Clinical trials: Unconscious
Traumatic Brain Injury, Coma
Optimized Therapy in Severe Traumatic Brain Injured Patients
Severe traumatic brain injury is associated with life-threatening and incapacitating secondary injury. Contemporary therapeutic interventions are aimed at preventing and treating secondary damage.
- Trial name
- NCT02130674
- Testing
- Dipeptiven
- Where
- Switzerland
- Volunteers
- 12 people
- Sponsor
- University of Zurich
Malaria, Seizures
Aggressive Antipyretics for Fever Reduction in CNS Malaria
The study will examine whether prophylactic and scheduled treatment with acetaminophen and ibuprofen can decrease the maximum temperature experienced during the acute illness in children with CNS malaria.
- Conditions
- Malaria, Seizures, Coma, Parasitemia
- Trial name
- NCT03399318
- Testing
- Acetaminophen, Ibuprofen
- Where
- 3 sites in Malawi, Zambia
- Volunteers
- 256 people
- Sponsor
- University of Rochester
Coma, Wounds and Injuries
Cervical Spine Clearance in Obtunded Trauma Patients
The optimal method of clearing the cervical spine in obtunded trauma patients is unclear. Computed tomography (CT) identifies most injuries but may miss ligamentous injuries.
- Trial name
- CSclearance (NCT00573014)
- Testing
- Cervical Spine Clearance
- Where
- United States
- Volunteers
- 197 people
- Sponsor
- MetroHealth Medical Center
Minimally Conscious State, Vegetative State
Further Psychometric Data for the Reliability and the Diagnostic Validity of CRS-R
This study aims to provide, in a large sample, further psychometric data as regards the internal consistency, the test-retest reliability and the diagnostic validity of the Coma Recovery Scale-Revised (CRS-R).
- Trial name
- NCT03126929
- Testing
- Coma Recovery Scale-Revised and Glasgow Coma Scale
- Volunteers
- 169 people
- Sponsor
- Hangzhou Normal University
Type1 Diabetes Mellitus, Hypoglycemia Unawareness
Amitriptyline in Treating Hypoglycemia
Patients with type 1 diabetes mellitus (T1DM) commonly experience hypoglycemia and develop impaired awareness of hypoglycemia. Many patients using continuous glucose monitoring (CGM) system to mitigate these complications, but…
- Trial name
- NCT03591458
- Testing
- Amitriptyline
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Utah
Syncope
CSRS Implementation - A Pilot Study
Syncope is a common reason for emergency department (ED) presentation. While often benign, some patients have serious and life-threatening underlying causes, both cardiac and non-cardiac, which may or may not be apparent at the…
- Trial name
- NCT04790058
- Testing
- Knowledge translation of the CSRS practice recommendations
- Where
- Canada
- Volunteers
- 900 people
- Sponsor
- Ottawa Hospital Research Institute
Syncope, Near Syncope
Validation of the San Francisco Syncope Rule
This study was designed to validate the "San Francisco Syncope Rule". This set of rules was derived by Quinn et. al. to help guide the treatment of patients evaluated in the Emergency Department who had an episode of syncope…
- Trial name
- NCT00300625
- Testing
- Application of the San Francisco Syncope Rule
- Where
- United States
- Sponsor
- Albert Einstein College of Medicine
Brain Death, Respiration, Artificial
Miniature In-line Respirator
This first-in-human pilot study will test an investigational miniature breathing device called the Hope inVent. The device is a small, single-use, in-line respirator that connects to a breathing tube and uses compressed oxygen to…
- Trial name
- NCT07768215
- Testing
- Hope inVent
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Stroke, Joint Replacement Surgery
SG Healthcare and Assistive Robotics Programme (SHARP) - Proof of Concept Study
Robots are commonly used in many settings to help with transportation needs, reduce human injuries, and assisting clinicians during surgeries.
- Conditions
- Stroke, Joint Replacement Surgery, Acquired Brain Injury, Spinal Cord Injuries
- Trial name
- SHARPCARE (NCT04315389)
- Testing
- (1) Mobile Assistant Balance Robot, (2) Transfer Assistive Cobot
- Where
- Singapore
- Volunteers
- 52 people
- Sponsor
- Tan Tock Seng Hospital
Cardiac Arrest
Neuroprognostication Bias: A Collaboration to Reduce the Impact of Self-fulfilling Prophecy in Cardiac ARrEst
Cardiovascular disease remains the leading cause of death in the United States. Mortality rates of cardiac arrest range from 60-85%, and approximately 80% of survivors are initially comatose.
- Trial name
- SPARE (NCT03261089)
- Where
- 8 sites in United States, Brazil
- Volunteers
- 600 people
- Sponsor
- Boston Medical Center
Disorder of Consciousness
Neurorehabilitation in Patients With Disorders of Consciousness: Multidimensional Ambispective Study on the Impact of Single and Combined Approaches
Disorders of consciousness (DOC), such as the vegetative state/unresponsive wakefulness syndrome (VS/UWS) and the minimally conscious state (MCS), represent severe clinical conditions arising from acquired brain injury (ABI)…
- Trial name
- NCT07385508
- Testing
- Multidisciplinary neurorehabilitation
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Hypoglycemia Unawareness, Type 1 Diabetes
Glucose Counterregulation in Long Standing Type 1 Diabetes
Enrollment for this study is complete. This study is designed to determine if use of a real-time continuous glucose monitor (RT-CGM) can reverse defective Glucose counter regulation and hypoglycemia unawareness in long standing…
- Conditions
- Hypoglycemia Unawareness, Type 1 Diabetes, Healthy
- Trial name
- NCT01474889
- Testing
- RT-CGM
- Where
- 3 sites in United States
- Volunteers
- 37 people
- Sponsor
- University of Pennsylvania
Vasovagal Syncope, Smoke Inhalation
Relation Between Vasovagal Tendency and Smoking Among University Students
Almost everyone is aware these days is aware about the risk of smoking. Still many people start this habit specially in early life and during college year.
- Trial name
- NCT02949804
- Testing
- Comparison between two groups
- Where
- Jordan
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Jordan Collaborating Cardiology Group
Malaria, Cerebral
Treating Brain Swelling in Pediatric Cerebral Malaria
This study evaluates the effectiveness of two interventions in Malawian children with cerebral malaria at high risk of death. One-third of the participants will receive treatment as usual, one-third will receive treatment as…
- Trial name
- TBS (NCT03300648)
- Testing
- Mechanical ventilation, Hypertonic saline
- Where
- Malawi
- Volunteers
- 57 people
- Sponsor
- Michigan State University
Obstructive Sleep Apnea, Vasovagal Syncope
Clinical Association Between Obstructive Sleep Apnea, Facial Pigmentation, and Vasovagal Symptoms.
The goal of this prospective cohort study is to study patients referred for sleep study by in-lab polysomnography in the Jordan University Hospital and the Jordan Hospital or with an at-home sleep study kit.
- Conditions
- Obstructive Sleep Apnea, Vasovagal Syncope, Smoking, Acanthosis Nigricans
- Trial name
- VasOSA (NCT06331819)
- Testing
- In-lab polysomnography, Continuous positive airway pressure, Home sleep study device
- Where
- Jordan
- Volunteers
- 200 people
- Sponsor
- Jordan Collaborating Cardiology Group
Vasovagal Syncope
Prevention of Syncope Trial 6 - Atomoxetine in Vasovagal Syncope
Objective: To determine if atomoxetine 40 mg bid (bis in die) in patients ≥18 years old with recurrent vasovagal syncope will better prevent syncope during tilt testing than placebo.
- Trial name
- POST6 (NCT02500732)
- Testing
- Atomoxetine
- Where
- Canada
- Volunteers
- 57 people
- Sponsor
- University of Calgary
Coma, Emotional Distress
The COMA Family Program: A Skills-Based Resiliency Program for Caregivers of Patients With Severe Acute Brain Injuries
The purpose of this study is to pilot a psychosocial skills-based intervention for caregivers of patients with severe acute brain injuries.
- Trial name
- COMA-F (NCT05761925)
- Testing
- COMA-F
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Circulatory Collapse, Circulatory Failure
Suspension Syndrome
Suspension syndrome refers to a potentially life-threatening condition that can occur in unconscious persons after prolonged suspension in a harness.
- Conditions
- Circulatory Collapse, Circulatory Failure, Syncope, Vasovagal, Neurally-Mediated, Orthostatic Hypotension
- Trial name
- NCT02726776
- Testing
- Suspension in a harness, Climbing
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Institute of Mountain Emergency Medicine
Coma, Disorder of Consciousness
Development of a Point of Care System for Automated Coma Prognosis
Electroencephalogram/event-related potentials (EEG/ERP) data will be collected from 50 participants in coma or other disorder of consciousness (DOC; i.e., Unresponsive Wakefulness Syndrome [UWS] or Minimally Conscious State…
- Conditions
- Coma, Disorder of Consciousness, Minimally Conscious State, Vegetative State
- Trial name
- NCT03826407
- Where
- Canada
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- McMaster University
Seizure, Syncope
Lactate Compared to Creatine Kinase as Diagnostic Marker in Generalized Epileptic Seizure
The investigators compared the feasibility of serum creatine kinase and serum lactate concentration as diagnostic markers to distinguish between generalized tonic-clonic seizures (GTCS) and syncopes in clinical settings that…
- Trial name
- NCT02926703
- Testing
- Serum lactate and CK concentrations in blood samples
- Where
- Germany
- Volunteers
- 85 people
- Sponsor
- RWTH Aachen University