Clinical trials: Upper Gastro Intestinal Bleeding
GastroIntestinal Bleeding
Navicam as a Triage Tool in the Management of Patients With Acute Upper Gastrointestinal Bleeding
Acute upper gastrointestinal bleeding(AUGIB) is a common emergency. The NaviCam (ANKON) is a miniaturised wireless endoscope in a single use capsule. It can be remotely controlled with the patient in a magnetic console..
- Trial name
- NCT04197843
- Testing
- NaviCam (ANKON)
- Where
- 2 sites in China, Hong Kong
- Volunteers
- 100 people
- Sponsor
- Chinese University of Hong Kong
Coronary Artery Disease, Percutaneous Coronary Intervention
Potassium-Competitive Acid Blocker Versus pROton-Pump Inhibitor for GastroproTECTion Strategies In Patients at High Gastro-Intestinal Bleeding Risk Receiving Antithrombotic Therapy
The primary aim of this study is to evaluate the efficacy and safety of novel P-CAB (tegoprazan 50 mg once daily) as compared with standard PPI (rabeprazole 20 mg once daily) for protection of GI events in patients with known…
- Conditions
- Coronary Artery Disease, Percutaneous Coronary Intervention, Acute Coronary Syndrome, Myocardial Infarction
- Trial name
- PROTECT-HBR (NCT04416581)
- Testing
- PPI, P-CAB 50
- Where
- 45 sites in South Korea
- Volunteers
- 3,320 people
- Sponsor
- Duk-Woo Park, MD
Upper Gastrointestinal Bleeding
PuraStat® Combined With Adrenaline Versus Standard of Care in Upper Gastrointestinal Bleeding
PuraStat® is a novel gel that offers several advantages over traditional hemostatic powders. Its transparency allows for continuous visualization of the bleeding site, and it can be applied in narrow spaces or in combination with…
- Trial name
- NCT06896409
- Testing
- PuraStat® combined with Adrenaline, Standard of Care
- Where
- Spain
- Volunteers
- 126 people
- Sponsor
- Tallaght University Hospital
Bleeding Ugi
PillSense for Suspected Upper Gastrointestinal Bleeding
This study aims to evaluate the efficacy and safety of a novel blood sensing capsule (PillSense), to help emergency doctors better evaluate if patients have active upper digestive tract bleeding, to determine if they can be…
- Trial name
- BLEED (NCT06500468)
- Testing
- PillSense System
- Where
- Singapore
- Volunteers
- 84 people
- Sponsor
- Tan Tock Seng Hospital
Congenital Heart Disease, Upper Gastrointestinal Bleeding
Stress Ulcer Prophylaxis Versus Placebo in Critically Ill Infants With Congenital Heart Disease
Infants with congenital heart disease often require an intervention during their first year of life. Infants are generally admitted to a cardiac intensive care unit and are routinely prescribed stress ulcer prophylaxis to…
- Conditions
- Congenital Heart Disease, Upper Gastrointestinal Bleeding, Stress Ulcer, Infection
- Trial name
- SUPPRESS-CHD (NCT03667703)
- Testing
- Famotidine
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Boston Children's Hospital
Upper Gastrointestinal Variceal Bleeding in Cirrhotic Patients
Predictive and Prognostic Significance of Age,Blood Tests,Comorbidities(ABC) Score,Cologne Watch(C-watch)Score and Rockall Score for Risk of Variceal Re-bleeding Among Cirrhotic Patients
Introduction Portal hypertension is a common complication of liver cirrhosis and is often underestimated in clinical diagnosis. The incidence of portal hypertension is approximately 20% to 98% in patients with cirrhosis (Wu et…
- Trial name
- NCT06335186
- Testing
- upper endoscopy
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Esophagogastroduodenoscopy, Upper Gastrointestinal Bleeding (UGIB)
Effect of Ondansetron on Patient Tolerance, Efficacy and Endoscopist Workload in Unsedated Endoscopy for Upper Gastrointestinal Bleeding
The goal of this clinical trial is to evaluate whether intravenous ondansetron can improve patient tolerance and reduce discomfort during unsedated emergency esophagogastroduodenoscopy (EGD).
- Trial name
- NCT07336680
- Testing
- intravenous ondansetron
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Peking Union Medical College Hospital
Gastrointestinal Hemorrhage
Bipolar Hemostatic Forceps Versus Standard Therapy in Acute Non-variceal Upper GI Bleeding
Bipolar hemostatic forceps will be tested against standard therapy in active, non-variceal, upper gastrointestinal bleeding by a prospective, randomized trial
- Trial name
- BeBop (NCT05353062)
- Testing
- Hemostatic therapy, Endoscopic therapy with hemoclip +/- injection of epinephrine solution
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Theresienkrankenhaus und St. Hedwig-Klinik GmbH
Gastrointestinal Hemorrhage, Tranexamic Acid
Local Administration of Tranexamic Acid in Upper Gastrointestinal Hemorrhage
Upper gastrointestinal hemorrhage is a frequently diagnosis in emergency departments. Although new drugs and endoscopic techniques were easily applied in various settings in this condition, the role of local administered…
- Conditions
- Gastrointestinal Hemorrhage, Tranexamic Acid, Emergency Department, Antifibrinolytic Agents
- Trial name
- NCT02903017
- Testing
- Tranexamic acid 5%
- Where
- Turkey (Türkiye)
- Volunteers
- 114 people
- Sponsor
- Kocaeli University
Upper Gastrointestinal Bleeding
HFNC Versus Conventional Oxygen Therapy in Prolonged Upper Gastrointestinal Endoscopy in the ICU
Conventional supplemental oxygen therapy (COT) during upper gastrointestinal (UGI) endoscopy via nasal catheter is considered the standard practice in maintenance of oxygenation and prevention of hypoxia.
- Trial name
- NCT06350864
- Testing
- High-flow nasal cannula (HFNC), Conventional nasal oxygen therapy (COT), Upper gastrointestinal endoscopy (UGE) including gastroscopy
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Ain Shams University
Gastrointestinal Hemorrhage
Transfusion in Gastrointestinal Bleeding
Aim: To evaluate the feasibility and safety of a restrictive versus liberal red blood cell (RBC) transfusion policy in adult patients admitted with Acute Upper Gastrointestinal Bleeding (AUGIB) in order to inform the design of a…
- Trial name
- TRIGGER (NCT02105532)
- Testing
- Restrictive transfusion policy, Liberal Transfusion Policy
- Where
- United Kingdom
- Volunteers
- 936 people
- Sponsor
- Dr Vipul Jairath
Upper Gastrointestinal Bleeding
Study of Incidence of Drug-induced Upper Gastrointestinal Bleeding
The purpose of this study is to determine and analyse the incidence, severity, risk factors and routine management of acute drug-induced upper gastrointestinal bleeding (UGIB) in the population of Russian patients
- Trial name
- NCT01155401
- Where
- Russia
- Volunteers
- 300 people
- Sponsor
- AstraZeneca
Esophageal Varices in Cirrhosis of the Liver, Upper Gastrointestinal Bleeding
Endoscopic Variceal Ligation in Children
This is an ambispective single-center cohort study of pediatric patients with portal hypertension and esophageal varices. The study was designed to evaluate the efficacy and safety of primary prophylaxis with endoscopic variceal…
- Conditions
- Esophageal Varices in Cirrhosis of the Liver, Upper Gastrointestinal Bleeding, Endoscopy, Child
- Trial name
- NCT03943784
- Testing
- Endoscopic Variceal Ligation, Non-Selective Beta-Blocking Agent
- Volunteers
- 60 people
- Sponsor
- Hospital Vall d'Hebron
Upper Gastrointestinal Bleeding
Safety & Efficacy of Omeprazole Sodium Bicarbonate for the Prevention of Upper GI Bleeding in the Critically Ill
Critically ill patients are at an increased risk of having upper gastrointestinal (GI) bleeding due to stress related mucosal damage.
- Trial name
- NCT00045799
- Testing
- Omeprazole sodium bicarbonate immediate release PWD/FS, Cimetidine IV
- Where
- 58 sites in United States
- Volunteers
- 354 people
- Sponsor
- Bausch Health Americas, Inc.
Upper GI Bleeding
Metoclopramide for Gastric Visualization in Active Upper GI Bleeding
This study aim to evaluate the efficacy of metoclopramide for gastric visualization in patients with active UGIB. This is a double-blinded, multicenter RCT.
- Trial name
- NCT06167837
- Testing
- Metoclopramide Sulfone, Normal Saline 10 mL Injection
- Where
- 2 sites in Thailand
- Volunteers
- 220 people
- Sponsor
- King Chulalongkorn Memorial Hospital
Gastro Intestinal Bleeding, Ischaemic Heart Diseases
Gastrointestinal Bleeding is Blood Loss in the Digestive Tract, Classified as Upper or Lower. Ischemic Heart Disease is Due to Blocked Heart Arteries. Antiplatelet Drugs Help Prevent Heart Attacks But Increase GI Bleeding Risk, Especially When Used Together as Dual Therapy.
Gastrointestinal bleeding is blood loss in the digestive tract, classified as upper or lower. Ischemic heart disease is due to blocked heart arteries.
- Conditions
- Gastro Intestinal Bleeding, Ischaemic Heart Diseases, Antiplatelet Drugs, Antiplatelet Drug-related Gastrointestinal Injury
- Trial name
- NCT07125651
- Volunteers
- 112 people
- Sponsor
- Assiut University
Acute Gastrointestinal Bleeding
Randomized Trial of UI-EWD vs. Conventional Endoscopic Therapy for Nonvariceal Upper Gastrointestinal Bleeding
A prospective, multi-center, noninferiority randomized controlled trial designed to compare the efficacy of UI-EWD (Nexpowder™) hemostatic powder versus conventional endoscopic hemostatic therapy in patients presenting with acute…
- Trial name
- TREET (NCT06188585)
- Testing
- UI-EWD, Conventional therapy
- Where
- 14 sites in United States, Canada and 4 more
- Volunteers
- 278 people
- Sponsor
- Medtronic - MITG
Upper Digestive Bleeding, Cirrhosis
Efficacity and Safety of Tranexamic Acid in Cirrhotic Patients Presenting With Acute Upper Gastrointestinal Bleeding
Upper digestive bleeding. Upper gastrointestinal haemorrhage is a common cause of decompensated cirrhosis and is associated with a high mortality rate among cirrhotic patients.
- Trial name
- EXARHOSE (NCT03023189)
- Testing
- Tranexamic acid
- Where
- 3 sites in France
- Volunteers
- 500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hematemesis, Melena
Point of Care Testing of Platelet Function in Patients With Acute Upper Gastrointestinal Bleeding
Acute upper gastrointestinal bleeding (AUGIB) is a common medical emergency. In an ageing population, antiplatelet drugs are increasingly being prescribed for treatment and prophylaxis against cardiovascular thrombo-embolic…
- Conditions
- Hematemesis, Melena, Gastrointestinal Hemorrhage, Platelet Dysfunction
- Trial name
- POCGIB (NCT03028064)
- Testing
- blood taking
- Where
- China
- Volunteers
- 476 people
- Sponsor
- Chinese University of Hong Kong
Upper Gastrointestinal Bleeding
Patients With Upper Gastrointestinal Bleeding in Emergency Department
More than 80% of patients with upper gastrointestinal bleeding (UGIB) are hospitalized after their visit to the emergency department (ED). However, some of these hospitalizations do not seem justified.
- Trial name
- UGIB-ED (NCT05927493)
- Where
- France
- Volunteers
- 2,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris