Clinical trials: Upper Gastrointestinal Cancer
Non-small Cell Lung Carcinoma, Urothelial Carcinoma
Study Assessing Activity of Molecularly Matched Targeted Therapies in Select Tumor Types Based on Genomic Alterations
With the increased availability of next-generation sequencing, oncologists are starting to incorporate genomic profiling into routine care of cancer patients.
- Conditions
- Non-small Cell Lung Carcinoma, Urothelial Carcinoma, Gastrointestinal Carcinoma, Non-colon, Upper Aerodigestive Tract Carcinoma
- Trial name
- NCT02795156
- Testing
- Afatinib, Regorafenib, Cabozantinib
- Where
- 8 sites in United States
- Volunteers
- 100 people
- Sponsor
- SCRI Development Innovations, LLC
Subepithelial Tumors of the Upper Gastrointestinal Tract
Role of Doppler Endoscopic Probe in the Diagnosis of Subepithelial Gastrointestinal Lesions.
RESEARCH PLAN I-TITLE Role of Doppler endoscopic probe in the diagnosis of subepithelial gastrointestinal lesions. II-BACKGROUND Subepithelial lesions (SEL) are commonly encountered during routine endoscopies with an estimated…
- Trial name
- DopplerSEL (NCT05983406)
- Testing
- Doppler investigation
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Francisco Baldaque-Silva
Upper Gastrointestinal Cancer Patients Upon Admission, Nutritional Status
Nutritional Status Among Upper Gastrointestinal Cancer Patients Upon Admission
Cross-sectional study. Data on clinical, anthropometric, biochemical profile and dietary intake Upper Gastrointestinal Cancer Patients upon admission are traced and collected.
- Trial name
- RSCH ID-22-012 (NCT05867810)
- Where
- Malaysia
- Volunteers
- 409 people
- Sponsor
- Universiti Putra Malaysia
Upper Gastrointestinal Disorders, Lower Gastrointestinal Disorders
Sarcopenia and Physiology Assessments in Cancer Patients
Primary Aim: To establish a reliable relationship between oxygen uptake (VO2) at estimated lactate threshold (AT) and CT-derived body composition measurments (e.g.
- Conditions
- Upper Gastrointestinal Disorders, Lower Gastrointestinal Disorders, Hepatobiliary Cancer
- Trial name
- NCT03641118
- Testing
- Cardiopulmonary exercise test
- Where
- United Kingdom
- Volunteers
- 639 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Acute Upper Gastrointestinal Bleeding, Tumor Bleeding
Over-the-scope Clips and Standard Treatments in Endoscopic Control of Acute Bleeding From Non-variceal Upper GI Causes
In the management of patients with acute upper gastrointestinal bleeding from non-variceal causes, endoscopic treatment and acid suppression are now the standard of care.
- Trial name
- NCT03216395
- Testing
- Over-the-scope Clips, Hemo-clipping, thermo-coagulation
- Where
- 8 sites in Australia, China and 1 more
- Volunteers
- 191 people
- Sponsor
- Chinese University of Hong Kong
Upper Gastrointestinal Subepithelial Tumors
Biopsy Protocol of Upper Gastrointestinal Subepithelial Tumors:Diagnostic Accuracy of EUS-FNB Versus Unroofing Biopsy
To increase the diagnostic accuracy of subepithelial tumors, larger tissue samples are required. It is difficult to obtain adequate tissue samples. There were several biopsy methods to obtain tissue samples.
- Trial name
- NCT02646241
- Testing
- unroofing biopsy, EUS-FNB(endoscopic ultrasonography guided fine needle biopsy)
- Where
- South Korea
- Volunteers
- 47 people
- Sponsor
- Yonsei University
Improve the Screening Criteria of Chinese Hereditary Upper Gastrointestinal Tumors
Screening of Hereditary Upper Gastrointestinal Cancer in China
Through exploring the specific genetic mutations in the upper gastrointestinal tract tumors with a family history and specific clinical pathological types，we establish a complete family and follow-up system，in order to improve…
- Trial name
- NCT03130621
- Testing
- Gene detection
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Peking University
Upper GI Cancer
Regorafenib Second Line Treatment of Metastatic or Advanced Upper GI Cancers
Regorafenib as a Second Line Single Agent in the Treatment of Metastatic or Advanced Adenocarcinoma of the Esophagus, Gastroesophageal Junction or Stomach
- Trial name
- NCT02241720
- Testing
- regorafenib
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Utah
Upper Gastrointestinal Bleeding
Evaluation of Prognostic Scores in Patients With Upper Gastrointestinal Bleeding and Cancer
This is a prospective and observational study to evaluate oncologic patients that presented upper gastrointestinal bleeding with the use of some prognostic scores.
- Trial name
- NCT02508883
- Where
- Brazil
- Volunteers
- 243 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Disorder of Upper Gastrointestinal Tract, Gastrointestinal Stromal Tumors
EUS-FNB vs. Single-incision Needle-knife (SINK) Biopsy for Gastrointestinal SELs
Sub epithelial lesions (SELs) of the gastrointestinal (GI) tract are commonly identified during routine endoscopy. Most of these lesions are benign.
- Conditions
- Disorder of Upper Gastrointestinal Tract, Gastrointestinal Stromal Tumors, Gastrointestinal Neoplasms
- Trial name
- NCT02866045
- Testing
- EUS-guided fine needle biopsy, Single incision needle knife biopsy
- Where
- Canada
- Volunteers
- 104 people
- Sponsor
- Unity Health Toronto
Upper Gastrointestinal Cancer
The Efficacy and Safety of Accufuser Omnibus® (Elastomeric Infusion Pump); Comparative Clinical Trial
Acute post-operative pain causes not only discomfort for the patient, but delays recovery by increasing the morbidity of the circulatory system, respiratory system, and immune system, so pain control is one of the important…
- Trial name
- NCT01976494
- Testing
- The domestic PCA equipment 'Accufuser Omnibus®', Imported PCA equipment 'Infusor SV®, Baxter, USA'
- Where
- South Korea
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Upper GI Cancer, Cisplatin Adverse Reaction
Evaluation of Effects of Silymarin on Cisplatin Induced Nephrotoxicity in Upper Gastrointestinal Adenocarcinoma
Cisplatin is a potent chemotherapeutic agent that has been widely used to treat many solid tumours. acute renal failure, despite conservative fluid and electrolyte management, frequently reported adverse event and limiting…
- Trial name
- NCT01829178
- Testing
- Silymarin, chemotherapy
- Where
- Iran
- Volunteers
- 30 people
- Sponsor
- Tehran University of Medical Sciences
Surgical Resection of an Upper Gastrointestinal Malignancy, Nutritional Supplementation Via a Jejunostomy Post Discharge From Hospital
Enteral Feeding in Discharged Patients
Patients due to undergo surgery for oesophageal and gastric malignancy are often malnourished. Up to 10% of patients preoperative weight may also be lost during the early postoperative period.
- Trial name
- NCT02155140
- Testing
- Jejunal feeding
- Where
- United Kingdom
- Volunteers
- 45 people
- Sponsor
- University Hospital Plymouth NHS Trust
Pain, Neuropathic Pain
Assessments on Current Pain Managements in Upper Gastrointestinal Cancer Patients
Pain is one of the most common symptoms associated with cancer. The approach to pain management compresses routine pain assessments, utilizes both pharmacologic and nonpharmacologic interventions, and requires ongoing…
- Conditions
- Pain, Neuropathic Pain, Depression, Quality of Life
- Trial name
- NCT01718821
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- National Cheng Kung University
Patients Need Upper Gastrointestinal Endoscopy, Peptic Ulcer
Adverse Events During Upper Gastrointestinal Endoscopy
The primary objective is to investigate the adverse events during upper gastrointestinal endoscopy with and without sedation in Chinese population
- Conditions
- Patients Need Upper Gastrointestinal Endoscopy, Peptic Ulcer, Gastric Cancer, Esophagus Cancer
- Trial name
- AEDUGESSH (NCT01979549)
- Where
- 3 sites in China
- Volunteers
- 6,000 people
- Sponsor
- RenJi Hospital
Upper Gastrointestinal Tumours
A Phase II Trial Evaluating Irinotecan Plus 5FU/LV in Patients With Relapsed/Refractory Upper GI Tumours
The objective of this study is to assess the efficacy and toxicity of a 2 weekly regimen containing irinotecan combined with leucovorin-modified 5-fluorouracil in the setting of relapsed or refractory upper gastrointestinal…
- Trial name
- NCT00220064
- Testing
- Irinotecan, 5-Fluorouracil, Leucovorin
- Volunteers
- 65 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Upper Gastrointestinal Submucosal Tumors (SMTs), Gastrointestinal Stromal Tumors (GISTs)
ESTD vs. VATS for Upper Gastrointestinal Submucosal Tumors
The purpose of this study is to determine the efficacy and safety of endoscopic submucosal tunnel dissection (ESTD) compared with video-assisted thoracoscopic surgery (VATS) in the treatment of upper gastrointestinal submucosal…
- Conditions
- Upper Gastrointestinal Submucosal Tumors (SMTs), Gastrointestinal Stromal Tumors (GISTs), Leiomyoma
- Trial name
- NCT01768104
- Testing
- ESTD, VATS
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Advanced Colorectal Neoplasms, Throat Cancer
Fecal Screening Assay for Taiwanese Population
Fecal occult blood test (FOBT) is a convenient tool for the screening of asymptomatic gastrointestinal (GI) bleeding while 「guaiac-based fecal occult test (G-FOBT) 」 is increasingly replaced by the use of an 「immunochemical-based…
- Conditions
- Advanced Colorectal Neoplasms, Throat Cancer, Esophageal Cancer, Gastric Cancer
- Trial name
- NCT01341197
- Testing
- Fecal immunochemical test, guaiac fecal occult-blood test, and Helicobacter pylori stool antigen test
- Where
- Taiwan
- Volunteers
- 3,172 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Subepithelial Tumors of the Upper Gastrointestinal Tract
22-G-Procore Needle for the Diagnosis of SETs of the Upper GI Tract
The goal of this prospective study is to evaluate the feasibility of the 22-G Core Biopsy Needle with reverse bevel (Procore TM) in biopsy sampling of subepithelial tumors of the upper gastrointestinal tract.
- Trial name
- PRO-SET (NCT01726010)
- Testing
- 22-G Procore Needle
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Technical University of Munich
Disorder of Upper Gastrointestinal Tract, Pancreatic Nodule
Tissue Characterisation by Endoscopic GI-elastography
In this single centre study we study the use of endoscopic ultrasonography (EUS) combined with elastography in order to separate malignant tissue from benign tissue in and adjacent to the upper gastrointestinal tract.
- Conditions
- Disorder of Upper Gastrointestinal Tract, Pancreatic Nodule, Secondary and Unspecified Malignant Neoplasm of Retroperitoneal Lymph Nodes, Secondary Malignant Neoplasm of Lymph Node
- Trial name
- NCT01360411
- Where
- Norway
- Volunteers
- 137 people
- Sponsor
- Haukeland University Hospital