Clinical trials: Urinary Tract Disease
Acute Kidney Injury
A Patient-centered Trial of a Process-of-care Intervention in Hospitalized AKI Patients: the COPE-AKI Trial
The COPE-AKI study is a randomized, pragmatic, parallel-arm trial comparing a multimodal intervention to usual care on hospital-free days through 90 days of study follow up.
- Trial name
- COPE-AKI (NCT05805709)
- Testing
- Study Physician/Advance Practice Provider, Nurse Navigator, Pharmacist
- Where
- 9 sites in United States
- Volunteers
- 2,145 people
- Sponsor
- University of Pittsburgh
Nephrotic Syndrome in Children, Nephrotic Syndrome, Minimal Change
CHILDNEPH The Canadian Childhood Nephrotic Syndrome Study
CHILDNEPH is a pan-Canadian project to observe clinical care for children with nephrotic syndrome. Previous studies have indicated that there is wide practice variation in how health care providers treat this remitting and…
- Conditions
- Nephrotic Syndrome in Children, Nephrotic Syndrome, Minimal Change, Nephrotic Syndrome，Idiopathic
- Trial name
- CHILDNEPH (NCT03786263)
- Where
- 12 sites in Canada
- Volunteers
- 400 people
- Sponsor
- University of Calgary
End-Stage Kidney Disease
End-Stage Kidney Disease Interactive Decision Aid for the Elderly (myKIDNEY)
Decision aids are highly recommended for decisions when there is no "right" treatment choice. The goal is to help patients choose a treatment that is consistent with their preferences and to minimize decisional conflict and…
- Trial name
- NCT05407896
- Testing
- myKIDNEY decision aid
- Where
- 2 sites in Singapore
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Duke-NUS Graduate Medical School
Pelvic Floor Disorders, Stress Urinary Incontinence
The Effect of Footwear Generated Biomechanical Manipulation on Symptoms of Stress Urinary Incontinence
FGBMM (footwear generated biomechanical manipulation) effects neuromuscular patterns of pelvic muscles. While there have been no published studies to our knowledge investigating the effect of FGBMM on urinary incontinence, FGBMM…
- Trial name
- SUI (NCT03194789)
- Testing
- Footwear Generated Bio-Mechanical Manipulation (using shoes with pertupods) along with Traditional Pelvic Floor Therapy, Traditional Pelvic Floor Therapy
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Montefiore Medical Center
Renal Failure, Chronic
Th1, Th2 and Monokine Responses as Risk Factors of Renal Transplant Rejection
Chronic transplant rejection remains the main cause of late kidney graft loss. We showed previously that patients with pretransplant CD4 helper defects and low in-vitro IL-10 responses demonstrated an extremely low risk of acute…
- Trial name
- NCT00150891
- Testing
- Kidney transplantation, cyclosporine A, tacrolimus
- Where
- Germany
- Volunteers
- 84 people
- Sponsor
- University of Giessen
Prostate Cancer, Kidney Cancer
Personal Web Page In Clinical Trial Participant Education
This research study is evaluating the effectiveness of video and web-based communication in clinical research compared to standard practices.
- Conditions
- Prostate Cancer, Kidney Cancer, Genitourinary Cancer
- Trial name
- NCT03887091
- Testing
- Postwire
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Dana-Farber Cancer Institute
Pancreatic Cancer, Breast Cancer
Study of NGM831 as Monotherapy and in Combination With Pembrolizumab or Pembrolizumab and NGM438 in Advanced or Metastatic Solid Tumors
Study of NGM831 as Monotherapy and in Combination with Pembrolizumab or Pembrolizumab and NGM438 in Advanced or Metastatic Solid Tumors
- Conditions
- Pancreatic Cancer, Breast Cancer, Gastric Cancer, Non-small Cell Lung Cancer
- Trial name
- NCT05215574
- Testing
- NGM831, NGM831 plus pembrolizumab (KEYTRUDA®), NGM831 and NGM438 plus pembrolizumab (KEYTRUDA®)
- Where
- 9 sites in United States
- Volunteers
- 130 people
- Sponsor
- NGM Biopharmaceuticals, Inc
Chronic Kidney Disease (Stages 4 and 5), Health Related Quality of Life
Symptom Monitoring With Supported Feedback in Advanced Chronic Kidney Disease
Patient-reported outcome measures (PROMs) are validated tools to reliably measure outcomes highly prioritized by patients, such as health-related quality of life (HRQOL) and symptoms, but the current clinical impact of PROMs is…
- Trial name
- NCT07186218
- Testing
- Electronic patient-reported outcome measure (ePROM) for symptom monitoring
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Massachusetts General Hospital
Chronic Kidney Disease
Inulin and Protein Fermentation in Hemodialysis Patients
An important group of protein-bound uremic retention solutes originate from protein fermentation in the colon. P-cresol is a putrefaction metabolite of tyrosine. Indole is generated by fermentation of tryptophan.
- Trial name
- NCT00695513
- Testing
- BENEO synergy1
- Where
- Belgium
- Volunteers
- 22 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Kidney Cancer
Talabostat in Treating Patients With Metastatic Kidney Cancer
RATIONALE: Talabostat may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. PURPOSE: This phase II trial is studying how well talabostat works in treating patients with metastatic kidney…
- Trial name
- NCT00489710
- Testing
- talabostat mesylate, enzyme inhibitor therapy, flow cytometry
- Sponsor
- University of Nebraska
Nephropathy
Evaluating the Protective Effect of Pentoxifylline on Contrast Induced Nephropathy
Contrast induced nephropathy (CIN) is of great concern when using contrast media in the new era of medicine. CIN is defined as 25-50% relative increase, 0.5-1 absolute increase in serum creatinin value or 25% fall in GFR.
- Trial name
- NCT01469624
- Testing
- Pentoxifylline
- Where
- Iran
- Volunteers
- healthy volunteers welcome
- Sponsor
- Shiraz University of Medical Sciences
IGA Nephropathy
"Steroids and Azathioprine Versus Steroids Alone in IgAN"
In a previous trial the investigators found that the effect of steroids in IgA nephropathy diminish over time. The difference in renal survival is striking up till the third year, but then remains constant.
- Trial name
- NCT00755859
- Testing
- steroids plus azathioprine, steroids
- Where
- 28 sites in Italy, Switzerland
- Volunteers
- 206 people
- Sponsor
- A. Manzoni Hospital
Chronic Kidney Diseases, Pain, Procedural
Effect of 4-7-8 Breathing on AV Fistula Needle Pain in Dialysis Patients
For many hemodialysis patients, needle insertion into the vascular access site (fistula) is a significant source of pain and anxiety.
- Conditions
- Chronic Kidney Diseases, Pain, Procedural, Arteriovenous Fistula
- Trial name
- NCT07700680
- Testing
- Breathing technique
- Volunteers
- 80 people
- Sponsor
- Izmir Kavram Vocational School
Type 1 Diabetes Mellitus With Diabetic Nephropathy
Validation of Biomarkers of Diabetic Nephropathy in Type I Diabetic Children
About 30 to 40% of patients suffering from type I diabetes are at risk of developing a diabetic nephropathy (DN) leading more or less rapidly to an end-stage renal disease.
- Trial name
- peeDIAB2 (NCT02164279)
- Testing
- Urinary sample collection
- Where
- 2 sites in France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Toulouse
End-Stage Renal Disease, Hemodialysis Catheter-associated Infection
A Novel Catheter Lock Solution for Treatment of Tunneled Hemodialysis Catheter-Associated Bacteremia
The primary objective is to investigate the ability of systemic intravenous antibiotic plus antibiotic/anti-biofilm (i.e. N-acetylcysteine) lock catheter technique in eradicating uncomplicated catheter associated bacteremia and…
- Trial name
- NCT00614679
- Testing
- catheter lock solution consisting of N-acetylcystein, tigecycline and heparin
- Where
- 3 sites in United States
- Volunteers
- 18 people
- Sponsor
- University of California, San Diego
Nephrectomy, Nephroureterectomy
Goal-directed Hemodynamic Management and Kidney Injury After Radical Nephrectomy or Nephroureterectomy
Radical nephrectomy and nephroureterectomy are common operations for the treatment of renal cell carcinoma and upper tract urothelial carcinoma, respectively. However, acute kidney injury frequently occurs after surgery.
- Conditions
- Nephrectomy, Nephroureterectomy, Hemodynamic Management, Acute Kidney Injury
- Trial name
- NCT05149196
- Testing
- Targeted hemodynamic management, Routine care
- Where
- China
- Volunteers
- 1,724 people
- Sponsor
- Peking University First Hospital
Urinary Incontinence, Urinary Incontinence, Urge
Safety and Performance of UCon Patch Electrode
UCon is a medical device for treating the symptoms of overactive bladder (OAB) and bowel dysfunction (BD). It electrically stimulates the DGN through the skin to obtain modulated behavior of the bladder/bowel musculature e.g.…
- Conditions
- Urinary Incontinence, Urinary Incontinence, Urge, Nocturia, Urinary Frequency More Than Once at Night
- Trial name
- NCT06754189
- Testing
- Time Limited stimulation
- Where
- 3 sites in Denmark
- Volunteers
- 180 people
- Sponsor
- InnoCon Medical
Renal Cell Carcinoma (RCC)
A Comparison of Vorolanib Tablets Combined With Everolimus Versus Sunitinib in Patients With Advanced Renal Cell Carcinoma Who Have Progressed After Treatment With Immunotherapy Monotherapy or in Combination With TKI
This study is a multicenter, open-label, randomized controlled trial that enrolled 116 patients with advanced or metastatic renal cell carcinoma who had failed first-line treatment with PD-1/PD-L1 monotherapy or VEGFR TKI…
- Trial name
- NCT07165418
- Testing
- Vorolanib Tablets+Everolimus, Sunitinib
- Where
- China
- Volunteers
- 116 people
- Sponsor
- Peking University Cancer Hospital & Institute
Kidney Failure, Chronic, Arthralgia
Safety Study of Renal Function in Patients With Chronic Kidney Failure Taking Lumiracoxib or Diclofenac for Arthralgia
The purpose of this study is to determine whether the use of lumiracoxib in this particular population is associated with a decrease in glomerular filtration rate (GFR) compared to diclofenac; and to compare the magnitude of such…
- Trial name
- NCT01481610
- Testing
- Lumiracoxib, Diclofenac
- Where
- Mexico
- Volunteers
- 28 people
- Sponsor
- Hospital Central Sur de Pemex
End Stage Kidney Disease, End Stage Renal Disease
Comparative Outcome Measures of Patients Receiving Acute Renal ThErapy Study
Retrospective, multicenter, comparative, post-market study of the Tablo Hemodialysis System in hospitalized participants with End-Stage Renal Disease or Acute Kidney Injury.
- Conditions
- End Stage Kidney Disease, End Stage Renal Disease, Acute Kidney Injury
- Trial name
- COMPARE (NCT04912024)
- Testing
- Intermittent Renal Replacement Therapy using the Tablo Hemodialysis System, Intermittent Renal Replacement Therapy using Conventional Hemodialysis Systems
- Where
- 2 sites in United States
- Volunteers
- 458 people
- Sponsor
- Outset Medical
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