Clinical trials: Upper Gastrointestinal Cancer
Upper Gastrointestinal Cancer
Real-World Use of Nivolumab for the Treatment of Patients With Metastatic Upper Gastrointestinal Cancer in Canada
The purpose of this observational study is to describe the demographics, and disease characteristics of participants with metastatic upper gastrointestinal cancer, along with the treatment characteristics of these patients when…
- Trial name
- NCT06361576
- Testing
- Nivolumab
- Where
- Canada
- Volunteers
- 700 people
- Sponsor
- Bristol-Myers Squibb
Upper GI Cancer, Cisplatin Adverse Reaction
Evaluation of Effects of Silymarin on Cisplatin Induced Nephrotoxicity in Upper Gastrointestinal Adenocarcinoma
Cisplatin is a potent chemotherapeutic agent that has been widely used to treat many solid tumours. acute renal failure, despite conservative fluid and electrolyte management, frequently reported adverse event and limiting…
- Trial name
- NCT01829178
- Testing
- Silymarin, chemotherapy
- Where
- Iran
- Volunteers
- 30 people
- Sponsor
- Tehran University of Medical Sciences
Esophageal Neoplasms, Stomach Neoplasms
Food Intake and Gut Hormones in Patients Who Have Undergone Upper Gastrointestinal Surgery for Cancer
Improvements to treatment strategies for patients upper gastrointestinal cancers have produced an increasing population of people who remain free from disease recurrence in the long term.
- Conditions
- Esophageal Neoplasms, Stomach Neoplasms, Weight Loss, Malnutrition
- Trial name
- NCT02385617
- Testing
- Octreotide
- Where
- 2 sites in Ireland, Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- St. James's Hospital, Ireland
Extrahepatic Bile Duct Cancer, Nausea
Aprepitant in Preventing Nausea and Vomiting in Patients Undergoing Chemotherapy and Radiation Therapy for Pancreatic Cancer
This pilot clinical trial is studying how well aprepitant works in preventing nausea and vomiting in patients undergoing chemotherapy and radiation therapy for pancreatic cancer.
- Conditions
- Extrahepatic Bile Duct Cancer, Nausea, Vomiting, Stage II Pancreatic Cancer
- Trial name
- NCT01534637
- Testing
- aprepitant, gemcitabine hydrochloride, capecitabine
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Wake Forest University Health Sciences
Cirrhosis, Neoplasms
Chemotherapy and Liver Cirrhosis in Frequently-associated Cancers
Cirrhosis and cancers of the upper digestive tract, colorectal and ENT share common risk factors. Liver cirrhosis can change the elimination of cancer drugs.
- Trial name
- CHIMIOSE (NCT04179773)
- Testing
- Current care study
- Where
- 2 sites in France
- Volunteers
- 7 people
- Sponsor
- University Hospital, Lille
Gastric Cancer
Laparoscopy-assisted Proximal Gastrectomy Versus and Laparoscopy-assisted Total Gastrectomy
The choice of surgical strategy for patients with proximal gastric cancer is controversial mainly because proximal gastrectomy is infamous for high rates of reflux symptoms and anastomotic stricture.
- Trial name
- PRAPT (NCT01433861)
- Testing
- Laparoscopy-assisted gastrectomy
- Where
- South Korea
- Volunteers
- 7 people
- Sponsor
- Seoul National University Bundang Hospital
Tumor of Esophagus, Stomach and Duodenum
The Effect of Chemotherapy and Surgery for Cancer on Exercise Capacity
Neoadjuvant chemotherapy (NAC) prior to surgery for upper gastrointestinal (oesophageal and gastric) cancer is associated with improved survival.
- Trial name
- NCT01325883
- Where
- United Kingdom
- Volunteers
- 253 people
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Gastric Cancer, Gastrectomy
Laparoscopic Spleen-Preserving No. 10 Lymph Node Dissection for AGC
The purpose of this study is to explore the safety and feasibility of laparoscopic spleen-preserving No. 10 lymph node dissection for patients with advanced middle or upper third gastric cancer.
- Conditions
- Gastric Cancer, Gastrectomy, Laparoscopic Surgery, Lymphadenectomy
- Trial name
- NCT03708783
- Testing
- laparoscopic Spleen-Preserving No. 10 Lymph Node Dissection
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Peking University Cancer Hospital & Institute
Surgical Resection of an Upper Gastrointestinal Malignancy, Nutritional Supplementation Via a Jejunostomy Post Discharge From Hospital
Enteral Feeding in Discharged Patients
Patients due to undergo surgery for oesophageal and gastric malignancy are often malnourished. Up to 10% of patients preoperative weight may also be lost during the early postoperative period.
- Trial name
- NCT02155140
- Testing
- Jejunal feeding
- Where
- United Kingdom
- Volunteers
- 45 people
- Sponsor
- University Hospital Plymouth NHS Trust
Gastric Carcinoma, Liver and Intrahepatic Bile Duct Carcinoma
Effects on Quality of Life With Zinc Supplementation in Patients With Gastrointestinal Cancer
This randomized study examines how well zinc works in improving quality of life in patients with gastrointestinal cancer that cannot be removed by surgery who are receiving chemotherapy.
- Conditions
- Gastric Carcinoma, Liver and Intrahepatic Bile Duct Carcinoma, Unresectable Esophageal Carcinoma, Unresectable Pancreatic Carcinoma
- Trial name
- NCT03819088
- Testing
- Zinc
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- Emory University