Clinical trials: Upper Gastrointestinal Symptoms
Cough, Cough Variant Asthma
MCT and Capsaicin Provocation Challenge in Diagnosis of Chronic Cough
The aim of the study is to assess the prevalence of bronchial hyperresponsiveness (BHR) in non-smoking adults with chronic cough and the prevalence of BHR in patients with upper airway cough syndrome (UACS) and gastroesophageal…
- Conditions
- Cough, Cough Variant Asthma, Upper-Airway Cough Syndrome, GERD
- Trial name
- NCT03363698
- Testing
- Cough variant asthma treatment
- Where
- Poland
- Volunteers
- 55 people
- Sponsor
- Medical University of Warsaw
Liver Diseases, Chronic Liver Disease
Superior Silybin Bioavailability in Healthy Volunteers
Twenty-four healthy volunteers of both genders, aged 18 to 44 years old and body mass indexes between 18 to 27 kg/m2,were selected to participate in a two-way, balanced, prospective, blind, single-dose crossover study with a…
- Trial name
- NCT03440164
- Testing
- Sylimarin and Sylibin
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Medica Sur Clinic & Foundation
Upper Gastrointestinal Bleeding
Hemostatic Powder Following Injection Therapy Versus Conventional Dual Therapy for Endoscopic Hemostasis for Non-variceal Upper Gastrointestinal Bleeding
Acute upper gastrointestinal hemorrhage (UGIH) is a common condition that leads to hospital admission, and has significant associated morbidity and mortality, especially in the elderly.
- Trial name
- NCT02717416
- Testing
- Endo-Clot, hemoclip or electrical coagulation
- Where
- South Korea
- Volunteers
- 226 people
- Sponsor
- Yonsei University
Gastro Intestinal Bleed
Validation of a New Score for UGI Bleeding in the ED: the Study of the TU-GIB Score
We have developed a new reliable, easy and reproducible clinical and biological score to select patients presenting to the emergency department with upper GI bleeding and at high risk of developing complications in order to plan…
- Trial name
- TU-GIBscore (NCT05646433)
- Where
- Tunisia
- Volunteers
- 500 people
- Sponsor
- Hôpital Universitaire Sahloul
Dyspepsia, Hematemesis
Efficacy Study of Articaine Lozenge to Enhance the Procedural Compliance of the Adults Undergoing Gastroduodenoscopy
The purpose of this study is to examine in prospective, double-blinded randomised manner the ability of novel articaine-containing lozenge to enhance the procedure related compliance (compared to placebo) of the adult patients…
- Conditions
- Dyspepsia, Hematemesis, Abdominal Pain, Heartburn
- Trial name
- NCT02105090
- Testing
- Anesthetics, Local, Sodium Chloride 0.9%
- Where
- Finland
- Volunteers
- 120 people
- Sponsor
- Helsinki University Central Hospital
Neurocognitive Impairment, Delirium
Neurocognitive Functioning in Patients With Newly Diagnosed Upper Aerodigestive Tract Cancer Receiving Treatment at Henry-Joyce Cancer Clinic
RATIONALE: Gathering information about how often problems with neurocognitive functioning occur in patients with newly diagnosed upper aerodigestive tract cancers may help doctors learn more about the disease.
- Conditions
- Neurocognitive Impairment, Delirium, Esophageal Cancer, Head and Neck Cancer
- Trial name
- NCT00533884
- Testing
- Assessment of therapy complications, Neurocognitive assessment, Quality-of-life assessment
- Where
- 4 sites in United States
- Volunteers
- 86 people
- Sponsor
- Vanderbilt University Medical Center
Carbon Footprint in Upper GI Endoscopy, Dyspepsia
The Difference in Carbon Footprint Between Diagnostic Upper GI Endoscopy in Dyspeptic Patients Versus Therapeutic Upper GI Bleeding
The goal of this observational study is to learn about the carbon footprint produced from diagnostic upper GI endoscopy in patients with dyspepsia and therapeutic upper GI endoscopy in patients with non-variceal upper GI…
- Conditions
- Carbon Footprint in Upper GI Endoscopy, Dyspepsia, Non-variceal Upper Gastrointestinal Bleeding
- Trial name
- NCT07261228
- Where
- 2 sites in Thailand
- Volunteers
- 75 people
- Sponsor
- King Chulalongkorn Memorial Hospital
Gastro Intestinal Bleeding
Efficacy of Tranexamic Acid in Upper Gastrointestinal Bleeding
Upper Gastrointestinal bleed is a common presentation in a medical emergency. Patients generally present with hematemesis, melena or in severe cases hematochezia.
- Trial name
- NCT04788121
- Testing
- Tranexamic acid, Standard of care
- Where
- India
- Volunteers
- 160 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Indigestion, Dyspepsia
A Prospective Multicentre Real-world Assessment of the Efficacy of Danning Tablets in Alleviating Digestive Symptoms
The goal of this observational study is to evaluate if Danning Tablets are effective in alleviating dyspepsia in patients with any of the following digestive symptoms: upper abdominal pain, bloating, loss of appetite, acid reflux…
- Conditions
- Indigestion, Dyspepsia, Bloating, Loss of Appetite
- Trial name
- NCT06755671
- Testing
- Danning Tablet
- Where
- China
- Volunteers
- 4,500 people
- Sponsor
- Shanghai Hutchison Pharmaceuticals Limited
Cancer, Rectum
Converted Laparoscopic Resection of Upper Rectal Carcinoma T1-4 N0-1 in Obese Patients.
Background: laparoscopic resection (LAR) is a safe approach and widely used for rectal cancer after neoadjuvant chemo-radiotherapy, but short term and oncological outcome for converted cases to open surgery (cLAR), may be…
- Trial name
- NCT04401787
- Testing
- Anterior resection for upper rectal cancer in obese
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Gastrointestinal Hemorrhage
Effect of Tranexamic Acid in Upper Gastrointestinal Bleeding
The investigators hypothesize that addition of Tranexamic acid, an antifibrinolytic agent, to conventional therapy will lead to an improved outcome characterized by lower transfusion requirements.
- Trial name
- NCT01005147
- Testing
- tranexamic acid
- Sponsor
- University of Oklahoma
Cystic Fibrosis (CF)
Exercises' Effect on Muscle Strength, Aerobic Capacity and Respiratory Functions in Cystic Fibrosis
This research aims to evaluate the effects of upper and lower limb exercises on muscle strength and pulmonary function in children diagnosed with CF.
- Trial name
- NCT07508904
- Testing
- Arm Cycle Ergometry, Leg Cycle Ergometry
- Where
- Pakistan
- Volunteers
- 22 people
- Sponsor
- Riphah International University
Gastroparesis
The Use Of Domperidone For The Relief Of Refractory Upper Gastrointestinal GI Symptoms
To prescribe oral domperidone for patients with upper GI symptoms who have failed or suffered adverse effects from standard medical therapy.
- Trial name
- NCT03810287
- Testing
- Domperidone
- Where
- United States
- Sponsor
- Yale University
Gastrointestinal Disease, Signs and Symptoms, Digestive
Nexium Dyspepsia/AST
The aim is to evaluate if the resolution of upper abdominal symptoms (pain or burning) during an acid suppressive test trial of esomprazole given daily for 7 days predicts symptoms resolution at the end of a subsequent treatment…
- Conditions
- Gastrointestinal Disease, Signs and Symptoms, Digestive, Dyspepsia
- Trial name
- NCT00251914
- Testing
- Esomeprazole
- Where
- 215 sites in Argentina, Belgium and 15 more
- Volunteers
- 1,500 people
- Sponsor
- AstraZeneca
Brain Stem Infarctions, Dysphagia, Oropharyngeal
Effect of Botulinum Toxin Injection Into Upper Esophageal Sphincter in Patients With Medullary Infarction
Dysphagia is an important complication in patients with medullary infarction, the incidence rate is 57%-69%. Compared with other brain infarctions, the medulla oblongata involves multiple swallowing-related nerve nuclei, and the…
- Conditions
- Brain Stem Infarctions, Dysphagia, Oropharyngeal, Dysphagia, Esophageal
- Trial name
- NCT06196606
- Testing
- Botulinum toxin type A for injection
- Where
- China
- Volunteers
- 20 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Bleeding Peptic Ulcer, Active Bleeding
Urgent vs. Early Endoscopy in High Risk Patients With Upper Gastrointestinal Bleeding (UGIB)
Acute upper gastrointestinal bleeding (UGIB) is one of the commonest medical emergencies. The condition accounts for 150 per 100,000 populations. A National United Kingdom reported a crude overall mortality rate of 10%.
- Conditions
- Bleeding Peptic Ulcer, Active Bleeding, Gastrointestinal Bleeding
- Trial name
- NCT01675856
- Testing
- Urgent endoscopy, Early endoscopy
- Where
- China
- Volunteers
- 516 people
- Sponsor
- Chinese University of Hong Kong
Gastrointestinal Fistula, Enteral Nutritional Support
Enteral Versus Parenteral Nutrition in the Conservative Treatment of Upper Gastrointestinal Fistula After Surgery
The incidence of clinically significant anastomotic leaks (AL) after upper gastrointestinal (GI) surgery is approximately 4 % - 20 %, and the associated mortality can be as high as 80 % .
- Trial name
- NUTRILEAK (NCT03742752)
- Testing
- Enteral nutrition, Parenteral nutrition
- Where
- France
- Volunteers
- 6 people
- Sponsor
- University Hospital, Lille
Intestinal Malrotation
Prenatal Ultrasound Screening of Intestinal Malrotation With a Higher Risk of Volvulus
The aim of this study was to assess the value of an unusual relative position of the superior mesenteric artery (SMA) and vein (SMV) to screen intestinal malrotation with a higher risk of volvulus.
- Trial name
- VOLMES (NCT03356314)
- Testing
- MRI between 30-35 GA, Pediatric surgeon meeting, Postnatal abdominal ultrasound, barium enema and upper gastrointestinal
- Where
- France
- Volunteers
- 9,000 people
- Sponsor
- University Hospital, Montpellier
Upper Gastrointestinal Bleeding
Detection of Upper Gastrointestinal (GI) Bleeding Using a Novel Bleeding Sensor Capsule -A Pilot Study
This is a multi-center, prospective, non-randomized, open-label, exploratory clinical investigation performed to evaluate safety and effectiveness of the PillSense System when used for detection of blood in the stomach of…
- Trial name
- NCT05631639
- Testing
- PillSense System
- Where
- 3 sites in Czechia
- Volunteers
- 30 people
- Sponsor
- EnteraSense Limited
Gastro Intestinal Bleeding, Upper Gastrointestinal Bleeding
Metoclopramide, Azithromycin, or Nondrug Pretreatment for UGIB to Reduce Second Endoscopy
Early endoscopy is an integral part of the management plan for patients presenting with clinical signs of severe or ongoing UGIB.
- Trial name
- MANPURSE (NCT03840057)
- Testing
- Azithromycin Injection, Metoclopramide Injectable Solution, Sodium chloride 0.9%
- Where
- United States
- Volunteers
- 435 people
- Sponsor
- Waihong Chung