Clinical trials: Urogenital
High Risk Pregnancy, Arterial Stiffness
Early Prediction of Preeclampsia Using arteriaL Stiffness in High-risk prEgnancies
Despite advances in obstetric care, preeclampsia (PE) remains the leading cause of maternal death and disability in both developed and developing countries, contributing to over 70,000 maternal and 500,000 fetal deaths annually…
- Conditions
- High Risk Pregnancy, Arterial Stiffness, Pre-Eclampsia
- Trial name
- PULSE (NCT04783597)
- Testing
- Arterial Stiffness and Wave Reflection
- Where
- Canada
- Volunteers
- 2,400 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Kidney Calculi, Nephrolithotomy, Percutaneous
Bilateral Synchronous Simultaneous Stone Surgery
Advancements in technology and endourological armamentarium provides multiple surgical options for complicated stone patients. To avoid multiple operations and shorten the total operation durations, bilateral synchronous…
- Conditions
- Kidney Calculi, Nephrolithotomy, Percutaneous, Ureteroscopy
- Trial name
- NCT03599297
- Testing
- Bilateral synchronous simultaneous stone surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Marmara University
Prostatic Neoplasms
Phase I/II Dose Escalation Study of VELCADE® and Docetaxel in Patients With Advanced Androgen-Independent Prostate Cancer
The purpose of this study is to evaluate how safe PS-341(VELCADE) is when given with Docetaxel (Taxotere) to patients with androgen-independent prostate cancer, and also to see what effects (good and bad) it has on you and on…
- Trial name
- NCT00064610
- Testing
- VELCADE TM (bortezomib) for Injection
- Where
- 4 sites in United States
- Volunteers
- 102 people
- Sponsor
- Millennium Pharmaceuticals, Inc.
Prostate Cancer
Apalutamide With Radiotherapy and Androgen Deprivation Therapy in Prostate Cancer
The main objective of the trial to determine if the combination of apalutamide with 6 months of androgen deprivation therapy by LHRH agonists in patients with intermediate and limited high-risk, localized prostate cancer…
- Trial name
- ARN-509 (NCT03488810)
- Testing
- Radiation Therapy, Apalutamide, Luteinising Hormone Releasing Hormone analog agonist (LHRHa)
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Cancer
Randomized Discontinuation Study of Lapatinib Versus Placebo in Subjects With Documented Tumor Progression After Chemotherapy, or Where no Approved Therapy Exists
This study will examine the efficacy and safety of lapatinib in patients with ErbB2 positive ovarian, gastric/esophageal adenocarcinoma, uterine serous papillary, or bladder cancers.
- Trial name
- NCT00447226
- Where
- 20 sites in United States
- Volunteers
- 32 people
- Sponsor
- GlaxoSmithKline
Premature Birth, Obstetric Labor, Premature
Family Nurture Intervention in the NICU at The Valley Hospital
The purpose of this study is to compare neurodevelopment and activity in infants born preterm (25 to 34 1/7 weeks gestational age (GA)) receiving Standard Care (SC) or Family Nurture Intervention (FNI) in the neonatal intensive…
- Trial name
- NCT03267043
- Testing
- Family Nurture Intervention (FNI), Standard Care
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- Columbia University
Pregnant Women, Pregnancies at Increased Risk of Preterm Birth
Comparison in Cervical Length and Prolongation of Gestation Age on Vaginal Progesterone Administration to Pregnant Women After the Acute Phase of Threatened Preterm Birth
This randomised clinical trial aims to investigate the effect of daily vaginal progesterone supplementation on pregnancy prolongation and cervical length changes following arrested preterm labor in singleton pregnancies.
- Trial name
- NCT06975943
- Testing
- Progesterone 200 mg vaginal capsules
- Where
- Indonesia
- Volunteers
- 48 people
- Sponsor
- Dr. Soetomo General Hospital
Peritoneal Dialysis, Hemodialysis, Home
Experiences and Health-related Quality of Life of Informal Caregivers of Dialysis Patients
The goal of this prospective, observational, multicentre cohort study is to assess the trajectory of the experiences (both positive and negative) and health-related quality of life (HRQOL) of informal caregivers of patients who…
- Conditions
- Peritoneal Dialysis, Hemodialysis, Home, Hemodialysis, Quality of Life
- Trial name
- NCT05646615
- Where
- 33 sites in Belgium, Netherlands
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- B.C. van Jaarsveld
Prostate Cancer
Effect of Ramosetron on Heart Rate-corrected QT Interval During Robot-assisted Laparoscopic Prostatectomy With Steep Trendelenburg Position
Intraperitoneal insufflation of carbon dioxide may affect the sympathetic activity that leads to changes in ventricular re-polarization. This in turn can result in changes of heart rate-corrected QT (QTc) interval.
- Trial name
- NCT03232125
- Testing
- Ramosetron, Normal saline
- Where
- South Korea
- Volunteers
- 54 people
- Sponsor
- Yonsei University
Prostate Cancer
VMAT for Dominant Intraprostatic Lesion
The aim of this study was to determine the efficacy and safety of the implementation of a program of " image-guided focal Intensification dose to intraprostatic dominant lesion " in men with localized prostate cancer (PCa) of…
- Trial name
- CaP-VMAT-DIL (NCT03030625)
- Testing
- IGRT/VMAT focal therapy boost to DIL
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Fundación de Investigación Biomédica - Hospital Universitario de La Princesa
Pre-Eclampsia
CA-125 and Severity of Pre-Eclampsia
The Aim of this study is to determine the relationship between serum concentrations of cancer antigen-125 (CA-125) and pre-eclampsia severity.
- Trial name
- NCT02704676
- Testing
- marker(CA-125)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
Polycystic Ovary Syndrome (PCOS), Menstrual Symptoms
Mindfulness-Based Education For Women With Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS), also known as polyendocrine metabolic ovarian syndrome (PMOS), is the most common endocrinologic disorder to affect women. Despite this, the disease's pathophysiology remains unclear.
- Conditions
- Polycystic Ovary Syndrome (PCOS), Menstrual Symptoms, Stress, Quality of Life
- Trial name
- NCT07718217
- Testing
- Mindfulness-Based Polycystic Ovary Syndrome (PCOS) Education
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Cervical Cancers, Cervical Intraepithelial Neoplasia (CIN)
Quality Control of Colposcopy Application
Colposcopy has become an important link and tool in the prevention and treatment of cervical cancer. The quality and pathological assessment of colposcopy is a key point in follow-up and treatment.The main purpose of this study…
- Trial name
- QCCA (NCT06823817)
- Testing
- colpscope
- Volunteers
- 10,000 people
- Sponsor
- Peking Union Medical College Hospital
Ovary Cancer, Endometrial Cancer
Multimedia Aid for Genetic Testing in Gynecologic Oncology
This pilot study aims to estimate rates of genetic testing in patients with ovarian and endometrial cancer before and after the implementation of educational videos about genetic testing.
- Trial name
- NCT07084168
- Testing
- Educational videos, Survey
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Prostate Cancer
Folate Study in Men With Advanced Prostate Cancer
The researchers hope to learn if Trimethoprim, 150mg taken daily for 3 months, is a safe and effective way to reduce folate levels at time of Androgen Deprivation Therapy (ADT) in men with advanced prostate cancer.
- Trial name
- NCT06536374
- Testing
- Trimethoprim Tablets
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Diego
Bladder Cancer
Celecoxib With Chemotherapy in Localized, Muscle-Invasive Bladder Cancer
The purpose of this study is to compare patient tumor tissue before and after treatment with chemotherapy plus celecoxib. Investigators will look at gene expression, to see what effect celecoxib may have on tumor cells.
- Trial name
- BLAST (NCT02885974)
- Testing
- Celecoxib, Gemcitabine, Cisplatin
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- Baylor College of Medicine
Infertility, Intracytoplasmic Sperm Injection
Health of Children Born From ICSI With AOA (AOA-BABIES)
The investigators follow up on the development of children born from ICSI-AOA using the Developmental Red Flags and Ages \& Stages Third Edition (ASQ-3) Questionnaires to give strong evidence about the safety of AOA in assisted…
- Trial name
- NCT05578118
- Where
- Vietnam
- Volunteers
- 63 people
- Sponsor
- Mỹ Đức Hospital
HIV Infections
Antiretroviral Therapy Intensification With Raltegravir or Addition of Hyper-immune Bovine Colostrum in HIV-1 Infected Patients With Suboptimal CD4+ T Cell Response
A research study to measure the effect on CD4 counts of adding to current anti-retroviral regimen raltegravir with or without hyper-immune bovine colostrum.
- Trial name
- CORAL (NCT00772590)
- Testing
- Raltegravir, Hyper-immune Bovine Colostrum, raltegravir and hyper-immune bovine colostrum
- Volunteers
- 75 people
- Sponsor
- Kirby Institute
Bladder Cancer, Bladder Carcinoma
Chemoradiation for Bladder Preservation After Complete Response to Neoadjuvant Chemotherapy
Bladder preservation in patients with complete response after neoadjuvant chemotherapy will lead to equivalent or superior relapse free rates compared to cystectomy rates from historical controls.
- Conditions
- Bladder Cancer, Bladder Carcinoma, Transition Cell Cancer, Muscle Invasive Bladder Carcinoma
- Trial name
- NCT02145390
- Testing
- Transurethral Resection of the Bladder Tumor & Cystoscopy, Intensity Modulated Radiation Therapy, Expanded Prostate Cancer Index Composite Short Form 12
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Miami
Epilepsy, Diabetic Nephropathy
Study on the Population Pharmacokinetics of Levetiracetam in Epileptic Patients With Diabetic Kidney Disease
The individualized drug delivery system of levetiracetam based on population pharmacokinetics and quantitative pharmacology model in patients with epilepsy complicated by diabetic kidney disease was established.
- Trial name
- NCT05330390
- Testing
- Levetiracetam
- Where
- China
- Volunteers
- 50 people
- Sponsor
- The Second Hospital of Shandong University
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