Clinical trials: Urinary Stone
Ureteral Stones, Ureteroscopic Lithotripsy
Ureteroscope Caliber and Surgeon Stress
This study aims to compare the efficacy, success rates, and stone-free rates of endoscopic ureteral stone treatment performed using two different sizes of ureteroscopes.
- Trial name
- NCT06935500
- Testing
- endoscopic ureteric lithotripsy
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people
- Sponsor
- Aydin Adnan Menderes University
Obesity
Obesity and Endogenous Oxalate Synthesis
The goal of this study is to determine if obesity is associated with increased endogenous oxalate synthesis as assessed by urinary oxalate excretion, which is a known risk factor for calcium oxalate kidney stones.
- Trial name
- NCT03808090
- Testing
- Normal Individuals
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Nephrolithiasis
Effect of Antihistamines on Ureteral Stent-Related Symptoms
This is a prospective, double-blind, randomized, open-label, single-center trial of up to 78 participants who are adult patients (aged 18-80 years) and are undergoing unilateral retrograde ureteroscopy with planned ureteral stent…
- Trial name
- NCT04726345
- Testing
- Fexofenadine Hcl 180Mg Tab
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Columbia University
Cystinuria
Lipoic Acid Supplement for Cystine Stone
This study evaluates how daily alpha lipoic acid supplementation affects cystine kidney stone recurrence. Half of the subjects will receive 1200 mg alpha lipoic acid orally daily for three years, while the other half will receive…
- Trial name
- ALA (NCT02910531)
- Testing
- Alpha lipoic acid
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Thomas Chi, MD
Calcium Phosphate Kidney Stones
Treatment for Calcium Phosphate Kidney Stone Disease
The investigators will examine in two studies whether citric acid or potassium citrate can reduce calcium phosphate saturation in urine of Calcium Phosphate stone formers.
- Trial name
- NCT01754779
- Testing
- Citric Acid, Potassium Citrate
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Texas Southwestern Medical Center
Ureteral Stone
Temperature Profiles During Laser Activation in Ureteroscopic Lithotripsy
The primary aim of this study is to investigate the temperature profiles in the renal pelvis during ureteroscopic Thulium Fiber Laser activation using different settings.
- Trial name
- NCT05677425
- Testing
- Temperature measurement
- Where
- Norway
- Volunteers
- 10 people
- Sponsor
- Haukeland University Hospital
Kidney Stones
Eye Gaze Guidance Evaluation in Phantoms
This project aims to develop an augmented reality (AR) tool to enhance skill acquisition for endoscopic kidney stone surgery. Of the 100,000 patients who undergo an endoscopic kidney stone treatment annually in the United States…
- Trial name
- NCT07174479
- Testing
- Augmented reality
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Nephrolithiasis, Hyperoxaluria
Use of Oral Probiotics to Reduce Urinary Oxalate Excretion
The purpose of this study was to determine the effect of two probiotic preparations (Agri-King Synbiotic and Oxadrop) on urinary oxalate excretion in patients with mild hyperoxaluria.
- Conditions
- Nephrolithiasis, Hyperoxaluria, Crohn's Disease
- Trial name
- NCT00587041
- Testing
- Oxadrop, Agri-King Synbiotic (AKSB)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Mayo Clinic
Renal Stones, Kidney Stone
CLinical Evaluation of Aspiration for Removal ANd ClearancE of Stones
The purpose of the study is to assess safety and efficacy of a novel steerable ureteral catheter system, the CVAC System for the treatment of urinary stones.
- Conditions
- Renal Stones, Kidney Stone, Urolithiasis
- Trial name
- CLEARANCE (NCT06615713)
- Testing
- Steerable Ureteroscopic Renal Evacuation (SURE) with the CVAC System
- Where
- India
- Volunteers
- 30 people
- Sponsor
- Calyxo, Inc.
Kidney Stone, Renal Stone
Antibiotic Selection Using Next Generation Sequencing vs Urine Culture
This is a randomized controlled clinical study evaluating the use of next-generation sequencing (NGS) to improve antibiotic prescribing before ureteroscopy or percutaneous nephrolithotomy.
- Conditions
- Kidney Stone, Renal Stone, Infection, Bacterial
- Trial name
- ACCESS (NCT04404855)
- Testing
- NGS + Antibiotic Recommendation, Standard of Care treatment
- Where
- 3 sites in United States
- Volunteers
- 240 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Flank Pain, Urinary Bladder, Overactive
Therapeutic Merit of Solifenacin in the Mitigation of Ureteral Stent-induced Pain and Lower Urinary Tract Symptoms
Most ureteral stent insertions follow ureteroscopy procedures for stone management. Stents are essentially designed to prevent the blockage of the ureter.
- Trial name
- NCT01381120
- Testing
- Solifenacin succinate treatment, Oxycodone and acetaminophen combination treatment
- Where
- Canada
- Volunteers
- 84 people
- Sponsor
- Barrie Urology Associates
Urinary Stones
Acoustic Enhancer Research on Laser Lithotripsy (AEROLITH)
A pivotal study to evaluate the safety and effectiveness of Applaud Acoustic Enhancer when used in conjunction with conventional ureteroscopic laser lithotripsy (URS-LL) in the treatment of subjects with urinary stones.
- Trial name
- AEROLITH (NCT04563039)
- Testing
- Ureteroscopy Laser Lithotripsy (URS-LL) with Acoustic Enhancer, Standard Ureteroscopic Laser Lithotripsy
- Where
- 23 sites in United States
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Avvio Medical
Nephrolithiasis, Urolithiasis
Perioperative Pregabalin in Ureteroscopy: a Pilot
The investigators propose a pilot clinical trial on the use of perioperative pregabalin in order to decrease ureteral stent related symptoms and decrease opioid usage after ureteroscopy with stent placement.
- Conditions
- Nephrolithiasis, Urolithiasis, Perioperative/Postoperative Complications, Pain, Postoperative
- Trial name
- NCT03927781
- Testing
- Pregabalin 300mg
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Missouri-Columbia
Renal Colic, Kidney Stone
Erector Spinae Plane Block for Uncomplicated Renal Colic
This research study is to determine how well the Erector Spinae Plane Block (ESPB) works for kidney stone pain and any possible side effects.
- Trial name
- NCT05625802
- Testing
- Erector Spinae Plane Block (ESPB), Ropivacaine
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Michigan
Kidney Stones
Trial Comparing Three Different Devices for Kidney Stone Removal During Percutaneous Surgery
The investigators plan to compare three different devices that are used to break up large kidney stones during surgery for removal to see if one is faster or more efficient than the others.
- Trial name
- NCT00952315
- Testing
- Cyberwand, Stonebreaker, Lithoclast Select
- Where
- 10 sites in United States, Canada
- Volunteers
- 270 people
- Sponsor
- Indiana Kidney Stone Institute
Calcium Oxalate Urolithiasis
Oxalobacter Formigenes Colonization and Urinary Oxalate Excretion
The purpose of this research study is to assess the efficacy of ingesting a small amount of the harmless bacterium Oxalobacter formigenes in establishing residence in the guts of healthy participants and to determine whether this…
- Trial name
- NCT03752684
- Testing
- Moderately high oxalate/low calcium diet non-colonized, Oxalobacter formigenes, Moderately high oxalate/low calcium diet colonized
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Hyperuricosuria, Kidney Stones
Febuxostat Versus Allopurinol or Placebo in Patients With Hyperuricosuria and Calcium Oxalate Stones
The purpose of this study is to determine the efficacy of febuxostat, once daily (QD), compared to allopurinol or placebo in patients with excessive amounts of uric acid in their urine and who have recently had kidney stones.
- Trial name
- NCT01077284
- Testing
- Febuxostat, Allopurinol
- Where
- 28 sites in United States
- Volunteers
- 99 people
- Sponsor
- Takeda
Kidney Stones
Trial Comparing Dual Probe Ultrasonic Lithotripsy to a Single Probe Ultrasonic Lithotripsy
Percutaneous nephrolithotomy (PNL), in conjunction with intracorporeal lithotripsy, allows for the rapid removal of any kidney stone regardless of size.
- Trial name
- NCT00351351
- Testing
- Cyberwand, single probe ultrasonic
- Where
- 7 sites in United States, Canada
- Volunteers
- 70 people
- Sponsor
- Indiana Kidney Stone Institute
Kidney Stone
Effect of Tamsulosin on Stone Expulsion and Pain Resolution in ED Patients With Ureterolithiasis
Tamsulosin (Flowmax)is approved by the FDA for the treatment for enlarged prostate. Several studies regarding the use of Tamsulosin for the treatment of lower kidney stones have been carried out in the non-Emergency Department…
- Trial name
- Flowmax (NCT00762424)
- Testing
- Flowmax
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- WellSpan Health
Kidney Stone
Opioid Free Management After Ureteroscopy
The purpose of this research study is to compare how well two medications work to control post-operative pain.
- Trial name
- NCT03872843
- Testing
- Norco 5milligram-325milligram Tablet, Ibuprofen 400 MILLIGRAM in 1 TABLET ORAL TABLET, FILM COATED
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Wake Forest University Health Sciences