Clinical trials: Urethra Stricture
Urethral Stricture
9000 URETHRA STUDY: a Study About Urethroplasty for Urethral Stricture Disease
It has been demonstrated that urethroplasty should be considered the gold standard treatment for urethral stricture disease as it yields higher long-term success rates than endoscopic treatment options such as direct vision…
- Trial name
- NCT04071925
- Testing
- Urethroplasty
- Where
- 2 sites in Belgium
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Ghent
Urethral Stricture
Bioengineered Collagen Implant for Urethral Stricture Repair
The field of research for this study is tissue engineering and the utilization of a bioengineered collagen implant as a substitute biomaterial for conventional buccal mucosa in substitution urethroplasty of distal urethral…
- Trial name
- NCT05463991
- Testing
- Bioengineered collagen implant
- Where
- Malaysia
- Volunteers
- 5 people
- Sponsor
- Regenosca SA
Bladder Neck Obstruction, Bladder Outlet Obstruction
Effectiveness and Safety of Adipose-derived Regenerative Cells for Reduction of Risk of Bladder Neck Contracture
Autologous adipose-derived regenerative cells (ADRC) will be extracted from lipoaspirate by enzymatic digestion from a portion of the fat harvested from the patient's front abdominal wall.
- Conditions
- Bladder Neck Obstruction, Bladder Outlet Obstruction, Benign Prostatic Hyperplasia, Urinary Bladder Neck Obstruction
- Trial name
- NCT02869061
- Testing
- Liposuction, Transurethral bladder neck resection., ADRC
- Where
- 2 sites in Russia
- Volunteers
- 12 people
- Sponsor
- Central Clinical Hospital w/Outpatient Health Center of Business Administration for the President of Russian Federation
Gastric Foreign Body, Nos, Disorder of Abdomen (Disorder)
Transluminal Flexible Endoscopic Procedure in Foregut and Urologic Surgery
NOTES access is safe and feasible in the controlled human setting and comparable to standard-of-care surgical techniques. NOTES exploration of the abdomen provides adequate visualization comparable to laparoscopy.
- Conditions
- Gastric Foreign Body, Nos, Disorder of Abdomen (Disorder), Foreign Body in Esophagus, Prostatic Diseases
- Trial name
- NOTES (NCT00484783)
- Testing
- Natural Orifice Transluminal Endoscopic Surgery (NOTES), Natural Orifice Translumenal Endoscopic Surgery (NOTES)
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University Hospitals Cleveland Medical Center
Urethral Stricture, Male
Comparison Between Two Techniques Used in Treatment of Long Anterior Urethral Stricture
To evaluate dorsolateral and dorsal approach urethroplasty in treatment of anterior urethral stricture by using buccal mucosal graft as regard voiding and sexual outcomes.
- Trial name
- NCT05918315
- Testing
- Buccal mucosa substitution urethroplasty
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Sohag University
Urethral Stricture
Memokath® 044TW Stent for Treatment of Urethral Stricture
The purpose of this study is to evaluate if the placement of a temporary urethral stent for up to 12 months, following dilation or internal urethrotomy (cutting open), results in a higher rate of urethral patency during the first…
- Trial name
- NCT00270504
- Testing
- Memokath stenting
- Where
- 7 sites in United States
- Volunteers
- 92 people
- Sponsor
- Pnn Medical DK
Urethral Stricture
Urethral Resistive Index (URI): A New Parameter for Diagnosing Urethral Obstruction
This prospective observational study aims to evaluate the diagnostic accuracy of a new, non-invasive uroflowmetry parameter called the Urethral Resistive Index (URI) for detecting urethral stricture in men.
- Trial name
- URI (NCT07403786)
- Testing
- Uroflowmetry with URI Calculation
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Stricture Urethra
Role of Paclitaxel in Stricture Urethra
Stricture urethra is a common disease and has various causing factors. The most common performed procedure is direct visual internal urethrotomy (DVIU), but unfortunately has a high recurrence rates.
- Trial name
- NCT05678413
- Testing
- DVIU with paclitaxel injection, DVIU
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Al-Azhar University
Urethral Stricture
Urethral Stricture: A Comparison Between Jugal or Labial Graft Urethroplasty
Buccal mucosa urethroplasty is a current fashion in urethral stricture management. In our university centre (Hospital de Clínicas de Porto Alegre) is a common surgical treatment choice.
- Trial name
- NCT03973619
- Testing
- Labial Graft, Jugal Graft
- Volunteers
- 77 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Stricture Urethra, Holmium Laser
Holmium Laser Versus Cold Knife Treatment in Urethral Strictures
The goal of this study is to assess the efficacy of optical internal urethrotomy, which uses a holmium laser in comparison to a cold knife, in treating short-segment urethral strictures in our local setting.
- Conditions
- Stricture Urethra, Holmium Laser, Recurrence
- Trial name
- NCT07505316
- Testing
- holmium laser, cold knife
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Shahida Islam Medical Complex
Urethral Stricture
Functional Outcome of Urethral Reconstructive Surgery
The analysis of the long-term outcomes and quality-of-life parameters after urethral reconstruction surgery.
- Trial name
- NCT01982136
- Testing
- end-to-end urethroplasty, substitution urethroplasty (buccal mucosa), substitution urethroplasty (pedicled skin flap)
- Where
- Belgium
- Volunteers
- 175 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Urethral Stricture
Dorsal vs. Ventral Buccal Graft Dorsal vs. Ventral Buccal Graft
This is a randomized non-blinded comparison of dorsal vs. ventral approach for buccal mucosa graft urethroplasty in the bulbar urethra. Buccal mucosa graft is a common method of repairing the strictured urethra.
- Trial name
- DoVeBuG (NCT02551783)
- Testing
- Urethroplasty with buccal mucosa graft, Ventral Buccal
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Minnesota
Urethra Stenosis, Urethral Stricture
Multi-stage Urethroplasty with Augmentation Using a Dorsal Graft Inlay Technique Comparing Graft Use in First or Second Stage
The principal aim of this pilot study is to directly compare both approaches and analyze the failure rate after one year of follow-up.
- Trial name
- MAGIC I (NCT04965025)
- Testing
- Multi-stage urethroplasty with graft inlay in first stage, Multi-stage urethroplasty with graft inlay in second stage
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- University Hospital, Ghent
Urethral Stricture
Re-establishing Flow Via Drug Coated Balloon For The Treatment Of Urethral Stricture Disease
The study described below is designed to assess the safety and device performance for the drug coated balloon (DCB) for the treatment of urethral stricture.
- Trial name
- ROBUST-II (NCT03270384)
- Testing
- Urotronic Drug Coated Balloon (DCB)
- Where
- 5 sites in United States
- Volunteers
- 16 people
- Sponsor
- Urotronic Inc.
Urethral Stricture, Anterior, Urethral Stricture Disease
Outcomes of Double-face Augmentation Urethroplasty
Combined dorsal and ventral onlay augmentation for bul¬bar urethral reconstruction. Nontraumatic near-obliterative bulbar urethral strictures (BUS) of <2 cm in length can be managed with non-transecting anastomotic bulbar…
- Trial name
- BMG (NCT07436819)
- Testing
- Double-face augmentation urethroplasty
- Where
- 2 sites in Egypt
- Volunteers
- 30 people
- Sponsor
- Menoufia University
Urethral Stricture, Bulbar
Optimal Duration of Foley Catheter After Bulbar Urethroplasty
The goal of this clinical trial is to learn when is the best time to remove a Foley catheter (tube used to drain urine from the bladder) after surgery in adult men who have a specific type of urethral stricture disease (narrowing…
- Trial name
- NCT07220980
- Testing
- Early catheter removal, Later catheter removal
- Where
- 4 sites in United States
- Volunteers
- 320 people
- Sponsor
- Jane Kurtzman
Urethral Stricture
A Study of Dorsal Versus Ventral Buccal Mucosa Graft Onlay for Bulbar Urethroplasty
The investigators propose a randomized non-blinded comparison of dorsal vs. ventral approach for buccal mucosa graft urethroplasty in the bulbar urethra. Buccal mucosa graft is a common method of repairing the strictured urethra.
- Trial name
- DvV (NCT02634619)
- Testing
- Ventral buccal mucosa onlay urethroplasty, Dorsal buccal mucosa onlay urethroplasty
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- University of California, San Francisco
Urethral Stricture, Urethral Diseases
REDUCER Trial (TXA in Urethroplasty)
This study will test whether tranexamic acid (TXA), a medication used to reduce bleeding, can decrease blood loss in patients having urethroplasty.
- Trial name
- REDUCER (NCT07501884)
- Testing
- Tranexamic Acid, Urethroplasty
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Amjad Alwaal, MD, MSc, FRCSC, FACS
Urethral Stricture, Male
Small Intestinal Submucosa Graft for Repair of Anterior Urethral Strictures
The field of research for this study is tissue engineering and the utilization of a small intestinal submucosa graft as a substitute biomaterial for conventional buccal mucosa in substitution urethroplasty of anterior urethral…
- Trial name
- NCT06192654
- Testing
- Small intestinal submucosa (SIS) graft urethroplasty, Autologous oral bucal mucosa graft urethroplasty
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Xiaoyong Zeng
Stricture Urethra
ROBUST I Pilot Study, Re-Establishing Flow Via Drug Coated Balloon For The Treatment Of Urethral Stricture Disease
Robust I study is a feasibility study for evaluating the safety and efficacy of DCB.
- Trial name
- ROBUST (NCT03014726)
- Testing
- Urotronic Drug Coated Balloon (DCB)
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Urotronic Inc.