Clinical trials: Unconscious
Fainting, Presyncope
Evaluation of the Efficiency of Hydration by Isotonic Solution in the Prevent of the Fainting Whole Blood Donors
Blood donation is a generous act carried out by healthy male and female volunteer donors. The safety of blood donation in France is based on rigorous well documented biological and medical criteria, in particular concerning the…
- Conditions
- Fainting, Presyncope, Syncopal Episode
- Trial name
- EVASION (NCT02075099)
- Testing
- tensing exercises, No tensing exercises
- Where
- 2 sites in France
- Volunteers
- 4,825 people, healthy volunteers welcome
- Sponsor
- Etablissement Français du Sang
Syncope
NICE Guideline 'Red Flags' to Predict Serious Outcome After Transient Loss of Consciousness
This study is designed to evaluate the accuracy of the National Institute for Health and Clinical Excellence (NICE) guideline 'red flags' to identify patients at high risk of short term serious outcome when presenting in the…
- Trial name
- NCT01498471
- Where
- Belgium
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Syncope, Vasovagal, Postural Orthostatic Tachycardia Syndrome
Postural Sway and Counterpressure Maneuvers for Pediatric Syncope
The investigators are interested in whether discrete counterpressure maneuvers, or muscle movements in the lower body, will boost blood pressure and cardiovascular control in children who faint.
- Conditions
- Syncope, Vasovagal, Postural Orthostatic Tachycardia Syndrome, Orthostatic Intolerance
- Trial name
- NCT05633693
- Testing
- Counterpressure Maneuvers, Baseline Stand
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Simon Fraser University
Status Epilepticus, Electrographic, Coma
VIGABatrin in Post-anoxic STATus Epilepticus - Phase IIa
This is a pilot trial of a single loading dose of vigabatrin in post-anoxic status epilepticus.
- Trial name
- VIGAB-STAT (NCT04772547)
- Testing
- Vigabatrin Only Product
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Florida
General Anesthesia
Effects of Intravenous Lidocaine on ED50, ED95 and NTI Values of Propofol Induced Unconsciousness
The effect of intravenous lidocaine on ED50 and ED95 of propofol, which causes unconsciousness, is unclear. In addition, it is not clear whether the depth of anesthesia induced by propofol changes when lidocaine is used in…
- Trial name
- NCT05573191
- Testing
- Lidocaine, Normal saline
- Where
- 2 sites in China
- Volunteers
- 100 people
- Sponsor
- General Hospital of Ningxia Medical University
Parkinson's Disease
Requirement of Propofol for Induction of Unconsciousness in Patients With Parkinson's Disease
Parkinson's disease (PD) is the second most prevalent neurodegenerative disease. The investigators clinical experience showed a trend of delayed emergence among patients undergoing deep brain stimulator (DBS) implantation and…
- Trial name
- NCT01998204
- Where
- China
- Volunteers
- 62 people
- Sponsor
- Changhai Hospital
Stroke, Acute, TBI
Tracheostomy With Bedside Simultaneous Gastrostomy Vs Usual Care Tracheostomy And Delayed Gastrostomy Placement
There is currently no prospective study analyzing the effect of tracheostomy with bedside simultaneous gastrostomy versus tracheostomy with delayed gastrostomy placement (TSG versus TDG) on the outcomes of neurocritically-ill…
- Conditions
- Stroke, Acute, TBI, Neuromuscular Diseases, Status Epilepticus
- Trial name
- BEGASTON (NCT04758052)
- Testing
- Timing of placement
- Where
- United States
- Sponsor
- University of Mississippi Medical Center
Traumatic Brain Injury With Loss of Consciousness
Mesenchymal Stromal Cells for Traumatic Brain Injury
Traumatic Brain Injury (TBI) is an alteration of brain function caused by an external force. Long-term mortality in TBI is substantial, TBI survivors can develop chronic progressive disabilities and have a life expectancy…
- Trial name
- MATRIx (NCT06163833)
- Testing
- Mesenchymal stromal cell low dosage-80*10^6 cells, Mesenchymal stromal cell low dosage-160*10^6 cells
- Where
- 3 sites in Italy
- Volunteers
- 78 people
- Sponsor
- Fondazione IRCCS San Gerardo dei Tintori
Age-Related Macular Degeneration, Cataract
The Effect of Ranibizumab on Eye Lens Opacity in Cases With Age-Related Macular Degeneration
Purpose To evaluate the cataractogenic effect of intravitreal ranibizumab with the use of Lens Opacity Classification System III (LOCS III).
- Trial name
- NCT01330797
- Where
- Turkey (Türkiye)
- Volunteers
- 13 people
- Sponsor
- Uludag University
Pulmonary Arterial Hypertension
Long-term Extension Study of the Safety and Pharmacokinetics of QCC374 in PAH Patients
This is a long-term open-label safety extension to the Phase 2a study of inhaled QCC374 in adult patients with PAH. This study provides the patients who completed the QCC374X2201 study with the option to continue receiving…
- Trial name
- NCT02939599
- Testing
- QCC374
- Where
- 4 sites in United States, Germany and 1 more
- Volunteers
- 5 people
- Sponsor
- Novartis Pharmaceuticals
Syncope
Prevalence of PE in ED Patients With Isolated Syncope
Syncope is a rapid onset, transient, loss of consciousness with a short duration. This symptom has been reported to be a specific presentation of patients with pulmonary embolism.
- Trial name
- PEEPS (NCT03487237)
- Testing
- Ddimer testing
- Where
- France
- Volunteers
- 459 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Syncope, Vasovagal, Neurally-Mediated
Assessment of the Durability of Cardioneuroablation Using Physiological Indices of Heart Rate Reactivity
Cardioneuroablation is a novel treatment option for reflex-mediated syncope. It involves thermal destruction of neural tissue in the close proximity of heart using catheter introduced to the heart through vein in the groin.
- Trial name
- NCT06697145
- Testing
- Cardioneuroablation
- Where
- Poland
- Volunteers
- 12 people
- Sponsor
- Wroclaw Medical University
Anesthesia, Surgery
Adherence Degree of Kasr-Alaini Hospital Pre-anesthetic Tests to the NICE-UK Guidelines
Routine preoperative tests aim to identify asymptomatic diseases that can't be recognized by history and examination. Identification and management of these diseases is thought to help minimizing perioperative morbidity and…
- Conditions
- Anesthesia, Surgery, Exanimation
- Trial name
- NCT04519268
- Testing
- Adult patients scheduled for an elective general surgical operation.
- Where
- Egypt
- Volunteers
- 185 people
- Sponsor
- Nazmy Edward Seif
Consciousness Disorders, Persistent Vegetative State
Multimodal Assessment and Prognosis in Disorders of Consciousness After Severe Brain Injury (CyDoC-MAP)
After a severe brain injury some patients survive but cannot communicate, and deciding early which of them are likely to recover consciousness remains one of the hardest problems in neurocritical care.
- Conditions
- Consciousness Disorders, Persistent Vegetative State, Unresponsive Wakefulness Syndrome, Minimally Conscious State
- Trial name
- CyDoC-MAP (NCT07736820)
- Where
- Cyprus
- Volunteers
- 40 people
- Sponsor
- Nicosia General Hospital
Diabetes Mellitus, Type 1
The Impact of Pancreatic Islet Cell Allotransplantation on Cognitive Function in Type 1 Diabetes Mellitus
In patients with Type 1 Diabetes Mellitus, hypoglycemia (low blood sugar) is the rate-limiting step to achieve glucose level control.
- Trial name
- NCT00590876
- Where
- 2 sites in United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Yale University
Brain Death, Organ Donation
Methods of Confirmation of Brain Death
The purpose of this study is to describe the use of methods confirming brain death in the real clinical practice of the transplant program in the Czech Republic.
- Trial name
- NCT04734574
- Where
- Czechia
- Volunteers
- 60 people
- Sponsor
- Brno University Hospital
ICU Patients, Under Mechanical Ventilation
Syndrome and Aspiration Pneumonia in Intensive Care
Inhalation is a common condition in patients with impaired their awareness requiring protection of the upper airway by endotracheal intubation. This inhalation may lead to chemical pneumonitis and/or bacterial pneumonia.
- Conditions
- ICU Patients, Under Mechanical Ventilation, In State of Coma (Define by Glasgow ≤ 8), No Antibiotic Treatment
- Trial name
- SPIRE (NCT01881672)
- Where
- France
- Volunteers
- 250 people
- Sponsor
- Centre Hospitalier Departemental Vendee
Brain Death
Non-randomized, Open-labeled, Interventional, Single Group, Proof of Concept Study With Multi-modality Approach in Cases of Brain Death Due to Traumatic Brain Injury Having Diffuse Axonal Injury
This is the proof of concept study with multi-modality approach (using intra-thecal bioactive peptides, stem cells, laser and transcranial IV laser and Median Nerve stimulation as adjuvants) in cases of brain death due to…
- Trial name
- NCT02742857
- Testing
- BQ-A Peptide Extract, Mesenchymal Stem Cells, Transcranial Laser Therapy
- Where
- India
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Bioquark Inc.
Acute Brain Injuries, Consciousness Disorders
CONNECT-ME: Consciousness in Neurocritical Care Cohort Study Using fMRI and EEG
Detecting preserved consciousness in brain-injured patients by traditional clinical means requires presence of motor function. Otherwise, patients may be erroneously classified as being in a vegetative state.
- Trial name
- CONNECT-ME (NCT02644265)
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Loss of Consciousness of Unspecified Duration, Cerebral Laceration and Contusion
The Clinical Research on the Relationship Between Circadian Rhythm and Gut Microbiota in TBI Patients
Microbiome studies may be highlighted as crucial in the development of sleep disorder for TBI patients. The microbiota-gut-brain connection may further provide an opportunity for microbiota manipulation to treat the TBI patients…
- Conditions
- Loss of Consciousness of Unspecified Duration, Cerebral Laceration and Contusion, Traumatic Brain Injury
- Trial name
- NCT02849028
- Testing
- sleep disorder
- Where
- China
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- General Hospital of Ningxia Medical University