Clinical trials: Upper Gastrointestinal Bleeding
Hematemesis, Melena
Point of Care Testing of Platelet Function in Patients With Acute Upper Gastrointestinal Bleeding
Acute upper gastrointestinal bleeding (AUGIB) is a common medical emergency. In an ageing population, antiplatelet drugs are increasingly being prescribed for treatment and prophylaxis against cardiovascular thrombo-embolic…
- Conditions
- Hematemesis, Melena, Gastrointestinal Hemorrhage, Platelet Dysfunction
- Trial name
- POCGIB (NCT03028064)
- Testing
- blood taking
- Where
- China
- Volunteers
- 476 people
- Sponsor
- Chinese University of Hong Kong
Esophageal Varices, Liver Cirrhoses
Comparison of 24-hours Versus 72-hours of Octreotide Infusion in Preventing Early Rebleed From Esophageal Varices
This study evaluates the safety and efficacy of 24-hour vs 72-hour octreotide infusion after variceal banding in cirrhotic patients with bleeding esophageal varices.
- Conditions
- Esophageal Varices, Liver Cirrhoses, Bleeding Esophageal Varices, Upper Gastrointestinal Bleeding
- Trial name
- LOVARB (NCT03624517)
- Testing
- Octreotide
- Where
- 8 sites in United States
- Volunteers
- 34 people
- Sponsor
- Medical University of South Carolina
Non-variceal Upper Gastrointestinal Bleeding
Effects of Different Omeprazole Dosing on Gastric pH in Non-variceal Upper Gastrointestinal Bleeding
The aim of the study is to identify the best method of omeprazole (OME) application with respect to intragastric pH, cytochrome P450 2C19 (CYP2C19) genotype and phenotype.
- Trial name
- NCT03980496
- Testing
- Omeprazole
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Medical University of Bialystok
Upper GI Bleeding
Analysis the Vocs in Upper GI Bleeding Patients
This project aims to collect the exhaled breath of patients with acute upper gastrointestinal bleeding clinically, divide them into large, small and no bleeding groups according to the results of gastroscopy, analyze the…
- Trial name
- NCT05457062
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Affiliated Hospital to Academy of Military Medical Sciences
Upper GI Bleeding
Presence or Absence of Blood in the GI Lumen
Bleedings in the upper digestive tract are common. Usually, laboratory and clinical parameters are considered to establish a suspicion for a bleeding in the digestive tract and to estimate urgency of the situation.
- Trial name
- NCT05415124
- Testing
- HemoPill, Endoscopy
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- NYU Langone Health
Peptic Ulcer Hemorrhage
The Dissemination of Consensus Recommendations on Upper Gastrointestinal Bleeding
The purpose of this study is to assess whether adherence to NVUGIB guidelines is improved with implementation of a national, tailored multifaceted intervention.
- Trial name
- REASON-II (NCT00840008)
- Testing
- Educational intervention
- Volunteers
- 3,157 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Acute Upper Gastrointestinal Hemorrhage, Cirrhosis
Timing of Endoscopic Intervention for Acute Variceal Hemorrhage: an RCT
Acute variceal upper gastrointestinal hemorrhage remains a hot potato in cirrhotic patients. The purpose of this study is to figure out whether urgent endoscopy (within 6h after gastroenterological consultation) is superior to…
- Conditions
- Acute Upper Gastrointestinal Hemorrhage, Cirrhosis, Varice Bleed, Gastroesophageal Varices
- Trial name
- TEACH (NCT04786743)
- Testing
- endoscopic intervention
- Where
- 4 sites in China
- Volunteers
- 412 people
- Sponsor
- Jinling Hospital, China
Gastrointestinal Bleeding, Cirrhosis
Effects of the Administration of Ornithine Phenylacetate in Patients With Cirrhosis and Upper Gastrointestinal Bleeding
The main objective is to evaluate the effectiveness of the experimental drug to reduce plasma ammonia concentration at a dose that is safe and well tolerated.
- Trial name
- NCT01434108
- Testing
- Ornithine-phenylacetate
- Where
- Spain
- Volunteers
- 48 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Actual or Potential Nonvariceal Bleeding in the Upper Gastrointestinal (GI) Tract
Clinical Evaluation of the Safety and Performance of Microwave Coagulation Using the HS1 Instrument
Clinical evaluation of the safety and performance of microwave coagulation using the HS1 Instrument for actual or potential non-variceal bleeding in the upper Gastrointestinal (GI) tract
- Trial name
- NCT04406116
- Testing
- Microwave coagulation using HS1 Instrument
- Where
- United Kingdom
- Volunteers
- 35 people
- Sponsor
- Creo Medical Limited
Upper Gastrointestinal Bleeding (UGIB), Glasgow-Blatchford Score
External Validation of the Glasgow-Blatchford Bleeding Score in a Tunisian Population
This study aims to externally validate the Glasgow-Blatchford Score (GBS) in a Tunisian population presenting with non-traumatic upper gastrointestinal bleeding.
- Trial name
- NCT07089277
- Where
- Tunisia
- Volunteers
- 250 people
- Sponsor
- Hôpital Universitaire Sahloul
Liver Cirrhosis
Terlipressin vs. Somatostatin in Cirrhotic Patients With Acute Variceal Bleeding and Renal Dysfunction
Acute upper gastrointestinal bleeding (AUGIB) is a common complication in the decompensated stage of liver cirrhosis, of which approximately 70% is acute variceal bleeding (AVB) caused by portal hypertension.
- Trial name
- NCT07252401
- Testing
- 2-4 mg of terlipressin, 3 mg of somatostatin
- Where
- China
- Volunteers
- 64 people
- Sponsor
- General Hospital of Shenyang Military Region
UGI Bleed
A Prospective Pilot Study to Evaluate the Diagnostic Performance of a Wireless Sensor Capsule in Detection of UGIB
It is a single-center, prospective study, which will be conducted in a tertiary academic hospital (Prince of Wales Hospital). All subjects will undergo a paired examination of HemoPill® acute capsule and…
- Trial name
- HemoPill (NCT06409182)
- Testing
- Hemopill
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- Chinese University of Hong Kong
UGI Bleed
Comparison of Risk Scores in Upper Gastrointestinal Bleeding
The goal of this prospective observational study is to compare the Glasgow-Blatchford Score (GBS), AIMS65, and pre-endoscopic Rockall Score in predicting outcomes among patients with upper gastrointestinal bleeding (UGIB).
- Trial name
- NCT07819942
- Where
- Nepal
- Volunteers
- 100 people
- Sponsor
- Kathmandu Medical College and Teaching Hospital
Patients With Acute Upper Gastrointestinal Bleeding
Prognostic Value of AIMS65 Score to Predict Outcome in Patients With Acute Upper Gastrointestinal Bleeding
Prognostic Value of AIMS65 Score to predict outcome in patients with acute upper gastrointestinal bleeding
- Trial name
- NCT05773339
- Testing
- AIMS65 score
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Upper Gastrointestinal Bleeding
Oral vs Intravenous and Proton Pump Inhibitor (PPI）for Peptic Ulcer Bleeding (PUB)
A bleeding peptic ulcer remains a serious medical problem with significant morbidity and mortality. Endoscopic therapy significantly reduces further bleeding, surgery, and mortality in patients with bleeding peptic ulcers and is…
- Trial name
- NCT01123031
- Testing
- lansoprazole, esomeprazole
- Sponsor
- Changhua Christian Hospital
Acute Coronary Syndrome, Myocardial Infarction
Clopidogrel and the Optimization of Gastrointestinal Events (COGENT-1)
The purpose of the COGENT-1 clinical trial is to determine whether CGT-2168 (clopidogrel and omeprazole) compared to clopidogrel is safe and effective in reducing the incidence of gastrointestinal bleeding and symptomatic ulcer…
- Conditions
- Acute Coronary Syndrome, Myocardial Infarction, Coronary Artery Disease, Percutaneous Coronary Intervention
- Trial name
- COGENT-1 (NCT00557921)
- Testing
- CGT-2168 (clopidogrel 75 mg/omeprazole 20 mg) and aspirin, Plavix (clopidogrel 75 mg) and aspirin
- Where
- 491 sites in United States, Australia and 14 more
- Volunteers
- 5,000 people
- Sponsor
- Cogentus Pharmaceuticals
GIT Bleeding
Impact of Diagnostic and Therapeutic Upper and Lower Gastrointestinal Endoscopic Management on Critically Ill Patients in Fayoum University Hospitals
Prospective study to evaluate the diagnostic and prognostic value of upper and lower gastrointestinal endoscopy in ICU
- Trial name
- NCT07829978
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Fayoum University
Intubation;Difficult, Gastrointestinal Bleeding
Evaluation of Prophylactic Endotracheal Intubation
Upper gastrointestinal (GI) bleeding is defined as patients who either presented with hematemesis or presented with melena along with evidence of hemodynamic compromise.
- Trial name
- NCT03716466
- Testing
- Endotracheal intubation, No airway intervention
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- University of Texas Southwestern Medical Center
Upper Gastrointestinal Bleeding (UGIB), High Risk Bleeding
A New Scoring System to Predict High-Risk Groups in Upper Gastrointestinal Bleeding
Upper gastrointestinal bleeding (UGIB) remains a common and potentially life-threatening emergency condition requiring early risk stratification to guide clinical management.
- Trial name
- UGIS (NCT07458178)
- Where
- Turkey (Türkiye)
- Volunteers
- 312 people
- Sponsor
- Izmir Katip Celebi University
Acute Non-variceal Upper Gastrointestinal Bleeding
Clinical Prediction Model for In-Hospital Rebleeding in Acute Non-Variceal Upper Gastrointestinal Bleeding
ANVUGIB is a serious condition that can cause symptoms like vomiting blood or passing black stools. Although treatments have improved, about 10% to 30% of patients experience rebleeding shortly after their initial treatment…
- Trial name
- NCT06697691
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Junwei Yan