Clinical trials: Urinary; Sepsis, open to volunteers
Kidney Calculi, Urolithiasis
Antibiotic Irrigation and Suction Ureteral Access Sheath in RIRS
Retrograde intrarenal surgery (RIRS) is a widely used treatment for kidney stones; however, postoperative infectious complications remain a significant concern.
- Conditions
- Kidney Calculi, Urolithiasis, Urinary Tract Infections
- Trial name
- NCT07655050
- Testing
- Standard Retrograde Intrarenal Surgery, Gentamicin Irrigation, Suction-Enabled Ureteral Access Sheath
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 180 people
- Sponsor
- Hitit University
Urosepsis, Kidney Stone
Effect of Emergency Urinary Drainage on Subsequent PCNL Outcomes in Obstructive Urosepsis
Obstructive urolithiasis complicated by urosepsis is a life-threatening medical emergency requiring urgent urinary tract decompression.
- Trial name
- NCT07826325
- Testing
- Retrograde Ureteral Stenting followed by PCNL, Percutaneous Nephrostomy followed by PCNL
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Beni-Suef University
Renal Stone Disease
Direct In-Scope Suction Versus Standard Flexible Ureterorenoscopy
This prospective study aims to compare the clinical, perioperative, and postoperative outcomes of flexible ureterorenoscopy using a direct in-scope suction system (DISS) with standard flexible ureterorenoscopy in patients…
- Trial name
- NCT07864194
- Testing
- Standard flexible ureterorenoscope, Flexible ureterorenoscope with direct in-scope suction
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Hitit University
Complicated Urinary Tract Infections, Antibiotic Resistance
Cefepime/Enmetazobactam for Bacteremic Complicated Urinary Tract Infections
This study is designed to better understand how well a new antibiotic combination, cefepime/enmetazobactam (FEP/META), works in patients with complicated urinary tract infections that have spread to the bloodstream (bacteremia).
- Trial name
- CP-CUTI (NCT07725848)
- Where
- 3 sites in Italy
- Volunteers
- 200 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Acute Disease, Sepsis
Acutelines: a Large Data-/Biobank of Acute and Emergency Medicine
Research in acute care faces many challenges, including enrollment challenges, legal limitations in data sharing, limited funding, and lack of singular ownership of the domain of acute care.
- Conditions
- Acute Disease, Sepsis, Pneumonia, Frailty
- Trial name
- Acutelines (NCT04615065)
- Where
- Netherlands
- Volunteers
- 35,000 people
- Sponsor
- University Medical Center Groningen
Hospital-acquired Bacterial Pneumonia (HABP), Ventilator-associated Bacterial Pneumonia (VABP)
Study to Assess the Efficacy and Safety of Meropenem and Pralurbactam in Carbapenem-Resistant Enterobacteriaceae Infections
The study will evaluate the efficacy and safety of Meropenem and Pralurbactam versus Best Available Therapy in the treatment of Carbapenem-Resistant Enterobacteriaceae Infections.
- Conditions
- Hospital-acquired Bacterial Pneumonia (HABP), Ventilator-associated Bacterial Pneumonia (VABP), Complicated Intra-abdominal Infection (cIAI), Complicated Urinary Tract Infection (cUTI)
- Trial name
- NCT07089186
- Testing
- Meropenem and Pralurbactam, Best Available Therapy (e.g., colistin, meropenem, tegecycline, amikacinceftezidime-avibatam)
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
Nephrolithiasis, Urosepsis
Serum Endotoxin Assay to Predict the Development of Postoperative Infectious Complications and Systemic Inflammatory Response Following Percutaneous Nephrolithotomy.
The aim of the study is to establish an infectious risk stratification system based on pre-and post-operative blood endotoxin profile.
- Trial name
- NCT04669886
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Miami
Febrile Illness Acute, Meningitis, Bacterial
Febrile Infants Swedish Study
Approximately one million febrile infants aged ≤60 days present annually to pediatric emergency departments (PEDs) in Europe and the United States.
- Conditions
- Febrile Illness Acute, Meningitis, Bacterial, Urinary Tract Infection (Diagnosis), Invasive Bacterial Infection
- Trial name
- FISS (NCT07134751)
- Where
- 11 sites in Sweden
- Volunteers
- 2,000 people
- Sponsor
- Region Skane
Urinary Tract Infections
Comparative Study of the Genomic Characteristics of Uropathogenic Escherichia Coli According to the Severity of Community-Acquired Urinary Tract Infections in Guadeloupe (COLIGENURI)
The aim is to identify genomic determinants (genes or gene clusters) associated with the severity of community-acquired E. coli urinary tract infections in Guadeloupe through a comparative approach integrating clinical…
- Trial name
- COLIGENURI (NCT07905638)
- Testing
- Whole-genome sequencing (WGS) of E. coli isolates (applies to all 3 groups)
- Volunteers
- 210 people
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Kidney Stone, Infection
Novel Antimicrobial Solution to Prevent Infections
Ureteroscopy is the most common surgical treatment for kidney stones. Although rare, sepsis after ureteroscopy can be a life-threatening complication, occuring in <3% of patients.
- Conditions
- Kidney Stone, Infection, Infection Associated With Catheter, Sepsis
- Trial name
- NCT07881822
- Testing
- antimicrobial irrigation
- Volunteers
- 50 people
- Sponsor
- Ohio State University
Patients Admitted to the ICU, Expected Hospital Stay ≥48 Hours
Enterocyte Injury and Acute Gastrointestinal Dysfunction in Critical Illness
Acute gastrointestinal injury (AGI) is a common but not fully understood organ dysfunction in critically ill patients. Current AGI grading systems rely primarily on clinical presentation and feeding tolerance, which are…
- Conditions
- Patients Admitted to the ICU, Expected Hospital Stay ≥48 Hours, Adult
- Trial name
- NCT07440368
- Testing
- Plasma and urine I-FABP measurement
- Volunteers
- 500 people
- Sponsor
- The First Hospital of Jilin University
Kidney Transplant Infection, Bloodstream Infection
Prediction and Prevention of Bloodstream Infections After Kidney Transplantation
Kidney transplant recipients take medicines that suppress the immune system to prevent rejection of the transplanted kidney. As a result, they have a high risk of infections, especially urinary tract infections (UTIs).
- Conditions
- Kidney Transplant Infection, Bloodstream Infection, Kidney Transplant, Kidney Transplant Recipients
- Trial name
- PREDICT (NCT07407673)
- Testing
- Pivmecillinam
- Where
- 3 sites in Denmark
- Volunteers
- 180 people
- Sponsor
- Susanne Dam Nielsen, MD, DMSc
Acute Kidney Injury, Septic Shock
Does Urinary TIMP2 and IGFBP7 Can Identify High Risk Patients of Progression From Mild and Moderate to Severe Acute Kidney Injury During Septic Shock?
Septic shock is one of the leading causes of death in patients admitted to the intensive care unit (ICU). Acute kidney injury (AKI) occurs in almost 50% of septic patients and is associated with significant mortality.
- Trial name
- HEMOCHECK (NCT03547414)
- Testing
- Nephrocheck test
- Where
- France
- Volunteers
- 110 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Falls Injury, Readmission Rates
Duke Virtual IntEgrated Workflow
This quality improvement initiative aims to evaluate the implementation, utilization, and impact of virtual care technologies and workflows being implemented at Duke University Health System (DUHS).
- Conditions
- Falls Injury, Readmission Rates, CLABSI - Central Line Associated Bloodstream Infection, Catheter Associated Urinary Tract Infection
- Trial name
- Duke VIEW (NCT07406074)
- Testing
- Co-Care
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- Duke University
Pseudomonas Infections, Pseudomonas Septicemia
Monocyte Profiles in Critically Ill Patients With Pseudomonas Aeruginosa Sepsis
The present study focuses on patients with Pseudomonas aeruginosa (PSA) sepsis. The aim of the present study is to find out whether the M1 (pro-inflammatory) or M2 (anti-inflammatory) phenotype predominates in blood monocytes in…
- Conditions
- Pseudomonas Infections, Pseudomonas Septicemia, Pseudomonas; Pneumonia, Pseudomonal Bacteraemia
- Trial name
- MIPSA (NCT03044223)
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Ulm
Pneumonia - Bacterial, Urinary Tract Infection Bacterial
Clinical Impact of a Machine Learning Decision Support System for Empirical Antibiotic Therapy
The goal of this quasi-experimental study is to analyze if a Machine Learning Clinical Decision Support System can improve the empirical antibiotic treatment in patients with pneumonia, urinary tract infection and / or sepsis.
- Conditions
- Pneumonia - Bacterial, Urinary Tract Infection Bacterial, Bloodstream Infection
- Trial name
- NCT07762378
- Testing
- Machine Learning Decision Support System
- Volunteers
- 486 people
- Sponsor
- Instituto de Investigación Sanitaria Gregorio Marañón
Urinary Tract Infections, Bacteremia
Pivmecillinam With Amoxicillin/Clavulanic Acid for Step Down Oral Therapy in ESBL UTIs
To evaluate if the combination of pivmecillinam and clavulanic acid (PAC) is non-inferior to ciprofloxacin, trimethoprim-sulfamethoxazole or ertapenem as step down oral therapy in patients with febrile UTI caused by extended…
- Conditions
- Urinary Tract Infections, Bacteremia, Antibiotic Resistant Infection
- Trial name
- PACUTI (NCT05224401)
- Testing
- Pivmecillinam and amoxicillin/clavulanic acid, Standard treatment, ciprofloxacin, trimethoprim/sulfamethoxazole or ertapenem depending on susceptibility
- Where
- 5 sites in Sweden
- Volunteers
- 330 people
- Sponsor
- Lund University
Kidney Stones, Nephrolithiasis
DISS vs FANS in Suction-Assisted RIRS for Medium-Sized Renal Stones
Kidney stones are a common health problem and may recur frequently, which can affect quality of life and kidney function. Retrograde intrarenal surgery (RIRS) is a minimally invasive treatment used for renal stones, but treatment…
- Conditions
- Kidney Stones, Nephrolithiasis, Renal Calculi
- Trial name
- NCT07516535
- Testing
- Direct In-Scope Suction, Flexible and Navigable Suction Ureteric Access Sheath
- Where
- Egypt
- Volunteers
- 126 people
- Sponsor
- Ain Shams University
Ventilator Acquired Pneumonia, Catheter Related Bloodstream Infection
Effect of Use of Probiotics on Systemic Infection in Critically Ill Patients: a Double Blind, Randomized, Placebo-controlled Trial
The primary goal of this study is to assess the benefit of probiotics in preventing or minimizing of various type of systemic infection in critically ill adult patients.
- Conditions
- Ventilator Acquired Pneumonia, Catheter Related Bloodstream Infection, Urinary Tract Infection, Diarrhea
- Trial name
- NCT07164781
- Testing
- Bacillus clausii, Sugar tablets
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Benha University
Catheter Associated Urinary Tract Infection
REPLACE: The Impact of Catheter Replacement in Patients With Catheter-associated Urinary Tract Infection
With this project the investigators aim to address the following question: "Is it beneficial to change bladder catheters during urinary tract infections?" There is debate regarding the usefulness of changing an indwelling…
- Trial name
- NCT06936631
- Testing
- Catheter replacement, Catheter retainment
- Where
- Netherlands
- Volunteers
- 300 people
- Sponsor
- Leiden University Medical Center