Clinical trials: Upper Aerodigestive Tract Neoplasms
Head and Neck Neoplasms, UADT Neoplasm
Post-Operative Antibiotic Efficacy in Clean Contaminated Head and Neck Surgery: A Randomized Controlled Trial
The "Post-Operative Antibiotic Efficacy in Clean Contaminated Head and Neck Surgery" (PEACH) trial is a study designed to assess the necessity of post-operative antibiotics for preventing surgical site infections (SSIs) in…
- Conditions
- Head and Neck Neoplasms, UADT Neoplasm, Cancer of the Head and Neck, Antibiotic Resistant Infection
- Trial name
- PEACH (NCT06672471)
- Testing
- No Post Operative Antibiotics for intervention group, Post Operative Antibiotics for one day
- Where
- Pakistan
- Volunteers
- 170 people
- Sponsor
- Shaukat Khanum Memorial Cancer Hospital & Research Centre
Head and Neck Squamous Cell Carcinoma
Stereotactic Radiotherapy Combined With Chemotherapy or Not for Treatment of Oligometastases in HNSCC
The aim of this study is to evaluate the rate of living patients at 1 year with a quality of life criteria (no decrease) and reduced toxicities.
- Trial name
- OMET (NCT03070366)
- Testing
- Chemotherapy, Stereotactic radiotherapy
- Where
- France
- Volunteers
- 78 people
- Sponsor
- Groupe Oncologie Radiotherapie Tete et Cou
Non-small Cell Lung Carcinoma, Urothelial Carcinoma
Study Assessing Activity of Molecularly Matched Targeted Therapies in Select Tumor Types Based on Genomic Alterations
With the increased availability of next-generation sequencing, oncologists are starting to incorporate genomic profiling into routine care of cancer patients.
- Conditions
- Non-small Cell Lung Carcinoma, Urothelial Carcinoma, Gastrointestinal Carcinoma, Non-colon, Upper Aerodigestive Tract Carcinoma
- Trial name
- NCT02795156
- Testing
- Afatinib, Regorafenib, Cabozantinib
- Where
- 8 sites in United States
- Volunteers
- 100 people
- Sponsor
- SCRI Development Innovations, LLC
Upper Aerodigestive Tract Neoplasms, Obstructive Sleep Apnea-hypopnea Syndrome
Obstructive Sleep Apnea Syndrome In Patients Treated For Cancer Of The Upper Aerodigestive Tract
Prospective open-label, non-randomized, monocentric, cohort study, to assess the prevalence and severity of sleep apnea syndrome in patients treated for cancer of the upper aerodigestive tract.
- Trial name
- SAOS-K (NCT04262453)
- Where
- France
- Volunteers
- 142 people
- Sponsor
- Centre Hospitalier Sud Francilien
Head and Neck Cancer, Pharynx Cancer
Angiogenic and EGFR Blockade With Curative Chemoradiation for Advanced Head and Neck Cancer
Radiotherapy (RT) with concurrent chemotherapy represents the state of the art in curative intent treatment for locally advanced squamous carcinoma of the head and neck.
- Trial name
- NCT00140556
- Testing
- Chemoradiotherapy, Cisplatin, Bevacizumab
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- David M. Brizel, MD
Head and Neck Cancer
Evolution of Masticatory Function, Orofacial Functions and Quality of Life of Patients Treated for Cancers of the Upper Aerodigestive Tract, Rehabilitated by Maxillofacial Prostheses.
This is a follow-up study of masticatory function, orofacial functions, and quality of life in patients with a history of upper aerodigestive tract cancer who have undergone rehabilitation with maxillofacial prostheses.
- Trial name
- RMF-CROC (NCT07471451)
- Testing
- Prosthetic oral rehabilitation
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Clermont-Ferrand
Pharynx Cancer, Larynx Cancer
Randomized Trial to Assess the Impact of a Screening Program on Upper Aerodigestive Tract Cancer Mortality in a High Risk Population
Randomized multicenter trial to assess the impact of a screening program for heavy alcohol drinkers and smokers treated in alcohol addiction clinics on upper aerodigestive tract cancer mortality.
- Conditions
- Pharynx Cancer, Larynx Cancer, Oral Cavity Cancer, Oesophageal Cancer
- Trial name
- NCT00359645
- Testing
- Screening by head and neck clinical examination with a fiberoptic nasolaryngoscopy and an oesopharyngeal brush biopsy annually during 3 years
- Where
- 35 sites in France
- Volunteers
- 1,993 people, healthy volunteers welcome
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Breast Cancer, Non-small Cell Lung Cancer
Integrated Molecular Profiling in Advanced Cancers Trial
Substantial progress has been made in the treatment of cancer through the use of targeted therapies, but what works for one patient might not work for another patient.
- Conditions
- Breast Cancer, Non-small Cell Lung Cancer, Colorectal Cancer, Genitourinary Cancer
- Trial name
- IMPACT (NCT01505400)
- Where
- Canada
- Volunteers
- 3,026 people
- Sponsor
- University Health Network, Toronto
Oral Mucositis, Carcinoma in Situ of Upper Respiratory Tract
Efficacy of MUCIPLIQ on the Incidence of Radio-chemotherapy-induced Mucositis in Patients Suffering From Oral Cancer
MUCIPLIQ is a nanopolymer engineered to mimic glycosaminoglycans such as heparan sulfates. Glycosaminoglycans are involved 1) in the stabilization of cells micro-environment, known as extracellular matrix, by binding to…
- Trial name
- MUCIPLIQ (NCT01840436)
- Testing
- MUCIPLIQ
- Where
- 5 sites in France
- Volunteers
- 136 people
- Sponsor
- Organ, Tissue, Regeneration, Repair and Replacement
Upper Gingival Squamous Cell Carcinoma
Role of FCγRIIIA and FCγRIIA Receptor Polymorphisms
Hypothesis: Cetuximab, an anti-EGFR antibody, is used with radiotherapy in the treatment of locally advanced and inoperable upper aerodigestive tract cancers.
- Trial name
- FCR-VADS (NCT01827956)
- Testing
- Cetuximab
- Where
- France
- Volunteers
- 121 people
- Sponsor
- Institut Bergonié
NK-T-Cell Lymphoma, Extranodal
A Study Comparing of P-GEMD Regimen Versus P-Gemox Regimen With Untreated Early-Stage NUAT or Advanced-Stage ENKTL.
Extranodal natural-killer (NK)/T-cell lymphoma (ENKTL) is an aggressive subtype of non-Hodgkin lymphoma with a poor prognosis. Notably, patients with advanced-stage disease or early-stage non-upper aero-digestive tract (NUAT)…
- Trial name
- NCT06953739
- Testing
- P-GEMD, P-Gemox
- Volunteers
- 60 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
HNSCC
Evaluation of the Tolerance of Afatinib in Combination With Docetaxel and Cisplatin in LAHNSCC Induction Chemotherapy
The purpose of the study is to determine the maximum tolerated dose (MTD) of afatinib administrated in combination with docetaxel (Taxotere®) and cisplatin in induction chemotherapy of locally advanced head and neck carcinoma in…
- Trial name
- TAPIS (NCT02216617)
- Testing
- Taxotere, Cisplatin, Afatinib
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Groupe Oncologie Radiotherapie Tete et Cou
Squamous Cell Carcinoma of the Oral Cavity and Oropharynx
A Study Evaluating the Contribution of Non-Coplanar Beam Arrangement in Reducing Toxicity in Radiotherapy for Upper Aerodigestive Tract Cancers
Cancers of the upper aerodigestive tract (UADT) are frequently treated with external beam radiotherapy, either alone or in combination with chemotherapy.
- Trial name
- BaReTox (NCT07413627)
- Testing
- Coplanar External Beam Radiotherapy, Non-Coplanar External Beam Radiotherapy
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Centre Georges Francois Leclerc
Upper AerodigestiveTract Cancer
Metabolomics of Cancers of the Upper Aerodigestive Tract
Metabolomics, thanks to advances in mass spectrometry, allows for the analysis of cellular metabolites to better understand biological processes.
- Trial name
- METABORL (NCT07377084)
- Testing
- Blood samples for the analysis of sildenafil in plasma, urine samples
- Where
- France
- Volunteers
- 250 people
- Sponsor
- Centre Antoine Lacassagne
Head and Neck Cancer
Post-operative Radiotherapy With Cisplatin Alone or in Combination With Iressa in Upper Aerodigestive Tract Carcinomas
This trial will be an open multicentric randomized phase II study comparing post-operative radiotherapy + cisplatin associated or not with Iressa in upper aerodigestive tract carcinomas.
- Trial name
- NCT00169221
- Testing
- Iressa (Gefitinib), chemoradiotherapy with cisplatin
- Where
- France
- Volunteers
- 54 people
- Sponsor
- Groupe Oncologie Radiotherapie Tete et Cou
Lung Cancer
Surveillance For New Lung Primaries
The primary goal of this study is to determine the prevalence of tracheobronchial carcinomas in patients with a history of squamous cell cancer of the aerodigestive tract who have been treated with a curative intent and remain…
- Trial name
- NCT00205439
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Wisconsin, Madison
Cancer of Head, Cancer of Head and Neck
Trial of Postoperative Radiation, Cisplatin, and Panitumumab in Locally Advanced Head and Neck Cancer
The objectives for this study is as follows: Primary: To evaluate the progression-free survival of locoregionally advanced (stages III/IV) SCCHN patients undergoing postoperative chemoradiotherapy with panitumumab.
- Conditions
- Cancer of Head, Cancer of Head and Neck, Cancer of Neck, Cancer of the Head
- Trial name
- NCT00798655
- Testing
- Panitumumab, Cisplatin, Radiation Therapy
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Robert Ferris
The Families or Next of Kin of Patients Treated at MSKCC for Non-cutaneous Squamous Cell Carcinomas of the, Upper Aerodigestive Tract
Improving End of Life Care in Head and Neck Cancer
The purpose of this study is to improve the quality of care provided for head and neck cancer patients. By better understanding the end of life experiences of dying patients and their families, the investigators hope to better…
- Trial name
- NCT01632969
- Testing
- The The Family Assessment of Treatment at the End of life (FATE ) survey
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Squamous Cell Carcinoma of Oropharynx, Squamous Cell Carcinoma of Hypopharynx
Interest of Narrow Band Imaging in Detection of Upper Aerodigestive Cancers
The aim of this study is to prospectively determine if the use of NBI endoscopy modifies the superficial extension of these tumors.
- Conditions
- Squamous Cell Carcinoma of Oropharynx, Squamous Cell Carcinoma of Hypopharynx, Squamous Cell Carcinoma of Larynx
- Trial name
- NCT02035735
- Testing
- WL and NBI
- Where
- France
- Volunteers
- 93 people
- Sponsor
- University Hospital, Toulouse
Upper Aerodigestive Tract Neoplasms, Lung Cancer
Alcohol and Tobacco Consumption in Patients With Head and Neck or Lung Cancer : Interest of an Addiction Treatment
This is a multicenter, interventional, randomized study among patients with a first lung or head \& neck cancer who are still active smokers ± alcohol misusers.The study will aim to compare the systematic implementation of an…
- Trial name
- ALTAKRA-1405 (NCT02540174)
- Testing
- integrated addiction treatment program, standard of care
- Where
- 3 sites in France
- Volunteers
- 133 people
- Sponsor
- Centre Oscar Lambret