Clinical trials: Urinary Urgency
Urinary Bladder, Overactive
Open-label Study of the Efficacy and Safety of VESIcare® in Patients With Overactive Bladder Symptoms
To evaluate the safety and efficacy of solifenacin succinate in subjects with overactive bladder symptoms (urgency, with or without urge incontinence, usually with frequency and nocturia).
- Trial name
- VOLT (NCT00463541)
- Testing
- solifenacin succinate
- Where
- 198 sites in United States
- Volunteers
- 2,225 people
- Sponsor
- Astellas Pharma Inc
Overactive Bladder, Overactive Bladder Syndrome
Optimal Intravesical Lidocaine Volume for Pain Relief During Office Intra-detrusor Onabotulinum Toxin a Injections
The purpose of our study is to evaluate the efficacy and safety of different volumes of bladder-numbing medication for pain relief at the time of office bladder Botox injections.
- Conditions
- Overactive Bladder, Overactive Bladder Syndrome, Urinary Urgency, Urinary Frequency
- Trial name
- NCT06695585
- Testing
- Lidocaine 2% without vessel constrictor
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Louisville
Urge Incontinence
Protect Chronic Tibial Nerve Stimulator (CTNS) System
30 patient Study. All patients implanted with StimGuard Protect System. Patient followed out to 90 days.
- Trial name
- NCT02781636
- Testing
- Device: StimGuard Protect System
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- Uro Medical Corporation
Urgency Urinary Incontinence
eCoin Tibial Nerve Stimulation for OAB
The study is a single arm, prospective study of the safety and effectiveness of the Valencia Technologies eCoin System to stimulate the tibial nerve for the treatment of patients with refractory urgency urinary incontinence.
- Trial name
- NCT03029624
- Testing
- eCoin
- Where
- 7 sites in United States, New Zealand
- Volunteers
- 46 people
- Sponsor
- Valencia Technologies Corporation
Benign Prostatic Hyperplasia (BPH)
Dutasteride With Tolterodine ER or Placebo to Treat Lower Urinary Tract Symptoms (LUTS)
This is an investigator-initiated study of safety, efficacy and tolerability of dutasteride given for 18 months, including a 1-year double-blind randomized co-administration with either tolterodine ER or placebo in men suffering…
- Trial name
- LUTS (NCT00939120)
- Testing
- Tolterodine ER 4mg, Pre-randomization Dutasteride
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Siami, Paul F., M.D.
Urinary Incontinence, Urge
Axonics SacRal NeuromodulaTIon System for Urinary Urgency Incontinence TreatmeNt
The ARTISAN-SNM study is designed to evaluate the safety and effectiveness of the Axonics Sacral Neuromodulation System as an aid in the treatment of the symptoms of urinary urgency incontinence (UUI) in patients who have failed…
- Trial name
- ARTISAN-SNM (NCT03327948)
- Testing
- Axonics Sacral Neuromodulation System (SNM) System
- Where
- 4 sites in United States, Netherlands and 1 more
- Volunteers
- 129 people
- Sponsor
- Axonics, Inc.
Overactive Bladder Syndrome, Urinary Incontinence, Urge
Transcutaneous Tibial Nerve Stimulation for Overactive Bladder Syndrome and Associated Gait Changes in Post-menopausal Women
The goal of this clinical trial is to learn if surface tibial electrical stimulation (mild electrical signals on the inside of the ankle) helps women 60 years or older with urine leakage that happens on the way to the bathroom or…
- Conditions
- Overactive Bladder Syndrome, Urinary Incontinence, Urge, Nocturia
- Trial name
- TTNS (NCT06617676)
- Testing
- Transcutaneous tibial nerve stimulation
- Volunteers
- 60 people
- Sponsor
- Louisiana State University Health Sciences Center Shreveport
Overactive Bladder, Bladder, Overactive
Transvaginal Botulinum Toxin A Chemodenervation for Overactive Bladder
Overactive bladder (OAB) is a highly prevalent disease process that, when refractory to oral medication therapy, can be effectively managed with injection of botulinum toxin A (BTA) into the detrusor muscle of the bladder.
- Conditions
- Overactive Bladder, Bladder, Overactive, Urge Incontinence, Urgency Urinary
- Trial name
- FETOC (NCT05463822)
- Testing
- Transvaginal botulinum toxin A (BTA) injection
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Stanford University
Painful Bladder Syndrome, Interstitial Cystitis
Acupuncture for Female IC/PBSyndrome and Its Effect on the Urinary Microbiome: A Randomized Controlled Trial
The investigators central hypothesis is that women with Interstitial Cystitis/Painful Bladder Syndrome (IC/PBS) will benefit from acupuncture compared with sham treatment and acupuncture responders will have a differential…
- Trial name
- NCT02232282
- Testing
- standard acupuncture treatment
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Loyola University
Urinary Urgency Incontinence
Neuspera's Implantable Sacral Nerve Stimulation System in Patients With Symptoms of Urinary Urgency Incontinence (UUI)
Prospective, multi-center, single-arm, seamless phase-pivotal study conducted in participants diagnosed with UUI who have failed or could not tolerate more conservative treatment. The trial will be conducted in two phases.
- Trial name
- NCT04232696
- Testing
- Neuspera Implantable Sacral Nerve Stimulation System
- Where
- 34 sites in United States, Belgium and 1 more
- Volunteers
- 331 people
- Sponsor
- Neuspera Medical, Inc.
Urinary Urgency Incontinence
Examining Bladder Control Using Mindful Based Approach
Urgency Incontinence (where the bladder muscles contract suddenly, causing an immediate urge to urinate that is difficult to prevent) is commonly experienced in patients with overactive bladder.
- Trial name
- NCT01843543
- Testing
- Mindfulness Based Stress Reduction Course
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Oregon Health and Science University
Urinary Incontinence, Urge
Brain-Centered Therapy Versus Medication for Urgency Urinary Incontinence : Hypnotherapy Or Pharmacotherapy
This study is randomized controlled trial in which urgency incontinent women (approximately 150-160) will be randomized to hypnotherapy or pharmacotherapy and evaluated at months 2, 6 \&12 Hypotheses: Among patients with urgency…
- Trial name
- Hyp-hOP (NCT01829425)
- Testing
- Anticholinergic medications, Hypnotherapy
- Where
- United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Genitourinary Abnormality, Breast Cancer Female
GSM (Genitourinary Syndrome Of Menopause) Management In Breast Cancer Survivors
The impact of treatment for GSM on the quality of life will be examined for postmenopausal women (defined as last menstrual period > 1 year ago or 6 months ago with FSH >40) who have been diagnosed with breast cancer.
- Conditions
- Genitourinary Abnormality, Breast Cancer Female, Vaginal Abnormality, Urinary Tract Infections
- Trial name
- GSM (NCT03185169)
- Testing
- Replens and coconut oil
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Alta Bates Summit Medical Center
Female Patients With Overactive Bladder Syndrome or Female Patients With Urgency or Urgency Urinary Incontinence
Low Dose Tadalafil for Treatment of Female OAB Syndrome: Short Term Follow up.
Evaluation of use of low dose tadalafil 5 mg daily for treatment of female OAB syndrome
- Trial name
- NCT04500860
- Testing
- Low dose tadalafil 5 mg, Tolterodine 4 Mg Oral Capsule, Extended Release
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Kasr El Aini Hospital
Overactive Bladder
Clinical Trial to Study a Non-invasive Neurostimulation Device on Urgency (Urinary) Incontinence Overactive Bladder (OAB)
The purpose of this study is to determine whether the non-invasive neurostimulation patch is effective in the treatment of urgency, frequency and urge (urinary) incontinence.
- Trial name
- NCT01125722
- Testing
- Non-invasive neurostimulation device
- Where
- 11 sites in United States, Sweden and 1 more
- Volunteers
- 74 people
- Sponsor
- Ethicon Endo-Surgery
Painful Bladder Syndrome, Interstitial Cystitis
Study of URG101 in Painful Bladder Syndrome and Interstitial Cystitis
A double-blind, placebo-controlled study to evaluate changes in pain, urgency and urinary frequency following administration of URG101 compared to placebo.
- Conditions
- Painful Bladder Syndrome, Interstitial Cystitis, Bladder Pain Syndrome
- Trial name
- NCT00517868
- Testing
- URG101
- Where
- 6 sites in United States
- Volunteers
- 28 people
- Sponsor
- Urigen
Overactive Bladder
Add-On ZIDA Sock Therapy for Overactive Bladder
Many people with overactive bladder (OAB) continue to experience symptoms despite pharmacologic treatment. This study evaluates the use of the ZIDA Control Sock, an FDA-cleared, noninvasive wearable device that delivers mild…
- Trial name
- NCT07432659
- Testing
- ZIDA Control Sock
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Medical University of South Carolina
Urinary Frequency/Urgency, Bladder Irritable
Mirabegron for the Treatment of Pain Motivated Urinary Frequency and Urgency in Women
The specific purpose of this study is to provide objective data in prospective open label design (n=40) to support the use of Mirabegron as a treatment for pain related urinary frequency and urgency.
- Conditions
- Urinary Frequency/Urgency, Bladder Irritable, Bladder Pain Syndrome
- Trial name
- NCT02981459
- Testing
- Mirabegron
- Where
- United States
- Sponsor
- State University of New York at Buffalo
Overactive Bladder, Overactive Bladder Syndrome
rTMS in Overactive Bladder
Overactive bladder (OAB) imposes a significant quality of life, mental health, and economic burdens. OAB with or without Urgency incontinence is associated with depression, sexual dysfunction, and limitation of social…
- Conditions
- Overactive Bladder, Overactive Bladder Syndrome, Urge Incontinence, Urgency-frequency Syndrome
- Trial name
- TMS_OAB (NCT06198439)
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- The Methodist Hospital Research Institute
Overactive Bladder, Urinary Incontinence in Old Age
Reduced-dose Botox for Urgency Incontinence Among Elder Females
The purpose of this study is to study the treatment of urgency urinary incontinence (UUI), specifically among women 70 years and older, by comparing reduced versus standard dose of onabotulinumtoxinA (BTX; trade name BOTOX(c))…
- Conditions
- Overactive Bladder, Urinary Incontinence in Old Age, Urgency Urinary Incontinence
- Trial name
- RELIEF (NCT05512039)
- Testing
- Botox 50 Unit Injection, Botox 100 Unit Injection
- Where
- 7 sites in United States
- Volunteers
- 376 people
- Sponsor
- Dartmouth-Hitchcock Medical Center