Clinical trials: Urinary Tract Disease
Acute Kidney Injury
A Study of THR-184 in Patients at Risk of Developing Cardiac Surgery Associated-Acute Kidney Injury (CSA-AKI)
The purpose of this study is to determine whether THR-184 when administered around the time of cardiac surgery that requires cardiopulmonary bypass can prevent or ameliorate the development of acute kidney injury.
- Trial name
- NCT01830920
- Testing
- THR-184
- Where
- 41 sites in United States, Canada
- Volunteers
- 452 people
- Sponsor
- Thrasos Innovation, Inc.
Chronic Kidney Disease
Putting Patients at the Center of Kidney Care Transitions (PREPARE NOW)
Objective: The investigators will change the health system to improve care patients receive as they transition through earlier stages of kidney disease toward kidney failure.
- Trial name
- NCT02722382
- Testing
- Patient-Centered Kidney Transitions Care
- Where
- United States
- Volunteers
- 1,572 people
- Sponsor
- Duke University
Stage IV Renal Cell Cancer AJCC V7
A Proof of Principle Study of Pembrolizumab With SBRT in TKI mRCC Patients
This study is designed as a phase-II proof of concept trial to investigate if a treatment strategy where stereotactic body radiation therapy (SBRT) is given with pembrolizumab is sufficiently active to warrant further…
- Trial name
- OZM-065 (NCT02599779)
- Testing
- Pembrolizumab, Stereotactic Body Radiation Therapy
- Where
- 3 sites in Canada
- Volunteers
- 4 people
- Sponsor
- Sunnybrook Health Sciences Centre
Pediatric Urolithiasis, Distal Ureteral Stone
Intravesical Aminophylline to Facilitate Ureteroscopic Access in Children With Distal Ureteral Stones.
This study will evaluate whether intravesical aminophylline can facilitate semi-rigid ureteroscopic access in children with distal ureteral stones when the first gentle attempt to enter the ureter is unsuccessful.
- Conditions
- Pediatric Urolithiasis, Distal Ureteral Stone, Ureteral Calculi
- Trial name
- NCT07617896
- Testing
- Aminophylline
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Beni-Suef University
Kidney Failure, Chronic
Trial of Aerobic Exercise in Patients Undergoing Outpatient Hemodialysis
Randomized controlled trial comparing effects of ergometer exercise during hemodialysis to effects of pedometer use outside of hemodialysis on exercise capacity, functional status, quality of life and adequacy of hemodialysis.
- Trial name
- NCT00492362
- Testing
- ergometer exercise during hemodialysis, pedometer activity outside of hemodialysis
- Where
- 4 sites in Canada
- Volunteers
- 60 people
- Sponsor
- University of Manitoba
Smoke Inhalation Patients
Impact of Hydroxocobalamine on Outcome of Smoke Inhalation Injury Admitted to the ICU
In Europe, hydroxocobalamin (cyanokit) has been used for suspicion of cyanide intoxication associated with the inhalation of fire smoke (1). However, the impact of hydroxocobalamin on outcome has never been thoroughly evaluated.
- Trial name
- COB-AKI (NCT03558646)
- Testing
- There is no intervention planned (observational)
- Where
- France
- Volunteers
- 739 people
- Sponsor
- Saint-Louis Hospital, Paris, France
Metastatic Renal Cell Carcinoma
Velcade and Sorafenib in Unresected or Metastatic Renal Cell Carcinoma
This is an open label, non-randomized, single arm phase II study. The primary objective of this study is to investigate the efficacy of combination of sorafenib and VELCADE® (bortezomib).
- Trial name
- NCT01100242
- Testing
- Velcade and Sorafenib
- Where
- 3 sites in United States
- Volunteers
- 17 people
- Sponsor
- New Mexico Cancer Research Alliance
Kidney Transplantation, End Stage Renal Disease
Live Kidney Donor Study
Kidney transplants from living donors now account for 40% of all the kidney transplants done in the United States. However, the current information on how donating a kidney can affect the donor's long term health needs further…
- Trial name
- NCT00608283
- Where
- 3 sites in United States
- Volunteers
- 8,951 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Urinary Incontinence, Urinary Incontinence,Stress
Adjustable Continence Therapy (ACT) for the Treatment of Female SUI
A prospective, single arm, non-randomized, multicenter, prospective case-series trial. The purpose of this trial is to demonstrate the safety and effectiveness of using the Adjustable Continence Therapy (ACT) to provide a…
- Trial name
- NCT04248283
- Testing
- Adjustable Continence Therapy for Women (ACT)
- Where
- 8 sites in United States, France
- Volunteers
- 167 people
- Sponsor
- Uromedica
Hypertension, Chronic Kidney Disease
Renal Nerve Ablation in Chronic Kidney Disease Patients
In patients with treatment resistent hypertension renal nerve ablation emerged as an effective interventional approach of treating hypertensive disease with a progressively increasing fall in blood pressure.
- Trial name
- NCT01442883
- Testing
- Simplicity Catheter
- Where
- 2 sites in Germany
- Volunteers
- 27 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Diabetes Mellitus, Type 2, Renal Insufficiency, Chronic
PANDIA IRIS: Patients With Diabetes and Kidney Failure, an Interdisciplinary Medication Adherence Support Program
Monocentric, randomised, controlled and open study. Subjects will be included prospectively and consecutively and randomly assigned into two groups.
- Trial name
- PANDIA_IRIS (NCT04190251)
- Testing
- Inteprofessional medication adherence support program (IMAP)
- Where
- 2 sites in Switzerland
- Volunteers
- 73 people
- Sponsor
- Center for Primary Care and Public Health (Unisante), University of Lausanne, Switzerland
Chronic Kidney Failure, Congenital Heart Defects
Chronic Kidney Disease in Teenagers With Congenital Cardiac Disease
The prevalence of chronic kidney injury (CKD) following cardiac surgery during childhood is not known, but there is evidence of CKD in young adults.
- Trial name
- PRECARDIO (NCT01845402)
- Testing
- blood and urine samples
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chronic Kidney Disease, Stage 5
Head to Head Study Against Sevelamer Hydrochloride
To compare the efficacy of Fosrenol (Lanthanum carbonate) and sevelamer hydrochloride in the reduction of serum phosphorus levels from baseline.
- Trial name
- NCT00441545
- Testing
- Fosrenol (Lanthanum Carbonate), Sevelamer hydrochloride
- Where
- 44 sites in United States, Germany and 2 more
- Volunteers
- 182 people
- Sponsor
- Shire
Hydronephrosis
Hydronephrosis ARFI Study
Pediatric upper urinary tract dilatation (hydronephrosis) is relatively common and may be either obstructive or nonobstructive. While the upper urinary tract is commonly evaluated by ultrasound, this imaging technique often fails…
- Trial name
- NCT01781845
- Testing
- AFRI-SVI Ultrasound
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Michigan
Advanced Melanoma, Non-small Cell Lung Cancer
APX005M With Nivolumab and Cabiralizumab in Advanced Melanoma, Non-small Cell Lung Cancer or Renal Cell Carcinoma
This trial is a phase 1/1b study to evaluate the safety, efficacy, and tolerability of APX005M in combination with nivolumab and cabiralizumab.
- Conditions
- Advanced Melanoma, Non-small Cell Lung Cancer, Renal Cell Carcinoma
- Trial name
- NCT03502330
- Testing
- APX005M, Cabiralizumab, Nivolumab
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Yale University
Locally Advanced or Metastatic Solid Tumours
A Study to Evaluate Safety and Efficacy of Multiple Dosing With VB10.NEO and Bempegaldesleukin (NKTR-214) Immunotherapy in Patients With Locally Advanced or Metastatic Cancer
This open labelled first in human dose phase 1/2a study is designed to evaluate safety, feasibility and efficacy of multiple dosing with individualised VB10.NEO and bempegaldesleukin (NKTR-214) immunotherapy in patients with…
- Trial name
- DIRECT-01 (NCT03548467)
- Testing
- VB10.NEO, Bempegaldesleukin
- Where
- 6 sites in Germany
- Volunteers
- 41 people
- Sponsor
- Nykode Therapeutics ASA
Type 2 Diabetes
Chronotherapy with Low-dose Aspirin for Primary Prevention
Brief summary: Aspirin (ASA) has been shown to provide marked benefits in primary and secondary prevention of cardiovascular events.
- Trial name
- CARING (NCT00725127)
- Testing
- aspirin
- Where
- 19 sites in Spain
- Volunteers
- 3,200 people, healthy volunteers welcome
- Sponsor
- University of Vigo
Urinary Tract Infections, Chronic Kidney Diseases
Urinary Tract Infection in Patients With Chronic Kidney Disease
This study aims to investigate the etiology and associated risk factors for UTI in Egyptian chronic kidney disease patients. In addition, to identify the isolated micro-organisms and their sensitivity patterns for better…
- Trial name
- NCT05674942
- Testing
- Patients with urinary tract infection and chronic kidney disease
- Where
- Egypt
- Volunteers
- 250 people
- Sponsor
- Alexandria University
Urinary Incontinence
Using Behavioral Therapy in Combination With Darifenacin for Symptoms of Overactive Bladder
This study is designed to investigate the efficacy and safety of treatment of overactive bladder with darifenacin administered alone or in conjunction with behavioral modification therapies.
- Trial name
- NCT00127270
- Testing
- Darifenacin, Behavioral therapy
- Where
- 67 sites in United States
- Volunteers
- 395 people
- Sponsor
- Novartis
Kidney Cancer
PEG-Interferon Alfa-2b, Sargramostim, and Thalidomide in Treating Patients With Metastatic Kidney Cancer
RATIONALE: PEG-interferon alfa-2b may interfere with the growth of tumor cells. Colony-stimulating factors such as sargramostim may increase the number of immune cells found in bone marrow or peripheral blood.
- Trial name
- NCT00090870
- Testing
- PEG-interferon alfa-2b, GM-CSF, thalidomide
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Medical University of South Carolina
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