Clinical trials: Upper Limb Dysfunction
Stroke, Transcranial Magnetic Stimulation
Effects of Individualized Accurate Positioning TMS Based on Task fMRI Activation on Upper Extremity Function After Stroke
Stroke is a global health problem and a leading cause of disability. Limitation of upper limb function occurs in 55 -75% of patients after stroke.
- Conditions
- Stroke, Transcranial Magnetic Stimulation, Functional Magnetic Resonance Imaging, Upper Extremity Dysfunction
- Trial name
- NCT05440292
- Testing
- Transcranial magnetic stimulation
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Parkinson Disease
Effects of Telerehabilitation Versus Clinic-based Task-oriented Circuit Training in Parkinson's Patients
This randomized clinical trial aims to determine effects of Telerehabilitation versus clinic-based task-oriented circuit training on upper extremity functions and quality of life in Parkinson's patient.
- Trial name
- NCT06111924
- Testing
- Task oriented circuit training based telerehabilitation, Clinic based Task oriented circuit training
- Where
- Pakistan
- Volunteers
- 34 people
- Sponsor
- Riphah International University
Ovarian Cancer, Breast Cancer
A Phase II Single Arm Pilot Study of the Chk1/2 Inhibitor (LY2606368) in BRCA1/2 Mutation Associated Breast or Ovarian Cancer, Triple Negative Breast Cancer, High Grade Serous Ovarian Cancer, and Metastatic Castrate-Resistant Prostate Cancer
Background: All cells go through cycles which allow them to divide. In normal cells, checkpoint kinase 1 (Chk1) and checkpoint kinase 2 (Chk2) (CHEK 2 (Chk1/2) stop cell division at various points to allow any damage to…
- Conditions
- Ovarian Cancer, Breast Cancer, Prostate Cancer
- Trial name
- NCT02203513
- Testing
- LY2606368
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- National Cancer Institute (NCI)
Upper Extremity Dysfunction, Gait, Unsteady
The Effect of Improvement in Function on Foot Pressure, Balance and Gait in Children With Upper Extremity Affected
It has been shown that movements of the upper extremity during walking are associated with lower extremity mobility. For example, when walking at a slow pace, the swing frequency of the arms is 2: 1 compared to the legs, while…
- Conditions
- Upper Extremity Dysfunction, Gait, Unsteady, Juvenile Idiopathic Arthritis, Balance
- Trial name
- NCT04671524
- Testing
- Exercise protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Intraoperative Arterial Blood Pressure Monitoring, Arterial Catheter Dysfunction
Distal Versus Conventional Radial Arterial Catheterization for Arterial Waveform Stability
During robot-assisted urologic surgery, both arms are often placed alongside the body and covered by surgical drapes. This position can make the arterial catheter difficult to access during surgery.
- Conditions
- Intraoperative Arterial Blood Pressure Monitoring, Arterial Catheter Dysfunction, Robotic Urologic Surgery
- Trial name
- DRA-stability (NCT07732296)
- Testing
- Conventional Radial Arterial Catheterization, Distal Radial Arterial Catheterization
- Volunteers
- 70 people
- Sponsor
- Seoul National University Hospital
Stroke, Upper Extremity Parasis
Transcranial Magnetic Stimulation Synchronized with Motor Task Training for Post-Stroke Rehabilitation
The goal of this clinical trials is to investigate the effectiveness of individualized online repetitive transcranial magnetic stimulation (rTMS) in enhancing upper limb motor rehabilitation during the subacute and chronic phase…
- Trial name
- TMS (NCT06849505)
- Testing
- online rTMS, offline rTMS
- Where
- China
- Volunteers
- 15 people
- Sponsor
- First Affiliated Hospital of the Chinese People's Liberation Army Naval Medical University
COPD, Upper Extremity
Cognitive Impairment and Upper Extremity Performance in COPD
Within the scope of this study, COPD patients will be divided into two groups according to cognitive dysfunction. Pulmonary function test, COPD assessment scale, Mini-Mental State Examination and Montreal Cognitive Assessment…
- Conditions
- COPD, Upper Extremity, Upper Limb Function, Cognitive Impairment
- Trial name
- COPD (NCT05137483)
- Testing
- Functional tests
- Volunteers
- 80 people
- Sponsor
- Izmir Katip Celebi University
Breast Cancer, Exercise
Virtual Reality-based Exercise Training in Radiotherapy Period After Breast Cancer Surgery
The main purpose of this study is to compare two different exercise approaches during the radiotherapy period in patients who have undergone breast cancer surgery.
- Conditions
- Breast Cancer, Exercise, Upper Extremity Dysfunction
- Trial name
- NCT04618120
- Testing
- Virtual reality-based exercise, Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Gazi University
Chronic Granulomatous Disease (CGD)
Open-label Gene Therapy Study in p47-CGD
Chronic granulomatous disease (CGD) caused by p47phox deficiency (p47-CGD) is a life-threatening genetic disorder causing nicotinamide adenine dinucleotide phosphate (NADPH) oxidase deficiency in phagocytes.
- Trial name
- NCT07826767
- Testing
- SGX-001
- Where
- 3 sites in Germany, Spain and 1 more
- Volunteers
- 5 people
- Sponsor
- Somagenetix AG
Ataxia Telangiectasia
Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With Nicotinamide Riboside
Study design: Single arm open-label clinical trial in ataxia-telangiectasia to test the effects of nicotinamide riboside on ataxia scales, immune function, and neurofilament light chain.
- Trial name
- ATNAD (NCT06324877)
- Testing
- Nicotinamide riboside
- Where
- Australia
- Volunteers
- 10 people
- Sponsor
- The University of Queensland
Breast Cancer
Comparison Of VR & CPT, With And Without Lifestyle Modification, On ULD In Breast Cancer Survivors
The proposed study will compare the effect of an application of non-immersive virtual reality (VR) and conventional physical therapy (CPT) with and without lifestyle changes on upper limb dysfunction in breast cancer survivors…
- Trial name
- NCT07068347
- Testing
- VR + lifestyle modification, VR only, Conventional physical therapy + lifestyle modification
- Where
- 3 sites in Pakistan
- Volunteers
- 60 people
- Sponsor
- Superior University
Pulmonary Hypertension, Pulmonary Arterial Hypertension
Subcutaneous Treprostinil as a Bridge to Lung Transplantation in Severe Pulmonary Hypertension: A Single-Arm Retrospective Study
This single-arm, retrospective study aims to evaluate the safety and efficacy of subcutaneous treprostinil as a bridge therapy for lung transplantation in patients with severe pulmonary hypertension (PH).
- Conditions
- Pulmonary Hypertension, Pulmonary Arterial Hypertension, Chronic Lung Disease-Associated Pulmonary Hypertension, Lung Transplantation
- Trial name
- NCT06605326
- Testing
- Subcutaneous Treprostinil
- Volunteers
- 46 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Myocardial Infarction
Efficacy and Safety of OPL-0301 Compared to Placebo in Adults With Post-Myocardial Infarction (MI)
Study OPL-0301-201 is intended to generate efficacy and safety data of OPL-0301 in participants with post-myocardial infarction (MI) left ventricular dysfunction (LVD)
- Trial name
- RESTORE (NCT05327855)
- Testing
- OPL-0301 Dose 1, OPL-0301 Dose 2
- Sponsor
- Valo Health, Inc.
Erectile Dysfunction
Assess the Effect of Daily Treatment of Vardenafil 20mg or Sildenafil 100mg and Placebo on Sperm Function
Assess the effect of daily treatment of vardenafil 20mg or sildenafil 100mg and placebo on sperm function
- Trial name
- NCT00655590
- Testing
- Levitra (Vardenafil, BAY38-9456), Sildenafil
- Where
- 18 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Bayer
Central Venous Catheter Thrombosis, Central Venous Catheter Related Bloodstream Infection
CLiCK in the Critical Care Unit
Insertion of a central venous access device (CVAD) allows clinicians to easily access the circulation of a patient to administer life-saving interventions.
- Conditions
- Central Venous Catheter Thrombosis, Central Venous Catheter Related Bloodstream Infection, Catheter Complications, Catheter Blockage
- Trial name
- CLiCK (NCT04548713)
- Testing
- 4% EDTA, Saline
- Where
- 6 sites in Canada
- Volunteers
- 1,449 people
- Sponsor
- Fraser Health
Cerebral Palsy, Sensation Disorders
Upper Extremity Sensation and Function in Children With Cerebral Palsy
This cross-sectional study was designed to evaluate upper extremity sensation in children with spastic cerebral palsy and to investigate its effect on upper extremity use in activities of daily living.
- Conditions
- Cerebral Palsy, Sensation Disorders, Upper Extremity Dysfunction
- Trial name
- NCT07352735
- Testing
- Vibration Sense Assessment, Stereognosis, Tactile Sense
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Stroke, Rehabilitation; Tobacco Use
Quantitative Prognostic Analysis of Upper Limb Motor Dysfunction After Stroke
30% - 66% of stroke survivors have upper limb dysfunction. Effective rehabilitation can improve the prognosis, but the rehabilitation resources are limited.
- Conditions
- Stroke, Rehabilitation; Tobacco Use, Upper Extremity Dysfunction, Prognosis
- Trial name
- NCT05410054
- Testing
- no intervention
- Volunteers
- 178 people
- Sponsor
- Fu Xing Hospital, Capital Medical University
Stroke, Incomplete Spinal Cord Injury (SCI)
ZEPU-2000 Limb Rehabilitation Trainer Study (ZEPU2000RCT)
The goal of this clinical trial is to learn whether the ZEPU-2000A, ZEPU-2000D and ZEPU-2000E robotic rehabilitation trainers help people with weakness or movement problems in their arms and legs.
- Conditions
- Stroke, Incomplete Spinal Cord Injury (SCI), Traumatic Brain Injury, Upper Extremity Motor Dysfunction
- Trial name
- NCT07749612
- Testing
- ZEPU-2000A, ZEPU-2000D, ZEPU-2000E
- Where
- Bangladesh
- Volunteers
- 36 people
- Sponsor
- Bangladesh Medical University
Cystometry, Sacral Neuromodulation
Efficacy of Sacral Nerve Modulation on Urinary and Defecation Dysfunction After Spinal Cord Injury：A Prospective, Single-arm Study
The aim of this study is to investigate the long-term efficacy of sacral nerve modulation surgery in the treatment of neurogenic lower urinary tract dysfunction caused by incomplete spinal cord injury, as well as its preventive…
- Conditions
- Cystometry, Sacral Neuromodulation, Ultrasound
- Trial name
- NCT06553469
- Testing
- sacral neuromodulation
- Where
- China
- Volunteers
- 41 people
- Sponsor
- Qilu Hospital of Shandong University
Breast Cancer (Early Breast Cancer), Postoperative Shoulder Dysfunction
Prehabilitation in Breast Cancer Surgery
This prospective, randomized, assessor-blinded, parallel-group clinical trial evaluates the effectiveness of a home-based upper extremity-focused prehabilitation program in women undergoing breast cancer surgery.
- Conditions
- Breast Cancer (Early Breast Cancer), Postoperative Shoulder Dysfunction, Lymphedema Arm, Cancer Rehabilitation
- Trial name
- NCT07425379
- Testing
- Home-Based Prehabilitation Exercise Program, Usual Care
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital