Clinical trials: Unconscious
Vasovagal Syncope (VVS)
Assesment of the Clinical Benefit of Provocation on Tilt-table in SYNCope Patients, TiltSYNC-trial
multicenter prospective randomized controlled comparison of biofeedback with tilt table testing (investigational management strategy) vs biofeedback without tilt table testing (reference management strategy) in patients with…
- Trial name
- TiltSYNC (NCT07459478)
- Testing
- biofeedback and standard of care with tilt table testing, no tilt table testing
- Where
- Netherlands
- Volunteers
- 238 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Disorder of Consciousness, Minimally Conscious State
Temporal Interference Stimulation for Disorders of Consciousness
This study aims to investigate whether a new non-invasive brain stimulation technique, called temporal interference stimulation, can influence brain activity and potentially improve signs of consciousness in patients with severe…
- Conditions
- Disorder of Consciousness, Minimally Conscious State, Vegetative State, Unresponsive Wakefulness Syndrome
- Trial name
- NCT07874178
- Testing
- Temporal Interference
- Volunteers
- 4 people
- Sponsor
- Centre Hospitalier Universitaire de Liege
Syncope
Clinical Audit on Evaluation of Patient With Syncope at Asssiut University Children Hospital
Evaluation of commitment of resident physician to the guidelines as regard management of cases of syncope at Assiut University Children Hospital and correction of the defect that will be discovered.
- Trial name
- NCT04575376
- Volunteers
- 30 people
- Sponsor
- Assiut University
Electroencephalogram, Consciousness, Loss of
The Electroencephalogram and Clinical Effect of Ketamine
The electroencephalography (EEG) is a noninvasive medical technique for monitoring and recording the electrical activity of brain.
- Trial name
- NCT03679390
- Testing
- Ketamine
- Where
- Taiwan
- Volunteers
- 17 people
- Sponsor
- National Taiwan University Hospital
Disorder of Consciousness
Emotional and Neutral Sounds for Neurophysiological Prognostic Assessment of Critically Ill Patients With a Disorder of Consciousness
The purpose of this study is to determine if the use of emotional sound as subject own name (SON) pronounced by a familiar voice (FV) compared to SON pronounced by a non-familiar voice (NFV) during event related potential (ERP)…
- Trial name
- ExpressComa (NCT05740735)
- Testing
- Use of "expressive" sounds, Having benefited from a prognostic evaluation by event related potentials (without sound research methods, only neutral sounds)
- Where
- 2 sites in France
- Volunteers
- 114 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Unconscious State, Pressure Ulcer
Nociception Monitoring in Intensive Care
Precisely, pain in the ICU is a multidimensional problem with a multivariate of reasons. Still, it would be simpler to manage it in unconscious palliative patients with less source of pain, but only if we can detect it…
- Trial name
- NCT06270264
- Testing
- the Nociception level index monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Haseki Training and Research Hospital
Acute Disease, Sepsis
Acutelines: a Large Data-/Biobank of Acute and Emergency Medicine
Research in acute care faces many challenges, including enrollment challenges, legal limitations in data sharing, limited funding, and lack of singular ownership of the domain of acute care.
- Conditions
- Acute Disease, Sepsis, Pneumonia, Frailty
- Trial name
- Acutelines (NCT04615065)
- Where
- Netherlands
- Volunteers
- 35,000 people
- Sponsor
- University Medical Center Groningen
Vasovagal Syncope, Postural Tachycardia Syndrome
Mechanisms of Vasovagal Syncope
Vasovagal Syncope (simple postural faint) is the most common cause of acute loss of consciousness. Postural tachycardia syndrome(POTS) is the most common chronic form of postural lightheadedness.
- Trial name
- NCT01791816
- Testing
- Phenylephrine, L-Ng-monomethyl Arginine (L-NMMA)
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- New York Medical College
Phobia
Unconscious Reduction of Fear Through Decoded Neuro-Reinforcement
This application investigates the efficacy of a novel method of neuro-reinforcement based on decoded fMRI activity to reduce fear responses in individuals with phobias (e.g., spiders, snakes).
- Trial name
- DecNef (NCT06420557)
- Testing
- Unconscious Neuro-reinforcement
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, Los Angeles
Syncope, Vasovagal
The Effectiveness of Metoprolol in the Prevention of Syncope Recurrence in Children and Adolescents
The purpose of this study to evaluate the effectiveness of metoprolol versus conventional treatment in the prevention of syncope recurrence in children and adolescents.
- Trial name
- NCT00475462
- Testing
- metoprolol, conventional treatment
- Volunteers
- 28 people
- Sponsor
- Peking University First Hospital
Urea Cycle Disorders, Organic Acidemias
Pilot Study For Hypothermia Treatment In Hyperammonemic Encephalopathy In Neonates And Very Young Infants
This is a pilot study which will test the safety and feasibility of hypothermia treatment as adjunct therapy to conventional treatment of hyperammonemic encephalopathy (HAE) in neonates versus conventional treatment (dialysis…
- Trial name
- NCT01624311
- Testing
- Therapeutic Hypothermia, Standard of Care Therapy
- Where
- 3 sites in United States
- Volunteers
- 5 people
- Sponsor
- Uta Lichter-Konecki
Dyspnea, Coma
The Use of a Point-of-care Thoracic Ultrasound Protocol for Hospital Medical Emergency Teams
Study to assess the possible effects of the use of a point-of-care thoracic ultrasound protocol for hospital medical emergency teams (MET)
- Conditions
- Dyspnea, Coma, Hypotension and Shock
- Trial name
- METUS (NCT03214809)
- Testing
- ultrasound protocol
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Rijnstate Hospital
Comatose
Ticagrelor for the Comatose
The study will investigate the effect of the oral antiplatelet agent ticagrelor (Brilique) when it is administrated through a nasogastric tube in comatose patients.
- Trial name
- TICOMA (NCT02175875)
- Where
- Denmark
- Volunteers
- 47 people
- Sponsor
- Lene Holmvang
Head Trauma, Traumatic Coma
The Effect of Auditory and Tactile Stimuli in Traumatic Coma
This study focused on examining the effects of auditory and tactile stimuli to reduce sensory deprivation on consciousness, oxygen saturation and mean arterial pressure in traumatic coma patients.
- Conditions
- Head Trauma, Traumatic Coma, Nursing Caries
- Trial name
- NCT05195606
- Testing
- Auditory stimulus, Tactile stimulus
- Volunteers
- 90 people
- Sponsor
- Akdeniz University
Acute Coronary Syndromes, Heart Failure
Registry Of Acute meDical Emergencies in Brazil
Critical patients in emergency room are seriously situations that need quickly diagnosis and treatment. Different predictors of prognosis can be related with mortality and morbidity in-hospital and in long-term.
- Conditions
- Acute Coronary Syndromes, Heart Failure, Pulmonary Edema, Aortic Aneurysm, Familial Thoracic 1
- Trial name
- ROAD-Brazil (NCT02753023)
- Testing
- no intervention
- Where
- 6 sites in Brazil
- Volunteers
- 1,650 people
- Sponsor
- University of Sao Paulo General Hospital
Syncope, Fall
Global Approach to Faint and Falls
Syncope is the most frequent cause of transient loss of consciousness. Falls are very common in older people. If the falls are unexplained and not accidental, it is likely that the patient had a syncope event and showed a lack of…
- Trial name
- F2 (NCT05752682)
- Testing
- Diagnostic pathway
- Where
- Italy
- Volunteers
- 340 people
- Sponsor
- Istituto Auxologico Italiano
Vasovagal Syndrome VVS, Cardioinhibitory Carotid Sinus Syndrome CSS
POLish Registry of CArdioneuroablation and CArdioneuromodulation
The multicentre observational study POL-CA involves a wide spectrum of patients with a history of syncopy. The study recruits patients with diagnosed vasovagal syndrome, cardioinhibitory carotid sinus syndrome, symptomatic sinus…
- Conditions
- Vasovagal Syndrome VVS, Cardioinhibitory Carotid Sinus Syndrome CSS, Symptomatic Sinus Bradycardia SB or Atrioventricular Block AV, Postural Orthostatic Tachycardia Syndrome POTS
- Trial name
- POL-CA (NCT07196397)
- Testing
- cardioneuroablation, SN sparing hybrid ablation, Cardiac sympathetic denervation
- Where
- Poland
- Volunteers
- 1,000 people
- Sponsor
- SABAMED Medical Center Ltd.
Coma, Brain Injuries, Traumatic
Evaluation of EEG Power Spectrum in Patients With Traumatic Coma
Development of objective, reliable, and convenient assessment methods of disorders of consciousness is crucial. We aim to conduct multicenter prospective observational study and non-invasively collect EEG from patients with…
- Trial name
- EPIC (NCT06321146)
- Where
- 5 sites in China
- Volunteers
- 210 people
- Sponsor
- RenJi Hospital
Lassa Fever, Lassa Virus Infection
Lassa Fever Clinical Course and Prognostic Factors in Nigeria
The investigators propose to conduct a nationwide (Nigeria), prospective, non-interventional cohort study describing the clinical course, biological characteristics, case management and outcomes in patients hospitalized for a…
- Conditions
- Lassa Fever, Lassa Virus Infection, Pregnancy Complications, Acute Kidney Injury
- Trial name
- LASCOPE (NCT03655561)
- Testing
- Non interventional research
- Where
- 2 sites in Nigeria
- Volunteers
- 1,100 people
- Sponsor
- Alliance for International Medical Action
Reflex Syncope
Cardioinhibitory Reflex Syncope. Permanent Pacemaker Therapy or Cardioneuroablation?
Reflex syncope is the most common form of syncope. It can lead to injuries and affect quality of life. Nonpharmacological and medical therapies have limited effectiveness.
- Trial name
- PANACEA (NCT05855603)
- Testing
- Cardioneuroablation, Permanent pacemaker therapy
- Where
- 10 sites in Spain
- Volunteers
- 90 people
- Sponsor
- Institut d'Investigació Biomèdica de Bellvitge