Clinical trials: Urogenital Pathology
Infections, Papillomavirus
Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Human Papillomavirus Vaccine (Cervarix™) When Co-administered With GSK Biologicals' Hepatitis A Vaccine (Havrix®) in Healthy Female Adolescents Aged 9-14 Years
The purpose of this study is to evaluate the immunogenicity and safety of two doses of GSK Biologicals' HPV-16/18 L1 VLP AS04 vaccine when co-administered with GSK Biologicals' HAV vaccine according to 0, 6 month schedule…
- Trial name
- NCT02082639
- Testing
- Cervarix™, Havrix
- Volunteers
- healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Chronic Kidney Disease, Diabetes
Effects of Febuxostat on Adipokines and Kidney Disease in Diabetic Chronic Kidney Disease
Hyperuricemia is emerging as a risk factor for development of diabetes and metabolic syndrome. Recently, it was shown in in-vitro cell culture experiments that hyperuricemia induces redox-dependent signaling and oxidative stress…
- Trial name
- NCT01350388
- Testing
- Febuxostat
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Utah
Chronic Kidney Disease, Hyperphosphatemia
An Open Label Dose Titration of Sevelamer Carbonate Tabs 3 Times a Day in Hyperphosphatemic CKD Patients Not On Dialysis
Approximately 45 hyperphosphatemic CKD patients not on dialysis will be entered into this study at approximately 20 sites within Europe and 5-10 in Australia.
- Trial name
- NCT00681941
- Testing
- Sevelamer carbonate (Renvela®)
- Where
- 25 sites in Australia, Denmark and 3 more
- Volunteers
- 49 people
- Sponsor
- Genzyme, a Sanofi Company
Prostate Cancer
Influence of EMT on CTCs and Disease Progression in Prostate Cancer
The presence of circulating tumor cells (CTCs) in the blood of prostate cancer patients has been shown to be an important indicator of metastatic disease and poor prognosis.
- Trial name
- NCT04021394
- Testing
- CellSearch CTC platform, Parsortix CTC platform
- Where
- Canada
- Volunteers
- 31 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Urinary Incontinence (UI)
Comparison of Home Versus Clinic Kegel Rehabilitation in Women With Urinary Incontinence in the Tabuk Region
Urinary incontinence is a common condition among women that significantly affects physical health, emotional well-being, social participation, and overall quality of life.
- Trial name
- Incontinence (NCT07795931)
- Testing
- Home -Based Kegel Trainer Exercises (Kegel Trainer Application) will be used by the participants at home for training the pelvic floor muscles over 9 levels., Clinic-Based Rehabilitation Program will consist of physiotherapist supervised pelvic floor strengthening exercises for the participant , 2 times per week for 3 months
- Where
- Saudi Arabia
- Volunteers
- 100 people
- Sponsor
- University of Tabuk
Kidney Calculi
FloSeal Tubeless Exit Versus Cope Loop Nephrostomy Versus Fascial Stitch Following Percutaneous Nephrolithotripsy
The patient will be asked to participate in a research project designed to determine the best way to prevent bleeding and promote patient comfort after having kidney stones removed.
- Trial name
- NCT00360477
- Testing
- Floseal, Cope Loop, Fascial Stitch
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- University of California, Irvine
Bladder Cancer, LUTS
Protoves M1® Syrup in Controlling Adverse Event During HIVEC® Instillations
100 patients with bladder cancer whose underwent Hyperthermic Intravesical Chemotherapy (HIVEC®) will be randomized in two groups (Group A: PROTOVES M1 SYRUP, Group B: NO TREATMENT).
- Conditions
- Bladder Cancer, LUTS, Pain
- Trial name
- NCT04148677
- Testing
- Protoves M1®
- Volunteers
- 100 people
- Sponsor
- Cardarelli Hospital
Kidney Stone, Normal Controls
Oxalate and Citrate
This is a single-center study that aims to earn more about how two different compounds found in food, oxalate and citrate, may affect a person's chances of forming kidney stones.
- Trial name
- NCT05334979
- Testing
- Kidney stones Normal controls Consuming a special drink (sodium oxalate) during an all day visit to the University of Chicago research clinic
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Renal Cell Cancer
Percutaneous Tumor Ablation Vs Partial Nephrectomy for Small Renal Mass: the Impact of Histologic Variant and Tumor Size
The aim, of this study is to investigate recurrence rates in patients with T1 renal cell carcinoma (RCC) undergone partial nephrectomy (PN), radiofrequency ablation (RFA) or cryoablation (Cryo).
- Trial name
- CRYO-BO-2021 (NCT06829888)
- Volunteers
- 955 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Preeclampsia, Hypertension
Effects of Nitrate-rich Beetroot Juice in Pregnant Women With High Blood Pressure
BACKGROUND: Preeclampsia (PE) is a serious syndrome that affects 3-7% of all pregnant women. PE is characterized by hypertension and kidney problems after the 20th week of pregnancy and is associated with an increased risk of…
- Conditions
- Preeclampsia, Hypertension, Endothelial Dysfunction, Nitric Oxide
- Trial name
- NITBEETPE (NCT05241327)
- Testing
- Beetroot Juice
- Where
- Sweden
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Malignant Digestive System Neoplasm, Metastatic Head and Neck Carcinoma
Thermal Ablation and Spine Stereotactic Radiosurgery in Treating Patients With Spine Metastases at Risk for Compressing the Spinal Cord
This phase II clinical trial studies how well thermal ablation and spine stereotactic radiosurgery work in treating patients with cancer that has spread to the spine (spine metastases) and is at risk for compressing the spinal…
- Conditions
- Malignant Digestive System Neoplasm, Metastatic Head and Neck Carcinoma, Metastatic Kidney Carcinoma, Metastatic Malignant Neoplasm in the Spine
- Trial name
- NCT02713269
- Testing
- Computed Tomography, Quality-of-Life Assessment, Questionnaire Administration
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- M.D. Anderson Cancer Center
Infertility Assisted Reproductive Technology, Infertility, Female
The Effect of Stress Ball Used During Intra Uterine Insemination on Pain, Anxiety, Comfort and Physiological Parameters
This study aimed to determine the effects of holding the patient's hand and using a stress ball during the Intrauterine Insemination procedure on pain, anxiety, comfort, and physiological parameters.
- Trial name
- NCT06759337
- Testing
- Stress Ball Group, Hand-Holding Group
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people
- Sponsor
- TC Erciyes University
Chronic Kidney Disease, Chronic Renal Insufficiency
STAAR-1 Clinical Study
To assess the effect of Aranesp on the hemoglobin of CRI subjects who are recombinant human erythropoetin (rHuEPO)-naïve or converting from rHuEPO therapy
- Conditions
- Chronic Kidney Disease, Chronic Renal Insufficiency, Kidney Disease, Pre-dialysis
- Trial name
- NCT00369772
- Testing
- darbepoetin alfa
- Volunteers
- 2,000 people
- Sponsor
- Amgen
Female Genital Fistula, Incontinence
Adverse Outcomes Following Female Genital Fistula Repair
Following genital fistula repair, fistula repair breakdown and recurrence, persistent and incidence incontinence are major adverse outcomes, limiting women's health and wellbeing.
- Trial name
- Mulisa (NCT05437939)
- Where
- Uganda
- Volunteers
- 802 people
- Sponsor
- University of California, San Francisco
Chronic Pain, Hiv
Harmonized Healing: Personalized Music Interventions to Address Chronic Pain in People Living With HIV
The goal of this randomized controlled trial is to understand the feasibility and acceptability of a music-based mobile application to address chronic pain in people with HIV.
- Trial name
- NCT07214077
- Testing
- Harmonized Healing App, Psychoeducation
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Surgical Site Infection, Vaginal Cuff Cellulitis
Prevention of Vaginal Cuff Infection After Hysterectomy by Addition of Vaginal Clindamycin
This study seeks to determine ways to reduce the hospitals surgical site infection rate during hysterectomy operations.
- Conditions
- Surgical Site Infection, Vaginal Cuff Cellulitis, Bacterial Vaginosis
- Trial name
- NCT07888101
- Testing
- Clindamycin Vaginal Gel
- Where
- United States
- Volunteers
- 900 people
- Sponsor
- Baylor Research Institute
Prostate Cancer (Diagnosis)
Investigating the Safety and Diagnostic Performance of 68Ga-NYM032 Injection PET/CT in Men With Newly Diagnosed Prostate Cancer.
The investigators are imaging patients with newly diagnosed prostate cancer using a new Positron Emission Tomography (PET) imaging agent (68Ga-NYM032) in order to evaluate the safety and diagnostic performance.
- Trial name
- NCT07615101
- Testing
- 68-Ga-NYM032
- Where
- 2 sites in China
- Volunteers
- 365 people
- Sponsor
- Norroy Bioscience Co., LTD
Anemia, Chronic Kidney Disease
A Study of the Efficacy and Safety of MK2578 for the Treatment of Anemia in Patients With Kidney Disease (MK2578-003-AM03-EXT12)
This study will evaluate the efficacy and safety of intravenous MK2578, given as maintenance treatment for renal anemia in chronic kidney disease patients on dialysis who were previously receiving erythropoietin stimulating…
- Trial name
- NCT00924781
- Testing
- MK2578 1mcg for every 600 Units (U) of Epogen® (epoetin alfa) received per week at Baseline, MK2578 1 mcg for every 350 U of Epogen (epoetin alfa) received per week at Baseline, MK2578 1 mcg for every 200 U of Epogen (epoetin alfa) received per week at Baseline
- Volunteers
- 39 people
- Sponsor
- Merck Sharp & Dohme LLC
HIV
Effectiveness and Implementation of Text Messaging to Improve HIV Testing in Adolescents
This study will test the effectiveness of a text message-based intervention on human immunodeficiency virus (HIV) testing behaviors among adolescent (13-19 year old).
- Trial name
- NCT06096519
- Testing
- Information, motivation, behavioral skills treatment arm, Information only control arm
- Where
- United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Northwestern University
End-stage Renal Disease
Physical Fitness/Training and Inflammatory Immune Responses in Patients With End-stage Renal Disease
The end-stage renal disease (ESRD) leading two causes of death are cardiovascular diseases and sepsis. Exercise improves low physical fitness, available research concerning its effect on the pro-/anti-inflammatory immune response…
- Trial name
- NCT04949919
- Testing
- aerobic training by a cycle ergometer and Biodex system 4 pro
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- Chang Gung Memorial Hospital
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