Clinical trials: Unconscious
Disorders of Consciousness Due to Severe Brain Injury, Disorders of Consciousness
fNIRS for Disorders of Consciousness
The goal of this observational study is to learn whether functional near-infrared spectroscopy (fNIRS) can measure brain activity in healthy adults and in people with disorders of consciousness (DoC) in the neuro-intensive care…
- Conditions
- Disorders of Consciousness Due to Severe Brain Injury, Disorders of Consciousness, Coma, Minimally Conscious State
- Trial name
- NCT07485361
- Testing
- Functional Near-Infrared Spectroscopy Monitoring
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Accidental Falls, Aged
Whole-Body Point-of-Care Ultrasound in Older Adults Presenting to the Emergency Department After a Fall
Falls are one of the most common reasons older adults visit the emergency department. In many older patients, a fall that looks "mechanical" is actually caused by an underlying medical problem such as syncope, heart disease…
- Conditions
- Accidental Falls, Aged, Syncope
- Trial name
- NCT07886164
- Testing
- Whole-body point-of-care ultrasound (POCUS)
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people
- Sponsor
- Kocaeli City Hospital
Type1diabetes, Hypoglycemia Unawareness
Hybrid Closed Loop Insulin Delivery System in Hypoglycemia
Can a type 1 diabetic adult avoid low glucoses and regain hypoglycemia awareness using a hybrid closed loop insulin delivery system? Involvement is 22 months (13 visits) and includes a 4-week Screening Phase and an 18-month…
- Conditions
- Type1diabetes, Hypoglycemia Unawareness, Nocturnal Hypoglycemia, Hypoglycemia Night
- Trial name
- Aim2 (NCT03215914)
- Testing
- MiniMed 670G system
- Where
- 3 sites in United States
- Volunteers
- 10 people
- Sponsor
- University of Pennsylvania
Propofol
The Effect of the ALDH2 Gene Polymorphism on the Propofol Potency for Inducing Loss of Consciousness
The aim of this study is to determine whether ALDH2 gene polymorphisms (G/G, G/A A/A) have effect on the potency of propofol.
- Trial name
- NCT03762538
- Testing
- Propofol
- Volunteers
- 100 people
- Sponsor
- Shanghai Zhongshan Hospital
Pulmonary Embolism, Syncope
Assessing the Risk of Pulmonary Embolism in Patients After Hospitalization for First Episode of Syncope
Acute pulmonary embolism (APE) is a common disease, which involves significant morbidity and mortality. The clinical presentation of APE has many faces but it is acceptable to suspect this disease when the patient presenting with…
- Trial name
- NCT03034525
- Volunteers
- 7,000 people
- Sponsor
- Rambam Health Care Campus
Vasovagal Syncope
Effect of Closed Loop Pacemaker Treatment on Recurrent Vasovagal Syncope
The main purpose is to prevent syncope in patients with recurrent syncopal episodes caused by malignant vasovagal faints and bradycardia.
- Trial name
- NCT00292825
- Testing
- Pacemaker treatment, pacemaker programmed as active = CLS, Pacemaker, programmed as passive = VVI 30 beats per minute (bpm)
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Aarhus University Hospital Skejby
Syncope, Syncope, Vasovagal
Head-up Tilt Test in Patients With Reflex Syncope and Asystolic Response Who Received a Dual-chamber Pacemaker With the Closed Loop Stimulation (CLS) and Participated in the BIOSync Trial
The purpose of this study is to explore changes in patients' hemodynamic parameters during the Head-Up Tilt Test ("HUTT") and their timing with respect to onset of the Closed Loop Stimulation (CLS) pacing.
- Trial name
- BIO|Sync-HUTT (NCT06038708)
- Where
- 2 sites in Italy
- Volunteers
- 20 people
- Sponsor
- Biotronik SE & Co. KG
Blood Donors
Addressing Fear and Risk of Vasovagal Reactions Among High School Donors
In this study, high school donors will be asked about their blood donation-related fears prior to their donation. Half of the donors reporting fear will be assigned to a brief coping skills intervention.
- Trial name
- NCT03835299
- Testing
- Fear Intervention
- Where
- United States
- Volunteers
- 4,035 people
- Sponsor
- Ohio University
Postoperative Intracranial Hematoma, Postoperative Intracranial Haemorrhage
A New Approach in Intensive Care Unit Consciousness Assessment: FIVE Score
1. The primary aim of this study is to investigate the correlation between the length of ICU stay and a newly developed FIVE score in neuro-intensive care patients. 2.
- Conditions
- Postoperative Intracranial Hematoma, Postoperative Intracranial Haemorrhage, Supratentorial Cancer, Infratentorial Neoplasms
- Trial name
- NCT06036732
- Where
- Turkey (Türkiye)
- Volunteers
- 223 people
- Sponsor
- Istanbul University - Cerrahpasa
Unconsciousness
Comparison of Three Methods for NG Tube Placement
Background and Aim: Tubular feeding is used, in patients who cannot take food through their mouths, but the digestive system has the ability to digest food.
- Trial name
- NG (NCT03699306)
- Testing
- NG tube insertion method
- Where
- 2 sites in Iran
- Volunteers
- 75 people
- Sponsor
- Isfahan University of Medical Sciences
Syncope
Comparison Between Standard and Ultrasound Integrated Approach for Risk Stratification of Syncope in the Emergency Department
This is a observational prospective study. For patients presenting to the Emergency Department with loss of consciousness, emergency physicians will be asked to screen the real syncope without an evident and immediate cause for…
- Trial name
- NCT02781207
- Where
- Italy
- Volunteers
- 196 people
- Sponsor
- University of Turin, Italy
Vegetative State, Minimally Conscious State
Prefontal tDCS in Patients With Disorders of Consciousness: Neurophysiological and Behavioural Outcomes
Non-invasive brain stimulations techniques have recently shown promising results in patients with disorders. Notably, transcranial direct current stimulation (tDCS) applied over the left dorsolateral prefrontal cortex has proved…
- Conditions
- Vegetative State, Minimally Conscious State, Disorder of Consciousness
- Trial name
- NCT03823508
- Testing
- anodal tDCS
- Where
- Belgium
- Volunteers
- 15 people
- Sponsor
- University of Liege
Arrhythmias, Cardiac, Bradycardia
One Hospital ClinicalService Project
The One Hospital ClinicalService Project is an integrated system composed by a network of International Hospital Departments, a clinical data repository and a shared environment for the collection, management, analysis and…
- Conditions
- Arrhythmias, Cardiac, Bradycardia, Syncope
- Trial name
- OHCS (NCT01007474)
- Testing
- Implantable Cardioverter-Defibrillator (ICD), Implantable Pacemaker Generator (IPG), Implantable Loop Recorder (ILR)
- Where
- 41 sites in Germany, Iceland and 7 more
- Sponsor
- Medtronic Italia
Covid19, Coma
Prognostication of Recovery in Early Disorders of Consciousness After COVID-19
The primary aim of this research proposal is to use multimodal metrics (e.g., clinical data and advanced neuroimaging) in the early (i.e., acute hospitalization) phase of recovery from COVID-19-related disorders of consciousness…
- Conditions
- Covid19, Coma, Consciousness Disorder
- Trial name
- PREDICT-COVID (NCT04476589)
- Testing
- Functional MRI
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Massachusetts General Hospital
Traumatic Brain Injury, Concussion, Intermediate
Intervention to Change Affect Recognition and Empathy
Determine the feasibility, practicality, and early efficacy of a TeleRehab program (ICARE) to improve outcomes for persons with traumatic brain injury (TBI) in recognizing and responding to others' emotions alongside their care…
- Conditions
- Traumatic Brain Injury, Concussion, Intermediate, Concussion, Severe, Concussion With LOC 31 to 59 Minutes
- Trial name
- ICARE (NCT05636020)
- Testing
- ICARE Treatment
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- Indiana University
Cardiac Arrhythmia, Cardiogenic Syncope
Optimizing Diagnostics Of Syncope Events Using Intelligent Telemetric Solutions.
The purpose of this study is to assess efficacy of prolonged Full Disclosure electrocardiogram (ECG) monitoring and signal analysis using advanced telemetric technology to diagnose syncope in comparison with standard diagnostic…
- Trial name
- TELEMARC3 (NCT01265290)
- Testing
- repeated 24 hours ECG Holter monitoring, Telemetric ECG monitoring
- Where
- 2 sites in Poland
- Volunteers
- 640 people
- Sponsor
- National Institute of Cardiology, Warsaw, Poland
Tissue and Organ Harvesting, Liver Transplantation
Evaluation of Liver Grafts With FibroScan® Before Organ Retrieval in Patients With Brain Death
According to the French Biomedicine Agency annual report on retrieval activities and transplants, 1,164 liver transplants were performed in 2011 and 1,161 in 2012.
- Conditions
- Tissue and Organ Harvesting, Liver Transplantation, Brain Death
- Trial name
- FIBROSCAME (NCT02460250)
- Testing
- Fibroscan
- Where
- 19 sites in France
- Volunteers
- 740 people
- Sponsor
- University Hospital, Limoges
Tachycardia Atrial, Atrial Fibrillation
BIO|STREAM.ICM Obesity
The aim of the submodule study is to assess whether a high BMI may influence the sensing performance and the sECG quality of the BIOMONITOR.
- Conditions
- Tachycardia Atrial, Atrial Fibrillation, Syncope, Bradycardia
- Trial name
- NCT04198220
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Biotronik SE & Co. KG
Asthma, Syncope
Vagal Nerve Stimulation Assessed by the Diving Reflex: An Investigation Into Mechanisms of Asthma Death
The investigators' hypothesis is that dysregulation of autonomic function, as revealed during a simulated dive reflex, may result in an attenuation of the heart rate response to a greater degree in asthmatics who collapse during…
- Trial name
- NCT02083029
- Testing
- Simulated dive reflex
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Syncope, Vasovagal
Respiration and Applied Tension Strategies to Reduce Vasovagal Reactions to Blood Donation
For a number of years, researchers have examined the effects of the muscle-tensing technique, Applied Tension (AT), on blood donation-related vasovagal symptoms and donor retention.
- Trial name
- NCT03159156
- Testing
- Applied Tension, Respiration Control, Applied Tension/Respiration Control
- Where
- Canada
- Volunteers
- 408 people, healthy volunteers welcome
- Sponsor
- McGill University