Clinical trials: Unconscious
Syncope, Vasovagal
Closed Loop Stimulation for Neuromediated Syncope (SPAIN Study)
Physiological stimulation therapy effectiveness will be proved with contractility sensor or CLS sensor (Closed Loop Stimulation), in BIOTRONIK CLS pacemakers to prevent from neuromediated syncope.
- Trial name
- SPAIN (NCT01621464)
- Testing
- Pacemaker with Closed Loop Stimulation (CLS sensor)
- Where
- Spain
- Volunteers
- 55 people
- Sponsor
- Spanish Society of Cardiology
Unconsciousness
The Impact of Different Recovery Positions on the Perfusion of the Lower Forearm and Comfort
Introduction: A side-lying recovery position is recommended when victims are unresponsive but breathing normally and, hence, do not require cardiopulmonary resuscitation.
- Trial name
- NCT05587179
- Testing
- recovery position
- Where
- Belgium
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Centre for Evidence-Based Practice, Belgium
Chronic Consciousness Disorders, Vegetative State
Vagal Nerve Stimulation in Coma Patients
Minimally Conscious (MCS) or Vegetative State (VS) are disorders of consciousness which often occur following traumatic brain injury or ischemia.
- Conditions
- Chronic Consciousness Disorders, Vegetative State, Minimally Conscious State, Akinetic Mutism
- Trial name
- SNV (NCT02591069)
- Testing
- stimulation device
- Where
- France
- Volunteers
- 4 people
- Sponsor
- Hospices Civils de Lyon
Orthostatic Hypotension, Diabetes
Insulin Therapy and Falls Due to Orthostatic Hypotension
In the proposed study, the investigators examine in older adults with Type 2 diabetes the impact of beginning insulin therapy on the orthostatic drop in blood pressure as well as the response of arterial blood pressure and…
- Conditions
- Orthostatic Hypotension, Diabetes, Syncope
- Trial name
- NCT01914146
- Testing
- Insulin, No Insulin
- Where
- Canada
- Sponsor
- University of British Columbia
Conscious Sedation
Feasability Test of a Handset Device to Detect Levels of Sedation and Loss of Consciousness
Sedation is often administered to relieve anxiety and discomfort during uncomfortable procedures in elderly patients. Patient control of sedation offers many potential benefits for patients and healthcare professionals, including…
- Trial name
- NCT01778608
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- University Medical Center Groningen
Brain Death
Brain Death Diagnosis at an Academic Tertiary Medical Care Center
The aim of this study is to assess and survey the quality of the process required to diagnose brain death in adult patients. This study of adult patients diagnosed brain dead or suspected of having brain death on the ICUs at the…
- Trial name
- NCT03984981
- Testing
- Assessment of process required to diagnose brain death in adult patients
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University Hospital, Basel, Switzerland
Epilepsy, Major Depressive Disorder (MDD)
Lethargic Depression Study
This is a study of Major Depressive Disorder (MDD) in patients with decreased energy, pleasure and interests.
- Trial name
- NCT00064467
- Testing
- Extended-release bupropion (HCl)
- Where
- 24 sites in United States
- Volunteers
- 268 people
- Sponsor
- GlaxoSmithKline
Traumatic Brain Injury, Cerebral Anoxia
Intrathecal Baclofen Therapy and Paroxysmal Dysautonomia in Severe Brain-Injured Patients
Within the framework of a prospective double-blind and randomized study evaluating the efficacy of continuous intrathecal baclofen therapy (CIBT) on paroxysmal dysautonomia (main objective) and hypertonia, recovery and tolerance…
- Conditions
- Traumatic Brain Injury, Cerebral Anoxia, Coma, Hypertonia
- Trial name
- NCT00221689
- Testing
- baclofen (drug)
- Where
- France
- Volunteers
- 4 people
- Sponsor
- University Hospital, Bordeaux
Syncope, Vasovagal
Midodrine and Fludrocortisone for Vasovagal Syncope
Syncope is a common condition which can disturb daily functions of the patients and impair their quality of lives. It contributes to 0.8 to 2.4% of the visits of emergency rooms.
- Trial name
- COMFORTS (NCT04595942)
- Testing
- Midodrine Hydrochloride Tablets, Fludrocortisone Acetate Tablets, Lifestyle modification
- Where
- Iran
- Volunteers
- 1,375 people
- Sponsor
- Tehran Heart Center
Median Nerve, Coma
The Safety and Efficacy of Median Nerve Electrical Stimulation for Improving Neurological Function Prognosis in Patients With Cardiac Arrest
Median nerve stimulation (MNS), a non-invasive brain stimulation technique, has been widely adopted in clinical arousal therapies and multiple clinical investigations have attested to the efficacy of this technique; nevertheless…
- Conditions
- Median Nerve, Coma, Post Cardiac Arrest Brain Injury
- Trial name
- NCT06696690
- Testing
- MNS
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Tang Ziren
Syncope
Haemodynamic Feasibility Study of Sensors Within a Tilting Table Examination
This study´s aim is to explore physiological associations concerning pulse wave velocity, heart rate and blood pressure in order to make taking the blood pressure more comfortable.
- Trial name
- NCT01831297
- Testing
- measurement of blood pressure
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- RWTH Aachen University
Disorder of Consciousness
Apomorphine in Severe Brain-injured Patients
Background: Patients who survive severe brain injury may develop chronic disorders of consciousness (DoC). Treating these patients to improve recovery is extremely challenging because of scarce and inefficient therapeutical…
- Trial name
- APODoC (NCT05213169)
- Testing
- Apomorphine Hydrochloride 5mg/ml, Sodium chloride 9mg/ml
- Where
- 4 sites in Belgium, Spain
- Volunteers
- 48 people
- Sponsor
- University of Liege
Infarction, Brain
CT-Angiography Versus Angiogram as Ancillary Tests in the Determination of Death by Neurologic Criteria
Diagnostic performance of a novel protocol for computed tomography-angiography, as ancillary test in the determination of complete cerebral infarction, in comparison to four vessel angiography.
- Trial name
- Tadaa (NCT07341490)
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Region Stockholm
Brain Injuries, Hypotension, Orthostatic
Study of Pulse Pressure During Tilttable and Erigo® in Adult Patients With Acquired Brain Injury
The purpose of this study is to determine if the pulse pressure changes are different whether patients are training in a traditional tilt table as compared to a robotic assisted tilt table, which induces leg movement.
- Conditions
- Brain Injuries, Hypotension, Orthostatic, Syncope
- Trial name
- NCT02700399
- Testing
- Erigo® Hocoma, Traditional tilt table from Rehab-Care
- Where
- Denmark
- Volunteers
- 13 people
- Sponsor
- University of Aarhus
Bifascicular Block, Syncope
Prevention of Syncope by Cardiac Pacing in Patients With Bifascicular Block
Study Objective The purpose of this study is to evaluate the efficacy of bradycardia pacing with respect to patient symptoms in patients with bifascicular block and syncope of unexplained origin.
- Trial name
- PRESS (NCT01463358)
- Testing
- DDD60 (INSIGNIA® pacing systems Guidant (Boston Scientific)
- Where
- 12 sites in Italy
- Volunteers
- 101 people
- Sponsor
- Boston Scientific Corporation
Diabetes Mellitus, Type 1, Hypoglycemia
Effect of Dapagliflozin on IAH in T1DM
Approximately 25% of patients with type 1 diabetes have lost the capacity to timely detect hypoglycaemia, a condition referred to as impaired awareness of hypoglycaemia (IAH) that causes a six-fold higher risk of severe…
- Conditions
- Diabetes Mellitus, Type 1, Hypoglycemia, Hypoglycemia Unawareness
- Trial name
- NCT03556033
- Testing
- Dapagliflozin
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Radboud University Medical Center
Out-Of-Hospital Cardiac Arrest, Emergencies
Livestreaming From Smartphones as a Supplement to Emergency Calls
The aim of the study is to analyse if live video as a supplement to emergency calls can improve medical dispatchers' situation awareness and enhance the assistance they provide including provision of pre-hospital resources.
- Conditions
- Out-Of-Hospital Cardiac Arrest, Emergencies, Unconscious
- Trial name
- NCT04061187
- Where
- Denmark
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Emergency Medical Services, Capital Region, Denmark
Type 1 Diabetes
Continuous Glucose Monitoring and Hypoglycemia Unawareness in Type 1 Diabetes
Looking for strict normoglycemia in type 1 diabetes increases the risk of hypoglycemia, exposing to hypoglycemia unawareness. It has been shown that the early correction of hypoglycemia can help recovering the perception of…
- Trial name
- NCT03605979
- Where
- France
- Volunteers
- 11 people
- Sponsor
- CHU de Reims
Tachycardia, Ventricular, Implantable Cardioverter Defibrillator (ICD)
PREPARE - Primary Prevention Parameters Evaluation
The purpose of this study is to test specific device programming in patients without a previous history of a life-threatening, abnormally fast heartbeat who are implanted with a Medtronic ICD (Implantable Cardioconverter…
- Conditions
- Tachycardia, Ventricular, Implantable Cardioverter Defibrillator (ICD), Fibrillation, Ventricular, Syncope
- Trial name
- NCT00279279
- Testing
- Implanted Device
- Where
- 32 sites in United States, Puerto Rico
- Volunteers
- 700 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Organ Donor, Brain Death
Therapeutic Hypothermia in "Expanded Criteria" Brain-dead Donors and Kidney-graft Function
Each year, only one third of patients registered on the waiting list receive a kidney transplant. Numerous paths are being explored with the aim of reversing this shortage.
- Conditions
- Organ Donor, Brain Death, Kidney Transplant; Complications, Critical Illness
- Trial name
- HYPOREME (NCT03098706)
- Testing
- Procedure control: normothermia, Procedure active
- Where
- 54 sites in France
- Volunteers
- 532 people
- Sponsor
- Nantes University Hospital