Clinical trials: Urogenital
Infertility, Female, Obesity
Effect of Lifestyle and/or Metformin Intervention on Pregnancy Outcome, A Pilot Randomized Controlled Trial
The purpose of pilot trial is to compare the efficacy of lifestyle intervention, metformin intervention, lifestyle combined with metformin intervention in improving assisted reproductive technology in non-polycystic ovary…
- Conditions
- Infertility, Female, Obesity, Insulin Resistance
- Trial name
- NCT03898037
- Testing
- weight loss intervention, metformin intervention
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Reproductive & Genetic Hospital of CITIC-Xiangya
Ovarian Cancer
Cabazitaxel in Patients With Recurrent Ovarian Cancer After Failure of Standard Therapy.
Many ovarian cancer patients have been offered different standard cytostatics and gradually develop chemo-resistance. However, a considerable fraction of these patients are still in good general health and have a strong wish for…
- Trial name
- CaTo-ROC (NCT02560337)
- Testing
- Cabazitaxel
- Where
- Denmark
- Volunteers
- 26 people
- Sponsor
- Vejle Hospital
Bladder Cancer
Blue Light Cystoscopy With Cysview® Registry
Registry study to gather more information on the current use of Blue Light Cystoscopy with Cysview (BLCC) in urologists' practices.
- Trial name
- BLCCR (NCT02660645)
- Testing
- Hexaminolevulinate hydrochloride (HCL), Karl Storz D-Light C Photodynamic Diagnostic (PDD) system
- Where
- 23 sites in United States
- Volunteers
- 4,400 people
- Sponsor
- Photocure
Fallopian Tube Cancer, Fallopian Tube Carcinosarcoma
Olaparib and Entinostat in Patients With Recurrent, Platinum-Refractory, Resistant Ovarian, Primary Peritoneal, Fallopian Tube Cancers
This phase I/II trial studies the side effects and best dose of olaparib and entinostat and to see how well they work in treating patients with ovarian, primary peritoneal, or fallopian tube cancers that have come back or do not…
- Conditions
- Fallopian Tube Cancer, Fallopian Tube Carcinosarcoma, Fallopian Tube Clear Cell Adenocarcinoma, Fallopian Tube Endometrioid Adenocarcinoma
- Trial name
- NCT03924245
- Testing
- Entinostat, Olaparib
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Eclampsia
Eclampsia and Posterior Reversible Encephalopathy Syndrome (PRES):
This is a double blinded, placebo-controlled trial to determine if IV dexamethasone more quickly than placebo assists resolution of Posterior Reversible Encephalopathy Syndrome (PRES) encountered in eclamptic patients.
- Trial name
- PRESIDEX (NCT02027272)
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Mississippi Medical Center
Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)
Ipilimumab After Allogeneic Stem Cell Transplant in Treating Patients With Persistent or Progressive Cancer
This phase I trial is studying how well ipilimumab works after allogeneic stem cell transplant in treating patients with persistent or progressive cancer.
- Conditions
- Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Inv(16)(p13;q22), Adult Acute Myeloid Leukemia With t(15;17)(q22;q12), Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)
- Trial name
- NCT00060372
- Testing
- ipilimumab, therapeutic allogeneic lymphocytes
- Where
- 5 sites in United States
- Volunteers
- 21 people
- Sponsor
- National Cancer Institute (NCI)
Advanced Solid Tumors
A Study of the Effects of ALKS 4230 (Nemvaleukin Alfa) on Subjects With Solid Tumors
To better understand the safety and tolerability of ALKS 4230 in humans
- Trial name
- NCT02799095
- Testing
- ALKS 4230, ALKS 4230 + pembrolizumab
- Where
- 31 sites in United States, Australia and 5 more
- Volunteers
- 243 people
- Sponsor
- Mural Oncology, Inc
Chronic Kidney Disease
Rifaximin Therapy in Chronic Kidney Disease
The purpose of this study is to determine if Rifaximin decreases serum and urine levels of bacterial byproducts and inflammatory markers in patients with chronic kidney disease and to evaluate changes in the bacterial content of…
- Trial name
- NCT02342639
- Testing
- Rifaximin
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Jason Stubbs, MD
Preeclampsia, Gestational Hypertension
Evaluation of sFlt-1/PlGF Ratio ,OPG and sEng as Predictive Biomarkers in the Diagnosis and Treatment Evaluation of Preeclampsia
his study investigates the effectiveness of three specific biological markers (biomarkers) in the blood-the sFlt-1/PlGF ratio, soluble endoglin (sEng), and osteoprotegerin (OPG)-to better diagnose and monitor preeclampsia.
- Conditions
- Preeclampsia, Gestational Hypertension, Hypertensive Disorders of Pregnancy
- Trial name
- PE-POSS (NCT07349277)
- Where
- Iraq
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ammar Jassim Abed
Erectile Dysfunction
Low Intensity Extracorporeal Shock Wave Therapy for the Treatment of Erectile Dysfunction- 4 Arms
Low intensity shock waves(LISW) have been proven in animal studies to induce local growth of new blood vessels. The investigators hypothesized that LISW therapy could improve the symptoms of patients with erectile dysfunction…
- Trial name
- NCT01442077
- Testing
- Extracorporeal Shockwave Therapy Generator (Omnispec ED1000)
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Rambam Health Care Campus
Brain Cancer, Lung Cancer (Diagnosis)
Head-to-Head Evaluation of the Cancer Ontology Supervised Multimodal Orchestration (COSMO) AI System Versus Pathologist-Only Review
This study evaluates the diagnostic performance of the Cancer Ontology Supervised Multimodal Orchestration (COSMO) AI system for cancer subtype classification and compares it head-to-head with pathologist-only review.
- Conditions
- Brain Cancer, Lung Cancer (Diagnosis), Renal Cancer
- Trial name
- COSMO (NCT07307157)
- Testing
- Digital Pathology Evaluation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Harvard Medical School (HMS and HSDM)
Vulvodynia
A Trial of Gabapentin in Vulvodynia: Biological Correlates of Response
The Specific aims of this project are to (1) test the prediction that pain from tampon insertion (primary outcome measure) is lower in PVD patients when treated with gabapentin compared to when treated with placebo.
- Trial name
- NCT01301001
- Testing
- Gabapentin
- Where
- 3 sites in United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- University of Tennessee
Bacterial Vaginosis
Recurrent Bacterial Vaginosis and Vaginal Acidifying Gel Trial
Bacterial vaginosis (BV) is a common, complex clinical syndrome characterized by alterations in the normal vaginal flora. Bacterial vaginosis has been associated with a variety of adverse health outcomes including endometritis…
- Trial name
- NCT00545181
- Testing
- Vaginal acidifying gel (RepHresh), Metronidazole control
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Indiana University
Systemic Lupus Erythematosus (SLE), Lupus Nephritis (LN)
A Phase IIa Study of ICG318 CAR-T in Refractory Systemic Lupus Erythematosus With or Without Lupus Nephritis
This Phase IIa, open-label, single-arm study includes an initial Safety Run-In followed by dose expansion to evaluate the safety, tolerability, cellular kinetics, pharmacodynamics, and preliminary clinical activity of a single…
- Trial name
- NCT07328581
- Testing
- ICG318, BCMA-CD19-IL-15/IL-15 sushi Compound CAR T following lymphodepletion
- Where
- 4 sites in United States
- Volunteers
- 20 people
- Sponsor
- iCell Gene Therapeutics
Kidney Diseases, Kidney Transplant Failure and Rejection
The Microbiota in Kidney Donation and Transplantation
The human gastrointestinal tract harbours ~40 trillion microbial cells, far outnumbering the cell number, and therefore the genetic content of its host.
- Conditions
- Kidney Diseases, Kidney Transplant Failure and Rejection, Urinary Tract Infections
- Trial name
- NCT04388930
- Testing
- Pre-operative assessment - blood, urine, & faecal sample, Post-operative day 3 assessment - blood, urine, & faecal sample, Post-operative week 4-6 assessment - blood, urine, & faecal sample
- Where
- United Kingdom
- Volunteers
- 130 people
- Sponsor
- Royal Free Hospital NHS Foundation Trust
Postpartum Hemorrhage
Rectal Misoprostol for Reducing Blood Loss in Elective Cesarean Section
This randomized controlled trial aims to evaluate the efficacy of adding preoperative rectal misoprostol to standard oxytocin for reducing intraoperative and postoperative blood loss in women undergoing elective cesarean section.
- Trial name
- NCT07188207
- Testing
- Oxytocin
- Volunteers
- 282 people
- Sponsor
- Assiut University
Pre-Eclampsia
Placental Volume, Flow, and Vascularity Study
The purpose of this preliminary study is to implement an automated and standardized computer-based method that accurately measures placental volume, blood flow, and vascularity.
- Trial name
- NCT04900207
- Where
- United States
- Volunteers
- 440 people
- Sponsor
- University of Minnesota
Cervical Adenocarcinoma, Cervical Adenosquamous Carcinoma
MRI and PET Imaging in Predicting Treatment Response in Patients With Stage IB-IVA Cervical Cancer
This trial studies magnetic resonance imaging (MRI) and positron emission tomography (PET) imaging in predictive treatment response in patients with stage IB-IVA cervical cancer.
- Conditions
- Cervical Adenocarcinoma, Cervical Adenosquamous Carcinoma, Cervical Squamous Cell Carcinoma, Not Otherwise Specified, Cervical Undifferentiated Carcinoma
- Trial name
- NCT01992861
- Testing
- Computed Tomography, Diffusion Weighted Imaging, Dynamic Contrast-Enhanced Magnetic Resonance Imaging
- Where
- 6 sites in United States, Canada and 1 more
- Volunteers
- 51 people
- Sponsor
- University of Washington
Atypical Hemolytic Uremic Syndrome
aHUS Observational Long Term Follow-Up
There is growing but limited information on the long term clinical status of aHUS patients who have previously received or are continuing to receive treatment with eculizumab.
- Trial name
- LTFU (NCT01522170)
- Where
- 56 sites in United States, Australia and 10 more
- Volunteers
- 94 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Infertility
Efficacy of Urinary Follicle-Stimulating Hormone (FSH) Among Poor Responders
We proposed to compare outcomes in women with DOR undergoing ART with rec-FSH + u-HMH with those with u-FSH only in GnRH antagonist protocols.
- Trial name
- NCT00677573
- Testing
- Fostimon
- Where
- Turkey (Türkiye)
- Volunteers
- healthy volunteers welcome
- Sponsor
- German Hospital, Istanbul
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