Clinical trials: Uremic Pruritis
Uremic Pruritus
The Effect of Phototherapy on Pruritus of Patients With Chronic Kidney Disease
The purpose of this study was to confirm the efficacy of NB UVB phototherapy in alleviating uremic pruritus and investigate the association between improvement of pruritus and change of serum parameters, including routine…
- Trial name
- NCT00494975
- Testing
- Narrow band UVB phototherapy , long wave UVA phototherapy
- Where
- Taiwan
- Volunteers
- 21 people
- Sponsor
- National Taiwan University Hospital
End Stage Renal Disease, Pruritus
DIalysis Symptom COntrol-Pruritus Outcome Trial
The purpose of this study is to test whether or not a medication called nabilone, which is a synthetic (non-natural) medication derived from cannabis, compared to placebo improves symptoms of itch in hemodialysis as measured by…
- Trial name
- DISCO-POT (NCT05180968)
- Testing
- Nabilone 0.5 MG Oral Capsule
- Where
- 2 sites in Canada
- Volunteers
- 14 people
- Sponsor
- University of Manitoba
Uremic Pruritus
The Efficacy of Hemp-containing Cream Versus Placebo in the Treatment of Uremic Pruritus
Uremic pruritus is a significant burden on hemodialysis patients, affecting approximately 46% of individuals undergoing dialysis.
- Trial name
- NCT06159686
- Testing
- Hemp
- Where
- Thailand
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Thammasat University Hospital
Uremic Pruritus
A Randomized-Withdrawal Phase 3 Study Evaluating the Safety and Efficacy of Oral Nalfurafine HCl (AC-820)in Subjects on Hemodialysis With Uremic Pruritus (Renal Itch)
Primary objective of this multicenter, double-blind, placebo controlled, randomized withdrawal study are to determine the effectiveness and safety of orally administered AC-820 in doses of 2.5 µg and 5.0 µg daily in patients with…
- Trial name
- AC120-8231 (NCT00793156)
- Testing
- Nalfurafine HCl 2.5 µg, Nalfurafine HCl 5.0 µg
- Volunteers
- 350 people
- Sponsor
- Acologix, Inc.
Chronic Kidney Diseases, Pruritus
A Study to Evaluate the Safety and Efficacy of CR845 in Chronic Kidney Disease Patients With Moderate-to-Severe Pruritus
This is a multicenter, double-blind, randomized, placebo-controlled study to evaluate the safety and efficacy of 3 dose levels of oral CR845 compared to placebo in reducing the intensity of itch in chronic kidney disease (CKD)…
- Trial name
- NCT03617536
- Testing
- CR845 0.25 mg Oral Tablet, CR845 0.5 mg Oral Tablet, CR845 1 mg Oral Tablet
- Where
- 60 sites in United States
- Volunteers
- 269 people
- Sponsor
- Cara Therapeutics, Inc.
Uremic Pruritus in Hemodialysis Patients
The Effect of Omega-3 Fatty Acids Versus Gabapentin in Uremic Pruritus in Hemodialysis Patients
omega-3 fatty acids versus gabapentin in uremic pruritus in hemodialysis patients.
- Trial name
- NCT06190132
- Testing
- Omega 3 fatty acid, gabapentin
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Uremic Pruritus
Safety and Efficacy of PG102P for Uremic Pruritus in HD Patients
In this study (SNUG trial), the investigators aim to investigate the anti-pruritic effect of PG102P in comparison with placebo in 80 patients undergoing HD.
- Trial name
- SNUG (NCT03576235)
- Testing
- PG102P
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Seoul National University Boramae Hospital
End-Stage Renal Disease, Pruritus
Evaluating the Effect of Fumaria Parviflora L. in Uremic Pruritus
The purpose of this study is to determine whether Fumaria Parviflora L. can minimize severity of pruritus in patients with end-stage renal disease.
- Trial name
- NCT02671162
- Testing
- Wheat, Fumaria
- Volunteers
- 63 people
- Sponsor
- Shiraz University of Medical Sciences
End Stage Renal Disease, Pruritus
Evaluating the Effect of Cromolyn Sodium in Uremic Pruritus
Pruritus is a major disorder among the skin derangements in advanced renal failure. Recent information suggests that interactions between dermal mast cells and distal ends of nonmyelinated C fibers may be important in the…
- Trial name
- NCT00745199
- Testing
- cromolyn sodium
- Where
- Iran
- Volunteers
- 62 people
- Sponsor
- Shiraz University of Medical Sciences
Pruritus, Uremia
Gabapentin - A Solution to Uremic Pruritus?
To investigate using the drug gabapentin to relieve the intense pruritic sensation associated with chronic renal failure patients undergoing peritoneal dialysis.
- Trial name
- NCT00577967
- Testing
- Gabapentin
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Hospital Authority, Hong Kong
Uremic Pruritus
Study to Investigate the Safety of LT5001 Drug Product for Uremic Pruritus in Hemodialysis Patients
A Randomized, Double Blind, Placebo-Controlled study to assess the Safety, Local Tolerance, and Pharmacokinetics of LT5001 drug product in Hemodialysis Patients with Uremic Pruritus
- Trial name
- NCT04393675
- Testing
- LT5001
- Where
- Taiwan
- Volunteers
- 18 people
- Sponsor
- Lumosa Therapeutics Co., Ltd.
Pruritus, Uremic Pruritus
Safety and Pharmacokinetics of IV CR845 in Hemodialysis Patients, and Its Efficacy in Patients With Uremic Pruritus
The primary purpose of this study is to: Evaluate the safety and pharmacokinetic profile of repeated doses IV CR845 over one week in patients who are undergoing hemodialysis.
- Trial name
- NCT02229929
- Testing
- Part A: CR845 0.5 mcg/kg, Part A: CR845 1.0 mcg/kg, Part A: CR845 2.5 mcg/kg
- Where
- 20 sites in United States
- Volunteers
- 89 people
- Sponsor
- Cara Therapeutics, Inc.
Uremic Pruritus
Efficacy of Pregabalin in the Management of Chronic Uremic Pruritus
Uraemic pruritus (UP) remains a frequent and distressing problem in patients with advanced or end-stage renal disease. Its intensity ranges from sporadic discomfort to complete restlessness during both the day- and night-time and…
- Trial name
- NCT01073501
- Testing
- Pregabalin
- Where
- Israel
- Volunteers
- 36 people
- Sponsor
- Shaare Zedek Medical Center
Uremic Pruritus
Using of Extra Virgin Olive Oil in Hemodialysis Patients to Improve Pruritus and Sleep Disorders
Background and Purpose: Itching is a common complication of hemodialysis patients, which can cause skin damage and affect the patient's comfort.
- Trial name
- NCT05466045
- Testing
- Olive oil application in hemodialysis patients with pruritus, Normal saline application in hemodialysis patients with pruritus
- Volunteers
- 86 people
- Sponsor
- National Taipei University of Nursing and Health Sciences
Pruritus
Does Indoxyl Sulfate Have a Role in Uremic Pruritus?
Itching is a widespread and disturbing complain from patients with chronic kidney disease (CKD); epidemiologic data have suggested that approximately 40% of patients with end-stage renal disease experience moderate to severe…
- Trial name
- NCT05634083
- Testing
- Uremic pateints with itching
- Where
- 2 sites in Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Benha University
Chronic Kidney Diseases, Pruritus
A Study to Evaluate the Safety and Efficacy of Difelikefalin in Advanced Chronic Kidney Disease Patients With Moderate-to-Severe Pruritus
This is a multicenter, double-blind, randomized, placebo-controlled study to evaluate the safety and efficacy of oral difelikefalin administered as a 1 mg tablet once daily compared to placebo in reducing the intensity of itch in…
- Trial name
- NCT05342623
- Testing
- Difelikefalin 1 mg Oral Tablet
- Where
- 83 sites in United States
- Volunteers
- 286 people
- Sponsor
- Cara Therapeutics, Inc.
Refractory Uremic Pruritis
PHOTOTHERAPY VERSUS PREGABALIN IN TREATMENT OF REFRACTORY UREAMIC PRURITIS
Patients will be randomly assigned into 2 groups: 1. Group A: (20 patients) will receive NB UVB phototherapy 3 sessions per week for 2 months. 2.
- Trial name
- NCT04660773
- Testing
- NB UVB phototherapy, Pregabalin
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Alexandria University
Uremic Pruritus
Phase 3 Study of QLG2198 in Haemodialysis Chinese Adult Subjects With Moderate-to-Severe Pruritus
This a multicentre study that consists of a 12-week double-blind period, and a 14-week open-label extension period and a 1-week follow-up period.
- Trial name
- NCT06446310
- Testing
- QLG2198
- Where
- 3 sites in China
- Volunteers
- 194 people
- Sponsor
- Qilu Pharmaceutical (Hainan) Co., Ltd.
Uremic Pruritus, Pruritus
Study of Nalbuphine HCl ER Tablets in Hemodialysis Patients With Uremic Pruritus
The primary objectives of the study to evaluate the effects of two doses of nalbuphine HCl ER tablets on the change from baseline in the worst itch Numerical Rating Scale (NRS) in hemodialysis patients with moderate to severe…
- Trial name
- NCT02143648
- Testing
- nalbuphine HCl ER tablets 60 mg BID, nalbuphine HCl ER tablets 120mg BID
- Where
- 47 sites in United States, Poland and 1 more
- Volunteers
- 373 people
- Sponsor
- Trevi Therapeutics