Clinical trials: Unipolar Major Depression
Major Depressive Disorder
Adjunct Minocyline in Treatment-resistant Depression
This study examines the antidepressant efficacy of minocycline as an adjunct to an antidepressant standard treatment (AD-ST), for patients with unipolar major depressive disorder (MDD).
- Trial name
- Mino-TRD (NCT02456948)
- Testing
- Minocycline
- Where
- 9 sites in Germany
- Volunteers
- 168 people
- Sponsor
- Charite University, Berlin, Germany
Unipolar Depression
The Effects of Quetiapine XR on Cognition, Mood and Anxiety Symptoms in SSRI-Resistant Unipolar Depression
Recently published work has examined the effects of "atypical antipsychotics" in SSRI-treatment resistant patients. In these studies, patients with unipolar depression who were treated with SSRI's, but not responsive to treatment…
- Trial name
- NCT00517387
- Testing
- Quetiapine XR
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- University of British Columbia
Unipolar Depression
Effect of Tao Calligraphy Meditation and Energized Water on Depression
The goal of this controlled randomized clinical study is to learn if a Tao Calligraphy Mindfulness and Energized water Practice works to improve Unipolar Depression.
- Trial name
- NCT06934330
- Testing
- Mindfulness practice with Tao Art (Calligraphy and Song Greatest Love), Drinking Energized water
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Sha Research Foundation
Major Depressive Disorder, Bipolar Disorder
Transcranial Electric Stimulation Therapy (TEST) for Treatment Resistant Depression (TRD)
Background: People with TRD are often helped by electroconvulsive therapy (ECT). But ECT can affect memory and thinking. Researchers want to study a treatment called TEST that uses less electricity.
- Conditions
- Major Depressive Disorder, Bipolar Disorder, Unipolar Major Depression
- Trial name
- NCT05172271
- Testing
- MagPro TMS Stimulator and coil, Thymatron(R) System IV, Magnetic Resonance Imaging Scanner
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- National Institute of Mental Health (NIMH)
Major Depressive Disorder, Healthy
Antidepressant Effects on cAMP Specific Phosphodiesterase (PDE4) in Depressed Patients
The primary purpose of this protocol is to compare PDE4 levels before and after starting a selective serotonin reuptake inhibitor (SSRI) sertraline, citalopram or escitalopram in unmedicated depressed patients.
- Trial name
- NCT00369798
- Testing
- PET scan, Rolipram
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Electroconvulsive Therapy, Major Depressive Disorder
Impact of Covid-19 Pandemic on Patients Receiving Continuation or Maintenance Electroconvulsive Therapy
Electroconvulsive therapy is a safe and effective therapeutic strategy in patients with treatment resistant depression. As relapse after successful ECT is significant even with adequate pharmacological strategies, continuation…
- Conditions
- Electroconvulsive Therapy, Major Depressive Disorder, Covid-19
- Trial name
- COVID-M-ECT (NCT05633368)
- Testing
- Questionnaires
- Where
- 2 sites in Belgium
- Volunteers
- 47 people
- Sponsor
- University Hospital, Ghent
Non-psychotic Unipolar Major Depression
Prevalence and Risk Factors in Unipolar Depression Patients Without Remission After One Antidepressant Trial
A non interventional, descriptive, longitudinal cohort study is designed, trying to obtain local data about the prevalence of non remitted depressed patients after an antidepressant treatment, and to get information about…
- Trial name
- PANTHER (NCT01887639)
- Where
- 8 sites in Argentina
- Volunteers
- 200 people
- Sponsor
- AstraZeneca
Unipolar Major Depressive Disorder
Non-invasive Brain Stimulation and Cognitive Processing in Depression
Depression is a serious mental health problem that affects millions. Depression is usually treated using drugs and/or psychotherapy, but neither approach is successful for everyone, and some people do not respond to either.
- Trial name
- NCT01875419
- Testing
- Transcranial direct current stimulation (tDCS), Cognitive Behavioural Therapy
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University College, London
Depression
Personalise Antidepressant Treatment for Unipolar Depression Combining Individual Choices, Risks and Big Data
PETRUSHKA is aimed at developing and subsequently testing a personalised approach to the pharmacological treatment of major depressive disorder in adults, which can be used in everyday NHS clinical settings.
- Trial name
- PETRUSHKA (NCT05608330)
- Testing
- PETRUSHKA tool, Usual Care
- Volunteers
- 504 people
- Sponsor
- University of Oxford
Depressive Disorder, Treatment-Resistant
Proof of Concept Study Evaluating the Efficacy and Safety of MIJ821 in Patients With Treatment-resistant Depression
This study evaluated the efficacy and safety of the compound MIJ821 compared to placebo in patients aged from 18 to 65 years diagnosed with treatment-resistant depression. The study was conducted in the US and in Europe (Spain).
- Trial name
- NCT03756129
- Testing
- MIJ821, Ketamine
- Where
- 12 sites in United States, Spain
- Volunteers
- 70 people
- Sponsor
- Novartis Pharmaceuticals
Unipolar Depression
Evaluation of Metacognitive Training for Depression (D-MCT) in Outpatient Care
Aim of the current study is to investigate the acceptance and efficacy of Metacognitive Training for Depression (D-MCT) compared to cognitive remediation in outpatients with major depressive disorders in a randomized, controlled…
- Trial name
- NCT03268434
- Testing
- D-MCT, Cognitive remediation
- Where
- Germany
- Volunteers
- 86 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Depressive Disorder, Major Depression
Pattern Separation, Brain Derived Neurotrophic Factors, and Mechanisms of Vortioxetine
The study is a 6-week, proof-of-concept, open trial of vortioxetine for 20 patients with major depressive disorder.
- Conditions
- Depressive Disorder, Major Depression, Depression, Depression, Unipolar
- Trial name
- VOR-IISR (NCT02969876)
- Testing
- Vortioxetine
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Massachusetts General Hospital
Major Depressive Episode (MDE), Unipolar Disorder
Evaluating the Therapeutic Potential of Focal Electrically Administered Seizure Therapy (FEAST) in the Treatment of Depression: A Multicenter Randomized Clinical Trial
A significant proportion of patients remain resistant to antidepressant therapies, even when treatment is well managed. Electroconvulsive therapy (ECT) is a well-established method for treating certain severe and resistant…
- Conditions
- Major Depressive Episode (MDE), Unipolar Disorder, Bipolar 1 Disorder
- Trial name
- FEAST-AFT (NCT07857122)
- Testing
- Stimulation by the Sigma ECT/FEAST device, Stimulation by Sigmastim ECT 200J device administered in right unilateral (RUL), Stimulation by Sigmastim ECT 200J device administered in bilateral (BT)
- Where
- 5 sites in France, Monaco
- Volunteers
- 108 people
- Sponsor
- Centre Hospitalier St Anne
Cardiovascular Risk, Depression, Unipolar
LIVES: Personalized Lifestyle Intervention for Patients With Depression
Persons with affective disorder have a considerably increased risk of cardiovascular disease. To a considerable extent, this is due to an unhealthy life style.
- Conditions
- Cardiovascular Risk, Depression, Unipolar, Depression, Bipolar
- Trial name
- LIVES (NCT05767073)
- Testing
- Lifestyle InterVEntion (LIVE)
- Where
- 2 sites in Netherlands
- Volunteers
- 38 people
- Sponsor
- University Medical Center Groningen
Major Depression, Bipolar Disorder
Triiodothyronine (T3) Supplementation in the Treatment of Bipolar and Unipolar Depression.
The purpose of this project is to determine whether concurrent treatment of patients with major depression (unipolar or bipolar) with triiodothyronine (T3) and sertraline, will lead to a stronger and/or more rapid antidepressant…
- Conditions
- Major Depression, Bipolar Disorder, Unipolar Depression
- Trial name
- NCT00158990
- Testing
- triiodothyronine, sertraline
- Where
- 2 sites in United States, Israel
- Volunteers
- 220 people
- Sponsor
- Hadassah Medical Organization
Unipolar Depression
RCT of Psychoeducational Program of Depression
The purpose of the study is to test the efficacy of a psychoeducational group program on unipolar depression
- Trial name
- NCT00319540
- Testing
- Control with depression course (CWD)
- Where
- Norway
- Volunteers
- 155 people
- Sponsor
- Norwegian Institute of Public Health
Depression, Unipolar, Mental Health Disorder
Reaching and Engaging Depressed Senior Center Clients (REDS)
The purpose of this study is to test the feasibility of two types of group therapy sessions. The research is being done because the researchers are trying to learn if these approaches could be used by therapist in the community…
- Trial name
- REDS (NCT03246789)
- Testing
- Engage-M, Wellness in Mind and Body
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Weill Medical College of Cornell University
Depression
Can Vitamin D3 Supplementation Affect Treatment Outcomes in Patients With Depression
The purpose of this study is to investigate whether patients with depression should be offered vitamin D supplements, or it has no significance in relation to treatment outcomes.
- Trial name
- D3-vit-dep (NCT01390662)
- Testing
- Vitamin D3
- Where
- 3 sites in Denmark
- Volunteers
- 150 people
- Sponsor
- Region Syddanmark
Depression, Unipolar Depression
Confirmatory Efficacy and Safety Trial of Magnetic Seizure Therapy for Depression
This trial aims to assess the efficacy and tolerability of Magnetic Seizure Therapy (MST) as an alternative to electroconvulsive therapy (ECT) for depression.
- Conditions
- Depression, Unipolar Depression, Treatment Resistant Depression
- Trial name
- CREST-MST (NCT03191058)
- Testing
- Magnetic Seizure Therapy, Electroconvulsive Therapy
- Where
- 3 sites in United States, Canada
- Volunteers
- 239 people
- Sponsor
- University of Texas Southwestern Medical Center
Major Depressive Disorder
A Clinical Trial of Adjunctive and Monotherapy PRAX-114 in Participants With Major Depressive Disorder
This is a randomized, double-blind, placebo-controlled clinical trial to evaluate the efficacy and safety of 10, 20, 40 and 60 mg oral PRAX-114 compared to placebo in the treatment of adults with MDD.
- Trial name
- NCT04969510
- Testing
- 10 mg PRAX-114, 20 mg PRAX-114, 40 mg PRAX-114
- Where
- 24 sites in United States, Australia
- Volunteers
- 110 people
- Sponsor
- Praxis Precision Medicines