Clinical trials: Urinary Tract Infection (UTI)
Urinary Tract Infections
Improving Antibiotic Prescribing for Urinary Tract Infections in Frail Elderly
The purpose of this study is to determine whether a tailored multifaceted antibiotic stewardship intervention reduces antibiotic use for urinary tract infections in residential care homes and nursing homes attended by general…
- Trial name
- ImpresU-WP2 (NCT03970356)
- Testing
- antibiotic stewardship intervention
- Where
- 4 sites in Netherlands, Norway and 2 more
- Volunteers
- 1,146 people
- Sponsor
- Cees Hertogh
Urinary Tract Infections
A Study in Pediatric Participants Aged ≥2 to <12 Years With a Suspected or Confirmed Bacterial Infection or Receiving Prophylaxis Antibiotics
The study will be conducted to evaluate how a single oral dose of Gepotidacin is processed in the body over time along with safety monitoring in hospitalized pediatric participants who are receiving a standard of care treatment…
- Trial name
- NCT07371429
- Testing
- Gepotidacin, SOC
- Where
- 4 sites in United States
- Volunteers
- 25 people
- Sponsor
- GlaxoSmithKline
Uncomplicated Urinary Tract Infection, Antibiotic Resistant Infection
Establish the Relationship Between Shift in Prescribing Pattern and Associated Shift in Sensitivity Pattern of Causative Microbes in UTI Patients in a Closed Community
To establish a relationship between changed prescribing pattern and associated shift in sensitivity trend of causative microbes in patients of uncomplicated urinary tract infection in a closed community
- Trial name
- UTI (NCT03716804)
- Testing
- Tablet Nitrofurantoin, Tablet Ciprofloxacin/ Tablet Cefixime/ Tablet Cefuroxime
- Where
- Bangladesh
- Volunteers
- 62 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Urinary Retention
Assessment of CymActive™ Catheter Technology for UrinAry ReTention and AcceptancE (The ACCTUATE Study)
The ACCTUATE study: Assessment of CymActive™ Catheter Technology for UrinAry reTention and acceptancE study will evaluate a novel catheter design that addresses the specific needs of male long term catheter users living in the…
- Trial name
- ACCTUATE (NCT05848037)
- Testing
- cymactive™ catheter device (CCD), Foley-type catheter device
- Where
- 5 sites in United Kingdom
- Volunteers
- 6 people
- Sponsor
- Ingenion Medical Limited
Catheterization
Study of a Urethral Catheter Coated With Eluting Silver Salts (SUCCESS)
Urinary catheters are often needed in hospital patients, but their use can increase the chance that a catheter associated urinary tract infection (called a CAUTI) may occur.
- Trial name
- SUCCESS (NCT00482547)
- Testing
- Hydrogel Silver Salts Coated Latex Urinary Catheter System, Bard silicone elastomer coated latex catheter system
- Where
- United States
- Volunteers
- 1,188 people
- Sponsor
- C. R. Bard
Fetal Membranes, Premature Rupture, Premature Birth
The Use of Cranberries in Women With Preterm Premature Rupture of Membranes
Cranberries have been proved to reduce the rate of urinary tract infections in a population of women with recurrent urinary tract infections in previous studies.
- Trial name
- NCT00247104
- Testing
- Cranberries - Vaccinium macrocarpon
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Urinary Tract Infections
Safety, Tolerability, and PK of LBP-EC01 in Patients With Lower Urinary Tract Colonization Caused by E. Coli
Study LBx-1001 is a multi-center randomized, double-blind study to assess the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of LBP-EC01 in patients with indwelling urinary catheters, or requiring…
- Trial name
- NCT04191148
- Testing
- LBP-EC01
- Where
- 7 sites in United States
- Volunteers
- 36 people
- Sponsor
- Locus Biosciences
Antibiotic Prophylaxis, Voiding Cystourethrogram
Antibiotic Prophylaxis to Prevent Post-procedure UTI After VCUG
The current practice of pre-VCUG antibiotic prophylaxis is highly variable. A recent unpublished survey of Society of Fetal Urologists (SFU) completed by this study team found that 87% of respondents reported having patients who…
- Conditions
- Antibiotic Prophylaxis, Voiding Cystourethrogram, Febrile Urinary Tract Infection
- Trial name
- APPrUV (NCT05438082)
- Testing
- Antibiotic Prophylaxis
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Pneumonia, Abdominal Infection
Target Site Pharmacokinetics of Doripenem at Steady State in Intubated Intensive Care Patients
The investigators will measure the pharmacokinetics of doripenem in skeletal muscle, subcutaneous adipose tissue, bronchoalveolar lavage and plasma of intubated intensive care patients.
- Conditions
- Pneumonia, Abdominal Infection, Urinary Tract Infection
- Trial name
- NCT01414959
- Where
- Austria
- Volunteers
- 16 people
- Sponsor
- Medical University of Vienna
Complicated Urinary Tract Infections
Efficacy and Safety Study of Eravacycline Compared With Ertapenem in Participants With Complicated Urinary Tract Infections
The purpose of this study is to assess the efficacy, safety, and pharmacokinetics of eravacycline compared to ertapenem in treating participants with complicated urinary tract infections (cUTI).
- Trial name
- IGNITE3 (NCT03032510)
- Testing
- Eravacycline, Ertapenem, Levofloxacin
- Where
- 69 sites in United States, Austria and 10 more
- Volunteers
- 1,205 people
- Sponsor
- Tetraphase Pharmaceuticals, Inc
Febrile Urinary Tract Infection
Individualized Antibiotic Therapy in Children With Acute Uncomplicated Febrile Urinary Tract Infection
An investigator-initiated, open-label, multi-center, randomized, non-inferiority trial of children aged 3 months to 13 years with acute uncomplicated febrile urinary tract infection.
- Trial name
- NCT05301023
- Testing
- Individualized antibiotic therapy, Standard antibiotic therapy
- Where
- 8 sites in Denmark
- Volunteers
- 408 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Urinary Retention, Chronic Kidney Infection
Comparison of Two Bladder Catheterization Strategies in Thoracic Surgery Patients With an Enhanced Recovery After Surgery (ERAS)
General anesthesia, thoracic epidural, and morphine inhibit the urination process and promote postoperative Acute Urinary Retention (AUR) after thoracic surgery.
- Conditions
- Urinary Retention, Chronic Kidney Infection, Urinary Infection
- Trial name
- URICATHOR (NCT05611255)
- Testing
- Systematic Intermittent Catheterization, Bladder Scan Guided Catheterization
- Where
- France
- Volunteers
- 21 people
- Sponsor
- University Hospital, Montpellier
Catheter Associated Urinary Tract Infection, Critically Ill Patients
Non-returning Catheter Valve for Reducing CAUTI
This study was to determine efficacy of the non-returning catheter valve for reducing catheter associated urinary tract infection compared with conventional urine bag in critically ill patients.
- Trial name
- NCT01963013
- Testing
- Non-returning catheter valve, Conventional urine bag
- Where
- Thailand
- Volunteers
- 100 people
- Sponsor
- Khon Kaen University
Catheter Associated Urinary Tract Infection
REPLACE: The Impact of Catheter Replacement in Patients With Catheter-associated Urinary Tract Infection
With this project the investigators aim to address the following question: "Is it beneficial to change bladder catheters during urinary tract infections?" There is debate regarding the usefulness of changing an indwelling…
- Trial name
- NCT06936631
- Testing
- Catheter replacement, Catheter retainment
- Where
- Netherlands
- Volunteers
- 300 people
- Sponsor
- Leiden University Medical Center
Urinary Tract Infections
Uqora Supplements in Women With UTIs
This is a virtual study which will invite females over the age of 18 who have had 2 or more UTIs in the past 6 months to participate.
- Trial name
- NCT04024046
- Testing
- Uqora, Group1, Group 2
- Where
- United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Hawthorne Effect Inc.
Complicated Urinary Tract Infections(cUTI), Acute Pyelonephritis
This is a Phase 2 Study to Evaluate the Efficacy, Safety, and Tolerability of Intravenous Ertapenem-zidebactam Versus Ceftazidime-Avibactam in the Treatment of Hospitalized Adult Patients With Complicated Urinary Tract Infection or Acute Pyelonephritis
This is a Phase 2 randomized open label multicentre three arm comparative study evaluating the efficacy safety tolerability and pharmacokinetics of intravenous ertapenem zidebactam ERT ZID compared with ceftazidime avibactam CAZ…
- Trial name
- NCT07840105
- Testing
- Ertapenem-zidebactam, Ceftazidime-Avibactam, Ertapenam-Zidebactam
- Where
- 19 sites in India
- Volunteers
- 279 people
- Sponsor
- Wockhardt
Ureteral Stent-Related Symptom, Urinary Tract Infections
Uroial Plus in the Management of Infections and Urinary Symptoms Associated With Ureteral Stents
Double-blind randomised interventional pilot study. To evaluate whether therapy with UroialTM Plus has a role in rebalancing homeostasis in ureteral stent patients, improving symptoms related to the presence of the ureteral stent…
- Trial name
- USSIAL (NCT06251336)
- Testing
- UroialTM Plus
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Urinary Tract Infections, Stress Urinary Incontinence
Prophylactic Antibiotics for Outpatient Urethral Bulking
The purpose of this study is to evaluate whether taking prophylactic (preventative) antibiotics at the time of standard of care clinic-based urethral bulking reduces the risk of post-procedural urinary tract infection (UTI).
- Conditions
- Urinary Tract Infections, Stress Urinary Incontinence, Urinary Incontinence
- Trial name
- NCT07501065
- Testing
- Bactrim (800/160 mg), Keflex (500 mg), Cipro (250 mg), or Macrobid (100mg)
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- University of Miami
Gram Negative Infections
A Study to Assess How Vaborem® is Taking up in the Body and Tolerated in Paediatric Patients With Gram Negative Infections, Including But Not Restricted to Complicated Urinary Tract Infections
The goal of this clinical trial is to assess the pharmacokinetic (PK) and safety and tolerability of Vaborem (fixed combination of meropenem and vaborbactam) in the paediatric population aged from birth to < 18 years with…
- Trial name
- NCT06828848
- Testing
- Meropenem plus vaborbactam
- Where
- 22 sites in Czechia, France and 3 more
- Volunteers
- 44 people
- Sponsor
- Menarini Group
Urinary Tract Infections
Clinical Trial to Study the Safety and Effectiveness of MK0826 and Other Antibiotic Therapy in Patients With Complicated Urinary Tract Infection (0826-054)
The purpose of this study is to demonstrate that MK0826 is comparable to Meropenem in the treatment of complicated Urinary Tract Infections (UTIs) in adults.
- Trial name
- NCT00771316
- Testing
- MK0826 (ertapenem), Comparator: meropenem
- Volunteers
- 6 people
- Sponsor
- Merck Sharp & Dohme LLC