Clinical trials: Urethral Obstruction
Urinary Stress Incontinence
Midurethral Synthetic Tape With Tension Control Mechanism Versus Midurethral Free Tape
This is a prospective, comparative randomized controled trial. The general purposes of this study is to compare the efficacy and safety of midurethral synthetic tape with tension control mechanism and conventional midurethral…
- Trial name
- NCT04101279
- Testing
- surgical management of stress urinary incontinence with midurethral tension free tape., surgical management of stress urinary incontinence with synthetic tape with tension control mechanism.
- Where
- Russia
- Volunteers
- 120 people
- Sponsor
- Moscow State University of Medicine and Dentistry
Lower Urinary Tract Symptoms, Benign Prostatic Hyperplasia
Impact of 80 W KTP Laser Vaporization Prostatectomy on Severity of Obstruction in Benign Prostatic Hyperplasia
The purpose of this study is to compared the efficacy of 80W KTP photoselective laser vaporization prostatectomy (PVP) and transurethral resection of the prostate (TURP) in reducing the volume of prostate and relieving the…
- Trial name
- NCT00908427
- Testing
- photoselective vaporization prostatectomy (PVP), Transurethral resection of the prostate
- Where
- South Korea
- Volunteers
- 86 people
- Sponsor
- Samsung Medical Center
Prostatectomy
Rectus Sheath Block May Relieve Urethral Catheter Pain
This study aimed to investigate the analgesic efficacy of rectus sheath block and its effect on urethral catheter discomfort in robotic prostatectomy operations.
- Trial name
- NCT05242198
- Testing
- Robotic prostatectomy
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- V.K.V. American Hospital, Istanbul
Urinary Bladder, Overactive, Urinary Bladder Neck Obstruction
Association With Low Compliance Bladder in Women With LUTS
Hypothesis / aims of study The clinical and urodynamic features on the severity of low compliance bladder in neurologically intact women with lower urinary tract symptoms are indeterminate.
- Conditions
- Urinary Bladder, Overactive, Urinary Bladder Neck Obstruction, Pelvic Organ Prolapse, Urinary Incontinence
- Trial name
- NCT06210477
- Testing
- medical treatment for lower urinary tract symptoms
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Overactive Bladder Syndrome, Bladder Outlet Obstruction
Urodynamics and Clinical Factors That Are Associated With Bladder Over-sensitivity
Urodynamic examination evaluates storage and empting phases of the urinary bladder. It enables the clinician to correlate physiologic findings to patients' complains.
- Conditions
- Overactive Bladder Syndrome, Bladder Outlet Obstruction, Benign Prostate Enlargement, Stress Incontinence (Female) (Male)
- Trial name
- NCT03486639
- Testing
- IPSS questionnaire
- Where
- Israel
- Volunteers
- 330 people
- Sponsor
- Assaf-Harofeh Medical Center
Urethral Stricture
Clostridium Histolyticum Collagenase Injection for Urethral Disease
The purpose of this study is to assess the efficacy of clostridium histolyticum collagenase (XIAFLEX®) in treating urethral strictures.
- Trial name
- NCT02948842
- Testing
- Clostridium Histolyticum Collagenase, Saline
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of South Florida
Detrusor Underactivity, Bladder Outlet Obstruction
DU and BOO in Women With and Without Symptoms of VD
Women with symptoms of voiding dysfunction may be associated with detrusor underactivity or bladder outlet obstruction. However, the prevalence of detrusor underactivity and bladder outlet obstruction remained obscure.
- Trial name
- NCT04981080
- Testing
- Urodynamic study
- Where
- Taiwan
- Volunteers
- 1,886 people
- Sponsor
- National Taiwan University Hospital
Bladder Outlet Obstruction, Pressure Flow Study
Comparison Between Invasive Pressure Flow Study and Non-invasive Penile Cuff Test
To provide evidence of promising tests to noninvasively diagnose bladder outlet obstruction (BOO) in men with benign prostatic hyperplasia. 1.
- Trial name
- NCT02031653
- Where
- South Korea
- Volunteers
- 335 people
- Sponsor
- Samsung Medical Center
Benign Prostatic Hyperplasia, Lower Urinary Tract Symptoms
Ultrasound IPP to Predict Response to Medical Therapy in LUTS/BPH
This prospective cohort study evaluated whether transabdominal ultrasound measurement of intravesical prostatic protrusion predicts symptom severity and response to medical therapy in men aged 50 years or older with lower urinary…
- Conditions
- Benign Prostatic Hyperplasia, Lower Urinary Tract Symptoms, Bladder Outlet Obstruction
- Trial name
- NCT07306767
- Testing
- Transabdominal ultrasound measurement of intravesical prostatic protrusion, Alpha-adrenergic blocker, 5-alpha reductase inhibitor
- Where
- Egypt
- Volunteers
- 130 people
- Sponsor
- Ain Shams University
Urethral Stricture
Effect of Mitomycin C on Urethral Stricture Recurrence After Internal Urethrotomy
The aim of this study is to evaluate the efficacy of local injected mitomycin C at the time of internal urethrotomy in order to prevent the recurrence of urethral strictures.
- Trial name
- NCT00918528
- Testing
- Internal urethrotomy, Mitomycin C - local injection
- Where
- Israel
- Sponsor
- Hillel Yaffe Medical Center
Urethral Stricture
Intraoperative Lidocaine or Dexmedetomidine for Postoperative Pain Modulation After Urethral Reconstruction.
The development of chronic postoperative pain (CPP) following surgery is influenced by several factors, among which the intensity of acute postoperative pain in the immediate perioperative period and mechanisms related to nerve…
- Trial name
- NCT07676942
- Testing
- Perioperative lidocaine infusion, Perioperative dexmedetomidine infusion
- Where
- Poland
- Volunteers
- 80 people
- Sponsor
- Centre of Postgraduate Medical Education
Urethral Stricture
A Study of Dorsal Versus Ventral Buccal Mucosa Graft Onlay for Bulbar Urethroplasty
The investigators propose a randomized non-blinded comparison of dorsal vs. ventral approach for buccal mucosa graft urethroplasty in the bulbar urethra. Buccal mucosa graft is a common method of repairing the strictured urethra.
- Trial name
- DvV (NCT02634619)
- Testing
- Ventral buccal mucosa onlay urethroplasty, Dorsal buccal mucosa onlay urethroplasty
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- University of California, San Francisco
Hypospadias
The Change of the Detrusor Thickness After Hypospadias Repair - Comparison With the Normal Control Group
Even successfully managed hypospadias without any complication, voiding problem could be developed due to the increased urethral resistance.
- Trial name
- NCT01762007
- Where
- South Korea
- Volunteers
- healthy volunteers welcome
- Sponsor
- Yonsei University
Bladder Outlet Obstruction
Antimuscarinics as the First-line Treatment for Male With IPSS-V/S≤1
This study is a prospective randomized, open label, controlled, double arm, post-marketing study to compare the treatment efficacy of first-line antimuscarinics and α-blockers monotherapy for men with moderate to severe lower…
- Trial name
- NCT01661621
- Testing
- Detrusitol 4 mg QD, Doxazosin 4 mg QD
- Where
- Taiwan
- Volunteers
- 395 people
- Sponsor
- Buddhist Tzu Chi General Hospital
Urethral Stricture
The Nanofat Regenerative Surgery for Management of Genital Lichen Sclerosus in Male and Female Patients
Regenerative surgery is an emerging multidisciplinary field actually based on derived adipose tissue. Autologous fat grafting was first described by Neuber in 1893 and since then it has developed over the next century.
- Trial name
- LSNanofat (NCT05464290)
- Testing
- NANOfat grafting
- Where
- Italy
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Male Urogenital Diseases, Genital Diseases, Male
Office Based Transperineal Laser Ablation for Benign Prostatic Hyperplasia HYPERPLASIA
This study is set up as a phase I-II prospective, single center, interventional pilot study carried in Office setting under local anesthesia.
- Conditions
- Male Urogenital Diseases, Genital Diseases, Male, Prostatic Disease, Prostatic Hyperplasia
- Trial name
- NCT04760483
- Testing
- SoracteLite(TM) TPLA for BPH
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Urological Research Network, LLC
Urologic Diseases, Male Urogenital Diseases
Safety and Feasibility Study of Autologous Engineered Urethral Constructs for the Treatment of Strictures
This is a Phase I clinical study to determine the safety and efficacy of using autologous, engineered urethral constructs for the treatment of urethral strictures in adult males.
- Conditions
- Urologic Diseases, Male Urogenital Diseases, Urethral Stricture, Urethral Injury
- Trial name
- NCT03258658
- Testing
- Autologous Engineered Urethral Construct
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Wake Forest University Health Sciences
Urethral Stricture, Male
Peri-operative Oral Pain Control Following Buccal Graft Urethroplasty
Patients undergoing buccal urethroplasty will often have significant post-operative oral pain from the graft site. Various graft harvest techniques and methods for post-harvest hemostasis including graft site closure have been…
- Trial name
- Buccal (NCT05300685)
- Testing
- Standard Buccal Harvest, Basic buccal procedure + Long acting local, Basic buccal procedure + Buccal block
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of California, San Francisco
Bladder Outlet Obstruction, Lower Urinary Tract Symptoms
The Value of Multiple Urine Flow Rate Measurements in Male Benign Prostatic Hyperplasia (BPH) Subjects
Crossover comparison of different flow meters with a digital home flow meter as a reference. Main hypothesis: Reapeated home flow measurements with a disposable device will provide a better understanding of the patients urinary…
- Trial name
- NCT00710749
- Testing
- Disposable device, Digital device, Clinic flow measurement
- Where
- 4 sites in United States, Netherlands and 2 more
- Volunteers
- 60 people
- Sponsor
- Wellspect HealthCare
Urethral Stricture, Erectile Dysfunction
Comparison Between Excision And Primary Anastomosis Urethroplasty And Tunica Vaginalis Graft Urethroplasty.
Urethroplasty is considered the gold standard for the treatment of urethral stricture disease, with a success rate of more than 93% in terms of stricture recurrence.
- Trial name
- NCT07668973
- Testing
- Excision and Primary Anastomosis Urethroplasty, Tunica Vaginalis Graft Urethroplasty
- Volunteers
- 94 people
- Sponsor
- Sahiwal medical college sahiwal