Clinical trials: Upper Gastrointestinal Tumours
Colorectal Cancer, BRAF V600E Mutation Positive
Encorafenib Plus Cetuximab in a Neoadjuvant Setting in Patients With BRAF Mutation Localised Colon or Upper Rectum Cancer
This is a pilot trial which aims to assess the concept of anti-BRAF neoadjuvant treatment (encorafenib) in combination with cetuximab in patients with colon cancer or rT3/T4 supra-peritoneal upper rectal cancer based on a…
- Trial name
- NEORAF (NCT05706779)
- Testing
- Encorafenib Oral Capsule + Cetuximab
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Federation Francophone de Cancerologie Digestive
Improve the Screening Criteria of Chinese Hereditary Upper Gastrointestinal Tumors
Screening of Hereditary Upper Gastrointestinal Cancer in China
Through exploring the specific genetic mutations in the upper gastrointestinal tract tumors with a family history and specific clinical pathological types，we establish a complete family and follow-up system，in order to improve…
- Trial name
- NCT03130621
- Testing
- Gene detection
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Peking University
Barrett Esophagus, Esophageal Dysplasia
trūFreeze® Spray Cryotherapy Patient Registry
To collect efficacy and outcomes data related to the use of trūFreeze® spray cryotherapy for the treatment of unwanted tissue in the pulmonary and gastrointestinal settings.
- Conditions
- Barrett Esophagus, Esophageal Dysplasia, Esophageal Neoplasm, Esophageal Stenosis
- Trial name
- NCT01802203
- Testing
- truFreeze Spray Cryotherapy
- Where
- 16 sites in United States
- Volunteers
- 275 people
- Sponsor
- US Endoscopy Group Inc.
Colorectal Neoplasm
Safety and Efficacy of Reduced-port Laparoscopic Surgery for Patients Of Colon and Upper Rectal Cancer
Colorectal cancer is the third most common malignant tumor. Radical resection is the mainstay of treatments for non-metastatic colorectal cancer.
- Trial name
- NCT05953662
- Testing
- Reduced-port laparoscopic surgery, conventional laparoscopic surgery
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Upper Gastrointestinal Bleeding
Evaluation of Prognostic Scores in Patients With Upper Gastrointestinal Bleeding and Cancer
This is a prospective and observational study to evaluate oncologic patients that presented upper gastrointestinal bleeding with the use of some prognostic scores.
- Trial name
- NCT02508883
- Where
- Brazil
- Volunteers
- 243 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Gastric Cancer
A Trial to Evaluate the Superior Mesenteric Vein (14V) Lymphadenectomy for Distal Advanced Gastric Cancer
This trial is going to evaluate the advantage of D2 radical gastrectomy plus 14v lymph node dissection in 3-year survival rates of advanced gastric cancers.
- Trial name
- NCT02272894
- Testing
- Dissection of the Superior Mesenteric Vein Lymph Node
- Where
- China
- Volunteers
- 510 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Upper Aerodigestive Tract Neoplasms
Evaluation of Low-Level Laser Therapy Efficacy in Pain Management of Grade 2 Oral Mucositis Induced by Radiotherapy or Chemoradiotherapy: a Study in Patients With Upper Aerodigestive Tract Cancer
Prospective, monocentric, randomized phase II study evaluating Low-Level Laser Therapy (LLLT) as a treatment for the pain due to grade 2 oral mucositis in patients with upper aero-digestive tract cancer treated by radiotherapy or…
- Trial name
- ESMULLLAT (NCT03955224)
- Testing
- Basic Oral Care + active LLLT, Basic oral Care + inactive LLLT, Basic Oral Care
- Where
- France
- Sponsor
- Institut Claudius Regaud
Stomach Neoplasms
Study on Laparoscopic Spleen-Preserving No. 10 Lymph Node Dissection for Advanced Middle or Upper Third Gastric Cancer
The purpose of this study is to explore the short-term, long-term and oncological outcomes of laparoscopic spleen-preserving No.
- Trial name
- LSPLN (NCT02333721)
- Testing
- D2 lymphadenectomy including No. 10, D2 lymphadenectomy excluding No. 10
- Where
- China
- Volunteers
- 536 people
- Sponsor
- Fujian Medical University
Cancer, Hepatic, Cancer, Esophagus
Expectation, Pain Outcomes, and Pain Medication Following Oncology Abdominal Surgery: A Cohort Study
This study includes participants undergoing major hepatic surgery, surgery in the esophagus or stomach, or major surgery on the pancreas performed at Copenhagen University Hospital, Rigshospitalet.
- Conditions
- Cancer, Hepatic, Cancer, Esophagus, Cancer, Pancreas
- Trial name
- NCT07176052
- Testing
- cancer surgery
- Volunteers
- 200 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Colorectal Cancer (Diagnosis), Laparoscopic Surgery
Superior HypogastrIc plExus bLock During Laparoscopic Colorectal Cancer Surgery
This trial seeks to assess the efficacy of a superior hypogastric plexus block for early quality of recovery after laparoscopic colorectal cancer surgery.
- Conditions
- Colorectal Cancer (Diagnosis), Laparoscopic Surgery, Superior Hypogastric Plexus Block
- Trial name
- SHIELDS (NCT07579780)
- Testing
- Superior hypogastric plexus block
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Cancer Screening, Lung Cancer
Precision Navigation to Improve Community Cancer Screening Participation
This study will evaluate whether a precision navigation intervention can help community residents at high risk for cancer complete recommended cancer screening.
- Conditions
- Cancer Screening, Lung Cancer, Breast Cancer, Colorectal Cancer
- Trial name
- NCT07676383
- Testing
- Precision Navigation Intervention, Usual Health Education
- Where
- 3 sites in China
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Hunan Cancer Hospital
Gastric Cancer
Comparison of Laparoscopic Proximal Gastrectomy and Laparoscopic Total Gastrectomy
Experimental: Laparoscopic proximal gastrectomy Laparoscopy proximal gastrectomy with esophago-jejunostomy, gastro-jejunostomy and jejuno-jejunostomy (double tract reconstruction).
- Trial name
- NCT02892643
- Testing
- Laparoscopic proximal gastrectomy, Laparoscopic total gastrectomy
- Where
- 16 sites in South Korea
- Volunteers
- 138 people
- Sponsor
- Seoul National University Bundang Hospital
Peptic Ulcer, Gastric Cancer
WEI NASAL JET for The Sedation of Outpatient Upper Gastrointestinal Endoscopy
Low pulse oximetry is the most common adverse events during sedation for upper gastrointestinal endoscopy. The main reason is the glossoptosis after sedation.
- Conditions
- Peptic Ulcer, Gastric Cancer, Esophagus Cancer, Oesophagitis
- Trial name
- NCT02436018
- Testing
- WEI NASAL JET, Nasopharyngeal airway without jet ventilator
- Where
- 3 sites in China
- Volunteers
- 1,800 people
- Sponsor
- RenJi Hospital
Esophageal Cancer
Esophagectomy in Middle and Lower Thoracic Esophageal Cancer Patients Through Left Versus Right Transthoracic Approach
Esophageal carcinoma is an aggressive malignant disease with poor prognosis. Surgical resection remains the most effective method for this malignancy.
- Trial name
- NCT02448979
- Testing
- Left thoracotomy, Right thoracotomy
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Chinese Academy of Medical Sciences
Obesity, Obesity, Morbid
Luso-Cor Stent Compared to Other Endoscopic Techniques for Management of Fistulas and Anastomotic Dehiscences(ES-LCCE-UDFM)
The global prevalence of obesity has prompted an increase in bariatric surgery, which is the only management strategy that provides long-term weight loss and improvement of obesity-related diseases.
- Conditions
- Obesity, Obesity, Morbid, Esophageal Cancer, Esophageal Neoplasms
- Trial name
- ES-LCCE-UDFM (NCT06862479)
- Testing
- Endoscopic management of fistulas with stents or vacum therapy
- Where
- Portugal
- Volunteers
- 180 people
- Sponsor
- Unidade Local de Saúde Santa Maria
Cirrhosis
Study of Two Fasting Procedures Before Gastroscopy: 6 Hours Versus 2 Hours for Clear Fluids
Upper gastrointestinal endoscopy is the key examination for screening for precancerous and cancerous lesions of the esophagus and stomach.
- Trial name
- GASTROPREP (NCT03706846)
- Testing
- fasting
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Adenocarcinoma of the Gastroesophageal Junction, Cervical Cancer
Study of Physical and Psychosocial Rehabilitation Needs of Patients After Diagnosis and Treatment of Upper Gastrointestinal Cancer or Gynecological Cancer
RATIONALE: Gathering information from patients who have undergone treatment for upper gastrointestinal cancer or gynecological cancer may help doctors learn more about patients' physical and psychosocial rehabilitation needs and…
- Conditions
- Adenocarcinoma of the Gastroesophageal Junction, Cervical Cancer, Endometrial Cancer, Esophageal Cancer
- Trial name
- NCT01216813
- Testing
- informational intervention, assessment of therapy complications, psychosocial assessment and care
- Where
- United Kingdom
- Volunteers
- 33 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Esophageal Cancer, Gastric Cancer
Irinotecan and Paclitaxel in Treating Patients With Metastatic or Recurrent Cancer of the Esophagus or Stomach
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00020761
- Testing
- irinotecan hydrochloride, paclitaxel
- Where
- 4 sites in United States
- Volunteers
- 51 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Upper Gastrointestinal Cancer
Real-World Use of Nivolumab for the Treatment of Patients With Metastatic Upper Gastrointestinal Cancer in Canada
The purpose of this observational study is to describe the demographics, and disease characteristics of participants with metastatic upper gastrointestinal cancer, along with the treatment characteristics of these patients when…
- Trial name
- NCT06361576
- Testing
- Nivolumab
- Where
- Canada
- Volunteers
- 700 people
- Sponsor
- Bristol-Myers Squibb
Upper Gastrointestinal Cancer Patients Upon Admission, Nutritional Status
Nutritional Status Among Upper Gastrointestinal Cancer Patients Upon Admission
Cross-sectional study. Data on clinical, anthropometric, biochemical profile and dietary intake Upper Gastrointestinal Cancer Patients upon admission are traced and collected.
- Trial name
- RSCH ID-22-012 (NCT05867810)
- Where
- Malaysia
- Volunteers
- 409 people
- Sponsor
- Universiti Putra Malaysia