Clinical trials: Uremic Pruritis
Uremic Pruritus
CR845-CLIN3103: A Global Study to Evaluate the Safety and Efficacy of CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus
This is a multicenter, international study to evaluate the safety and efficacy of intravenous (IV) CR845 at a dose of 0.5 mcg/kg administered after each dialysis session.
- Trial name
- KALM-2 (NCT03636269)
- Testing
- CR845 0.5 mcg/kg
- Where
- 92 sites in United States, Australia and 9 more
- Volunteers
- 473 people
- Sponsor
- Cara Therapeutics, Inc.
Uremic Pruritus
Study to Evaluate IV CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus
2 Part Study: Part A will assess 3 different dosing levels of IV CR845 versus placebo in patient on hemodialysis who have moderate-to-severe itching due to uremic pruritus.
- Trial name
- NCT02858726
- Testing
- CR845 0.5 mcg/kg, CR845 1 mcg/kg, CR845 1.5mcg/kg
- Where
- 29 sites in United States
- Volunteers
- 226 people
- Sponsor
- Cara Therapeutics, Inc.
Uremic Pruritus
Phase 3 Study of QLG2198 in Haemodialysis Chinese Adult Subjects With Moderate-to-Severe Pruritus
This a multicentre study that consists of a 12-week double-blind period, and a 14-week open-label extension period and a 1-week follow-up period.
- Trial name
- NCT06446310
- Testing
- QLG2198
- Where
- 3 sites in China
- Volunteers
- 194 people
- Sponsor
- Qilu Pharmaceutical (Hainan) Co., Ltd.
Chronic Kidney Disease, Uremic Pruritus
The Effect of Probiotics vs Activated Charcoal in the Management of CKD Patients Suffering From Uremic Pruritus.
This study aims to evaluate the efficacy and safety of probiotics versus activated charcoal in management of chronic kidney disease patients suffering from uremic pruritus.
- Trial name
- NCT06579066
- Testing
- Probiotic Blend Capsule, Activated Charcoal
- Volunteers
- 123 people
- Sponsor
- Ain Shams University
Pruritus, Kidney Failure, Chronic
Efficacy of Laser Acupuncture on Pruritus in Patients With Chronic Kidney Disease Undergoing Hemodialysis
Uremic pruritus is a clinically significant symptom which imposes heavy impact on the quality of life of patients with chronic kidney disease undergoing hemodialysis.
- Trial name
- NCT02432508
- Testing
- Laser acupuncture (Olympic)
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Uremic Pruritus
A Randomized-Withdrawal Phase 3 Study Evaluating the Safety and Efficacy of Oral Nalfurafine HCl (AC-820)in Subjects on Hemodialysis With Uremic Pruritus (Renal Itch)
Primary objective of this multicenter, double-blind, placebo controlled, randomized withdrawal study are to determine the effectiveness and safety of orally administered AC-820 in doses of 2.5 µg and 5.0 µg daily in patients with…
- Trial name
- AC120-8231 (NCT00793156)
- Testing
- Nalfurafine HCl 2.5 µg, Nalfurafine HCl 5.0 µg
- Volunteers
- 350 people
- Sponsor
- Acologix, Inc.
Uremic Pruritus
Comparison of Gabapentin With Doxepin in the Management of Uremic Pruritus
This is a single blind randomized trial to compare efficacy and side effects of Gabapentin with Doxepin. Hemodialysis patients with uremic pruritus at one dialysis center of Saint George Hospital University Medical Centre were…
- Trial name
- NCT03758079
- Testing
- Doxepin, Gabapentin
- Where
- Lebanon
- Volunteers
- 14 people
- Sponsor
- University of Balamand
Refractory Uremic Pruritis
PHOTOTHERAPY VERSUS PREGABALIN IN TREATMENT OF REFRACTORY UREAMIC PRURITIS
Patients will be randomly assigned into 2 groups: 1. Group A: (20 patients) will receive NB UVB phototherapy 3 sessions per week for 2 months. 2.
- Trial name
- NCT04660773
- Testing
- NB UVB phototherapy, Pregabalin
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Alexandria University
End Stage Renal Disease, Pruritus
Evaluating the Effect of Cromolyn Sodium in Uremic Pruritus
Pruritus is a major disorder among the skin derangements in advanced renal failure. Recent information suggests that interactions between dermal mast cells and distal ends of nonmyelinated C fibers may be important in the…
- Trial name
- NCT00745199
- Testing
- cromolyn sodium
- Where
- Iran
- Volunteers
- 62 people
- Sponsor
- Shiraz University of Medical Sciences
Uremic Pruritus in Hemodialysis Patients
The Effect of Omega-3 Fatty Acids Versus Gabapentin in Uremic Pruritus in Hemodialysis Patients
omega-3 fatty acids versus gabapentin in uremic pruritus in hemodialysis patients.
- Trial name
- NCT06190132
- Testing
- Omega 3 fatty acid, gabapentin
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Chronic Kidney Diseases, Dialysis
CKD-aP Among Adults on Dialysis in Switzerland
Chronic Kidney Disease Associated Pruritus (CKD-aP) represents a localized or a generalized skin itch, which is a common symptom occurring in end-stage renal disease and dialysis.
- Conditions
- Chronic Kidney Diseases, Dialysis, Chronic Kidney Diseases Associated Pruritus
- Trial name
- UP-RAISE (NCT05415969)
- Testing
- CKD-aP
- Where
- Switzerland
- Volunteers
- 401 people
- Sponsor
- University of Applied Sciences of Western Switzerland
Uremic Pruritus
Study to Investigate the Safety of LT5001 Drug Product for Uremic Pruritus in Hemodialysis Patients
A Randomized, Double Blind, Placebo-Controlled study to assess the Safety, Local Tolerance, and Pharmacokinetics of LT5001 drug product in Hemodialysis Patients with Uremic Pruritus
- Trial name
- NCT04393675
- Testing
- LT5001
- Where
- Taiwan
- Volunteers
- 18 people
- Sponsor
- Lumosa Therapeutics Co., Ltd.
Pruritus, Uremia
Gabapentin Versus Loratadine in Uremic Pruritus
The goal of this clinical trial is to compare the efficacy of gabapentin with loratadine in reducing the severity of uremic pruritus in patients of chronic kidney disease and to compare the side effects of both drugs.
- Conditions
- Pruritus, Uremia, Chronic Kidney Diseases
- Trial name
- NCT05750875
- Testing
- Loratadine, Gabapentin
- Where
- Pakistan
- Volunteers
- 64 people
- Sponsor
- King Edward Medical University
Chronic Kidney Diseases, Pruritus
CR845-310302: A Study to Evaluate the Safety and Efficacy of Difelikefalin in Advanced Chronic Kidney Disease Patients With Moderate-to-Severe Pruritus
This is a multicenter, double-blind, randomized, placebo-controlled study to evaluate the safety and efficacy of oral difelikefalin administered as a 1 mg tablet once daily compared to placebo in reducing the intensity of itch in…
- Trial name
- NCT05356403
- Testing
- Difelikefalin 1 mg Oral Tablet
- Where
- 75 sites in United States, Argentina and 11 more
- Volunteers
- 105 people
- Sponsor
- Cara Therapeutics, Inc.
Uremic Pruritus
A Phase III Clinical Study of MR13A9 in Hemodialysis Patients With Pruritus.
Double-blind, Placebo-controlled study to confirm the superiority of MR13A9 to placebo, and followed by extension, open-label treatment to confirm long-term safety of MA13A9 in hemodialysis patients with pruritus.
- Trial name
- NCT04711603
- Testing
- MR13A9
- Where
- Japan
- Volunteers
- 178 people
- Sponsor
- Kissei Pharmaceutical Co., Ltd.
Pruritus
Does Indoxyl Sulfate Have a Role in Uremic Pruritus?
Itching is a widespread and disturbing complain from patients with chronic kidney disease (CKD); epidemiologic data have suggested that approximately 40% of patients with end-stage renal disease experience moderate to severe…
- Trial name
- NCT05634083
- Testing
- Uremic pateints with itching
- Where
- 2 sites in Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Benha University
Pruritus, Cholestasis
Evaluate the Safety, Tolerability, and PK of EP547 in Healthy Subjects and Subjects With Cholestatic or Uremic Pruritus
This first in human, Phase 1/1b trial will evaluate the safety, tolerability, and pharmacokinetics of single and multiple ascending doses of EP547 in healthy subjects and subjects with cholestatic or uremic pruritus.
- Conditions
- Pruritus, Cholestasis, Kidney Failure
- Trial name
- NCT04510090
- Testing
- EP547
- Where
- 4 sites in Australia, New Zealand
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Escient Pharmaceuticals, Inc
Renal Insufficiency, Chronic
Montelukast for Treatment of Uremic Pruritus
In this study hemodialysis patients that underwent dialysis thrice weekly screen for uremic pruritus and 80 patients that at least have refractive pruritus that lead to sleep and daily activity disorders enroll in this study.
- Trial name
- NCT02559388
- Testing
- Montelukast
- Volunteers
- 73 people
- Sponsor
- Shiraz University of Medical Sciences
Uremic Pruritus
Phase 1 Study of Nalbuphine HCl ER Tablets in Hemodialysis Patients With Uremic Pruritus
This is a single-center clinical research study with the purpose to evaluate the safety, tolerability, and pharmacokinetics (PK) of nalbuphine HCl ER (extended release) tablets in end-stage renal disease (ESRD) patients receiving…
- Trial name
- NCT02373215
- Testing
- Nalbuphine HCL ER
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Trevi Therapeutics
End-Stage Kidney Disease (ESKD), Hemodialysis
Cardiovascular and Bone Mineral Markers in Dialysis Patients and Healthy Controls
This observational study will compare cardiovascular status, bone mineral metabolism, systemic inflammation, body composition, functional status, quality of life, pruritus, and pain among patients receiving different renal…
- Conditions
- End-Stage Kidney Disease (ESKD), Hemodialysis, Peritoneal Dialysis (PD)
- Trial name
- NCT07686978
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Gazi University