Clinical trials: Unexplained Infertility
Male Idiopathic Infertility
A Trial to Compare Efficacy and Safety of Follitropin Delta Versus Placebo (Inactive Treatment) in the Treatment of Men With Idiopathic Infertility (Unexplained Reduction of Semen Quality) (ADAM)
The primary purpose of this trial is to investigate whether men with idiopathic infertility (unexplained reduction of semen quality), after being treated with a daily dose of 12 µg recombinant follicle stimulating hormone (rFSH)…
- Trial name
- NCT05403476
- Testing
- FE 999049
- Where
- 22 sites in United States, Belgium and 5 more
- Volunteers
- 4 people
- Sponsor
- Ferring Pharmaceuticals
Perimenopausal Disorder, Menopause
Inovium Ovarian Rejuvenation Trials
The Inovium Ovarian Rejuvenation Treatment is a PRP-based autologous treatment used in combination with a stimulated IVF sequence and Pre-Implantation Genetic Screening to treat infertility in women experiencing menopause…
- Conditions
- Perimenopausal Disorder, Menopause, Menopause, Premature, Menopause Related Conditions
- Trial name
- NCT03178695
- Testing
- Autologous PRP injection into human ovarian tissue
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ascendance Biomedical
Unexplained Infertility, Ovulation Disorder
Incremental Clomiphene Citrate Doses in Successive Cycles and FSH, LH and Steroid Hormone Levels
This study was planned to assess the initial and endogenous FSH, LH and steroid responses to incremental CC doses in successive ovulation induction cycles to treat anovulation in patients with unexplained infertility.
- Trial name
- NCT04210765
- Testing
- Clomiphene Citrate
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Bagcilar Training and Research Hospital
Infertility, Female
Effect of Oral Sildenafil Citrate on Improvement of Endometrial Thickness
One hundred thirty women with unexplained infertility participated in a prospective clinical study. Patients were assigned at random to one of two groups.
- Trial name
- NCT05846906
- Testing
- Sildenafil Citrate, Clomiphene Citrate 50mg
- Where
- Egypt
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Infertility, Female, Unexplained Infertility
Serum Kisspeptin Levels in Infertile Women
The study population is comprise of 90 women those age varies between 18-38 year-old. The first group will comprise of 30 women with polycystic ovaries or anovulatory cycles, the second group will comprise of 30 women with…
- Conditions
- Infertility, Female, Unexplained Infertility, Anovulation
- Trial name
- NCT03018314
- Testing
- Blood sample
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Unexplained Infertility, Male Infertility
Royal Jelly Supplementation in Unexplained Male Infertility
This randomized, double-blind, placebo-controlled clinical trial investigates the effects of oral Royal Jelly supplementation on sperm DNA fragmentation and pregnancy rates in couples with unexplained infertility.
- Conditions
- Unexplained Infertility, Male Infertility, Sperm DNA Fragmentation
- Trial name
- NCT07337265
- Testing
- Lyophilized Royal Jelly
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Medipol University
Infertility Unexplained
Only Gonadotropin Vs. Letrozole Combined Gonadotropin Stimulation in IUI Cycles
The present randomized controlled study aims to investigate the effectiveness of a combined regimen of letrozole and gonadotropin with dose adjustments based on body mass index (BMI) compared to a conventional only gonadotropin…
- Trial name
- NCT06413771
- Testing
- Letrozole 2.5mg, Gonadotropin
- Where
- Turkey (Türkiye)
- Volunteers
- 131 people
- Sponsor
- Uludag University
Infertility Unexplained, Endometriosis
Relation Between MicroRNA 203 and 210 and Sparing the Laparoscopic Examination in Cases of Unexplained Infertility
The study targets to evaluate the role of estimation of plasma expression levels of gene of microRNAs 203 and 210 in helping to diagnose and grade endometriosis.
- Trial name
- NCT05680350
- Testing
- Laparoscopic Exploration, Estimation of Plasma Expression level of MICRO RNA 203 & 210
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Benha University
Sperm DNA Fragmentation, Embryo Quality
Sperm Selection by Microfluidic Separation Improves Embryo Quality
This is a randomized controlled trial of couples with a history of poor embryo quality undergoing a repeat in vitro fertilization (IVF) cycle for unexplained infertility.
- Conditions
- Sperm DNA Fragmentation, Embryo Quality, Fertility Disorders, Infertility
- Trial name
- SPERM (NCT03085433)
- Testing
- Microfluidic Sperm Sorting, in vitro fertilization
- Where
- United States
- Volunteers
- 393 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Intrauterine Insemination
Timing and Intrauterine Insemination in Unexplained Infertility
to determine the most suitable time for administration of (human chorionic gonadotropin )hCG prior to intrauterine insemination (IUI) to optimize pregnancy outcome and to have the best success rates so the cases divided in to…
- Trial name
- NCT03920514
- Testing
- hCG
- Volunteers
- 80 people
- Sponsor
- Sohag University
Unexplained Infertility, Infertility
Preovulatory Uterine Flushing With Saline as a Treatment for Unexplained Infertility
The purpose of this study is to determine whether preovulatory uterine flushing with physiological saline is effective in the treatment of unexplained infertility.
- Trial name
- NCT02539290
- Testing
- Detection of ovulation, Uterine flushing, Vaginal flushing
- Where
- Canada
- Volunteers
- 192 people
- Sponsor
- CHU de Quebec-Universite Laval
Infertility, Infertility,Female
The Role of Granulocyte Colony Stimulating Factor in Embryo Transfer Outcomes
The goal of this clinical trial is to test the effect of granulocyte colony-stimulating factor (G-CSF, A.K.A. Filgrastim) in infertility patients undergoing in vitro fertilization (IVF) treatment.
- Conditions
- Infertility, Infertility,Female, Infertility; Female, Nonimplantation, Infertility Unexplained
- Trial name
- NCT06174298
- Testing
- Granulocyte Colony-Stimulating Factor (Filgrastim), Standard Embryo Transfer Media
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- Newlife Fertility Centre
Infertility, Unexplained Infertility
Uterine Scratching in Intra-Uterine Insemination
This study will evaluate the potential benefits of uterine injury during the follicular phase of an intra-uterine insemination cycle on the rate of ongoing pregnancy during the first trimester ultrasound.
- Trial name
- NCT03828786
- Testing
- Endometrial scratching
- Where
- Canada
- Volunteers
- 394 people, healthy volunteers welcome
- Sponsor
- Clinique Ovo
Infertility
Role of Laparoscopy in Unexplained Infertility
In this randomized controlled trial the investigators were looking for the best policy for management of women with unexplained infertility after normal hysterosalpingogram (HSG).
- Trial name
- NCT00886041
- Testing
- laparoscopy, ovarian stimulation
- Where
- Egypt
- Volunteers
- 512 people
- Sponsor
- Mansoura University
Male Infertility
CMV IGG Antibodies in Semen as a Predictor for Blood Testis Barrier Damage
To assess whether the presence of Cytomegalovirus (CMV) Immunoglobulin G (IGG) antibodies in semen is a reliable predictor of male subfertility or infertility.
- Trial name
- NCT05302856
- Testing
- Blood test (CMV IGG, Anti sperm antibody, Testosterone levels)
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Infertility
Extended Letrozole Regimen Versus Clomiphene Citrate for Superovulation in Patients With Unexplained Infertility Undergoing Intrauterine Insemination
The aim of this randomized controlled trial is to compare the efficacy of extended letrozole regimen (2.5mg/day from cycle day 1 to 9) with clomiphene citrate (100 mg/day from cycle day 3 to 7) in women with unexplained…
- Trial name
- NCT01232075
- Testing
- Extended letrozole regimen, Clomiphene citrate regimen
- Where
- 2 sites in Egypt
- Volunteers
- 214 people
- Sponsor
- Cairo University
Unexplained Infertility
Acupuncture for Unexplained Subfertiliy
Infertility affects one in six couples. In a quarter of them, routine tests of semen quality, ovulation or tubal patency fail to reveal any abnormalities and the cause of infertility is unexplained.
- Trial name
- AURIS (NCT02624076)
- Testing
- Acupuncture, expectant management
- Where
- 16 sites in China
- Volunteers
- 1,423 people
- Sponsor
- Heilongjiang University of Chinese Medicine
Endometriosis, Uterine Diseases
SIRT-1 Antagonism for Endometrial Receptivity
Progesterone resistance is mediated through epigenetic modification through SirT1 activation and is thought to contribute to infertility and progression of endometriosis.
- Conditions
- Endometriosis, Uterine Diseases, Endometrial Diseases, Infertility Unexplained
- Trial name
- SAFER (NCT04184323)
- Testing
- EX-527 (Selisistat)
- Where
- United States
- Sponsor
- Wake Forest University Health Sciences
Infertility
Clinical Pregnancy Rate After Removal of Unsuspected Polyps
Polyps are fleshy outgrowths of the inner lining of the womb which may hinder implantation of embryo and lead to subfertility.This study evaluates whether removal of endometrial polyps in womb affects chances of pregnancy in…
- Trial name
- NCT02762097
- Testing
- polypectomy, saline sonography, normal saline
- Sponsor
- Karachi Medical and Dental College
Insulin Resistance, Oligospermia
Insulin Resistance in Idiopathic Oligospermia and Azoospermia
Insulin resistance in men can be the underlying major factor in reproductive abnormalities ( chronic hypospermatogenesis ) as well as metabolic abnormalities similar to polycystic ovarian syndrome ( PCOS ) in women.
- Conditions
- Insulin Resistance, Oligospermia, Azoospermia
- Trial name
- NCT01509482
- Testing
- blood samples
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The Egyptian IVF-ET Center