Clinical trials: Upper Gastrointestinal Tumours
Cancer, Digestive System, Cancer, Rectum
PREHAB - Improving Condition Before Surgery
The pilot research project is focused on the feasibility of a prehabilitation program for two groups of diagnoses (esophageal and stomach cancer, rectal cancer).
- Trial name
- NCT05646043
- Testing
- Physical training, Muscle strength training
- Where
- Czechia
- Volunteers
- 40 people
- Sponsor
- University Hospital Ostrava
Upper Gastrointestinal Disorders, Lower Gastrointestinal Disorders
Sarcopenia and Physiology Assessments in Cancer Patients
Primary Aim: To establish a reliable relationship between oxygen uptake (VO2) at estimated lactate threshold (AT) and CT-derived body composition measurments (e.g.
- Conditions
- Upper Gastrointestinal Disorders, Lower Gastrointestinal Disorders, Hepatobiliary Cancer
- Trial name
- NCT03641118
- Testing
- Cardiopulmonary exercise test
- Where
- United Kingdom
- Volunteers
- 639 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Gastric Cancer, Pancreatic Cancer
The Impact of Immunostimulating Nutrition on the Outcome of Surgery
The aim of the study was to assess the clinical effect of immunostimulatory enteral and parenteral nutrition in patients undergoing resection for gastrointestinal cancer.
- Trial name
- NCT00558155
- Testing
- peptisorb, Stresson, Parenteral nutrition
- Where
- Poland
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- Jagiellonian University
Effects of Chemotherapy, Cancer
The Effect of Chemotherapy on Lactate Threshold in Cancer Patients
It is important to assess patients' fitness for major cancer surgery which carries a high risk of mortality. Patients with poor heart and lung function have a higher risk of death after major cancer surgery.
- Trial name
- NCT01335555
- Where
- United Kingdom
- Volunteers
- 89 people
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Common Bile Duct Calculi, Biliary Tract Cancer
Multibending vs Conventional Endoscope for Direct Peroral Cholangioscopy
The aim of this study is to evaluate the usefulness of a newly developed multibending ultra-slim upper endoscope for the successful direct peroral cholangioscopy (POC) without assisting accessory in comparison with conventional…
- Conditions
- Common Bile Duct Calculi, Biliary Tract Cancer, Biliary Stricture, Bile Duct Diseases
- Trial name
- NCT02189421
- Testing
- ultra-slim upper endoscope
- Where
- South Korea
- Volunteers
- 110 people
- Sponsor
- Soonchunhyang University Hospital
Gastrointestinal Neoplasms, Mesenteric Traction Syndrome
Mesenteric Traction Syndrome During Upper Gastrointestinal Surgery
It is the hypothesis of this project that the Mesenteric Traction Syndrome (MTS) is a common event during upper gastrointestinal cancer surgery (UGC surgery) and that the induction of the syndrome is an important factor in…
- Trial name
- NCT02507414
- Testing
- Blood samples, Measurement of microcirculation, Head down tilt
- Volunteers
- 75 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Breast Carcinoma, Cholangiocarcinoma
Nutritional Preferences and Product Accessibility in Oral Nutritional Supplements in Participants With Breast, Colorectal, Upper Gastrointestinal, or Prostate Cancer
This trial studies nutritional preferences and product accessibility in oral nutritional supplements in participants with breast, colorectal, upper gastrointestinal, or prostate cancer.
- Conditions
- Breast Carcinoma, Cholangiocarcinoma, Colorectal Carcinoma, Gastric Carcinoma
- Trial name
- NCT03563352
- Testing
- Interview, Survey Administration
- Where
- United States
- Sponsor
- University of Southern California
Rectal Cancer
Comparing of Different Biomarkers From Vena Rectalis Superior and Vena Cubiti in Patients Undergoing Low Anterior Resection for Rectum Cancer
The primary aim of the present study is to investigate different biomarkers like VEGF, EVGF and others ability to predict time to recidive and progressions free survival.
- Trial name
- NCT01706809
- Testing
- blood sampels from vena rectalis superior and vena cubiti
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Odense University Hospital
Gastric Cancer
Articulated Laparoscopic Instruments Clinical Study
Recently, with the development of minimally invasive surgery and the development of instruments, laparoscopic and robotic surgery are increasing, and laparoscopic and robotic surgery are evolving.
- Trial name
- NCT05550974
- Testing
- Minimally Invasive Surgery
- Where
- South Korea
- Volunteers
- 1,155 people
- Sponsor
- Yonsei University
TAS 102, Regorafenib
TAS-102 in Combination With Regorafenib or Fruquintinib for Third-line and Above Advanced Colorectal Cancer
This is a single-arm, multicentre real-world observational study of TAS-102 in combination with regorafenib or fruquintinib for third-line and above advanced colorectal cancer.
- Conditions
- TAS 102, Regorafenib, Fruquintinib, Gastrointestinal Tumours
- Trial name
- NCT05993702
- Testing
- regorafenib, fruquintinib
- Volunteers
- 45 people
- Sponsor
- China Medical University, China
Hepatoma, Pancreas Cancer
Opioid Sparing Effect of Thoracic Epidural Analgesia for Open Upper Abdominal Surgery
This prospective randomized controlled study is aimed to determine the advantages of thoracic epidural analgesia for open upper abdominal surgery in combination with multimodal analgesia compared with no thoracic epidural…
- Trial name
- NCT04920019
- Testing
- Thoracic continuous epidural analgesia
- Where
- Thailand
- Volunteers
- 140 people
- Sponsor
- Mahidol University
Gastrointestinal Hemorrhage, Gastrointestinal Neoplasms
Hemostatic Powder Versus Clinical Management for the Treatment of Upper Gastrointestinal Bleeding From Tumor Lesions
This study evaluates the efficacy of the endoscopic hemostatic powder for the treatment of bleeding from malignant lesions of the upper GI tract.
- Trial name
- NCT02820077
- Testing
- Hemospray (Endoscopic treatment with hemostatic powder)
- Volunteers
- 62 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Cancer of Stomach, Oesophageal Cancer
The Australia and New Zealand Multicentre Upper Gastrointestinal Endoscopic Tissue Resection Study
To determine the long term outcomes of Endoscopic Submucosal Dissection (ESD), Endoscopic Full Thickness Resection (EFTR) and Submucosal-Tunnelling Endoscopic Resection (STER) for upper gastrointestinal neoplastic lesions
- Conditions
- Cancer of Stomach, Oesophageal Cancer, Gastric Cancer, Gastric Adenocarcinoma
- Trial name
- ANZ UGI (NCT05804331)
- Where
- Australia
- Volunteers
- 500 people
- Sponsor
- Western Sydney Local Health District
Immunotherapy, Colorectal Cancer
TAS-102 Combined With Bevacizumab and Tislelizumab Third-line or Above in the Treatment of Liver Metastasis in Colorectal Cancer
To evaluate the clinical efficacy and safety of TAS-102 combined with bevacizumab and tislelizumab in third-line or above treatment in patients with advanced colorectal adenocarcinoma with liver metastasis.
- Trial name
- NCT05314101
- Testing
- Tislelizumab, bevacizumab, TAS-102
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Fujian Cancer Hospital
Colon Cancer Stage I, Colon Cancer Stage II
Comparison Between Results of 2 Laparoscopic Surgical Procedures in Operable Colon Cancer Cases in Upper Egypt
The investigators will assess and compare Surgical, pathological and oncological outcomes between two laparoscopic procedures conventional colectomy versus complete mesocolic excision for operable colon cancer cases in Upper Egypt
- Trial name
- NCT05421702
- Testing
- laparoscopic conventional colectomy, laparoscopic complete mesocolic excision
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Sohag University
Subepithelial Tumors of the Upper Gastrointestinal Tract
Role of Doppler Endoscopic Probe in the Diagnosis of Subepithelial Gastrointestinal Lesions.
RESEARCH PLAN I-TITLE Role of Doppler endoscopic probe in the diagnosis of subepithelial gastrointestinal lesions. II-BACKGROUND Subepithelial lesions (SEL) are commonly encountered during routine endoscopies with an estimated…
- Trial name
- DopplerSEL (NCT05983406)
- Testing
- Doppler investigation
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Francisco Baldaque-Silva
Pancreatic Ductal Adenocarcinoma, Esophageal Cancer
POP-UP: a Single-arm, Two-cohort Study: an 8-week Trimodal Pre-habilitation Program for Patients With Pancreatic Ductal Adenocarcinoma and Oesogastric
This is a prospective, multicenter, two-cohort, open-label, single-arm feasibility study of a trimodal (nutritional, psychological, and personalized Adapted Physical Activity (APA)-individualized interventions) 8-week…
- Trial name
- POP-UP (NCT06275737)
- Testing
- Prehabilitation program
- Where
- 11 sites in France
- Volunteers
- 72 people
- Sponsor
- GERCOR - Multidisciplinary Oncology Cooperative Group
Gastrointestinal Tract Malignancies
A Safety and Efficacy Study of Treatment Combinations With and Without Chemotherapy in Adult Participants With Advanced Upper Gastrointestinal Tract Malignancies
The purpose of this study is to evaluate the safety and preliminary clinical activity of treatment combinations with and without chemotherapy in participants with locally advanced unresectable or metastatic gastric, GEJ, and…
- Trial name
- EDGE-Gastric (NCT05329766)
- Testing
- Domvanalimab, Quemliclustat, Zimberelimab
- Where
- 43 sites in United States, Canada and 4 more
- Volunteers
- 332 people
- Sponsor
- Arcus Biosciences, Inc.
Cholangiocarcinoma Non-resectable, Gall Bladder Cancer
Primary Percutaneous Stenting Above the Ampulla Versus Endoscopic Drainage for Unresectable Malignant Hilar Biliary Obstruction
The goal of this clinical randomized controlled trial is to perform primary percutaneous stenting (PPS) in patients with malignant hilar biliary obstruction (MHBO).
- Conditions
- Cholangiocarcinoma Non-resectable, Gall Bladder Cancer, Liver Metastasis, Malignant Hilar Stricture
- Trial name
- TESLA RCT (NCT06671418)
- Testing
- Primary percutaneous stenting (PPS), Endoscopic biliary drainage
- Where
- Netherlands
- Volunteers
- 148 people
- Sponsor
- Erasmus Medical Center
Esophageal Cancer, Gastric Cancer
Evaluation of the Preventive Effect of Chlorhexidine Acetate Gargle for Upper Gastrointestinal Tract Infection After ESD
Backgrounds： With the continuous improvement of sterilization and endoscopic structure, the infection caused by endoscopy has gradually declined.With the rapid development of digestive endoscopic therapy in the past decade…
- Trial name
- NCT03492827
- Testing
- chlorhexidine acetate gargle
- Where
- China
- Volunteers
- 306 people
- Sponsor
- Peking University Third Hospital