Clinical trials: Urinary Tract Disease
Hyponatremia
Study of Ascending Levels of Tolvaptan in Hyponatremia
The purpose of this study was to determine whether tolvaptan can safely and effectively return the body's balance of sodium and water toward normal and to characterize and quantify the potential clinical benefits of this…
- Trial name
- SALT2 (NCT00201994)
- Testing
- Tolvaptan
- Where
- Germany
- Volunteers
- 243 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
End Stage Renal Disease
Modeling of Regional Citrate Anticoagulation With a Dialysate Containing Calcium in Intermittent Hemodialysis (MARC)
The primary purpose of this study is to validate a mathematical modeling of treatment by intermittent hemodialysis using regional citrate anticoagulation with a dialysate containing calcium
- Trial name
- MARC (NCT04530175)
- Testing
- blood sampling
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Clermont-Ferrand
Chronic Kidney Disease
OPTIMISE-CKD Drug Utilization
This is a multi-national, observational study program using secondary data sources to address research questions related to 1) real-world dapagliflozin utilisation in CKD and potential for further utilisation, 2), the current CKD…
- Trial name
- OPTIMISE-CKD (NCT05932901)
- Where
- 5 sites in United States, Japan and 1 more
- Volunteers
- 2,682,052 people
- Sponsor
- AstraZeneca
Brain Tumor, Kidney Tumor
Engineering Immune Organoids to Study Pediatric Cancer
To engineer immune organoids from pediatric patient tissues using induced-pluripotent stem cells (iPSC)
- Conditions
- Brain Tumor, Kidney Tumor, Neuroblastoma, Sarcoma
- Trial name
- IMMUNEORGANOID (NCT05890781)
- Testing
- Skin biopsy, Fresh tumor sample, Blood sample
- Where
- 2 sites in France
- Volunteers
- 108 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Septic Shock
Hypotension in the Weaning From Vasopressor Drugs
Although there is consensus in the literature on hemodynamic management of septic shock in the resuscitation phase, the best way to conduct the weaning of vasopressor drugs in the stabilization phase remains open.
- Trial name
- RENOVA (NCT05506319)
- Testing
- Norepinephrine, Vasopressin
- Where
- Brazil
- Volunteers
- 78 people
- Sponsor
- Hospital Nossa Senhora da Conceicao
Type 2 Diabetes, Kidney Disease
Efficacy of the Use of Real-time Continuous Glucose Monitoring on Glycemic Control in Patients With Type 2 Diabetes and Stage 3 and 4 Chronic Kidney Disease.
Rationale: Glucose control in patients with kidney disease is challenging, as traditional metrics can be unreliable and there is a high risk of hypoglycemia (low blood sugar).
- Conditions
- Type 2 Diabetes, Kidney Disease, CGM, Time in Range
- Trial name
- NCT07668219
- Testing
- Real time continuos glucose monitoring, self blood glucose monitoring
- Where
- Colombia
- Volunteers
- 30 people
- Sponsor
- Hospital Universitario San Ignacio
Benign Prostate Obstruction (BPO)
The Effects of Holmium Laser Enucleation and Thulium Laser Enucleation on Continence, Urethral Stricture, and Sexual Function in Benign Prostatic Hyperplasia
This study aims to evaluate the effects of Holmium Laser Enucleation of the Prostate (HoLEP) and Thulium Laser Enucleation of the Prostate (ThuLEP), performed for the treatment of benign prostatic hyperplasia (BPH), on the…
- Trial name
- EHTCUS (NCT07334730)
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- TC Erciyes University
Renal Cell Cancer
A Study Evaluating the Effect of Pembrolizumab (MK-3475) in Participants With Renal Cell Cancer (MK-3475-031)
This study will examine the effect of treatment with the neoadjuvant antibody pembrolizumab (MK-3475) on tumors of participants with renal cell cancer (RCC).
- Trial name
- NCT02212730
- Testing
- Pembrolizumab Pre-Resection, Surgical Resection, Pembrolizumab Post-Resection
- Volunteers
- 10 people
- Sponsor
- Merck Sharp & Dohme LLC
Worsening Chronic Heart Failure, Chronic Kidney Disease
A Study to Learn How BAY94-8862 Moves Into, Through and Out of the Body, How Safe it is and How it Affects the Body in Adult Participants With Reduced Kidney Function and in Healthy Participants With Similar Age, Weight and Gender Distribution
Researchers are looking for a better way to treat people who have worsening of chronic heart failure, a long-term condition where the heart does not pump blood as well as it should.
- Trial name
- NCT04908436
- Testing
- Finerenone (BAY94-8862)
- Where
- Germany
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Bayer
Bladder Tumour, Prostate Hyperplasia
Clasic Laryngeal Mask Airway(C-LMA) and I-gel Releated Regurgitation and Complications
1. i-gel 2. C-LMA Compare the effect on gastroeosephageal reflux Postoperative complicatios.
- Trial name
- C-LMA (NCT01876836)
- Testing
- i-gel, C-LMA
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Diskapi Yildirim Beyazit Education and Research Hospital
Renal Disease, Chronic
Comparison of Infraclavicular Brachial Plexus Block and Local Anesthesia in Arteriovenous Fistula Surgeries and Their Effects on Tissue Oxygen Saturation
In arteriovenous fistula surgery, the effect of infraclavicular brachial plexus block and local anesthesia on tissue oxygenation and the effect of primary patency of the AV fistula is intended to research.
- Trial name
- NCT06416111
- Testing
- NIRS, Pinprick Test, Modified Bromage Scale
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ankara City Hospital Bilkent
Bone Disorder, Chronic Kidney Diseases
Effect of Active Vitamin D and Etelcalcetide on Human Osteoclasts in Patients With Chronic Kidney Disease
The optimal management of mineral and bone disorders associated to chronic kidney disease (CKD-MBD) is a daily challenge for nephrologists.
- Trial name
- RENOCLASTE (NCT03527511)
- Testing
- Measure of etecalcetide on osteoclastic biology
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Hospices Civils de Lyon
Fanconi Anemia Complementation Group A, Fanconi Anemia
Long-Term Follow-up of Subjects With Fanconi Anaemia Subtype A Treated With ex Vivo Gene Therapy
This is a long-term safety and efficacy follow-up study for subjects with Fanconi Anaemia Subtype A who have been treated with ex vivo gene therapy on the FANCOLEN-I trial.
- Trial name
- NCT04437771
- Testing
- Safety and efficacy assessments
- Where
- Spain
- Volunteers
- 9 people
- Sponsor
- Rocket Pharmaceuticals Inc.
Renal Cell Carcinoma, Advanced
Neoantigen Peptide Vaccine Plus Pembrolizumab in Renal Cell Carcinoma
This is a Phase I, single-center, open-label, single-arm clinical trial to evaluate the safety and efficacy of personalized neoantigen polyepitope peptide vaccine combined with pembrolizumab in patients with advanced, recurrent…
- Conditions
- Renal Cell Carcinoma, Advanced, Recurrent, Refractory
- Trial name
- NPVPP (NCT07686744)
- Testing
- Personalized Neoantigen Polyepitope Peptide Vaccine
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Jian Lin
Acute Kidney Failure
Protocol to Assess the Severity of Acute Kidney Injury
The principal objective is to safely determine if we can identify the severity of Acute Kidney Injury (AKI) early in the course of the disease. Once enrolled, we will draw blood and urine for relevant biomarkers.
- Trial name
- AKI (NCT00673244)
- Testing
- Furosemide
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- George Washington University
Renal Impairment
Evaluation of Effect of Renal Impairment on the PK of Tenofovir Exalidex
This is a Phase 1 study to investigate the effects of Renal Impairment on the pharmacokinetics of Tenofovir exalidex
- Trial name
- NCT03284164
- Testing
- Tenofovir Exalidex (TXL)
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- ContraVir Pharmaceuticals, Inc.
Hepatorenal Syndrome
The Effect of Terlipressin in the Prevention of Type 2 Hepatorenal Syndrome by Improving Mean Arterial Pressure
Appreciation of the central role for arterial vasodilatation in the pathogenesis of hepatorenal syndrome (HRS) has led to routine use of vasoconstrictors in combination with albumin as a medical therapy for HRS.
- Trial name
- NCT02489864
- Testing
- Terlipressin
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Sun Yat-sen University
Bladder Cancer, Recurrent Bladder Cancer
A Study of Oral Erdafitinib in People With Recurrent Non-Invasive Bladder Cancer
The purpose of this study is to assess the effectiveness of erdafitinib in people with non-muscle invasive bladder cancer (NMIBC) that has come back after standard treatment, such as Bacillus Calmette-Guerin (BCG) or chemotherapy…
- Conditions
- Bladder Cancer, Recurrent Bladder Cancer, FGFR3 Gene Mutation
- Trial name
- NCT04917809
- Testing
- Erdafitinib
- Where
- 7 sites in United States
- Volunteers
- 20 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Breast Cancer, Colorectal Cancer
Role of Geriatric Intervention in Treatment of Older Patients With Cancer (PREPARE)
Randomized trials have already demonstrated that geriatric intervention was able to improve survival in the general elderly population but only a few have been performed in cancer patients.
- Conditions
- Breast Cancer, Colorectal Cancer, Lung Cancer, Prostate Cancer
- Trial name
- PREPARE (NCT02704832)
- Testing
- Geriatrician Intervention
- Where
- 50 sites in France
- Volunteers
- 792 people
- Sponsor
- Institut Bergonié
Chronic Kidney Disease, Type 2 Diabetes
A Pharmacodynamic Study of Measured Glomerular Filtration Rate in Patients With Chronic Kidney Disease and Type 2 Diabetes
This is a 24-week multi-center, double-blind, randomized, exploratory study of bardoxolone methyl treatment in 18 patients with Stage 3 CKD (eGFR greater than or equal to 30.0 to less than 60.0 ml/min/1.73m2) and diabetes to…
- Trial name
- NCT01500798
- Testing
- 20 mg bardoxolone methyl
- Volunteers
- 18 people
- Sponsor
- Biogen
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