Clinical trials: Urogenital Pathology
Vaginal Bleeding
Tamoxifen Versus Estradiol for Unscheduled Bleeding in Etonogestrel Implant Users, a Randomized Pilot Trial
The purpose of this research study is to evaluate the ability of medicines called tamoxifen or estradiol to prevent annoying vaginal bleeding for arm implant users.
- Trial name
- NCT04933240
- Testing
- Tamoxifen Citrate 10Mg Tab, Estradiol
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Meconium Aspiration Syndrome, Infant, Newborn, Disease
Time of Positive Pressure Ventilation in Non-vigorous Infants Born Through Meconium-stained Amniotic Fluid
Background: Meconium stained amniotic fluid (MSAF) complicates 3 to 14% of pregnancies, causing meconium aspiration syndrome (MAS) in 5-10% of neonates born.
- Conditions
- Meconium Aspiration Syndrome, Infant, Newborn, Disease, Neonatal Resuscitation
- Trial name
- MASTIME (NCT04076189)
- Testing
- Endotracheal suctioning, No endotracheal suctioning
- Where
- 2 sites in Italy
- Volunteers
- 40 people
- Sponsor
- University Hospital Padova
Sexual Assault and Rape, Sexually Transmitted Diseases
Prevalence of Sexually Transmitted Infections Among People Attending the Sexual Assault Centre in Oslo, Norway.
In this study the investigators seek to register the prevalence of sexually transmitted infections (STI) among people attending the Sexual Assault Centre in Oslo, Norway.
- Trial name
- NCT03132389
- Testing
- No intervention
- Where
- Norway
- Volunteers
- 640 people
- Sponsor
- University of Oslo
Chronic Kidney Disease, Anemia
Conversion Study From Epoetin Alfa to Monthly Peginesatide Injection in Patients With Chronic Kidney Disease on Dialysis
The purpose of this study is to understand the effects of a dialysis center switching its dialysis patients from using Epoetin alfa to peginesatide injection on hemoglobin levels and other parameters.
- Trial name
- DIAMOND (NCT01478971)
- Testing
- Epoetin, Peginesatide
- Where
- 5 sites in United States
- Volunteers
- 184 people
- Sponsor
- Takeda
Endothelial Function, Lipids
Effects of Etravirine on Endothelial Function in HIV-uninfected Adults: A Pilot Study
The purpose of this study is to determine the safety and effects of etravirine, an HIV antiretroviral medication, on vascular function.
- Conditions
- Endothelial Function, Lipids, Insulin Resistance, Inflammation
- Trial name
- NCT00871234
- Testing
- Etravirine
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Indiana University
Prostate Cancer, Prostate Cancer (Diagnosis)
Assessing a Digital Exercise Intervention for Health Outcomes and Engagement in Regular Exercise
Patients diagnosed with prostate cancer and receiving hormone therapy in conjunction with radiotherapy are likely to suffer from adverse effects caused by ADT treatment either short term or long term.
- Trial name
- ADHERE (NCT07243834)
- Testing
- Participation in a digital exercise intervention with virtual supervised group exercise sessions
- Where
- United Kingdom
- Volunteers
- 160 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Renal Insufficiency
Dalteparin's Influence on Renally Compromised: Anti-Ten-A Study (DIRECT)
The investigators' primary research objective is: To determine the safety of dalteparin prophylaxis, 5,000 IU once-daily, in Intensive Care Unit (ICU) patients based on: the proportion of patients with trough anti-Xa > 0.40 IU/mL…
- Trial name
- NCT00138099
- Testing
- Fragmin (dalteparin sodium)
- Where
- 14 sites in Canada
- Volunteers
- 140 people
- Sponsor
- Hamilton Health Sciences Corporation
Lower Urinary Tract Symptoms
A Pilot Study to Assess Effects of Self-Administered Nitrous Oxide (SANO) on Urodynamic Study (UDS) Parameters
A urodynamic study (UDS) is a common procedure done to learn more about the cause of urinary symptoms. For some patients, UDS can be associated with anxiety or discomfort.
- Trial name
- NCT05883332
- Testing
- Self-Administered Nitrous Oxide, Oxygen
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Acquired Immunodeficiency Syndrome, Healthy Volunteers
Effects of Crofelemer on the Gut Microbiome in Healthy Volunteers and in HIV+ Patients With Non-Infectious Diarrhea
This study is intended to evaluate: 1. Any changes in the gut microbiome from baseline compared to end of study in both healthy (HIV-negative) subjects and HIV+ patients with or without chronic diarrhea, following one month of…
- Conditions
- Acquired Immunodeficiency Syndrome, Healthy Volunteers, HIV/AIDS, HIV Diarrhea
- Trial name
- NCT04192487
- Testing
- Crofelemer delayed-release tablets 125mg
- Where
- 3 sites in United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Napo Pharmaceuticals, Inc.
Liver Cirrhosis, Renal Failure
Rifaximin Versus Lactulose in Renal Failure
The purpose of this study is to evaluate patients with cirrhosis of the liver and renal failure and determine if the administration of rifaximin as compared to lactulose is associated with less frequent and/or slower progression…
- Trial name
- NCT00748904
- Testing
- Rifaximin, Lactulose
- Where
- United States
- Sponsor
- Weill Medical College of Cornell University
Urinary Incontinence, Diabetes
Urinary Incontinence and Endocrine Factors. A Part of Lolland-Falster Health Study (LOFUS).
Previous studies have shown an increase in the prevalence of urgency and urgency incontinence in women with diabetes. Regarding the condition urinary stress incontinence, the literature is diverted.
- Conditions
- Urinary Incontinence, Diabetes, Thyroid Diseases
- Trial name
- EFUI (NCT04279184)
- Where
- Denmark
- Volunteers
- 6,000 people
- Sponsor
- Nykøbing Falster County Hospital
Fluid Loss, Dehydration
The Application of Sterile Water to the Skin of Extremely Low Birth Weight (ELBW) Infants
Extremely low birth weight infants have significant water loss through their skin immediately after birth. This significant fluid loss is because they have large amounts of fluids, have immature skin and large surface area.
- Conditions
- Fluid Loss, Dehydration, Extreme Immaturity
- Trial name
- NCT02052284
- Testing
- Sterile water application
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- George Washington University
HIV Infection, Opioid-use Disorder
Effect of Heroin Use on Immune Activation and Cardiovascular Risk in HIV
Despite the advent of safer HIV therapies, high levels of markers of systemic inflammation and increased cardiovascular risk threaten the well-being of individuals living with HIV and present a significant challenge for HIV…
- Conditions
- HIV Infection, Opioid-use Disorder, Cardiovascular Diseases
- Trial name
- NCT03976258
- Testing
- buprenorphine/naloxone, Methadone, Naltrexone Injection
- Where
- 2 sites in United States
- Volunteers
- 190 people
- Sponsor
- MetroHealth Medical Center
End Stage Renal Disease, Catheter Infection
AUSTrian Randomized Interventional Study on Dialysis Accesses
Patients with diagnosed end stage renal disease and indication for chronic dialysis rely on a well-functioning access for dialysis.
- Conditions
- End Stage Renal Disease, Catheter Infection, Shunt Malfunction
- Trial name
- AUSTRIA (NCT03764358)
- Testing
- Arteriovenous Fistula, Tunneled Cuffed Catheter
- Where
- Austria
- Volunteers
- 220 people
- Sponsor
- Medical University of Vienna
Secondary Hyperparathyroidism
Observational Program of Zemplar in Patients With End Stage Chronic Kidney Disease and Parathyroid Disorder on Hemodialysis in the Russian Federation
Eighty-six eligible participants with secondary hyperparathyroidism will be enrolled at thirteen sites in Russia. Planned therapy will be six months.
- Trial name
- NCT01401478
- Where
- 13 sites in Russia
- Volunteers
- 86 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Precancerous Lesions, Conization
A Cohort Study for the Following up of Conization
This study is to investigate the oncologic and obstetric outcomes in patients with conization for uterine cervical lesions from January 1, 2000 to January 1, 2019 in Peking Union Medical College Hospital.
- Conditions
- Precancerous Lesions, Conization, High Grade Intraepithelial Neoplasia, Uterine Cervical Cancer
- Trial name
- NCT03961178
- Testing
- High-risk HPV, TCT
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Lei Li
Gonorrhea, Chlamydia
Pay-it-forward Gonorrhea and Chlamydia Testing Among Men in China
PIONEER is a three-arm, programmatic cluster randomized controlled trial (RCT) to compare effectiveness of three implementation strategies, followed by a mixed-methods implementation evaluation study
- Trial name
- NCT05723263
- Testing
- Standard Pay-it-forward, Community Engaged Pay-it-forward, Control arm
- Where
- China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Renal Cell Carcinoma
Stereotactic Body Radiotherapy (SBRT) and Sorafenib in Patients With Metastatic, Recurrent, or Unresectable Renal Cell Cancer (RCC)
The purpose of this study is to determine the safety and efficacy of combined stereotactic body radiotherapy (SBRT) + sorafenib in the treatment of patients with Stage IV renal cell carcinoma (RCC) who have recurred locally…
- Trial name
- NCT00672178
- Testing
- Stereotactic body radiation
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Duke University
Malnutrition, Cancer
Impact of a New Plant-based High-energy Oral Nutritional Supplement on Nutritional Outcomes in Malnourished Patients
This study aims to compare nutritional outcomes in terms of percentage of weight gain between a new planted-based high-energy ONS and a standard high-energy ONS with animal protein (cow's mil protein) in patients at malnutrition…
- Conditions
- Malnutrition, Cancer, Inflammatory Bowel Diseases, Chronic Obstructive Pulmonary Disease (COPD)
- Trial name
- NCT06055543
- Testing
- Fortimel
- Where
- 6 sites in Spain
- Volunteers
- 140 people
- Sponsor
- Danone Specialized Nutrition
Prostate Cancer, Castration Resistant Prostate Cancer
Study of Cabozantinib (XL184) Versus Mitoxantrone Plus Prednisone in Men With Previously Treated Symptomatic Castration-resistant Prostate Cancer
Bone metastases and associated pain are a major cause of morbidity and mortality in castration-resistant prostate cancer (CRPC).
- Conditions
- Prostate Cancer, Castration Resistant Prostate Cancer, Pain, Prostatic Neoplasms
- Trial name
- COMET-2 (NCT01522443)
- Testing
- cabozantinib, mitoxantrone, prednisone
- Where
- 82 sites in United States, Australia and 3 more
- Volunteers
- 119 people
- Sponsor
- Exelixis
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