumatic Brain Injury: Its Effects on Coma Recovery
Family-centered affective stimulation involves creating an environment in which family members actively participate in the patient's recovery by providing emotional support, positive reinforcement, and a supportive presence.
- Trial name
- NCT07537023
- Testing
- Family-Centered Affective Stimulation (FCAS)
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Cairo University
EEG Data Analysis, Orthopedic Surgery
Characteristic Electroencephalogram of General Anesthesia
Patients were enrolled according to predefined inclusion and exclusion criteria. Following surgical admission, standard monitoring was initiated, including continuous assessment of heart rate, blood pressure, electrocardiogram…
- Trial name
- NCT07468162
- Testing
- After the use of sedative drugs, the changes in the electroencephalogram (EEG) spectrum were observed with an EEG monitor
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Brain Injury Traumatic Severe (Diagnosis), Coma
Stimulant Therapy Targeted to Individualized Connectivity Maps to Promote ReACTivation of Consciousness
Phase 1 of the STIMPACT trial is an open label,dose-escalation,safety study of intravenous (IV) methylphenidate (MPH) therapy in patients with disorders of consciousness (DoC) caused by severe brain injuries.
- Conditions
- Brain Injury Traumatic Severe (Diagnosis), Coma, Consciousness, Level Altered, Anoxic Brain Injury
- Trial name
- STIMPACT (NCT03814356)
- Testing
- Methylphenidate
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital
Nuclear Cataract
Microinterventional Endocapsular Nuclear Fragmentation Assisted Cataract Surgery
Rationale: In cataract surgery, fragmentation of a hard nucleus requires relatively much ultrasound energy. It is suspected that the level of energy used is associated with the degree of corneal endothelial loss.
- Trial name
- NCT05736042
- Testing
- Lens fragmentation
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- Oogziekenhuis Rotterdam
Syncope
ELIAS: Early Loop-Recorder in Suspected Arrhythmogenic Syncope
This is a prospective, controlled, opened randomized study to evaluate the cost benefit of a primary implantation of a loop recorder versus the conventional diagnostic cascade for syncope most likely due to cardiac arrhythmia.
- Trial name
- NCT00170261
- Testing
- Use of an Implantable Loop Recorder
- Where
- 3 sites in Germany
- Volunteers
- 100 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Brain Death
Nutritional Status and Enteral Absorption Capability After Brain Death
The investigators propose to assess 36 donors' nutritional status using accepted parameters (prealbumin, resting energy expenditure); to assess nutrient intestinal absorption through 13Curacil breath tests; and to evaluate serum…
- Trial name
- HRSA Nutrition (NCT00858390)
- Testing
- enteral feeding with Oxepa® and Glutasolve®
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- The University of Texas Health Science Center, Houston
Syncope, Bradycardia
Registry of Device Implantation
The implantable device therapy for cardiac arrhythmias has been an established therapy, and one of the common standard procedures in cardiac clinical practice.
- Conditions
- Syncope, Bradycardia, Tachycardia, Sudden Cardiac Death
- Trial name
- NCT03360227
- Testing
- implantation of cardiac devices
- Where
- Germany
- Volunteers
- 2,000 people
- Sponsor
- Klinik für Kardiologie, Pneumologie und Angiologie
Ventilator Associated Pneumonia
Antibiotic Prophylaxis for Early Ventilator-associated Pneumonia in Neurological Patients
This study seeks to assess whether coma patients really benefit from the use of antibiotics as a prophylactic for reducing the incidence of early ventilator-associated pneumonia in this population group.
- Trial name
- NAVPRO (NCT01118403)
- Testing
- Sultamicillin
- Where
- Colombia
- Sponsor
- Hospital Pablo Tobón Uribe
Vegetative State, Minimally Conscious State
Transcranial Brain Stimulation in Vegetative State Patients
The aim of this study is to determine whether transcranial brain stimulations, such as repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS), are effective in terms of EEG…
- Trial name
- NCT01820923
- Testing
- Transcranial direct current stimulation (tDCS), Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- IRCCS San Camillo, Venezia, Italy
Cardiovascular Diseases, Medical Device
Validation of PMcardio AI-assisted Clinical Assistant in Primary Care
This study aimed to analyze and investigate whether the use of the PMcardio clinical assistant leads to a more efficient patient management in primary care and more accessible specialised care compared to usual standards of care…
- Conditions
- Cardiovascular Diseases, Medical Device, Primary Health Care, Electrocardiogram
- Trial name
- PMCARDIO-PT1 (NCT05329246)
- Testing
- AI-assisted Clinical Assistant PMcardio
- Where
- 56 sites in Slovakia
- Volunteers
- 836 people
- Sponsor
- Powerful Medical
Type 1 Diabetes Mellitus
Islet Transplantation for Type 1 Diabetes Mellitus
The complex program of insulin replacement for type 1 diabetes that is current clinical standard of care is difficult to implement for long periods of time, associated with an increased risk of severe hypoglycemia and implemented…
- Trial name
- NCT00437398
- Testing
- Islet Transplant
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Mayo Clinic
Delirium, Confusion
Improving Safety of Diagnosis and Therapy in the Inpatient Setting
To improve the safety of diagnosis and therapy for a set of conditions and undifferentiated symptoms for hospitalized patients, the investigators will employ a set of methods and tools from the disciplines of systems engineering…
- Conditions
- Delirium, Confusion, Mental Status Change, Back Pain
- Trial name
- PSLL2-0 (NCT04393909)
- Testing
- Diagnostic Uncertainty Educational Curriculum, Diagnostic Timeout, Patient Diagnostic (Dx) Questionnaire
- Where
- United States
- Volunteers
- 700 people
- Sponsor
- Brigham and Women's Hospital
Cognitive Sensory Perception Level, in Unconscious Patients
The Effect of Aromatherapy Massage-Based Sensory Stımulatıon Program on Cognıtıve and Sensory Functıon ın Intensıve Care Patıents
Background: Sensory stimulation is a treatment that uses auditory, visual, tactile, gustatory, and olfactory stimuli, as well as balance and position modes, with intensity and frequency adjusted to the patient's individual…
- Conditions
- Cognitive Sensory Perception Level, in Unconscious Patients, Lung Disaases, Cerebro Vascular Disease
- Trial name
- NCT07593430
- Testing
- Intervention 1, Intervention 2, plasebo group
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Nigde Omer Halisdemir University