Clinical trials: Unipolar Depression
Therapeutic Drug Monitoring (TDM), Menopause
Escitalopram Plasma Concentrations in Premenopausal and Postmenopausal Women
This observational cross-sectional case-control study aims to evaluate the effects of menopausal status on escitalopram metabolism in women.
- Conditions
- Therapeutic Drug Monitoring (TDM), Menopause, Depression - Major Depressive Disorder, General Anxiety Disorder
- Trial name
- MENO-ES (NCT07259525)
- Where
- Turkey (Türkiye)
- Volunteers
- 94 people
- Sponsor
- Eskisehir Osmangazi University
Depressive Disorder
Modeling and Predicting Real World Behavior Using Mobile Sensor Data on Patients With Major Depressive Disorder
The purpose of this study is to validate the effectiveness of using an integrated mobile sensing platform to deliver large-scale data-driven interventions to patients with depression.
- Trial name
- NCT02499094
- Testing
- Behavioral-data driven support
- Volunteers
- 1,004 people
- Sponsor
- Ginger.io
Major Depression, Anhedonia
Study on iTBS Regulating the Reward Circuit Function to Improve Anhedonia in Depression
The goal of this clinical trial is to learn if the proposed intermittent theta burst stimulation (iTBS) protocol can effectively improve anhedonia symptoms in depressed patients.
- Conditions
- Major Depression, Anhedonia, Melancholic Depression, Theta Burst Stimulation
- Trial name
- iTMMDD (NCT07813169)
- Testing
- Left DLPFC + OFC iTBS, Left DLPFC iTBS
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Guo Wenbin
Major Depressive Disorder, Mobile Health
A Trial of Enhanced Versus Standard Measurement-Based Care Implementation for Depression
Measurement-based care (MBC) is an evidence-based practice that incorporates routine outcome assessment using validated rating scales to guide collaborative clinical decision-making.
- Trial name
- NCT05577494
- Testing
- Questionnaire online
- Where
- China
- Volunteers
- 700 people
- Sponsor
- Shanghai Mental Health Center
Major Depressive Disorder
Ketamine for Severe Adolescent Depression: Intermediate-term Safety and Efficacy
The purpose of this study is to evaluate the intermediate-term efficacy and tolerability of a multiple-dosing ketamine infusion paradigm for the treatment of medication-refractory major depressive disorder (MDD).
- Trial name
- SAD-KIDS (NCT03889756)
- Testing
- Ketamine infusion, Midazolam infusion
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Yale University
Major Depressive Disorder
A Dose Escalation Phase I Study of PDC-1421 Capsule Targeting in Depression
The purpose of this study is to evaluate the safety of PDC-1421 Capsule in healthy subject, find the effective adequate dose for the next stage of the study, and accumulate information of possible mechanism of its anti-depressive…
- Trial name
- NCT01774045
- Testing
- PDC-1421
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- BioLite, Inc.
Unipolar Depression, Bipolar Depression
RNA Editing as a Biomarker of Antidepressant Response in Unipolar and Bipolar Depression (EDIT-ANDRE)
The purpose of this research is to understand how changes in RNA editing relate to treatment response in unipolar and bipolar depression.
- Trial name
- NCT07266545
- Testing
- Vortioxetine, Cariprazine (Augmentation Phase)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Mayo Clinic
Mild to Moderate Depression.
Cost-effectiveness of a Non-Pharmacological Treatment (Active Monitoring) vs. a Pharmacological Treatment for Major Depression in Primary Care.
Major Depression (MD) is highly prevalent and has associated a high burden and economic costs. Mild levels of MD could be treated without antidepressants at Primary Care (PC).
- Trial name
- NCT02245373
- Testing
- Antidepressants, Active Monitoring
- Volunteers
- 263 people
- Sponsor
- Fundació Sant Joan de Déu
Major Depressive Disorder
Stony Brook Medicine Anti-Inflammatory Trial
This is an experimental study designed to measure the effect of celecoxib or minocycline on depressive symptoms in unipolar and bipolar depression. Participants will be equally randomized to either celecoxib or minocycline.
- Trial name
- NCT06699966
- Testing
- Celecoxib, Minocycline
- Volunteers
- 42 people
- Sponsor
- Stony Brook University
Major Depressive Disorder
Treatment for Cognitive Impairment in Depression
The proposed study seeks to investigate the effects of modafinil on cognitive function in depression, which holds promise for better treating cognitive impairment in depression, as well as better understand cognitive dysfunction…
- Trial name
- T-CID (NCT04317001)
- Testing
- Modafinil
- Sponsor
- Stanford University
Depression / Major Depressive Disorder, Anxiety
Digital Single-Session Cognitive Behavioural Therapy in Healthy Adults
The goal of this study is to learn if digital single-session cognitive behavioural therapy can treat mental health in adults. The main question it aims to answer is: Does digital single-session cognitive behavioural therapy…
- Conditions
- Depression / Major Depressive Disorder, Anxiety, Anxiety Disorder Generalized
- Trial name
- CBT (NCT07873905)
- Testing
- Digital single-session cognitive behavioural therapy, Digital memory task
- Where
- United Kingdom
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Brunel University
Depressive Disorder, Major
Study of Monotherapy Rapastinel in the Prevention of Relapse in Patients With Major Depressive Disorder (MDD)
The study will evaluate the efficacy, safety, and tolerability of 450 milligrams (mg) or 225 mg of Rapastinel compared to placebo in the prevention of relapse in participants with major depressive disorder (MDD).
- Trial name
- NCT03614156
- Testing
- Rapastinel
- Where
- 52 sites in United States, Hungary and 3 more
- Volunteers
- 363 people
- Sponsor
- Naurex, Inc, an affiliate of Allergan plc
Major Depressive Disorder
Aripiprazole for the Augmentation of Antidepressant Therapy
The study aims to evaluate effectiveness and tolerability of aripiprazole augmentation in outpatients with major depressive disorder who have had inadequate response to antidepressants in Taiwan clinical practice.
- Trial name
- NCT01429831
- Testing
- Aripiprazole
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- Taiwan Otsuka Pharm. Co., Ltd
Major Depressive Disorder
A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder
X-NOVA2 is a Phase 3, multicenter, randomized, double-blind, placebo-controlled study to evaluate the clinical efficacy, safety, and tolerability of azetukalner as a monotherapy in adult participants diagnosed with Major…
- Trial name
- X-NOVA2 (NCT06775379)
- Testing
- Azetukalner
- Where
- 45 sites in United States
- Volunteers
- 450 people
- Sponsor
- Xenon Pharmaceuticals Inc.
Depression
Assessing Treatment Emergent Suicidal Ideation in Patients With Major Depression
This study will develop a new methodology to evaluate any treatment-emergent suicidal ideation that might occur when an antidepressant treatment has been started and/or during times when doses are increased in patients with major…
- Trial name
- SAMS (NCT00532103)
- Where
- 15 sites in United States
- Volunteers
- 300 people
- Sponsor
- National Institute of Mental Health (NIMH)
Depression
AZD6765 for Treatment Resistant Depression
The purpose of this study is to determine whether treatment with AZD6765 will have an antidepressant effect with patients who have treatment resistant depression.
- Trial name
- NCT00491686
- Testing
- AZD6765
- Where
- 5 sites in United States
- Volunteers
- 34 people
- Sponsor
- AstraZeneca
Major Depressive Disorder
Electrophysiologic Parameters and Biomarkers Predicting Treatment Response in Patients With Major Depressive Disorder
To explore electrophysiologic parameters and biomarkers predicting treatment response of patients with major depressive disorder To explore electrophysiologic parameters and biomarkers predicting suicide risk of patients with…
- Trial name
- NCT01997580
- Testing
- escitalopram
- Where
- South Korea
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Treatment Resistant Depression, Major Depressive Disorder (MDD)
Behavioural Activation Therapy and Ketamine for Treatment-Resistant Depression
The goal of this clinical trial is to see if combining ketamine with behavioral activation (BA) therapy to treat moderate to severe treatment-resistant depression improves depressive symptoms and general functioning more than…
- Trial name
- NCT07801703
- Testing
- Ketamine (0.5 mg/kg), Behavioural Activation Therapy
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- The Royal's Institute of Mental Health Research
Major Depressive Disorder
Mindfulness-Based Cognitive Therapy Effect on Depression and C-Reactive Protein Levels After 8 Weeks of Treatment
This study will investigate the efficacy of an 8-week course in Mindfulness-Based Cognitive Therapy (MBCT) for adults with major depressive disorder (MDD) by ;measuring change from baseline to completion of treatment at 8 weeks…
- Trial name
- NCT02385786
- Testing
- Mindfulness-Based Cognitive Therapy
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Major Depressive Disorder
Comparison of Anodal Transcranial Direct Current Stimulation (t-DCS) and Sham Stimulation in Patients With Treatment-resistant Depression
Major depressive disorder (MDD) is a significant public health problem. Existing treatment modalities are not always sufficient to alleviate this disorder. Treatment refractoriness is a common clinical problem.
- Trial name
- NCT02141776
- Testing
- Transcranial direct current stimulation (t-DCS)
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Florida