Clinical trials: Upper Limb Surgery
Lymphedema, Lymphedema Arm
The Robot-LVA Study: Robot-assisted Microsurgical Lymphaticovenous Anastomosis in Breast Cancer-related Lymphedema
This study assesses the performance of robot-assisted microsurgery. Lymphaticovenous anastomosis (LVA) is the most difficult procedure in microsurgery at this moment.
- Conditions
- Lymphedema, Lymphedema Arm, Lymphedema of Upper Arm, Lymphedema of Upper Limb
- Trial name
- NCT06532955
- Testing
- Lymphaticovenous anastomosis using Microsure Motion Stabilizer, Lymphaticovenous anastomosis (manual)
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Maastricht University Medical Center
Ureteral Stricture, Hydronephrosis
Application of the Sentire C1000 for Ureteral Stricture Repair
The purpose of this clinical study is to evaluate the safety and efficacy of the Sten® Laparoendoscopic Surgical System C1000 for benign ureteral reconstruction surgery.
- Trial name
- ROBUST-C1000 (NCT06983067)
- Testing
- Cornerstone C1000 Robotic Surgery System
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Xuesong Li
Soft Tissue Sarcoma (Excluding GIST), Soft Tissue Sarcoma Adult
Hypofractionated, 3-week, Preoperative Proton or X-ray Radiotherapy for Patients With Localized Soft Tissue Sarcoma
The purpose of the study is to investigate whether a personalized selection of patients with localized soft tissue sarcoma for preoperative proton radiation therapy can reduce long-term radiation side effects without increasing…
- Conditions
- Soft Tissue Sarcoma (Excluding GIST), Soft Tissue Sarcoma Adult, Soft Tissue Sarcoma of the Trunk and Extremities, Synovial Sarcomas
- Trial name
- PROSARC-1 (NCT07169344)
- Testing
- preoperative, Quality of life, Functional outcome
- Where
- 4 sites in Norway
- Volunteers
- 110 people
- Sponsor
- Oslo University Hospital
Cutaneous Squamous Cell Carcinoma
Neoadjuvant Plus Adjuvant Treatment With Cemiplimab in Cutaneaous Squamous Cell Carcinoma
Neoadjuvant plus adjuvant treatment with immunotherapy may have an anti-tumor activity and reduce the risk of relapse in patients with high risk surgically resectable stage III cutaneous squamous cell carcinoma.
- Trial name
- NCT04632433
- Testing
- Cemiplimab
- Where
- 7 sites in Italy
- Volunteers
- 25 people
- Sponsor
- Fondazione Melanoma Onlus
Breast Cancer Invasive
Omission of Breast Surgery for Breast Cancer Patients With pCR on MRI and Vacuum-assisted Biopsy After NST (OPTIMIST)
A prospective, multicenter, single-arm non-inferiority trial to demonstrate that breast cancer patients who are predicted to have a pathologic complete response on MRI and vacuum-assisted biopsy after neoadjuvant systemic…
- Trial name
- OPTIMIST (NCT05505357)
- Testing
- Breast surgery omission
- Where
- South Korea
- Volunteers
- 533 people
- Sponsor
- Seoul National University Hospital
Elbow Fracture, Elbow Arthropathy
Can Secondary Total Elbow Arthroplasty After Failed Internal Fixation or Non-operative Treatment of Distal Humeral Fractures Achieve Equal Results as Primary Arthroplasty?
Total elbow arthroplasty (TEA) results in immediate pain release with good functional results after distal humerus fractures. But still open reduction and internal fixation is recommended as treatment of choise due to a lifelong…
- Trial name
- NCT03302533
- Testing
- Total elbow arthroplasty
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Diakoniekrankenhaus Friederikenstift
Musculoskeletal Diseases or Conditions
Musculoskeletal Pathologies of the Upper Extremity in Surgical Device Mechanics
Work-related upper extremity musculoskeletal disorders (WRUEMSDs) have shown to be related to many occupational situations and specific industries.
- Trial name
- PEIN (NCT03014128)
- Testing
- Clinical examination and data processing of questionnaires
- Where
- Germany
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- District Hospital, Tuttlingen
Arthroplasty, Replacement, Hip
Evaluation of Four Surgical Techniques in Primary Total Hip Arthroplasty
Current "Minimally Invasive THR" includes: (1) Minimally Invasive Two-Incision THR (MIS-2), (2) Minimally Invasive Modified Watson-Jones THR (MIS-WJ).
- Trial name
- NCT01031732
- Testing
- MIS-2 THA, MIS-WJ, MIS-AL THA
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Chang Gung Memorial Hospital
Upper Extremity Fractures, Upper Extremity Non-Fracture Bone and Joint Conditions
Upper-Extremity Bone or Joint Surgery: Long Term Outcome
The specific aim of the study is to obtain long-term follow-up information on patients who have completed their standard clinical care in the Orthopaedic Hand and Upper Extremity Service.
- Trial name
- NCT02366221
- Testing
- 60-minute visit to the outpatient clinic, Phone Interview
- Volunteers
- 750 people
- Sponsor
- Massachusetts General Hospital
Delirium
A Research Study to Evaluate the Effectiveness of Dexmedetomidine in Preventing Delirium After Heart Surgery
The purpose of this study is to evaluate the efficacy and safety of dexmedetomidine in the prevention of postoperative delirium in subjects undergoing heart valve surgery with or without coronary artery bypass surgery (CABG)…
- Trial name
- NCT00464763
- Testing
- Dexmedetomidine
- Where
- 11 sites in United States
- Sponsor
- Hospira, now a wholly owned subsidiary of Pfizer
Cerebral Palsy
Soft Tissue Release for Elbow Pronation in Cerebral Palsy
Upper extremity deformities are highly common in individuals with cerebral palsy (CP) as a result of motor control impairment and muscle imbalance.
- Trial name
- NCT07601165
- Testing
- Upper extremity soft-tissue release
- Volunteers
- 28 people
- Sponsor
- Istanbul University - Cerrahpasa
Sinonasal Carcinoma
Induction Chemotherapy and Tazemetostat for Locally Advanced SMARCB1-deficient Sinonasal Carcinoma
SMARCB1-deficient sinonasal carcinoma is very locally advanced malignancy at diagnosis which often precluded upfront radical resection.
- Trial name
- NCT05151588
- Testing
- Docetaxel, Cis Platinum, 5-FU
- Volunteers
- 30 people
- Sponsor
- Dr. Victor H.F. Lee
Epicondylitis of the Elbow, Tennis Elbow
Tendon Fenestration Versus Surgery for the Treatment of Chronic Lateral Epicondylosis
Lateral epicondylosis, also called tennis elbow or lateral epicondylitis, is a prevalent, painful syndrome of the elbow. It is refractory to conservative treatment measures, including rest, excentric and concentric exercises in…
- Trial name
- NCT02710682
- Testing
- Mini-open surgery, Ultrasound-guided Tendon fenestration
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Lung Cancer, Lung Cancer Metastatic
Safety of PDT-Photofrin® Prior to Lung Surgery
This research study is being conducted to assess the safety of PDT in subjects with peripherally located malignant tumors in lung parenchyma prior to surgical resection. It will involve up to 10 sites in USA.
- Trial name
- NCT03344861
- Testing
- Porfimer Sodium, Fiber optic
- Where
- 8 sites in United States
- Volunteers
- 10 people
- Sponsor
- Concordia Laboratories Inc.
Cervical Cancer
A Study of Camrelizumab Combined With Concurrent Chemoradiation in Patients With Cervical Cancer
In this single-arm study, patient with cervical cancer who had recurrence of the pelvic wall after surgery ± Abdominal aortic lymph node metastasis will be included to evaluate the efficacy and safety of camrelizumab combined…
- Trial name
- NCT04974827
- Testing
- Camrelizumab, Cisplatin or Carboplatin
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Hunan Cancer Hospital
Osteosarcoma, Resection Margins
B7-H3 NIR Imaging for Osteosarcoma Surgery
Complete removal of all tumor tissue with a wide surgical margin is essential for the treatment of osteosarcoma (OS). However, it's difficult, sometimes impossible, to achieve due to the invisible small satellite lesions and…
- Conditions
- Osteosarcoma, Resection Margins, B7-H3 Probe, Local Recurrence
- Trial name
- ROLN-B7-H3 (NCT06778603)
- Testing
- a targeted probe B7H3-IRDye800CW
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Peking University People's Hospital
Regional Anaesthesia
Ultrasound-Guided Infraclvicular Block Using Dexmedetomidine Versus Nalbuphine as Adjuvants to Bupivacaine in Upper Limb Orthopedic Surgery
this study is designed to evaluate and compare the efficacy of dexmedetomidine and nalbuphine as adjuvants to 0.5% bupivacaine in ultrasound-guided infraclavicular brachial plexus block for patients undergoing elective upper limb…
- Trial name
- NCT07279727
- Testing
- Nalbuphine, Dexmedetomidine
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Assiut University
Elastosis
PEAK PlasmaBlade™ vs. Traditional Electrosurgery in Abdominoplasty
The objective of this clinical study is to evaluate healing of incisions made with the PEAK PlasmaBlade 4.0 compared to scalpel and traditional electrosurgery (Bovie); to monitor and record key post-operative metrics following…
- Trial name
- PRECISE (NCT00943150)
- Testing
- PEAK PlasmaBlade, Standard of Care (SOC)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Medtronic Surgical Technologies
Acute Pain
A Single-arm Study Evaluating the Effectiveness and Safety of Suzetrigine (SUZ) for Acute Pain After Selected Surgeries
The purpose of this study is to evaluate the effectiveness, safety, and tolerability of SUZ for acute pain after laparoscopic procedures of the intraperitoneal or retroperitoneal cavities or arthroscopic orthopedic procedures.
- Trial name
- NCT06887959
- Testing
- Suzetrigine
- Where
- 17 sites in United States
- Volunteers
- 47 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Anesthesia, Anesthesia Management
SIFIB As an Anesthesia Method for Lower Extremity Surgeries
The Ultrasound-guided Supra-inguinal Fascia Iliaca Block (SIFIB) is an advanced regional anesthesia technique strategically directed at the three primary nerves of the lumbar plexus.
- Conditions
- Anesthesia, Anesthesia Management, Regional Anesthesia
- Trial name
- NCT06076096
- Testing
- Suprainguinal fascia iliaca block
- Where
- Turkey (Türkiye)
- Volunteers
- 16 people
- Sponsor
- Samsun University