Clinical trials: Upper Respiratory Tract Infection (URTI)
Upper Respiratory Tract Infection, Gut Microbiota
The Effect of Synbiotics on the Upper Respiratory Tract Infection
Gut microbiome manipulation to alter the gut-lung axis may potentially protect humans against respiratory infections. However, clinical trials of synbiotics, one of the microbiota-targeted intervention, in this regard is few.
- Conditions
- Upper Respiratory Tract Infection, Gut Microbiota, Immune Function
- Trial name
- NCT04960878
- Testing
- Synbiotic
- Where
- China
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Huazhong University of Science and Technology
Upper Respiratory Infections, Influenza
Effectiveness of a Handwashing Programme in the Prevention of School Absenteeism Due to Respiratory Infections
The aim of the study was to assess the effectiveness of a hand-washing programme using hand sanitizer in the prevention of school absenteeism due to upper respiratory infections.
- Conditions
- Upper Respiratory Infections, Influenza, Common Cold
- Trial name
- NCT01728090
- Testing
- hand sanitizer
- Volunteers
- 1,640 people
- Sponsor
- Fundación Pública Andaluza para la Investigación Biomédica Andalucía Oriental
Upper Respiratory Tract Infections
A Safety Study to Compare the Effect of Two PrEP-001 Nasal Powder Formulations on Nasal Mucosa and Serum Cytokine Production
A safety study to compare the effect of two different formulations of PrEP-001 nasal powder when dosed in healthy subjects
- Trial name
- NCT03198676
- Testing
- PrEP-001 6.4 mg, PrEP-001 3.2 mg
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Prep Biopharm Limited
Respiratory Virus Infection
Epidemiology Of Respiratory Virus Infections In Children
This study aims to prospectively estimate the incidence of Respiratory virus (RV) infections in children with symptoms of an upper respiratory tract infection (URTI) or lower respiratory tract infection (LRTI) at St.
- Trial name
- NCT01167361
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- St. Jude Children's Research Hospital
Lower Respiratory Tract Infection
Placebo-Controlled Trial of Antibiotic Therapy in Adults With Suspect Lower Respiratory Tract Infection (LRTI) and a Procalcitonin Level
This is a randomized, double-blinded, placebo-controlled, non-inferiority multicenter clinical trial of azithromycin vs. placebo in adults presenting as outpatients with suspect Lower Respiratory Tract Infection (LRTI) and a…
- Trial name
- NCT03341273
- Testing
- Azithromycin, VIDAS B.R.A.H.M.S Procalcitonin Test (PCT)
- Where
- 5 sites in United States
- Volunteers
- 514 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Respiratory Syncytial Virus
A Study in Japanese Children Hospitalized With Respiratory Syncytial Virus Related Lower Respiratory Tract Infections
The purpose of the study is to assess viral kinetics and clinical symptoms kinetics of Respiratory Syncytial Virus (RSV) in pediatric patients hospitalized with RSV confirmed lower respiratory tract infection (LRTI).
- Trial name
- NCT02132923
- Testing
- No intervention
- Where
- Japan
- Volunteers
- 49 people
- Sponsor
- Janssen R&D Ireland
Hay Fever, Asthma
Evaluating the Potential of Large Language Models for Respiratory Disease Consultations
The clinical trial aimes to evaluate multiple large language models in respiratory disease consultations by comparing their performance to that of human doctors across three major medical consultation scenarios.
- Conditions
- Hay Fever, Asthma, Acute Upper Respiratory Infection, Pulmonary Embolism
- Trial name
- EPLLMMRDC (NCT06457269)
- Testing
- Diagnosis by three human doctors, Diagnosis by ChatGPT-3.5 (with search capabilities), Diagnosis by ChatGPT-3.5 (without search capabilities)
- Where
- China
- Volunteers
- 703 people
- Sponsor
- North Sichuan Medical College
Upper Respiratory Infection
Use of Novel Sinusonic Device for Prevention of Community Acquired Upper Respiratory Infection (URI)
This study aims to test the safety, efficacy and potential mechanism of action of the SinuSonic device on adults with upper respiratory infection (URI).
- Trial name
- NCT04468204
- Testing
- SinuSonic Device
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Medical University of South Carolina
Respiratory Syncytial Virus Infections, Severe Acute Respiratory Infection
Effectiveness of Immunization in Preventing Severe Acute Respiratory Infection RSV in Children Under 6 Months in Bogotá
This study aims to evaluate the real-world effectiveness of two preventive immunization strategies against Respiratory Syncytial Virus (RSV)-associated severe acute respiratory infection in infants less than six months of age in…
- Conditions
- Respiratory Syncytial Virus Infections, Severe Acute Respiratory Infection, Bronchiolitis, Viral, Viral Respiratory Tract Infection
- Trial name
- NCT07279298
- Testing
- RSVpreF vaccine (Abrysvo) and Nirsevimab (Beyfortus) or unexposed
- Where
- Colombia
- Volunteers
- 1,097 people
- Sponsor
- Bogotá District Health Secretariat
Chronic Rhinosinusitis (CRS), Exacerbations
Effect of Pleuran on the Clinical Course of Patients With Chronic Rhinosinusitis
The goal of this clinical research is to learn if Imunoglukan P4H® as an add-on therapy to the standard of care treatment according to the EPOS guidelines (intranasal corticosteroids and saline irrigation) can help to prevent CRS…
- Conditions
- Chronic Rhinosinusitis (CRS), Exacerbations, Respiratory Tract Infections (RTI), Antibiotic Prophylaxis
- Trial name
- EPCCOR (NCT07460934)
- Testing
- Imunoglukan P4H® capsules
- Where
- 5 sites in Czechia, Slovakia
- Volunteers
- 85 people
- Sponsor
- Pleuran, s.r.o.
Common Cold
Study to Evaluate the Efficacy of EZC Pak in Adults With Upper Respiratory Infection (URI)
A randomized-controlled interventional clinical trial to evaluate the effectiveness of EZC Pak \& EZC Pak+D for the treatment of the common cold and/or a URI.
- Trial name
- NCT04943575
- Testing
- EZC Pak, EZC Pak +D
- Where
- United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- PPC Pharmaceuticals
Influenza
Intravenous N-acetylcysteine and Oseltamivir Versus Oseltamivir in Adults Hospitalized With Influenza and Pneumonia
Seasonal influenza epidemics are important causes of morbidity and mortality. Cytokine dysregulation, with high levels of pro-inflammatory cytokines, occurs in patients with severe influenza.
- Trial name
- NCT03900988
- Testing
- N-acetyl cysteine, 5% Dextrose
- Where
- Hong Kong
- Volunteers
- 160 people
- Sponsor
- Chinese University of Hong Kong
Acute Upper Respiratory Tract Infection and Acute Bacterial Rhinosinusitis
Acute Upper Respiratory Tract Infection - When is Bacteria Involved?
The purpose of this study is to find out if we can predict the progress of acute upper respiratory tract infection to acute bacterial rhinosinusitis in Finnish conscripts by symptoms, clinical, endoscopic or radiological…
- Trial name
- NCT01580137
- Where
- Finland
- Volunteers
- 48 people
- Sponsor
- Oulu University Hospital
Lower Respiratory Tract Infection, Pneumonia
Reducing Overuse of Antibiotics With Decision Support
Eliminating inappropriate antibiotic use in pediatric lower respiratory tract infections (LRTI) is the central focus of this research.
- Conditions
- Lower Respiratory Tract Infection, Pneumonia, Asthma, Bronchiolitis, Viral
- Trial name
- ROADS (NCT06788093)
- Testing
- ED Clinical Decision Support (CDS-ED), Transitions Clinical Decision Support (CDS-Tr)
- Where
- 3 sites in United States
- Volunteers
- 2,800 people
- Sponsor
- Vanderbilt University Medical Center
Pneumonia, Lower Respiratory Tract Infection
Recurrent Pneumonia in Children
This study aimed to analyses the clinical characteristics, risk factors and underlying causes as predictors of recurrent pneumonia in children attending AUCH
- Conditions
- Pneumonia, Lower Respiratory Tract Infection, Chest Infection
- Trial name
- NCT06583317
- Volunteers
- 53 people
- Sponsor
- Assiut University
Lower Respiratory Tract Infection, Upper Respiratory Tract Infection
Antiviral Activity of Oral Probiotics
The aim of this study is to test saliva samples obtained from healthy human participants for anti-viral activity after they have consumed S. salivarius probiotic in a powder format.
- Trial name
- NCT05374070
- Testing
- Streptococcus salivarius K12 Powder 1 Billion colony forming units /g), Streptococcus salivarius K12 Powder (1 Billion colony forming units /g) with a prebiotic included, Streptococcus salivarius M18 Powder (1 Billion colony forming units /g)
- Where
- New Zealand
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- John Hale
Upper Respiratory Tract Infection
A Clinical Study to Determine the Safety and Efficacy of an Oral Supplementation of Bio-Immune®for Managing Upper Respiratory Tract Infection and Its Symptoms.
This is a prospective, interventional, randomised, double-blind, placebo-controlled, proof-of-science, in-use safety and efficacy study of an oral supplementation of Bio-Immune® for managing upper respiratory tract infection and…
- Trial name
- NCT06689995
- Testing
- Bio-immune Capsule
- Where
- India
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- NovoBliss Research Pvt Ltd
Upper Respiratory Tract Infections, Lower Respiratory Tract Infections
Maternal Vitamin D for Acute Respiratory Infections in Infancy
There is a growing body of data suggesting that vitamin D modulates the host's immune response to acute respiratory infection (ARI).
- Trial name
- MDARI (NCT02388516)
- Testing
- Vitamin D3
- Where
- Bangladesh
- Volunteers
- 1,214 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Respiratory Syncytial Virus Infection, Bronchiolitis
Gut Microbiome and Immune Response in Severe RSV Infection in Vietnamese Infants
Respiratory syncytial virus (RSV) is a leading cause of severe lower respiratory tract infection in young children, and a substantial proportion of severe cases occur in previously healthy infants.
- Conditions
- Respiratory Syncytial Virus Infection, Bronchiolitis, Viral Lower Respiratory Tract Infection (LRTI)
- Trial name
- GUT-LUNG RSV (NCT07417657)
- Where
- Vietnam
- Volunteers
- 250 people
- Sponsor
- Phuc Huu Phan
Acute Upper Respiratory Infection, Fever
Phase 3 Study of Pelubiprofen & Loxoprofen in Patients With Upper Respiratory Tract Infection
Multi-center, Randomized, Double blind, Controlled Parallel-group Comparative Phase 3 Clinical trial to assess the efficacy and safety of Pelubiprofen Compared to Loxoprofen in patients with Acute upper respiratory infection.
- Trial name
- NCT01779271
- Testing
- Pelubiprofen, Loxoprofen
- Where
- South Korea
- Volunteers
- 183 people
- Sponsor
- Daewon Pharmaceutical Co., Ltd.