Clinical trials: Urinary Lithiasis, open to volunteers
Kidney Calculi, Ureteral Calculi
New Laser and Suction Sheath for Kidney Stone Treatment
The goal of this clinical trial is to learn if the combination of super pulsed thulium fiber laser (sTFL) with a flexible negative pressure suction sheath is more effective and safer than sTFL with a conventional sheath in…
- Trial name
- NCT06667466
- Testing
- Super Pulsed Thulium Fiber Laser (sTFL) + Flexible Negative Pressure Ureteral Access Sheath (UAS) Intervention, Super Pulsed Thulium Fiber Laser (sTFL) + Conventional Ureteral Access Sheath (UAS) Intervention
- Volunteers
- 140 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Renal Stone, Stone in Calyceal Diverticulum
Retrograde Intrarenal Surgery Versus Extracorporeal Shockwave Lithotripsy
The study's aim is to determine which treatment modality, either ESWL or RIRS, is more effective in achieving stone clearance for lower calyceal calculi.
- Trial name
- NCT07510178
- Testing
- Retrograde intrarenal surgery, Extracorporeal shock wave lithotripsy
- Where
- Pakistan
- Volunteers
- 66 people
- Sponsor
- Sindh Institute of Urology and Transplantation
Pediatric Urolithiasis, Distal Ureteral Stone
Intravesical Aminophylline to Facilitate Ureteroscopic Access in Children With Distal Ureteral Stones.
This study will evaluate whether intravesical aminophylline can facilitate semi-rigid ureteroscopic access in children with distal ureteral stones when the first gentle attempt to enter the ureter is unsuccessful.
- Conditions
- Pediatric Urolithiasis, Distal Ureteral Stone, Ureteral Calculi
- Trial name
- NCT07617896
- Testing
- Aminophylline
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Beni-Suef University
Kidney Stones, Nephrolithiasis
DISS vs FANS in Suction-Assisted RIRS for Medium-Sized Renal Stones
Kidney stones are a common health problem and may recur frequently, which can affect quality of life and kidney function. Retrograde intrarenal surgery (RIRS) is a minimally invasive treatment used for renal stones, but treatment…
- Conditions
- Kidney Stones, Nephrolithiasis, Renal Calculi
- Trial name
- NCT07516535
- Testing
- Direct In-Scope Suction, Flexible and Navigable Suction Ureteric Access Sheath
- Where
- Egypt
- Volunteers
- 126 people
- Sponsor
- Ain Shams University
Kidney Calculi
Ureteroscopy Combined With Negative Pressure Sheath Treatment of Kidney Stones
The removal rate, complication risk and operation time of ureteral soft scope combined with negative pressure suction sheath therapy for patients with high-load kidney stones (2-3cm) are still controversial.
- Trial name
- NCT06938113
- Where
- China
- Volunteers
- 115 people
- Sponsor
- Peking University First Hospital
Renal Stones
Efficacy and Safety of Flexible Ureteroscopy Versus Percutaneous Nephrolithotomy in Management of Staghorn Stones
Percutaneous nephrolithotomy (PCNL) is considered the treatment of choice for management of large renal calculi larger than 2 cm based on the yearly updated European Association of Urology (EAU) guidelines.
- Trial name
- NCT07322471
- Testing
- Percutaneous nephrolithotomy, Flexible ureteroscopy
- Where
- Egypt
- Volunteers
- 138 people
- Sponsor
- Menoufia University
Renal Calculi, Urinary Calculi
Break Wave(TM) Extracorporeal Lithotripter First-in-Human Study
This is a prospective, open-label, multi-center, single-arm (non-randomized) study to assess the safety and effectiveness of breaking stones in the upper urinary tract using the SonoMotion Break Wave technology.
- Trial name
- NCT03811171
- Testing
- Break Wave extracorporeal lithotripsy
- Where
- 6 sites in United States, Canada
- Volunteers
- 70 people
- Sponsor
- SonoMotion
Urolithiasis, Stones, Kidney
Stone Clearance With Aspiration vs Other Technologies: a Real-world Evidence Study
The goal of this clinical trial is to evaluate the effectiveness and safety of Steerable Ureteroscopic Renal Evacuation (SURE) with the CVAC System versus other commonly used renal-stone interventions.
- Conditions
- Urolithiasis, Stones, Kidney, Renal Stones, Kidney Stones
- Trial name
- SCORE (NCT07155005)
- Testing
- CVAC® SYSTEM, FLEXIBLE AND NAVIGATIONAL URETERAL ACCESS SHEATH (FANS) IN FLEXIBLE URETEROSCOPY (FURS), DIRECT IN-SCOPE SUCTION (DISS) IN FLEXIBLE URETEROSCOPY (FURS)
- Where
- 10 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Calyxo, Inc.
Kidney Stone, Kidney Calculi
Outcomes of Using FANS With FURS in TTT of Lower Calyceal Stones.
The aim of this study is to evaluate and assess the outcomes of flexible ureteroscopy (FURS) with flexible and navigable suction UAS (FANS) in the treatment of lower calyceal stones.
- Trial name
- NCT07238803
- Testing
- flexible and navigable suction sheath with flexible ureteroscopy
- Where
- Egypt
- Volunteers
- 33 people
- Sponsor
- Zagazig University
Kidney Calculi, Ureteral Calculi
Impact of Humid-Heat on Gut-Tryptophan-Stone Pathway
Investigating the differences in gut microbiota composition and tryptophan metabolite levels between kidney stone patients and healthy individuals, with special focus on: 1.
- Trial name
- NCT07043374
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Kidney Stone, Ureteric Stone
Safety and Efficacy of Combination of Tamsulosin 0.4 mg Plus Tadalafil 5mg Versus 2.5 mg
Ureteral stenting is a common urological procedure performed to relieve obstruction and facilitate urinary drainage. Despite its effectiveness, stent-related symptoms (SRS) such as dysuria, frequency, urgency, flank pain, and…
- Trial name
- NCT07562282
- Testing
- Tamsulosin
- Where
- Egypt
- Volunteers
- 140 people
- Sponsor
- Ain Shams University
Renal Calculi
Using Retrograde Intrarenal Surgery for Managing Staghorn Renal Stones.
This prospective, randomized study is comparing the safety and efficacy of using two types of ureteral access sheaths in managing staghorn renal stones by retrograde intrarenal surgery.
- Trial name
- NCT07342361
- Testing
- Retrograde intrarenal surgery
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Helwan University
Urolithiasis, Strategy Training
Real-World Study of Obstructive Upper Urinary Tract Stones and Acute Pyelonephritis
Upper urinary tract stone obstruction complicated by acute pyelonephritis is a critical urological emergency requiring urgent decompression and infection control, yet real-world clinical decisions regarding the choice between…
- Conditions
- Urolithiasis, Strategy Training, Observation, Pyelonephritis Acute
- Trial name
- NCT07816991
- Testing
- Ureteral Stent, Percutaneous Nephrostomy, Initial Medical Therapy
- Volunteers
- 1,650 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Renal Calculi, Nephrolithiasis
Comparison Between Different Types of Flexible Ureteroscopes
The current study aims to compare the performance of three distinct single-use digital flexible ureteroscope types in terms of cost-effectiveness, postoperative complications, operating time, and stone-free rates (SFRs).
- Trial name
- FURS (NCT07360353)
- Testing
- LithoVue™ (Boston Scientific Corporation), WiScope® (OTU Medical Inc. (Silicon Valley, USA)), Single-Use Ureterorenoscope (Scivita Medical Technology Co., Ltd.)
- Where
- Egypt
- Volunteers
- 180 people
- Sponsor
- Ain Shams University
Pediatric Bladder Stones, Bladder Calculi
Vacuum-Assisted Mini-Percutaneous Versus Transurethral Cystolithotripsy in Pediatric Bladder Stones
This prospective randomized pilot study will compare vacuum-assisted mini-percutaneous cystolithotripsy with standard transurethral cystolithotripsy for the treatment of bladder stones in children.
- Conditions
- Pediatric Bladder Stones, Bladder Calculi, Pediatric Urolithiasis
- Trial name
- VAMPCL-Ped (NCT07614880)
- Testing
- Vacuum-Assisted Mini-Percutaneous Cystolithotripsy, Transurethral Cystolithotripsy
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Beni-Suef University
Kidney Stone, Healthy
Oxalate and Citrate in Humans - Response to Citrate
This is a single-center study that aims to learn more about how two compounds found in food, oxalate and citrate, interact in the body and may influence a person's chances of forming kidney stones.
- Trial name
- NCT06944223
- Testing
- Kidney stone formers, Control cohort
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Kidney Stone, Normal Controls
Oxalate and Citrate
This is a single-center study that aims to earn more about how two different compounds found in food, oxalate and citrate, may affect a person's chances of forming kidney stones.
- Trial name
- NCT05334979
- Testing
- Kidney stones Normal controls Consuming a special drink (sodium oxalate) during an all day visit to the University of Chicago research clinic
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Urologic Injuries, Kidney Disease
The Clinical Research of Traditional Chinese Medicine Formula
This study examines the efficacy and safety of Bushen Huoxue Simiao formula for tonifying the kidneys and promoting blood circulation in treating postoperative complications of upper urinary tract stones, thereby providing…
- Trial name
- NCT07746219
- Testing
- Bushen Huoxue Simiao Formula, control group
- Volunteers
- 80 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Nephrolithiasis, Kidney Stone
Observational Approach Versus Surgical Intervention for Stones
The aims of the Observational Approach versus Surgical Intervention for Asymptomatic Stone (OASIS) trial are: 1) to determine whether observation compared to upfront surgery results in less healthcare-related life disruption due…
- Trial name
- OASIS (NCT07718802)
- Testing
- Surgery, Observation
- Where
- 4 sites in United States
- Volunteers
- 1,658 people
- Sponsor
- Children's Hospital of Philadelphia
Pediatric Urolithiasis, Ureteral Stent-Related Symptoms
Comparison of Ureteral Stent Designs in Children With Kidney Stones
This study will compare two commonly used ureteral stents in children and adolescents undergoing staged treatment for kidney stones.
- Trial name
- NCT07742358
- Testing
- Polaris Ultra Ureteral Stent, Cook Double-J Ureteral Stent
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- The Hospital for Sick Children