Clinical trials: Upper Aerodigestive Tract Cancer
Head and Neck Squamous Cell Carcinoma
Stereotactic Radiotherapy Combined With Chemotherapy or Not for Treatment of Oligometastases in HNSCC
The aim of this study is to evaluate the rate of living patients at 1 year with a quality of life criteria (no decrease) and reduced toxicities.
- Trial name
- OMET (NCT03070366)
- Testing
- Chemotherapy, Stereotactic radiotherapy
- Where
- France
- Volunteers
- 78 people
- Sponsor
- Groupe Oncologie Radiotherapie Tete et Cou
Upper Aerodigestive Tract Lesions, Neoplasms, Oropharyngeal
Concordance of Two Endoscopic Procedures for Diagnosis of Carcinoma of the Upper Aerodigestive Tract
This study will compare TNFE-NBI and biopsy, with DRE and biopsy for the diagnostic evaluation and staging of patients with suspicious UADT lesions.
- Conditions
- Upper Aerodigestive Tract Lesions, Neoplasms, Oropharyngeal, Oropharyngeal Cancer, Neoplasms, Hypopharyngeal
- Trial name
- TNFE-NBI (NCT01175499)
- Testing
- Direct Rigid Endoscopy, Transnasal Flexible Endoscopy with Narrowband Imaging
- Sponsor
- University of California, San Francisco
Aerodigestive Tract Cancer, Lung Cancer
A Clinical Trial to Validate Molecular Targets of Vorinostat in Patients With Aerodigestive Tract Cancer
The primary aim is to study the effects of vorinostat on cyclin E, cyclin D1 and Ki-67 expression in aerodigestive tract tumors (lung, esophagus, and head and neck).
- Conditions
- Aerodigestive Tract Cancer, Lung Cancer, Esophageal Cancer, Head and Neck Cancer
- Trial name
- NCT00735826
- Testing
- Vorinostat
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Cervical Cancers, Endometrial Cancer
Emergence of Bacterial Resistance to Antibiotics in the Digestive Microbiota of Patients Treated With Anticancer Drugs
Solid cancers are frequently treated with chemotherapies that target the DNA of cancer cells. It has recently come to light that bacteria are also the target of chemotherapies used in oncology.
- Conditions
- Cervical Cancers, Endometrial Cancer, Gynecological Cancers, Pancreatic Adenocarcinoma
- Trial name
- RAMA (NCT07093593)
- Testing
- Mandatory biological samples (blood and sell)
- Volunteers
- 260 people
- Sponsor
- Centre Georges Francois Leclerc
Upper Aerodigestive Tract Neoplasms, Lung Cancer
Alcohol and Tobacco Consumption in Patients With Head and Neck or Lung Cancer : Interest of an Addiction Treatment
This is a multicenter, interventional, randomized study among patients with a first lung or head \& neck cancer who are still active smokers ± alcohol misusers.The study will aim to compare the systematic implementation of an…
- Trial name
- ALTAKRA-1405 (NCT02540174)
- Testing
- integrated addiction treatment program, standard of care
- Where
- 3 sites in France
- Volunteers
- 133 people
- Sponsor
- Centre Oscar Lambret
Carcinoma
Anatomical Relationship of Level IB Lymph Nodes to the Submandibular Gland in Cancer Patients
Hypothesis 1. The submandibular gland is not a lymphatic organ and usually remains uninvolved with head and neck cancer despite the presence of metastatic disease in the lymph nodes that surround it. 2.
- Trial name
- NCT00728130
- Testing
- neck dissection of at least the ipsilateral sub-level 1B
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Southern Illinois University
Squamous Cell Carcinoma of the Oropharynx
Identification of Individual Histological and Blood Markers in Patients With Recurrent or Metastatic Upper Aerodigestive Tract Squamous Cell Carcinoma in Response to Immunotherapies
Epidermoid Carcinoma of the Upper Aerodigestive Tract (CEVADS) is the 6th most common cancer worldwide. Despite current therapies (radiotherapy, surgery and chemotherapy), cancers of the Upper Aerodigestive Tract (UAT) have a…
- Trial name
- iMonitORL (NCT06061705)
- Testing
- Tumor Biopsy
- Where
- 3 sites in France
- Volunteers
- 100 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Swallowing Disorders
Radiation-Related Dysphagia Development Prediction Using a Two-Step Ultrasonographic Model (R-2D-2)
Radiotherapy for head and neck cancers (H\&NC) heightens the risk of swallowing disorders (SD), impacting nutrition, quality of life, and overall health, leading to increased hospitalization and mortality.
- Trial name
- R-2D-2 (NCT06387004)
- Where
- France
- Volunteers
- 112 people
- Sponsor
- Hopital Forcilles
Upper Aerodigestive Tract Neoplasms, Upper AerodigestiveTract Cancer
AI-Assisted Endoscopy for Upper Aerodigestive Tract Lesions
This is a prospective observational clinical study designed to evaluate the performance of artificial intelligence (AI) algorithms applied to upper aerodigestive tract (UADT) video-endoscopy.
- Conditions
- Upper Aerodigestive Tract Neoplasms, Upper AerodigestiveTract Cancer, Upper Aero-digestive Tract (UADT) Neoplasm, Squamous Cell Carcinoma
- Trial name
- H&NANCE (NCT07596355)
- Where
- 3 sites in Belgium, Italy and 1 more
- Volunteers
- 283 people
- Sponsor
- Istituto Italiano di Tecnologia
Upper Aerodigestive Tract Neoplasms
Tracheal Exposure Without Tracheostomy Completion in Trans-oral Robotic Oncologic Surgery
Upper aerodigestive tract neoplasms surgery results in important trauma, including swelling (oedemas) that can lead to respiratory tract obstruction and death from suffocation.
- Trial name
- TRACH (NCT06857396)
- Testing
- PREPA-TRACH
- Where
- France
- Volunteers
- 81 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Oncology, Aerodigestive Tract Cancer
Impact of Adapted Aesthetic Onco in Patients With Upper Aerodigestive Tract Cancer During Their Management
Treatment for cancers of the pharyngolarynx is mutilating, with major consequences for patients' lives in terms of physical and functional after-effects.
- Conditions
- Oncology, Aerodigestive Tract Cancer, Suportive Care
- Trial name
- OEUVRE (NCT06959810)
- Testing
- Adapted Onco-Esthetics sessions
- Where
- France
- Volunteers
- 55 people
- Sponsor
- Centre Francois Baclesse
Squamous Cell Carcinoma of the Oral Cavity, Oropharynx
Ex Vivo Multimodal Imaging of Upper Aerodigestive Epithelium
The purpose of this research study is to collect information on whether images made using investigational microscopes can improve researchers' ability to evaluate and distinguish between normal and abnormal areas in tissue…
- Conditions
- Squamous Cell Carcinoma of the Oral Cavity, Oropharynx, Larynx, Hypopharynx
- Trial name
- NCT01321892
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Esophageal Neoplasm, Head and Neck Neoplasm
The Effects of Upper Airway and Digestive Tract Tumors on the Immune System
The goal of this study is to learn how tumors of the upper airway and digestive passages (tongue, throat, mouth, and voicebox) affect the body's immune defenses and energy storage.
- Conditions
- Esophageal Neoplasm, Head and Neck Neoplasm, Laryngeal Neoplasm, Papilloma
- Trial name
- NCT00001603
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- National Institute on Deafness and Other Communication Disorders (NIDCD)
Lung Cancer, Head and Neck Cancer
Phase I Study of LBH589 & Erlotinib for Advanced Aerodigestive Tract Cancers
The main purpose of the study is to: Determine the safety and tolerability of erlotinib and LBH589B. Establish a recommended phase II expansion dosing of LBH589B and erlotinib in patients with advanced aerodigestive tract cancers.
- Trial name
- NCT00738751
- Testing
- Panobinostat (LBH589), erlotinib
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Head and Neck Neoplasms
Frequency of Xerostomia and Their Management in Upper Aerodigestive Tract Cancer Patients After the End of Radiotherapy
The aim of this study is the evaluation of the frequency of xerostomia and their management after radiotherapy in head and neck cancer.
- Trial name
- XEROSTOMIA (NCT02857413)
- Where
- France
- Volunteers
- 42 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Head and Neck Neoplasms
Prospective Evaluation of ENDOSWIR Device Versus Pathology for Squamous Cell Carcinoma of Upper Aerodigestive Tract (ENDOSWIR-VADS)
A new medical optical device named ENDOSWIR is tested to determine its ability to determine if tissues are cancer or normal tissue on ex-vivo condition for specimen of ENT squamous cell cancers.
- Trial name
- ENDOSWIR-VADS (NCT05318872)
- Testing
- ENDOSWIR
- Volunteers
- 10 people
- Sponsor
- University Hospital, Grenoble
Upper Aerodigestive Tract Cancer, Head and Neck Cancer
Effect of Physical Activity Program on Sedentary of Patients With Upper Aerodigestive Tract Cancer
APAORL2 study aims to evaluate the efficacy of a physical activity program on the sedentary and physical activity level during the 18-month program.
- Trial name
- APAORL2 (NCT06184880)
- Testing
- behavioral, Sedentary
- Where
- France
- Volunteers
- 96 people
- Sponsor
- Centre Hospitalier de Valence
Upper Gingival Squamous Cell Carcinoma
Role of FCγRIIIA and FCγRIIA Receptor Polymorphisms
Hypothesis: Cetuximab, an anti-EGFR antibody, is used with radiotherapy in the treatment of locally advanced and inoperable upper aerodigestive tract cancers.
- Trial name
- FCR-VADS (NCT01827956)
- Testing
- Cetuximab
- Where
- France
- Volunteers
- 121 people
- Sponsor
- Institut Bergonié
Head and Neck Cancer, Pharynx Cancer
Angiogenic and EGFR Blockade With Curative Chemoradiation for Advanced Head and Neck Cancer
Radiotherapy (RT) with concurrent chemotherapy represents the state of the art in curative intent treatment for locally advanced squamous carcinoma of the head and neck.
- Trial name
- NCT00140556
- Testing
- Chemoradiotherapy, Cisplatin, Bevacizumab
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- David M. Brizel, MD
Head and Neck Cancer
Evolution of Masticatory Function, Orofacial Functions and Quality of Life of Patients Treated for Cancers of the Upper Aerodigestive Tract, Rehabilitated by Maxillofacial Prostheses.
This is a follow-up study of masticatory function, orofacial functions, and quality of life in patients with a history of upper aerodigestive tract cancer who have undergone rehabilitation with maxillofacial prostheses.
- Trial name
- RMF-CROC (NCT07471451)
- Testing
- Prosthetic oral rehabilitation
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Clermont-Ferrand