Clinical trials: Urinary Tract Disease
Renal Cell Carcinoma, Melanoma
Study of ARRY-614 Plus Either Nivolumab or Nivolumab+Ipilimumab
In this study, the Phase Ib portion aims to establish safety and tolerability of ARRY-614 with either nivolumab or ipilimumab and to determine a recommended phase II dose of ARRY-614 in combination with either nivolumab or…
- Conditions
- Renal Cell Carcinoma, Melanoma, Solid Tumor, Non-small Cell Lung Cancer
- Trial name
- NCT04074967
- Testing
- Phase Ib ARRY-614 + nivolumab, Phase Ib ARRY-614 + nivolumab+ipilimumab, Phase II ARRY-614 + nivolumab
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Dan Zandberg
Kidney Diseases
Omega-3 Fatty Acids That Affect the Immune System in Kidney Transplant Patients
The purpose of this study is to evaluate the effectiveness of nutritional supplements in increasing the amount of omega-3 fatty acids (and arginine) in the red blood cell membranes and plasma of kidney transplant patients, and…
- Trial name
- NCT00047983
- Testing
- Canola oil, Arginine, Fish oil emulsion
- Where
- 4 sites in United States
- Volunteers
- 75 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Diabetic Nephropathies
Intervention Using Vitamin D for Elevated Urinary Albumin Treated With Losartan in Diabetes (IDEAL)
This study is a single center open-label randomized controlled trial designed to evaluate the efficacy of calcitriol plus losartan therapy in subjects with type II diabetes and macroalbuminuria.
- Trial name
- IDEAL (NCT02410005)
- Testing
- Calcitriol, Losartan
- Where
- 3 sites in United States, Qatar
- Volunteers
- 56 people
- Sponsor
- Weill Cornell Medical College in Qatar
Chronic Kidney Diseases, Renal Disease
Evaluation of Renastep
Evaluation of Renastep is a 28-day long, prospective nutritional study that will recruit 15 patients aged between 3 and 18 years of age with Chronic Kidney Disease.
- Trial name
- Renastep (NCT03602937)
- Testing
- Renastep
- Where
- 3 sites in United Kingdom
- Volunteers
- 20 people
- Sponsor
- Vitaflo International, Ltd
Urothelial Carcinoma, Bladder Cancer
Trial of Adjuvant Sutent for Patients With High Risk Urothelial Carcinoma After Neoadjuvant Chemotherapy and Cystectomy
The purpose of this study is to determine whether sutent (sunitinib)is effective in preventing tumor recurrence in patients with high risk bladder cancer who have previously had chemotherapy and cystectomy (bladder removal).
- Trial name
- NCT01042795
- Testing
- Sunitinib
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Michigan
Chronic Kidney Diseases
Pyrophosphate and Arterial Calcification in Chronic Kidney Disease
Arterial calcifications start at early stages of chronic kidney disease (CKD) and are associated to cardiovascular mortality. Pyrophosphate (PPi) is an endogenous compound, which stops the mineralization process in bones and is…
- Trial name
- Predical (NCT04950439)
- Testing
- Collect blood sample
- Where
- France
- Volunteers
- 242 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Chronic Hemodialysis Patients
Chronic Anticoagulation With a Reduced Dose Regimen of Rivaroxaban in End-stage Renal Disease Patients
Atrial fibrillation is the most frequent cardiac rhythm disorder and its prognosis is essentially marked by the risk of embolic events.
- Trial name
- CARD-AXA (NCT05410275)
- Testing
- Rivaroxaban
- Where
- 2 sites in France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Tours
Metastatic Papillary Renal Cell Carcinoma, Stage IV Renal Cell Cancer AJCC v8
Testing Cabozantinib With or Without Atezolizumab in Patients With Advanced Papillary Kidney Cancer, PAPMET2 Trial
This phase II trial compares the effect of atezolizumab in combination with usual treatment with cabozantinib to cabozantinib alone in patients with papillary renal cell carcinoma that has spread from where it first started…
- Trial name
- NCT05411081
- Testing
- Atezolizumab, Biospecimen Collection, Bone Scan
- Where
- 198 sites in United States
- Volunteers
- 200 people
- Sponsor
- National Cancer Institute (NCI)
Urinary Bladder, Overactive, Lower Urinary Tract Symptoms
Use of Medium Frequency Electrotherapy in the Treatment of OAB, LUTS and Pelvic Pain
The aim of this study is to assess the effectiveness of medium frequency electrotherapy (interferential currents) treatment for overactive bladder (OAB), lower urinary tract symptoms (LUTS) and pelvic pain
- Conditions
- Urinary Bladder, Overactive, Lower Urinary Tract Symptoms, Pelvic Pain
- Trial name
- NCT03520166
- Testing
- Medium frequency electrotherapy (interferential currents), No treatment
- Volunteers
- 100 people
- Sponsor
- Fisioterapia Pélvica Avanzada Madrid, SRL
Renal Stone
Prospective Assessment of Procedure-Related and Patient-Reported Outcomes After Retrograde Intrarenal Surgery (RIRS) for Renal Calculi Less Than 20 mm
The investigators aim at this study to prospectively assess procedure-related outcomes after RIRS for renal calculi less than 20 mm, including stone free rate (SFR), predictors of successful outcome, complications types/rate…
- Trial name
- NCT03719456
- Testing
- Retrograde Intrarenal Surgery
- Where
- 2 sites in Egypt
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Urinary Incontinence, Overactive Bladder Syndrome
Examining the Effects of Intra-detrusor Botox at Time of HoLEP in Men With Overactive Bladder Symptoms
The objective of our multi-center randomized single-blind study is to examine the safety and effect of intra-detrusor OnabotulinumtoxinA injections at the time of holium laser enucleation of the prostate (HoLEP) in men with…
- Conditions
- Urinary Incontinence, Overactive Bladder Syndrome, Overactive Bladder, Urologic Diseases
- Trial name
- NCT05878951
- Testing
- OnabotulinumtoxinA
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Northwestern University
Renal Failure, Chronic
Temperature Control During Dialysis Treatment
The purpose is to measure the effect of glucose in the dialysis water on blood pressure, pulse rate, and plasma glucose with and without body temperature control
- Trial name
- NCT00438295
- Testing
- temperature control
- Where
- Denmark
- Volunteers
- 18 people
- Sponsor
- Regional Hospital Holstebro
Major Depression, End Stage Renal Disease
Bupropion for Depression in ESRD Patients on Hemodialysis
The proposed study will evaluate the response and remission rates for major depressive disorder (MDD) in end-stage renal disease (ESRD) patients undergoing maintenance hemodialysis (HD) treated with bupropion or fluoxetine for 12…
- Trial name
- NCT02238977
- Testing
- Fluoxetine, Bupropion
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Arkansas
Urinary Incontinence (UI)
Effectiveness of Chinese Herbal Medicine for Older Adults With Urinary Incontinence
This study aims to evaluate the effectiveness and safety of Chinese herbal medicine in improving urinary incontinence symptoms among older adults.
- Trial name
- NCT07637175
- Testing
- Chinese Herbal Medicine (CHM) supplement
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- Kwantlen Polytechnic University
Bladder Cancer
Intravesical Recombinant BCG Followed by Perioperative Chemo-immunotherapy for Patients With MIBC
Current treatment of localized muscle-invasive bladder cancer is still associated with high relapse and death rate as well as the need for complete bladder resection or irradiation.
- Trial name
- NCT04630730
- Testing
- Recombinant intravesical BCG (Bacillus Calmette-Guérin VPM1002BC), Atezolizumab, Cisplatin
- Where
- 10 sites in Switzerland
- Volunteers
- 46 people
- Sponsor
- Swiss Cancer Institute
Kidney Failure
Prognosis Study of Renal Transplantation in Children
Kidney transplantation is the worldwide recognized best renal replacement treatment for children with end-stage renal disease. Successful kidney transplantation can not only alleviate uremia symptoms, improve survival and quality…
- Trial name
- NCT03708094
- Testing
- molecular diagnosis
- Where
- China
- Volunteers
- 184 people
- Sponsor
- Children's Hospital of Fudan University
Healthy Volunteers
FIH Ph 1 Study of TRPC5 Channel Inhibitor GFB-887 in Healthy Subjects
The study will comprise primarily a single-ascending dose (SAD) escalation component.
- Trial name
- NCT03970122
- Testing
- GFB-887
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Goldfinch Bio, Inc.
Chronic Kidney Disease
A Phase 1, Open-label Safety Study of NKA in Patients With Type 2 Diabetes
The purpose of this study is to determine if selected renal cells, obtained by biopsy from a patient with chronic kidney disease (CKD) and Type 2 Diabetes (i.e., autologous cells) can be safely implanted back into the patient.
- Trial name
- NCT02008851
- Testing
- Neo-kidney augment
- Where
- 5 sites in United States
- Volunteers
- 1 people
- Sponsor
- Tengion
Secondary Hyperparathyroidism, Chronic Kidney Disease
Vitamin D Deficiency in Chronic Kidney Disease (CKD) Patients
This is an open label, single center, randomized, active comparator controlled study, comparing the effects of vitamin D replacement using oral ergocalciferol versus paricalcitol on parathyroid hormone (PTH) levels in patients…
- Trial name
- NCT00958451
- Testing
- Paricalcitol, Ergocalciferol
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Salem Veterans Affairs Medical Center
Diabetes Mellitus, Type 2, Diabetes Complications
The Use of Cilostazol in Patients With Diabetic Nephropathy
Patients with type 2 diabetes have a long duration of disease for the development of complications. Among all complications, microangiopathic complications are major causes of mortality and morbidity in diabetic patients.
- Trial name
- NCT00272831
- Testing
- Cilostazol
- Volunteers
- 62 people
- Sponsor
- Chinese University of Hong Kong
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