Clinical trials: Unipolar Depression
Major Depressive Diorder
Efficacy and Safety of DTMS in Adolescent Major Depressive Disorder
The goal of this randomized controlled trial is to explore the efficacy and safety of two different dTMS devices in adolescent depression: deep TMS H1 coil and deep TMS H7 coil.
- Trial name
- NCT06728280
- Testing
- deep transcranial magnetic stimulation with H1coil, deep transcranial magnetic stimulation with H7 coil
- Where
- 2 sites in China
- Volunteers
- 100 people
- Sponsor
- Zhifen Liu
Major Depressive Disorder
JAK Signaling in Depression
This study will test the hypothesis that Janus kinase (JAK) signaling is involved in major depression (MD) with high inflammation by determining whether its inhibition with baricitinib can improve functional connectivity in…
- Trial name
- NCT07003997
- Testing
- Baricitinib
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Emory University
Major Depressive Disorder
Effect of Food, Gender, and Age on the Pharmacokinetic Profile of SUVN-911 in Healthy Subjects
The purpose of the study is to investigate the effect of Food, Gender, and Age on the Pharmacokinetic Profile of SUVN-911 in Healthy Subjects
- Trial name
- SUVN-911 (NCT03551288)
- Testing
- SUVN-911
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Suven Life Sciences Limited
Treatment Resistant Depression, Major Depressive Disorder
Clinical Study of GH001 in Depression
The aim of the study is to investigate the safety of GH001 (containing 5-methoxy-dimethyltryptamine; 5-MeO-DMT), and to investigate its effects on severity of depressive symptoms, and its dose-related psychoactive effects in…
- Conditions
- Treatment Resistant Depression, Major Depressive Disorder, Depression
- Trial name
- NCT04698603
- Testing
- 5 Methoxy N,N Dimethyltryptamine
- Where
- Netherlands
- Volunteers
- 16 people
- Sponsor
- GH Research Ireland Limited
Major Depressive Disorder
Closed-loop Optimized rTMS for Depression
Targeted and individualized treatments for mental health disorders are critically needed. Repetitive transcranial magnetic stimulation (rTMS) represents the front-line of new and innovative approaches to normalizing dysfunctional…
- Trial name
- NCT04142320
- Testing
- Neuronavigated rTMS
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Stanford University
Depressive Disorder, Major
Active Reference (Fluoxetine) Fixed-dose Study of Vortioxetine in Paediatric Patients Aged 12 to 17 Years With Major Depressive Disorder (MDD)
Evaluating the efficacy of vortioxetine 10 mg/day and 20 mg/day versus placebo on depressive symptoms in adolescents (age ≥12 and ≤17 years) with a DSM-5™ (Diagnostic and Statistical Manual of Mental Disorders, 5th edition)…
- Trial name
- NCT02709746
- Testing
- Vortioxetine 10 mg/day, Vortioxetine 20 mg/day, Fluoxetine 20 mg/day
- Where
- 124 sites in United States, Bulgaria and 17 more
- Volunteers
- 784 people
- Sponsor
- H. Lundbeck A/S
Major Depressive Disorder \(MDD, Depressive Disorder, Major
Electrical Vestibular Nerve Stimulation (VeNS) as a Treatment for Major Depressive Disorder (MDD)
Trial title: A Randomized, Double Blind Sham Controlled Clinical Trial to Evaluate the Efficacy of Electrical Vestibular Nerve Stimulation (VeNS), Compared to a Sham Control for Treatment of Major Depressive Disorder (MDD) …
- Trial name
- NCT06470035
- Testing
- Active VeNS Device
- Where
- 2 sites in United States, United Kingdom
- Volunteers
- 170 people
- Sponsor
- Neurovalens Ltd.
Depression / Major Depressive Disorder, Mood
Intern Health Study 2026
The aim of this study is to evaluate the efficacy of using a reinforcement learning algorithm to determine the optimal content of a mobile health intervention (message delivered via smartphone) for improving the mood, physical…
- Conditions
- Depression / Major Depressive Disorder, Mood, Sleep, Physical Activity
- Trial name
- IHS 2026 (NCT07685925)
- Testing
- Intern Health Study behavioral change mobile notification
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Major Depressive Disorder
Safety of REL-1017 for Major Depressive Disorder
This was a 1-year, multicenter, open-label, long-term study to assess the safety of REL-1017 once daily (QD) as monotherapy or as adjunctive treatment of Major Depressive Disorder.
- Trial name
- RELIANCE-OLS (NCT04855760)
- Testing
- REL-1017
- Where
- 9 sites in United States
- Volunteers
- 627 people
- Sponsor
- Relmada Therapeutics, Inc.
Major Depressive Disorder 1
Treatment of Major Depressive Disorder Post Stroke With Transcranial Direct Current Stimulation
Stroke is one of the main public health problems in America Latina. It can be associated with several neuropsychiatric complications, which include a broad spectrum of emotional distress and cognitive, results in important…
- Trial name
- NCT01525524
- Testing
- Transcranial Direct Current Stimulation
- Where
- Brazil
- Volunteers
- 48 people
- Sponsor
- University of Sao Paulo
Depression NOS, Major Depressive Disorder
Meditation to Reduce Caregiver Stress
The purpose of this study is to determine whether meditation will reduce stress and depressive of adult caregivers of a person with dementia.
- Conditions
- Depression NOS, Major Depressive Disorder, Anxiety NOS
- Trial name
- Meditation (NCT01537679)
- Testing
- Kirtan Kriya meditation, Relaxation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of California, Los Angeles
Major Depression
Brain Abnormalities in Late-Onset Major Depression
The objective of this project is to examine the state of the brain in people over 50 years old suffering from late-onset depression by means of an extensive clinical assessment programme, including magnetic resonance imaging…
- Trial name
- NCT00260468
- Testing
- Clinical examination program
- Where
- Denmark
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Unipolar Depression, Impulsive Behavior
How to Reduce Suicidal Thoughts and Impulsivity in Depression
The study aims at investigating if tDCS applied to left DLPFC or to right OFC to treatment as usual is effective in reducing severe suicidal ideas in major depressive episode.
- Conditions
- Unipolar Depression, Impulsive Behavior, Suicidal Ideation
- Trial name
- DEPIMPULSE (NCT05894980)
- Testing
- active tDCS stimulating left DLPFC, active tDCS stimulating right OFC
- Where
- 4 sites in France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Major Depressive Disorder
Spectral TMS (s-TMS)
This study will analyze the feasibility, safety, and tolerability of administering repetitive Transcranial magnetic stimulation(TMS) at frequencies other than standard 10 Hz.
- Trial name
- STMS (NCT04040062)
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of California, Los Angeles
Major Depressive Disorder
Cellular Aging and Neurobiology of Depression Study
We are conducting an eight week longitudinal study to learn if blood levels of certain naturally occurring compounds and genetic markers differ between patients with depression and healthy adults who are not depressed, and if any…
- Trial name
- CAN-D (NCT00285935)
- Testing
- Standard Clinical Care with an SSRI
- Where
- United States
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Major Depressive Disorder
Efficacy and Safety of Light Therapy in the Treatment of Non-seasonal Depressive Disorder in Chinese Population
Depression is a kind of mental illness with high incidence, high recurrence and high disability. But so far, treatment remission rates for depression remain low. Therefore, it is necessary to develop more new treatments.
- Trial name
- NCT05499117
- Testing
- Light terapy, pseudo-light therapy
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Shanghai Mental Health Center
Major Depressive Disorder
The Phosphodiesterase Inhibitor Tadalafil as an Adjunct to Antidepressants in Major Depressive Disorder Patients
Antidepressant-like effects of tadalafil to its ability to modulate transduction pathways responsible for neuroplasticity. Treatment with tadalafil was shown to be PKG-dependent and lead to increased expression of cGMP, pCREB…
- Trial name
- NCT05030623
- Testing
- Tadalafil 5Mg Tab
- Where
- Egypt
- Sponsor
- Sadat City University
Major Depressive Disorder
Stress Reduction Intervention for Enhancing Treatment Outcome for Depressed Minority Patients
The purpose of this study is to determine the usefulness of a stress reduction treatment in helping minority patients with major depression get better.
- Trial name
- NCT00998959
- Testing
- Mindfulness Based Stress Reduction and Psychoeducation, Psychoeducation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Trina E. Chang, MD
Depression, Unipolar, Mental Health Disorder
Reaching and Engaging Depressed Senior Center Clients (REDS)
The purpose of this study is to test the feasibility of two types of group therapy sessions. The research is being done because the researchers are trying to learn if these approaches could be used by therapist in the community…
- Trial name
- REDS (NCT03246789)
- Testing
- Engage-M, Wellness in Mind and Body
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Weill Medical College of Cornell University
Depression
Role of Slow-wave Activity and Plasticity in MDD
The hypothesis underlying this proposal is that deficits of synaptic plasticity underlie the slow-wave activity (SWA) abnormalities observed n major depressive disorder (MDD), and that manipulating SWA may serve to circumvent…
- Trial name
- SWIP (NCT04150718)
- Testing
- slow-wave disruption
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania