Clinical trials: Urogenital
Cervical Cancer, Radiotherapy Side Effect
Study on Adaptive Radiotherapy and Multimodal Information of Cervical Cancer Assisted by Artificial Intelligence
The standard treatment for non-operative cervical cancer is concurrent external radiation therapy and chemotherapy followed by brachytherapy.
- Conditions
- Cervical Cancer, Radiotherapy Side Effect, Biomarker, Artificial Intelligence
- Trial name
- SOARAMIOCC (NCT04022018)
- Testing
- Adaptive radiotherapy, no adaptive radiotherapy
- Where
- China
- Volunteers
- 122 people
- Sponsor
- The University of Hong Kong-Shenzhen Hospital
HIV Infection
Combination Drug Treatment of Pediatric HIV Infection
This study will test the safety and effectiveness of hydroxyurea, an anti-cancer drug, given together with the anti-HIV drugs didanosine, stavudine and efavirenz for treating children infected with human immunodeficiency virus…
- Trial name
- NCT00001818
- Testing
- Hydroxyurea
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Cancer Institute (NCI)
Infertility, Ovarian Stimulation
AI-TOP Study Artificial Intelligence for Trigger Optimization.
To evaluate, in a randomized controlled trial, whether AI-guided monitoring and ovulation triggering leads to clinical outcomes comparable to those achieved through physician-led decision-making in patients undergoing ovarian…
- Conditions
- Infertility, Ovarian Stimulation, Artificial Intelligence
- Trial name
- AI-TOP (NCT07515118)
- Testing
- STIMAI®., Routine clinical management
- Where
- 5 sites in Spain
- Volunteers
- 644 people
- Sponsor
- Fundacion Dexeus
Urinary Incontinence, Stress Urinary Incontinence
Lessening Incontinence by Learning Yoga
The purpose of this study is to assess the feasibility of recruiting women with urinary incontinence into a randomized controlled trial of a yoga therapy program.
- Conditions
- Urinary Incontinence, Stress Urinary Incontinence, Urge Urinary Incontinence, Over Active Bladder
- Trial name
- LILY (NCT01672190)
- Testing
- Yoga Therapy Program
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Gastric Cancer, Bladder Cancer
Safety, Tolerability and Pharmacokinetics of Oral CPL304110, in Adult Subjects With Advanced Solid Malignancies
The purpose of the study is to determine to evaluate safety and tolerability of CPL304110 when administered once daily to adults with advanced solid malignancies.
- Conditions
- Gastric Cancer, Bladder Cancer, Squamous Non-small Cell Lung Cancer, Cholangiocarcinoma
- Trial name
- NCT04149691
- Testing
- CPL304110
- Where
- 7 sites in Poland
- Volunteers
- 37 people
- Sponsor
- Celon Pharma SA
Kidney Cancer Stage Iv, Advanced Melanoma
Tolerability and Pharmacokinetics of Toripalimab in Combination With Axitinib in Patients With Kidney Cancer and Melanoma
This is a phase Ib, open, mono-center, dose-escalation, tolerability and pharmacokinetic study evaluating the Recombinant Humanized Anti-PD-1 mAb for Injection in combination with Axitinib in patients with advanced kidney cancer…
- Trial name
- NCT03086174
- Testing
- humanized anti-PD-1 monoclonal antibody Toripalimab
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Shanghai Junshi Bioscience Co., Ltd.
Sexually Transmitted Diseases
Madagascar Female Condom Study
The study was designed to measure the effects of male and female condom promotion on STI prevalence and reported condom use by sex workers and their partners.
- Trial name
- NCT00272974
- Testing
- Clinic-based counseling
- Where
- 2 sites in Madagascar
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- FHI 360
Preterm, Preterm Birth
The Effect of Rocking Bed on Preterm Newborns
The study was planned to determine the effect of rocking bed applied to preterm newborns on comfort, physiological parameters and cerebral oxygenase level (rSO2).
- Conditions
- Preterm, Preterm Birth, Nurse's Role
- Trial name
- NCT05978674
- Testing
- rocking bed group
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Prostate Cancer, Lymph Node Metastases
Use of Indocyanine Green During Pelvic Lymph Node Dissection in Prostate Cancer.
Standard treatment of local or locally advanced prostate cancer is radical prostatectomy (RRP) surgery. During RRP in certain patients extended lymph node dissection (ELND) is recommended.
- Trial name
- NCT04882618
- Testing
- Indocyanine green
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Sexually Transmitted Diseases, Bacterial, HIV Infections
Evaluation of Presumptive Periodic Treatment (PPT) of Sexually Transmitted Infections (STIs)
Sexually transmitted infections (STI) are important causes of reproductive health morbidity and mortality, and have long been implicated as major co-factors in the sexual transmission of HIV.
- Trial name
- PPT (NCT04036318)
- Where
- 2 sites in Tanzania
- Volunteers
- 3,022 people
- Sponsor
- National Institute for Medical Research, Tanzania
Kidney Neoplasms
Axitinib (AG-013736) For the Treatment of Metastatic Renal Cell Cancer
The study is designed to demonstrate that axitinib (AG-013736) is superior to sorafenib in delaying tumor progression in patients with metastatic renal cell cancer.
- Trial name
- NCT00920816
- Testing
- Axitinib (AG-013736), Sorafenib
- Where
- 125 sites in United States, Bosnia and Herzegovina and 12 more
- Volunteers
- 492 people
- Sponsor
- Pfizer
Endometriosis
Acupuncture for Pain of Endometriosis
This proposed trial is a multicenter,randomized and controlled clinical trial. The aim of this trial is to evaluate the efficacy and safety of acupuncture for treating pain of Endometriosis.The trial period will consist of three…
- Trial name
- NCT03125304
- Testing
- acupuncture
- Where
- China
- Volunteers
- 106 people
- Sponsor
- State Administration of Traditional Chinese Medicine of the People's Republic of China
HIV, Hepatitis C
Injecting Drug Use Community Intervention Trial
The purpose of this study is to reduce the HIV/HCV incidence among the clients attending community-based methadone maintenance treatment (MMT) , and to prevent the secondary sexual transmission from HIV+ clients to their spouse…
- Conditions
- HIV, Hepatitis C, Syphilis, HSV-2
- Trial name
- NCT01108614
- Testing
- Intervention
- Where
- 5 sites in China
- Volunteers
- 12,000 people
- Sponsor
- National Center for AIDS/STD Control and Prevention, China CDC
Ovarian Cancer
A Study of ZL-2306 (Niraparib) as Maintenance Treatment Following First-line Chemotherapy in Patients With Advanced Ovarian Cancer
Niraparib is a PARP inhibitor. This is a 2:1 randomized, double-blind, placebo-controlled study conducted in patients with advanced (FIGO Stage III or IV) ovarian cancer to evaluate Efficacy and Safety of ZL-2306 (Niraparib) for…
- Trial name
- NCT03709316
- Testing
- ZL-2306 (Nirapairb)
- Where
- 31 sites in China
- Volunteers
- 384 people
- Sponsor
- Zai Lab (Shanghai) Co., Ltd.
Acute Kidney Injury
Chloride Transfer During Continuous Renal Replacement Therapy in the Intensive Care Unit: a Prospective Observational Cohort Study
Acute kidney injury (AKI) is a frequently encountered complication in the intensive care unit (ICU), affecting on average 25 to 35% of patients. It is associated with an increased mortality, proportional to AKI severity.
- Trial name
- CLODICUS (NCT04755491)
- Testing
- Continuous veno-venous hemofiltration, Continuous veno-venous hemodialysis, Continuous veno-venous hemodiafiltration
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Hospices Civils de Lyon
Breast Cancer, Cervical Cancer
Community Clinic Model to Improve Early Detection of Breast and Cervical Cancers in Kenya
Kenya has a high incidence of breast and cervical cancers, and most women are diagnosed with late-stage disease. The investigators will conduct a study to assess the effectiveness and cost-effectiveness of strategies to increase…
- Trial name
- C3Link (NCT06572774)
- Testing
- C3Link Strategies
- Where
- Kenya
- Volunteers
- 5,400 people, healthy volunteers welcome
- Sponsor
- Implenomics
Genetic Disease, Genetic Syndrome
Ensuring Patients' Informed Access to Noninvasive Prenatal Testing
Noninvasive prenatal genetic testing (NIPT) is an important new screening test option provided to pregnant women in the first trimester of pregnancy.
- Conditions
- Genetic Disease, Genetic Syndrome, Prenatal Disorder, Prenatal Maternal Abnormality
- Trial name
- NEST (NCT03420274)
- Testing
- NEST, Usual care
- Where
- 2 sites in United States
- Volunteers
- 691 people
- Sponsor
- The Cleveland Clinic
HIV Infections
Large Scale Transition to a Dolutegravir-based First-line ART in the South: Virological Response and Impact on HIV Drug Resistance in a Real Life Context (DoReaL Study)
Main objective The main objective of the study is to assess the virological efficacy of a Dolutegravir-based first-line ART in use under real-life conditions in national programs in resource-limited settings in patients infected…
- Trial name
- NCT05312918
- Where
- 3 sites in Côte d’Ivoire, Mali and 1 more
- Volunteers
- 487 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Non-Muscle-Invasive Bladder Cancer (NMIBC)
A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of SIM0237 Alone or in Combination with BCG in NMIBC
This is an open-label, multicenter phase 1 study to evaluate the safety, efficacy, and pharmacokinetics (PK) characteristics of SIM0237 alone or in combination with bacillus Calmette-Guerin (BCG) in participants with…
- Trial name
- NCT06186414
- Testing
- SIM0237, SIM0237 and BCG
- Where
- 14 sites in China
- Volunteers
- 152 people
- Sponsor
- Jiangsu Simcere Pharmaceutical Co., Ltd.
Meningitis, Cryptococcal, HIV Infections
A Study of Fluconazole in the Treatment of Cryptococcal Meningitis in Patients Who Have Not Had Success With Amphotericin B
To evaluate the safety and effectiveness of fluconazole as treatment for acute cryptococcal meningitis in patients who have had an unsatisfactory response to or have experienced unacceptable toxicity with amphotericin B.
- Trial name
- NCT00002306
- Testing
- Fluconazole
- Where
- 14 sites in United States
- Sponsor
- Pfizer
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