Clinical trials: Urinary Stones
Cystinuria
TCUPS- Tolvaptan Use in Cystinuria and Urolithiasis: A Pilot Study
The goal of this research project is to establish that in short-term use, tolvaptan is a safe and potentially effective new therapy for cystinuria, by conducting a short-term pilot study of the safety and tolerability of this…
- Trial name
- TCUPS (NCT02538016)
- Testing
- Tolvaptan
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Caleb Nelson
Nephrolithiasis
Pain Outcomes of Non-opioid vs. Opioid Analgesia for Kidney Stone Surgery.
There are two options for postoperative pain management: opioid and non-opioid analgesia. Pain outcomes will be compared in patients undergoing ureteroscopy and percutaneous nephrolithotomy by randomly administering opioid and…
- Trial name
- PO-NOA (NCT03584373)
- Testing
- Ketorolac Oral Tablet [Toradol], Acetaminophen, Oxycodone Acetaminophen
- Where
- 2 sites in United States
- Volunteers
- 119 people
- Sponsor
- Montefiore Medical Center
Ureteral Stone
Temperature Profiles During Laser Activation in Ureteroscopic Lithotripsy
The primary aim of this study is to investigate the temperature profiles in the renal pelvis during ureteroscopic Thulium Fiber Laser activation using different settings.
- Trial name
- NCT05677425
- Testing
- Temperature measurement
- Where
- Norway
- Volunteers
- 10 people
- Sponsor
- Haukeland University Hospital
Hyperoxaluria, Nephrolithiasis
Evaluating ALLN-177 for Reducing Urinary Oxalate Excretion in Calcium Oxalate Kidney Stone Formers With Hyperoxaluria
The purpose of this study is to evaluate the effect of ALLN-177 to reduce urinary oxalate excretion in patients with recurring kidney stones and enteric or idiopathic hyperoxaluria.
- Trial name
- NCT02289755
- Testing
- ALLN-177
- Where
- 4 sites in United States
- Volunteers
- 16 people
- Sponsor
- Allena Pharmaceuticals
Calcium Phosphate Kidney Stones
Treatment for Calcium Phosphate Kidney Stone Disease
The investigators will examine in two studies whether citric acid or potassium citrate can reduce calcium phosphate saturation in urine of Calcium Phosphate stone formers.
- Trial name
- NCT01754779
- Testing
- Citric Acid, Potassium Citrate
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Texas Southwestern Medical Center
Urolithiasis
A Prospective Comparison of Fluoroscopic, Sonographic or Combined Approach for Renal Access in Percutaneous Nephrolithotomy
Purpose: The aim of this present study is to compare the result of fluoroscopy, ultrasonography (US) and US combined with fluoroscopy in the guidance of minimally invasive percutaneous nephrolithotomy (MPCNL).
- Trial name
- NCT02266381
- Testing
- US-guided renal access, Fluoroscopy-guided renal access, US combined with fluoroscopy-guided renal access
- Where
- China
- Volunteers
- 450 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Kidney Stones, Ureteral Stones
The Efficacy of Tamsulosin in the Treatment of Ureteral Stones in Emergency Department Patients
To determine if emergency department patients with acute ureteral colic pain due to a ureteral stone who are treated with tamsulosin, versus placebo, will experience a shorter time to passage of their stone or resolution of their…
- Trial name
- NCT00448123
- Testing
- Tamsulosin
- Where
- United States
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- Robert Swor
Flank Pain, Urinary Bladder, Overactive
Therapeutic Merit of Solifenacin in the Mitigation of Ureteral Stent-induced Pain and Lower Urinary Tract Symptoms
Most ureteral stent insertions follow ureteroscopy procedures for stone management. Stents are essentially designed to prevent the blockage of the ureter.
- Trial name
- NCT01381120
- Testing
- Solifenacin succinate treatment, Oxycodone and acetaminophen combination treatment
- Where
- Canada
- Volunteers
- 84 people
- Sponsor
- Barrie Urology Associates
Nephrolithiasis
Hydrochlorothiazide for Kidney Stone Recurrence Prevention
The investigators plan to assess the efficacy of standard and low dose HCTZ treatment in the recurrence prevention of calcium-containing kidney stones.
- Trial name
- NOSTONE (NCT03057431)
- Testing
- 12.5 mg hydrochlorothiazide, 25.0 mg hydrochlorothiazide, 50.0 mg hydrochlorothiazide
- Where
- 12 sites in Switzerland
- Volunteers
- 416 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Nephrolithiasis
Evaluation of a Nonopioid Recovery Pathway Following Surgery for Kidney Stones
Evaluation of a nonopioid recovery pathway after percutaneous nephrolithotomy is a pragmatic pilot study that will apply the knowledge and experience gained with development of an outpatient opioid reduction protocol to…
- Trial name
- NCT04597619
- Testing
- Novel Nonopioid Pathway
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- The Miriam Hospital
Kidney Calculi
Stone Access and Removal (STAR) Study
The purpose of the study is to assess procedural completion, the post-operative stone clearance and the safety profile following robotic mini-Percutaneous Nephrolithotomy (PCNL) performed with the MONARCH Platform, Urology.
- Trial name
- STAR (NCT06330701)
- Testing
- Robotic-assisted mini-PCNL
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Auris Health, Inc.
Ureteral Obstruction, Flank Pain
Mirabegron as Medical Expulsive Therapy (MET) for Ureteral Stones and Ureteral Stent Pain
The study will be a prospective randomized double-blind placebo-controlled trial of mirabegron for medical expulsive therapy (MET) in patients with a CT (Computed Tomography) scan-proven ureteral stone between 4 to 10 mm…
- Trial name
- NCT02744430
- Testing
- Mirabegron
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Baylor College of Medicine
Hyperuricosuria, Kidney Stones
Febuxostat Versus Allopurinol or Placebo in Patients With Hyperuricosuria and Calcium Oxalate Stones
The purpose of this study is to determine the efficacy of febuxostat, once daily (QD), compared to allopurinol or placebo in patients with excessive amounts of uric acid in their urine and who have recently had kidney stones.
- Trial name
- NCT01077284
- Testing
- Febuxostat, Allopurinol
- Where
- 28 sites in United States
- Volunteers
- 99 people
- Sponsor
- Takeda
Renal Stones, Kidney Stone
CLinical Evaluation of Aspiration for Removal ANd ClearancE of Stones
The purpose of the study is to assess safety and efficacy of a novel steerable ureteral catheter system, the CVAC System for the treatment of urinary stones.
- Conditions
- Renal Stones, Kidney Stone, Urolithiasis
- Trial name
- CLEARANCE (NCT06615713)
- Testing
- Steerable Ureteroscopic Renal Evacuation (SURE) with the CVAC System
- Where
- India
- Volunteers
- 30 people
- Sponsor
- Calyxo, Inc.
Pain, Acute Postoperative, Renal Stone
Continuous Erector Spinae Plane Blocks to Treat Pain Following Percutaneous Nephrolithotomy
This is a randomized, triple-masked, placebo-controlled parallel-arm human subjects clinical trial investigating the addition of a continuous erector spinae plane nerve block to a single-injection erector spinae plane block to…
- Trial name
- NCT05121168
- Testing
- Active bupivacaine 0.25% via an erector spinae plane perineural catheter
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Diego
Kidney Calculi
MOSES Lithotripsy Technology Applied to Stone Fragmentation During Ureteroscopy
To determine if the effects of MOSES laser modulation technology can improve the safety and efficiency to laser fragmentation resulting in decreased total laser time, reduced potential for injury to the patient, and total OR time…
- Trial name
- NCT03995758
- Testing
- MOSES
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- Indiana University
Ureterolithiases
Tamsulosin for Urolithiasis in the Emergency Dept
Urolithiasis is a disease that effects 12% of the population and its incidence is growing. In the US there are over 1.1 million visits annually to Emergency Departments for renal colic.
- Trial name
- STONE (NCT00382265)
- Testing
- tamsulosin
- Where
- 4 sites in United States
- Volunteers
- 512 people
- Sponsor
- Andrew Meltzer
Urinary Lithiasis, Kidney Diseases
Toradol to Reduce Ureteroscopic Symptoms Trial
Double blinded randomized controlled clinical trial to assess the impact of intraoperative Toradol on post-operative pain scores for patients undergoing ureteroscopy for urinary stone management.
- Conditions
- Urinary Lithiasis, Kidney Diseases, Kidney Stone, Pain, Postoperative
- Trial name
- TRUST (NCT03111381)
- Testing
- Toradol
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Yale University
Kidney Stone, Ureteral Calculi
Noninvasive Electrical Stimulator as a Pain Control Treatment Post-ureteroscopy
The investigators will assess the use of Transcutaneous Neurostimulation (TENS), a pharmacological alternative, for treatment of ureteral stent pain post-ureteroscopy.
- Conditions
- Kidney Stone, Ureteral Calculi, Nephrolithiasis
- Trial name
- NCT05153629
- Testing
- TENS
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Stanford University
Urolithiasis
Feasibility of Using sipIT Tools to Increase Compliance With Fluid Consumption Guidelines in Urolithiasis-Prone Subjects
The purpose of this study is to examine the feasibility of using sipIT tools (i.e., wrist-worn sensors, smart water bottles, mobile applications) to increase compliance with physician-recommended fluid consumption guidelines in…
- Trial name
- sipIT (NCT03787615)
- Testing
- sipIT tools
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Penn State University