Clinical trials: Urine
Cocaine Use Disorder
Cariprazine Effects on Brain and Behavior in Cocaine Use Disorder
This is a phase II, randomized, single-blind, placebo-controlled study to examine whether cariprazine (1.5 or 3 mg/d) 1) alters brain and/or behavioral responses to probes of reward and inhibition and 2) decreases cocaine use in…
- Trial name
- NCT03430544
- Testing
- Cariprazine Oral Capsule [Vraylar]
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Anna Rose Childress, Ph.D.
Overactive Detrusor
"Swallow my Urine Back" : Inhibition of Detrusor Overactivity by Swallowing Maneuver
The purpose of this study is to find out whether swallowing has an effect on the degree of urinary urgency and on the amplitude of detrusor contraction during filling cystometry in patients with detrusor overactivity (DO).
- Trial name
- NCT01408771
- Volunteers
- 20 people
- Sponsor
- Assaf-Harofeh Medical Center
Cystinuria
TCUPS- Tolvaptan Use in Cystinuria and Urolithiasis: A Pilot Study
The goal of this research project is to establish that in short-term use, tolvaptan is a safe and potentially effective new therapy for cystinuria, by conducting a short-term pilot study of the safety and tolerability of this…
- Trial name
- TCUPS (NCT02538016)
- Testing
- Tolvaptan
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Caleb Nelson
Congenital Urological Abnormalities
Pilot Study of Mycophenolate Mofetil in Congenital Uropathies
Congenital or hereditary structural anomalies of the genitourinary tract account for approximately half of all cases of end stage renal disease in the pediatric population.
- Trial name
- NCT00193635
- Testing
- mycophenolate mofetil
- Where
- 3 sites in United States
- Volunteers
- 12 people
- Sponsor
- Northwell Health
Laboratory Assay
Collection of Biological and Environmental Samples and Clinical Data From Anonymous Adult Men and Women for Quality Control and Methods Development and Evaluation (ASCA)
Background: Scientists want to improve new studies on how the environment, diet, and genetic factors affect human health. To do this, they need biological samples and clinical data.
- Trial name
- NCT02940015
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Metastatic Colorectal Cancer
"Cancersensor": Circadian Rhythms
Observational, non randomized study aimed at measuring the circadian rhythms in the urinary concentrations of physiological modified nucleosides in 30 patients with metastatic colorectal cancer and in 30 age and sex-matched…
- Trial name
- NCT01693835
- Where
- France
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Healthy
Normal Reference Ranges for Urinary Metabolites and Supersaturation Indices in Pediatric Populations
The reported normal values used in diagnosing and treating pediatric kidney stone formers are based on adult values or historic data from small studies.
- Trial name
- NCT00591097
- Where
- 2 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Pregnancy
Onset of Labor and Metabolomics (GEM-2)
Premature birth is a public health problem and its incidence has recently increased in all developed countries. In Canada, it represented 6.4% of births in 1981 and 7.6% in 2000.
- Trial name
- GEM-2 (NCT01071668)
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Université de Sherbrooke
Nephrogenic Diabetes Insipidus
Pharmacologic Treatment of Congenital Nephrogenic Diabetes Insipidus
The purpose of this research study is to determine if two investigational medications will be more effective in decreasing urine output than the currently available and routinely used medications in patients with congenital…
- Trial name
- NCT00478335
- Testing
- sildenafil, calcitonin, hydrochlorothiazide/amiloride
- Where
- 2 sites in United States, Denmark
- Volunteers
- 4 people
- Sponsor
- University of Colorado, Denver
Overactive Bladder, Overactive Detrusor
Sensitivity of Extended Cultures in Diagnosing Urinary Tract Infections
There is some evidence to suggest standard urine cultures may not be adequate in identifying patients with low grade urinary tract infections.
- Conditions
- Overactive Bladder, Overactive Detrusor, Urgency-Frequency Syndrome, UTI
- Trial name
- NCT03080389
- Testing
- Extended Urine Culture
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- The Cleveland Clinic
Bacteriuria
Retained Urine Volume and Bacteriuria in Traditional Versus Vented Urine Drainage Systems
The purpose of this study is to see if there are differences in urine drainage between two types of indwelling bladder catheter systems (Foley catheter) in hospitalized patients.
- Trial name
- NCT02052674
- Testing
- Vented urinary drainage system, Non-vented urinary drainage system
- Sponsor
- University of Florida
Acute Lung Injury
Omics Sequencing of Exosomes in Body Fluids of Patients With Acute Lung Injury
The exosomes in the experimental group and the control group were sequenced to find the difference of the two groups, providing a basis for subsequent basic research.
- Trial name
- NCT05058768
- Testing
- The lungs causes and extrapulmonary factors
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Thyroid Cancer, Papillary Thyroid Cancer
Urinary Exosomal Biomarkers of Thyroglobulin and Galectin-3 for Prognosis and Follow-up in Patients of Thyroid Cancer
Now, the investigators carried out a prospective study enrolling patients with thyroid cancer, who had received ablative thyroidectomy and /or radioactive iodine therapy for two more years.
- Conditions
- Thyroid Cancer, Papillary Thyroid Cancer, Follicular Thyroid Cancer
- Trial name
- NCT04948437
- Where
- Taiwan
- Volunteers
- 103 people
- Sponsor
- National Taiwan University Hospital
Cancer, Healthy
Collection and Distribution of Biospecimens for Novel Research
iSpecimen aims to create a clinical partner network of hospitals, laboratories, academic institutions, and other healthcare organizations ("institutions") capable of providing researchers and educators ("researchers") with…
- Conditions
- Cancer, Healthy, Gastrointestinal Complication, Autoimmune Diseases
- Trial name
- NCT05080907
- Testing
- Observational
- Where
- 7 sites in United States
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- iSpecimen Inc
Urinary Tract Infection Complicated, Urinary Tract Infection (cUTI)
Clinical Utility of a PCR Compared to Culture and Sensitivity Testing for the Management of cUTI in Adults.
Complicated urinary tract infections (cUTIs) often lead to the overuse of empiric antibiotics, risking inappropriate treatment and contributing to antimicrobial resistance.
- Conditions
- Urinary Tract Infection Complicated, Urinary Tract Infection (cUTI), Urinary Tract Infection (Diagnosis)
- Trial name
- PCR (NCT06996301)
- Testing
- Treatment guided by the PCR results, Treatment guided by the C&S results
- Where
- 6 sites in United States
- Volunteers
- 773 people
- Sponsor
- Doc Lab Inc
Environmental Exposure
Behavioural Intervention to Decrease Exposure to Emerging Chemical Pollutants
The purpose of this study is to evaluate the effectiveness of a behavioural intervention designed to reduce exposure to environmental chemical pollutants among adults in Spain.
- Trial name
- INPOL (NCT07465315)
- Testing
- Guidelines from the public healthcare system, INPOL healthy lifestyle informative guidelines
- Where
- 5 sites in Spain
- Volunteers
- 740 people, healthy volunteers welcome
- Sponsor
- Universidad de Granada
Bladder Cancer
Urine-based Detection of Non-muscle Invasive Bladder
Non-muscle invasive bladder cancer (NMIBC), which comprises approximately 75% of bladder tumors, has the highest recurrence rate of all cancers, with around 70% of the patients developing local recurrences, despite elaborated…
- Trial name
- SOLUSION (NCT03962933)
- Where
- Denmark
- Volunteers
- 196 people
- Sponsor
- Nessn Azawi
Healthy
The Influence of High and Low Salt on Exosomes in the Urine
The hypothesis is that changes in the epithelial sodium channel (ENaC) in the kidney is reflected in urinary exosomes and that the amount of ENaC as well as the cleavage degree is upregulated in conditions with low salt.
- Trial name
- NCT02823613
- Testing
- High salt diet followed by low salt diet, Low salt diet followed by high salt diet
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Pharmacokinetics of Mirabegron, Healthy Subjects
To Compare Blood and Urine Concentrations of Mirabegron (YM178) in Healthy Poor or Extensive Metabolizers for CYP2D6 and to Assess the Effect of Mirabegron on the Metabolism of Metoprolol
The study aims to compare blood and urine concentrations of mirabegron (YM178) in healthy poor or extensive metabolizers for CYP2D6 and to evaluate if blood levels of metoprolol change whilst being dosed at the same time with…
- Trial name
- NCT01478490
- Testing
- mirabegron, metoprolol
- Where
- Netherlands
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Inc
Diabetes, Healthy
Metabolism and Excretion of Liraglutide in Healthy Male Volunteers
This trial is conducted in Europe. The aim of this trial is characterise the metabolic profile of liraglutide in plasma, urine, and faeces after a single injection of [3H]-liraglutide.
- Trial name
- NCT01517568
- Testing
- liraglutide [3H]
- Where
- Netherlands
- Volunteers
- 7 people
- Sponsor
- Novo Nordisk A/S